Abstracts Archive - Page 2285 of 2607 - ACR Meeting Abstracts

Abstract Number: 2211 • 2013 ACR/ARHP Annual Meeting
Hospital For Special Surgery’s Charla De Lupus ( Lupus Chat)® Teen/Young Adult/ Parent Group: Holistic Support For Lupus Patients and Their Families
Erica Sandoval¹, Lillian Mendez², Roberta Horton³, Josephine Isgro⁴ and Shawn Rose⁵, ¹Social Work Programs, Hospital For Special Surgery, New York, NY, ²Social Work Programs, Hospital for Speical Surgery, New York, NY, ³Department of Social Work Programs, Hospital for Special Surgery, New York, NY, ⁴Pediatric Rheumatology, Morgan Stanley Children's Hospital of New-York Presbyterian, Columbia University Medical Center, New York, NY, ⁵Cardiovascular and Pulmonary Branch, NIAMS, NHLBI, Bethesda, MD
Background/Purpose: Teens with chronic illnesses are faced with challenges to their identity, peer relationships, self-esteem, and developmental milestones, which can have a lasting impact on…
Abstract Number: 2212 • 2013 ACR/ARHP Annual Meeting
Development Of Tools To Facilitate Shared Decision Making About Medications For Juvenile Idiopathic Arthritis – A Project Of The Pediatric Rheumatology Care and Outcomes Improvement Network
Esi Morgan DeWitt¹, Ellen A. Lipstein², Katie Staun³, Linda Scherer⁴, Janalee Taylor⁵, Carole M. Lannon⁴ and William B. Brinkman⁶, ¹Department of Pediatrics, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵William S. Rowe Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Medication options for juvenile idiopathic arthritis (JIA) are increasing. Medications differ on a variety of attributes, including mechanisms of action, dosing intervals, modes of…
Abstract Number: 2213 • 2013 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Normalizes Both DKK-1 and Sclerostin As Wnt Inhibitors In a Mouse Model Of Collagen-Induced Arthritis
Hiroto Yoshida¹, Mika Yagoto¹, Miho Suzuki¹, Keisuke Tanaka¹, Isao Matsumoto², Takayuki Sumida³ and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: The Wnt pathway plays an important role in bone formation and regeneration. This pathway is regulated by several soluble inhibitors such as Dickkopf-1 (DKK-1)…
Abstract Number: 2214 • 2013 ACR/ARHP Annual Meeting
STAT3 Blockade Suppresses Autoimmune Arthritis In Mice Via The Reciprocal Regulation Of Treg and Th17 Cells
Jennifer Lee¹, Jae Ho Lee¹, Seung Min Jung², Young Sun Suh¹, Jung Hee Koh¹, Soo Young Lee³, Dae Chul Jeong⁴, Mi-La Cho⁵, Seung-Ki Kwok¹, Ji Hyeon Ju¹, Kyung-Su Park¹ and Sung-Hwan Park⁶, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Department of Pediatrics, School of Medicine, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, South Korea, ⁴Division of Rheumatology, Department of Pediatrics, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁵Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁶Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: IL-6-mediated STAT3 signaling which is essential to Th17 differentiation plays the central role in the pathogenesis of rheumatoid arthritis. To investigate the molecular mechanism…
Abstract Number: 2215 • 2013 ACR/ARHP Annual Meeting
Apoptotic Cell-Based Therapy To Treat Collagen-Induced Experimental Arthritis. Rationale For The Use Of Apoptotic Cells In The Treatment Of Rheumatoid Arthritis
Sylvain Perruche¹, Amandine Clauzon¹, Francis Bonnefoy¹, Eric Toussirot² and Philippe Saas³, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, ³Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France
Background/Purpose: Most of the currently available biological agents used in the treatment of rheumatoid arthritis (RA) target a cellular or soluble factor involved in the…
Abstract Number: 2216 • 2013 ACR/ARHP Annual Meeting
Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model
Joong Kyong Ahn¹, Jaejoon Lee², Hyemin Jeong², Jiwon Hwang², Seulkee Lee², Ji Young Chai³, Inyoung Kim^2,4, Eun Chung Hong⁵, Eun-Kyung Bae⁵, Hoon-Suk Cha² and Eun-Mi Koh², ¹Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, ⁴MD, Seoul, South Korea, ⁵Samsung Biomedical Research Institute, Seoul, South Korea
Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…
Abstract Number: 2217 • 2013 ACR/ARHP Annual Meeting
Experimental Arthritis Exacerbates Periodontal Disease But Periodontal Infection Does Not Exacerbated Experimental Arthritis
John Butcher¹, Jessica Oliver-Bell¹, Robert Benson¹, James Brewer², Paul Garside¹, Iain B. McInnes¹ and Shauna Culshaw³, ¹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Immunology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: There is a proposed link between periodontal disease (PD) and rheumatoid arthritis (RA). A substantial, although not unanimous, body of epidemiological evidence indicates a…
Abstract Number: 2218 • 2013 ACR/ARHP Annual Meeting
Gingival Stem Cells Suppress Osteoclast Formation and Bone Erosion In CIA Through CD39 Signal
Song Guo Zheng¹, Jian Gu², Maogeng Chen¹ and Yi Shen³, ¹Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Medcine, University of Southern California Keck School of Medicine, Los Angeles, CA, ³Medicine, Shanghai East Hospital at Tongji University, Shanghai, China
Background/Purpose: We recently have reported that human-derived gingival mesenchymal stem cells (GMSC) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis, however,…
Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting
Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis
Emilie Duvallet¹, Laure Foulboeuf¹, Luca Semerano², Nadia Belmellat¹, Marc Lecouvey³, Eric Assier¹, Sylviane Muller⁴ and Marie-Christophe Boissier⁵, ¹EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³CSPBAT Paris 13 University, Bobigny, France, ⁴Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, ⁵INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
Abstract Number: 2220 • 2013 ACR/ARHP Annual Meeting
The Role Of CD11c+ Dendritic Cells In Inflammatory Arthritis
Antonia Puchner¹, Stephan Blüml¹, Victoria Saferding², Harald Leiss¹, Josef S. Smolen³ and Kurt Redlich⁴, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are…
Abstract Number: 2221 • 2013 ACR/ARHP Annual Meeting
The Histamine H₄ Receptor Drives Inflammation In Preclinical Models Of Arthritis
Paul J. Dunford¹, Jeffery Cowden², Fuqu Yu², Homayon Banie², Mandana Farahani², Ping Ling², Steven Nguyen², Jason Riley², Mai Zhang², Jian Zhu² and Robin L. Thurmond², ¹Immunology, Janssen R&D, LLC, San Diego, CA, ²Janssen R&D, LLC, San Diego, CA
Background/Purpose: The histamine H4 receptor (H4R) has been shown to drive inflammatory responses in models of asthma, colitis and dermatitis and in these models it…
Abstract Number: 2223 • 2013 ACR/ARHP Annual Meeting
Monitoring Of Active Matrix Metalloproteinase-3 Using
Sung Jae Choi¹, Young Ho Seo², Young Ho Lee³, Jong Dae Ji¹, Gwan Gyu Song⁴, Aeju Lee² and Jae-Hoon Kim⁴, ¹Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Rheumatology, Korea University Medical center, Seoul, South Korea, ³Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ⁴Div of Rheum, Dept of Int Med, Korea Univ College of Med, Seoul, South Korea
Background/Purpose: Active matrix metalloproteinase-3 (MMP-3) is a prognostic marker of rheumatoid arthritis (RA). Recently, we developed the MMP-3 probe which can specifically detect an active…
Abstract Number: 2224 • 2013 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Induces Anti-Citrullinated Protein Antibodies and Arthritis In Part Through Peptidyl Arginine Deiminase 4
Miriam A. Shelef¹, Jeremy Sokolove², Catriona Wagner³, Eric Sackmann⁴, Thomas Warner⁵, David Beebe⁴, William H. Robinson⁶ and Anna Huttenlocher⁷, ¹Medicine, Univ of Wisconsin Schl of Med, Madison, WI, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁴Materials Science Program and Department of Biomedical Engineering, University of Wisconsin, Madison, WI, ⁵Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Dept of Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI
Background/Purpose: Rheumatoid arthritis is an autoimmune, destructive arthritis characterized by anti-citrullinated protein antibodies (ACPAs) and high levels of inflammatory cytokines like tumor necrosis factor alpha…
Abstract Number: 2226 • 2013 ACR/ARHP Annual Meeting
Involvement Of Suppressor Of Cytokine Signaling In Anti-Arthritic Effect Induced By Anti-IL-6 Receptor Antibody
Miho Suzuki¹, Hiroto Yoshida¹, Keisuke Tanaka¹, Isao Matsumoto², Takayuki Sumida³ and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: In the treatment of rheumatoid arthritis (RA), biologics such as IL-6 and TNF inhibitors have high therapeutic efficacy with extended duration of effect [“LITHE…
Abstract Number: 2227 • 2013 ACR/ARHP Annual Meeting
The Anti-Proliferative Function of RSK2 in Synovial Fibroblasts Protects Against TNF-á-Induced Joint Destruction in Inflammatory Arthritis
Anja Derer¹, Christina Boehm¹, Bettina Groetsch¹, Michael Stock¹, Kirsten Neubert², Sybille Boehm³, Bettina Sehnert¹, Georg Schett¹, Axel J. Hueber⁴ and Jean-Pierre David⁵, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Clinical Research Group, Nikolaus-Fiebiger Center, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Group Genes and Transcription, Institute of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Background/Purpose: The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) directly activates the ribosomal S6 kinase RSK2 in vitro. We recently demonstrated the protective effect of…

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