Abstracts Archive - Page 2304 of 2425 - ACR Meeting Abstracts

Abstract Number: 1762 • 2012 ACR/ARHP Annual Meeting
IL-6 Receptor Inhibition by Tocilizumab Modulates Double Negative (CD19+IgD-CD27-) B Cells in RA
Zafar Mahmood¹, Khalid Muhammad¹, Petra Roll², Stefan Kleinert³, Thomas Dörner⁴ and Hans Peter Tony⁵, ¹Department of Medicine II, Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Department of Medicine II, Rheumatology/Clinical immunology, University of Würzburg, Würzburg, Germany, ³Rheumatology/Clinical Immunology,, University Hospital Würzburg, Würzburg, Germany, ⁴CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ⁵Rheumatology/Immunology, University of Würzburg, Würzburg, Germany
Background/Purpose: Double negative (CD19+IgD-CD27-) B cells have been reported to be part of human memory B cell compartment. Detailed studies of DN B cells in…
Abstract Number: 1763 • 2012 ACR/ARHP Annual Meeting
The Role of SYK in Human B CELL Activation and Its Relevance to Autoimmune Diseases
Shigeru Iwata¹, Kunihiro Yamaoka¹, Hiroaki Niiro², Kazuhisa Nakano¹, Sheau-Pey Wang¹, Koichi Akashi² and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, ²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Japan
Background/Purpose: B cells play a pivotal role in pathological processes of autoimmune diseases. Spleen tyrosine kinase (Syk) functions as a key molecule in B-cell receptor…
Abstract Number: 1764 • 2012 ACR/ARHP Annual Meeting
B Cells in Early Rheumatoid Arthritis: ZAP-70 More Than SYK Characterize Seropositive Disease
Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Silvia Laura Bosello, Angela Carbonella, Silvia Canestri and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: B cells are involved as central players in the pathogenesis of rheumatoid arthritis (RA). Our aim was to define whether a specific B cell…
Abstract Number: 1765 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated with Signaling Alterations in Naturally Occurring Autoreactive B-Lymphocytes
Taras Lyubchenko¹, Ganna Liubchenko², Holly C. Appleberry², Christopher C. Striebich², Karen E. Franklin², Lezlie A. Derber³ and V. Michael Holers⁴, ¹Medicine, University of Colorado Denver, Aurora, CO, ²University of Colorado Denver, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Alterations in B cell immune tolerance are important in the development of autoimmune rheumatoid arthritis (RA). Recent studies in healthy human subjects have identified…
Abstract Number: 1766 • 2012 ACR/ARHP Annual Meeting
Synovial Gene Expression and Response to Rituximab: Preliminary Data
Yasser El-Sherbiny¹, Sarah Churchman², Frederique Ponchel³, Paul Emery⁴ and Edward M. Vital¹, ¹Section of Musculoskeletal Disease, NIHR Leeds Biomedical Research Unit, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
Background/Purpose: Quality and duration of response to rituximab in rheumatoid arthritis have not been completely explained. In the synovium, three studies have indicated a relationship…
Abstract Number: 1767 • 2012 ACR/ARHP Annual Meeting
Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis
Priscilla Kerkman, Ellen I.H. van der Voort, Leendert A. Trouw, Tom W.J. Huizinga, René E.M. Toes and Hans Ulrich Scherer, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and predict disease onset and severity. Accumulating evidence indicates that ACPA could…
Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting
The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations
Annemiek Willemze, Jing Shi, Marlies Mulder, Gerrie Stoeken-Rijsbergen, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…
Abstract Number: 1769 • 2012 ACR/ARHP Annual Meeting
Affinity Purification and Characterisation of Anti-CCP Antibodies From Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis
Elena Ossipova¹, Catia Cerqueira², Evan Reed², Nastya Kharlamova², Lena Israelsson², Rikard Holmdahl³, Anca Catrina², Vivianne Malmström², Yngve Sommarin⁴, Lars Klareskog², Per Johan Jakobsson² and Karin Lundberg², ¹Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, ⁴Euro-Diagnostica AB, Malmö, Sweden
Background/Purpose: Autoimmunity in rheumatoid arthritis (RA) is characterized by autoantibodies to citrullinated proteins/peptides (ACPA). These antibodies (present in 60-70% of patients) antedate clinical onset and…
Abstract Number: 1770 • 2012 ACR/ARHP Annual Meeting
Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method
Jing Shi¹, George Janssen², Peter van Veelen², Janwouter Drijfhout², Antony Cerami³, Tom Huizinga⁴, Leendert A. Trouw⁵ and René E.M. Toes⁴, ¹Rheumatology, LUMC, Leiden, Netherlands, ²Immunohematology and Bloodbank, LUMC, Leiden, Netherlands, ³Nephrology, LUMC, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play an important role in the diagnosis and prognosis of Rheumatoid Arthritis (RA). The Anti-Modified Citrulline (AMC) (‘Senshu’) method is…
Abstract Number: 1771 • 2012 ACR/ARHP Annual Meeting
Anti Carbamylated Protein Antibodies (Anti-CarP) Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis
Jing Shi¹, Lotte van de Stadt², Nivine Levarht³, T.W.J. Huizinga⁴, R. E. M. Toes⁴, Leendert A. Trouw⁵ and Dirkjan van Schaardenburg², ¹Rheumatology, LUMC, Leiden, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA): anti carbamylated protein antibodies (anti-CarP). These antibodies have additional prognostic value in predicting…
Abstract Number: 1772 • 2012 ACR/ARHP Annual Meeting
Expansion of Autoreactive Unresponsive CD21^-/Low B Cells in Sjögren’s Syndrome Associated Lymphoproliferation
David Saadoun¹, Benjamin Terrier², J. Bannock Sr.³, T. Vazquez Sr.⁴, C. Massad Sr.³, Florence Joly Sr.⁵, Michelle Rosenzwajg Sr.⁶, Damien Sene Sr.⁷, Philippe Benech Sr.⁵, David Klatzmann Sr.⁶, Eric Meffre Sr.³ and Patrice Cacoub Sr.⁸, ¹Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ²Internal Medicine, Cochin University Hospital, Paris, France, ³Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ⁴I3 “Immunology, Immunopathology, Immunotherapy” laboratory, CNRS UMR 7211 and INSERM U959, Paris, France, ⁵Prediguard, Marseille, France, ⁶Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Paris, France, ⁷Department of Internal Medicine; 5 P3S post-genomic plateform, Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie, Paris, France, ⁸Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Primary Sjögren's syndrome (pSS) is the autoimmune disease associated with the higher risk of developing non-Hodgkin lymphoma. Objective: To determine the nature of B…
Abstract Number: 1773 • 2012 ACR/ARHP Annual Meeting
Hyperammaglobulinemia in Primary Sjögren’s Syndrome Is Induced by Triggering of TLR7 and 9
Susanna Brauner¹, Marika Kvarnstrom¹, Gunnel Nordmark² and Marie Wahren-Herlenius¹, ¹Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Background/Purpose: Multiple B cell aberrances have been linked to primary Sjögren’s syndrome (pSS), including autoantibody production and a skewed B cell differentiation. Further, approximately 50%…
Abstract Number: 1774 • 2012 ACR/ARHP Annual Meeting
Identification of Target Antigens of Anti-Endothelial Cell Antibodies in Patients with ANCA-Associated Systemic Vasculitis: A Proteomic Approach
Alexis Régent¹, Hanadi Dib², Guillaume Bussone¹, Mathieu C. Tamby¹, Nicolas Tamas², Christian Federici³, Cédric Broussard³, Loic Guillevin⁴ and Luc Mouthon¹, ¹Internal Medicine, Hopital Cochin, Paris, France, ²Université Paris Descartes, Paris, France, ³Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁴Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Anti-endothelial cell antibodies (AECA) are frequently detected in anti-neutrophil cytoplasm antibodies (ANCA)-associated systemic vasculitis (AAV) and are considered to play pathological roles but their…
Abstract Number: 1775 • 2012 ACR/ARHP Annual Meeting
The Phosphoinositide 3-Kinase Pathway Regulates Fibroblast-Like Synoviocyte Invasion
Beatrix Bartok¹, Deepa Hammaker² and Gary S. Firestein³, ¹Rheumatology, UCSD, La Jolla, CA, ²MC 0656, Univ of California San Diego, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of RA. Increased cell migration and degradation of extracellular matrix…
Abstract Number: 1776 • 2012 ACR/ARHP Annual Meeting
Anti-SSA/Ro Mediated Injury to the Endothelium Via Urokinase Plasminogen Activator Receptor/Tgfbeta Activation: Implications in the Pathogenesis of Congenital Heart Block
Paraskevi Briasouli¹, Mark Halushka², Jill P. Buyon³ and Robert M. Clancy⁴, ¹Rheumatology, New York University Medical Center, New York, NY, ²Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: One mechanism by which anti-Ro antibodies are linked to the pathogenesis of (cardiac-NL) neonatal lupus is the increased urokinase plasminogen activator (uPA)/urokinase-type plasminogen activator receptor…

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