Abstract Number: 1787 • 2012 ACR/ARHP Annual Meeting
Evolution of the Cytokine and Chemokine Profile in Patients Receiving Oral Daily Vitamin D: Results From a Randomized Controlled Trial
Background/Purpose: Immunomodulatory effects of vitamin D were recently described in vitro, notably the expansion of regulatory T cells able to suppress inflammatory responses and the…Abstract Number: 1788 • 2012 ACR/ARHP Annual Meeting
TSLP Induces TNFα Production by CD1c Myeloid Dendritic Cells and Myeloid DC-Activated T Cells From Rheumatoid Arthritis Patients
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Fibroblasts from rheumatoid arthritis…Abstract Number: 1789 • 2012 ACR/ARHP Annual Meeting
Evidence for an Additive Effect of Tumor Necrosis Factor Alpha and Hypoxia to Promote Bone Destruction in Arthritis
Background/Purpose: Hypoxia is a major feature of the inflamed rheumatoid arthritis synovial membrane and promotes osteoclasts formation in vitro. We aimed to investigate the molecular…Abstract Number: 1790 • 2012 ACR/ARHP Annual Meeting
Notch Promotes Matrix Metalloproteinase 13 Expression by Inducing Interleukin-6 in Primary Murine Chondrocytes
Background/Purpose: Notch1 to Notch4 are transmembrane receptors that determine cell differentiation and function. Interactions of Notch with its ligands result in the cleavage of the…Abstract Number: 1791 • 2012 ACR/ARHP Annual Meeting
Different Mechanisms Responsible for IVIG Inhibition of Immune Complex Versus TLR Stimulated Interferon-Alpha
Background/Purpose: SLE immune complexes (IC) induce IFN-α production by stimulation of TLR7 and 9 in plasmacytoid dendritic cells (pDC). Serum from normal human donors…Abstract Number: 1792 • 2012 ACR/ARHP Annual Meeting
Identification of the Antimicrobial Peptide LL-37 As a Potential Mediator of Synovial Inflammation in Rheumatoid Arthritis
Background/Purpose: LL-37, a member of the cathelicidin family of host defense peptides, has a broad range of antimicrobial and immunomodulatory effects that potentially can have…Abstract Number: 1793 • 2012 ACR/ARHP Annual Meeting
The Cyclooxygenase/Prostaglandin-E2 Pathway Is Critical for Autocrine IL-17A Production by Th17 Cells Upon Synovial Fibroblast Interaction
Background/Purpose: Recently, we have shown that Th17, but not Th1 cells, from patients with early rheumatoid arthritis (RA) are potent activators of RA synovial fibroblasts…Abstract Number: 1794 • 2012 ACR/ARHP Annual Meeting
Matrix Metalloproteinase 3 and Acute Phase Proteins As Markers of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis
Background/Purpose: Although matrix metalloproteinase-3 (MMP-3) is believed to be intimately involved in the immunopathogenesis of rheumatoid arthritis (RA), relatively little is known about its relationships…Abstract Number: 1795 • 2012 ACR/ARHP Annual Meeting
Correction for Basophil and Monocyte Frequencies Identifies Specific Gene Expression Differences Associated with SLE Disease Flare: Interim Report From the Bold (Biomarkers of Lupus Disease) Study
Background/Purpose: Heterogeneity of clinical manifestations and pathogenic mechanisms has complicated treatment of SLE patients. The BOLD study allows evaluation of gene expression changes associated with…Abstract Number: 1796 • 2012 ACR/ARHP Annual Meeting
Anti-IL-20 Targets Local Tissue Inflammation As Opposed to Systemic Inflammation
Background/Purpose: In a recent Phase 2a clinical trial in patients with rheumatoid arthritis, the novel human anti-IL-20 monoclonal antibody NNC0109-0012 was shown to reduce…Abstract Number: 1797 • 2012 ACR/ARHP Annual Meeting
Wnt Signaling Pathway Status, Determined by Serum Dkk-1 and R-Spondin 1 Levels, in Rheumatoid Arthritis and Ankylosing Spondylitis
Background/Purpose: Dickkopf-1 (Dkk-1), known as inhibitor of Wnt signaling pathway, is involved in joint damage in inflammatory arthritis. While R-spondin 1 (Rspo1) reported to protect…Abstract Number: 1758 • 2012 ACR/ARHP Annual Meeting
Serum BAFF Levels and Relationship with BAFF Binding Receptors in Patients with Rheumatoid Arthritis Relapsing After B Cell Depletion Therapy
Background/Purpose: B-cell-activating-factor (BAFF) coordinates differentiation of B cells into immunoglobulin secreting cells (ISC) by binding to 3 different receptors (BBRs), namely BAFF-R, transmembrane activator and…Abstract Number: 1759 • 2012 ACR/ARHP Annual Meeting
Expression of Surface APRIL and Its Receptor, TACI, Is Upregulated On B Cells From Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients
Background/Purpose: Autoimmune disease affects more than 23 million Americans. Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) are chronic, systemic B-cell mediated autoimmune diseases. During…Abstract Number: 1760 • 2012 ACR/ARHP Annual Meeting
A Gene Expression Signature to Monitor Depletion of Plasma Cells Following MEDI-551 (anti-CD19) Administration
Background/Purpose: Production of pathogenic autoantibodies by inappropriately self-reactive plasma cells (PC) is a hallmark of autoimmune diseases. MEDI-551 is an anti-CD19 antibody which is expected…Abstract Number: 1761 • 2012 ACR/ARHP Annual Meeting
Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti-CD19 Monoclonal Antibody That Co-Engages the B Cell Antigen Receptor and the FcγRIIb Inhibitory Receptor
Background/Purpose: XmAb®5871 is a humanized and Fc-engineered antibody that coengages CD19, part of the B cell receptor (BCR) complex, with the inhibitory receptor FcγRIIb (CD32b).…
ACR Meeting Abstracts