Abstracts Archive - Page 2284 of 2425 - ACR Meeting Abstracts

Abstract Number: 2065 • 2012 ACR/ARHP Annual Meeting
Uptake of the American College of Rheumatology’s (ACR) Rheumatology Clinical Registry (RCR): Quality Measure Summary Data
Salahuddin Kazi¹, Itara Barnes², Jinoos Yazdany³ and Rachel Myslinski⁴, ¹Internal Medicine/Rheumatology, UT Southwestern Medical Center, Dallas, TX, ²Quality, Registries, and Health Informatics, American College of Rheumatology, Atlanta, GA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Practice, Advocacy, & Quality, American College of Rheumatology, Atlanta, GA
Background: The RCR was launched by the ACR to provide members with an infrastructure for quality reporting related to rheumatoid arthritis, gout, osteoarthritis, osteoporosis, and…
Abstract Number: 2066 • 2012 ACR/ARHP Annual Meeting
Improving Outpatient Follow-up for Osteoporosis Management After a Hip Fracture
Anika Alarakhia and Robert Quinet, Rheumatology, Ochsner Medical Center, New Orleans, LA
Background/Purpose: Patients hospitalized for hip fractures are routinely scheduled for a Rheumatology follow-up appointment to assess their risk of future fractures and need for treatment.…
Abstract Number: 2067 • 2012 ACR/ARHP Annual Meeting
Access to Technology and Interest in Mobile “app” for Disease Management Among Patients with Systemic Lupus Erythematosus Seeking Care At a Large Referral Center
Wendy Marder¹, Holly Witteman², Margaret Hyzy³, Martha Ganser¹, Emily C. Somers⁴ and Lawrence An⁵, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²The Center for Bioethics and Social Sciences in Medicine, University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, Universitiy of Michigan, Ann Arbor, MI, ⁴IntMed, Environmental Health, and OB/GYN, University of Michigan, Ann Arbor, MI, ⁵Center for Health Communications Research, Universitiy of Michigan, Ann Arbor, MI
Background/Purpose: Some of the challenges facing patients with chronic diseases such as systemic lupus erythematosus (SLE) include identifying triggers for disease “flares” and accurately recalling…
Abstract Number: 2068 • 2012 ACR/ARHP Annual Meeting
Is There a Difference in Rheumatology Patient Reported Outcomes When Measured At Home Versus the Clinic Setting?
C.J. Inman¹, Frederick Wolfe² and Kaleb Michaud³, ¹Pediatric Administration, University of Utah, Salt Lake City, UT, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Registries have become a common tool for collecting patient-centered outcome measures. Clinical effectiveness research may be improved if data from multiple registries could be…
Abstract Number: 2069 • 2012 ACR/ARHP Annual Meeting
Proteinase Activated Receptor-4 Stimulation Promotes Leukocyte Adhesion in the Rat Knee Joint
Jason J. McDougall, Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada
Background/Purpose: Proteinase activated receptors (PARs) are a family of G protein-coupled receptors that signal by enzymatic cleavage of the receptor in a specific extracellular domain.…
Abstract Number: 2070 • 2012 ACR/ARHP Annual Meeting
Myeloid-Derived Suppressor Cells Accumulated in Spleens of Mice with Collagen-Induced Arthritis and Inhibited Immune Response of CD4⁺ T Cells
Wataru Fujii¹, Eishi Ashihara², Hideyo Hirai³, Hidetake Nagahara¹, Kazuki Fujioka¹, Ken Murakami¹, Kaoru Nakamura¹, Takahiro Seno¹, Aihiro Yamamoto¹, Hidetaka Ishino¹, Masataka Kohno¹, Taira Maekawa³ and Yutaka Kawahito¹, ¹Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan, ³Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan
Background/Purpose: Myeloid-derived suppressor cells (MDSCs), firstly reported in patients with cancer, have a myeloid origin and an ability to suppress T cell responses. MDSCs are…
Abstract Number: 2071 • 2012 ACR/ARHP Annual Meeting
The Potent, Highly Selective and Orally Bioavailable Spleen Tyrosine Kinase Inhibitor GSK143 Demonstrates Efficacy in B Cell Receptor and Fc Receptor Signalling in Models of Inflammatory and Autoimmune Disease
Marion C. Dickson¹, Nicholas Smithers², Huw Lewis¹, Cesar Ramirez-Molina¹, Scott McCleary¹, Mike Barker¹ and John Liddle¹, ¹Immuno Inflammation, GSK, Stevenage, United Kingdom, ²Immuno Inflammation, GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: Spleen tyrosine kinase (Syk), a 72 KDa cytosolic non-receptor tyrosine kinase is a key mediator of B cell receptor (BCR) and Fc receptor (FcR)…
Abstract Number: 2072 • 2012 ACR/ARHP Annual Meeting
Bone Formation and Resorption Are Both Increased in Autoimmune Arthritis
Kresten K. Keller¹, Jesper Skovhus Thomsen², Kristian Stengaard-Pedersen¹, Frederik Dagnæs-Hansen³, Jens R. Nyengaard⁴ and Ellen-Margrethe Hauge¹, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Institute of Anatomy, Aarhus University, ³Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark, ⁴Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advanced Bioimaging. Aarhus University hospital, Aarhus, Denmark
Background/Purpose: Bone destruction in the joints of patients with rheumatoid arthritis (RA) is the result of a combination of osteoclastic bone resorption and osteoblastic bone…
Abstract Number: 2073 • 2012 ACR/ARHP Annual Meeting
Green Tea Epigallocatechin-3-Gallate Ameliorates Murine Arthritis by Inducing IDO Producing Dendritic Cells Via Nrf2 Antioxidant Pathway
Soyoun Min¹, Mei Yan¹, Kamala Vanarsa², Anna Bashmakov¹ and Chandra Mohan¹, ¹Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: To examine the immunomodulatory effects and mechanisms of Green Tea (−)-epigallocatechin-3-gallate (EGCG) on experimental arthritis in mice, we investigated whether EGCG can afford therapeutic…
Abstract Number: 2074 • 2012 ACR/ARHP Annual Meeting
Combined Effects of a c-Fos/AP-1 Inhibitor T-5224 and Methotrexate On Collagen-Induced Arthritis in Mice
Tomomi Date¹, Yukihiko Aikawa¹, Tetsuya Yamamoto¹, Hirokazu Narita¹, Shuichi Hirono² and Shunichi Shiozawa³, ¹Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan, ²Department of Pharmaceutical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan, ³Department of Medicine & Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: Activator protein-1 (AP-1) is an important transcription factor for cytokine production and joint destruction in rheumatoid arthritis (RA), and a potential target for the…
Abstract Number: 2075 • 2012 ACR/ARHP Annual Meeting
CCR6⁺Foxp3⁺ Regulatory T Cells Regulate the Development of Collagen Induced Arthritis in T Cell Specific RORγt Transgenic Mice
Yuya Kondo¹, Masahiro Tahara¹, Mana Iizuka¹, Hiroto Tsuboi¹, Satoru Takahashi², Isao Matsumoto¹ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Recent studies reported that IL-17 producing Th-17 cells appear to play an important role in the generation of several autoimmune arthritis models. We previously…
Abstract Number: 2076 • 2012 ACR/ARHP Annual Meeting
Efficacy of the Potent PI3K-δ,γ Inhibitor IPI-145 in Rat Adjuvant Arthritis
David L. Boyle¹, Katharyn Topoleweski¹ and Gary S. Firestein², ¹Div of Rheum, UCSD School of Medicine, La Jolla, CA, ²Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Phosphoinositide 3-kinase (PI3K) is a family of intracellular signaling transducers and could be targeted to treat inflammatory diseases like rheumatoid arthritis (RA). However, blockade…
Abstract Number: 2077 • 2012 ACR/ARHP Annual Meeting
IL-6 Blockade Augments the Anti-Inflammatory Effect without Increasing the Side Effects of Steroids in Collagen-Induced Arthritis
Miho Suzuki¹, Hiroto Yoshida², Misato Hashizume¹, Masashi Shiina², Keisuke Tanaka¹ and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
Background/Purpose: Steroids are the main therapy for chronic inflammatory diseases. They are very effective, but induce many side effects, such as osteoporosis, making it important…
Abstract Number: 2078 • 2012 ACR/ARHP Annual Meeting
Low-Density Lipoprotein Receptor Deficiency Ameliorates the Development of Inflammatory Arthritis
Shawn Rose¹ and Harris R. Perlman², ¹Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Patients with rheumatoid arthritis (RA) carry a higher risk of cardiovascular disease compared to the general population. The low-density lipoprotein receptor (LDLR) and Apolipoprotein…
Abstract Number: 2079 • 2012 ACR/ARHP Annual Meeting
Anti-Interleukin-6 Receptor Antibody Improves Systemic Osteoporosis in a Mice Model of Glucose-6-Phosphate Isomerase-Induced Arthritis
Hiroto Yoshida¹, Miho Suzuki¹, Misato Hashizume¹, Keisuke Tanaka², Masashi Shiina², Isao Matsumoto³, Takayuki Sumida³ and Yoshihiro Matsumoto², ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan, ³Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) have a high risk of osteoporosis and osteoporotic fracture. In addition to the primary risk factors for osteoporosis, osteoporosis…

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