Abstracts Archive - Page 2283 of 2607 - ACR Meeting Abstracts

Abstract Number: 2262 • 2013 ACR/ARHP Annual Meeting
Antibody To Malondialdehyde-Acetaldehyde Adducts (MAA) Is a Biomarker Of Inflammation and Is Correlated With The Disease Activity In Rheumatoid Arthritis
Kathleen Young¹, Dathe Benissan-Messan², Michael J. Duryee³, Daniel Anderson⁴, Liron Caplan^5,6, Lisa A. Davis^7,8,9, Harlan Sayles⁴, Carlos D. Hunter³, Lynell W. Klassen¹⁰, James R. O'Dell¹¹, Ted R. Mikuls⁴ and Geoffrey M Thiele¹², ¹Int Med/Sec of Rheum/Immun, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO, ⁶Department of Medicine, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, Univ. of Colorado Sch. of Medicine, Aurora, CO, ⁸Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, ⁹Denver Veterans Affairs Medical Center, Denver, CO, ¹⁰Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹¹Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ¹²Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). While there are many markers used…
Abstract Number: 2264 • 2013 ACR/ARHP Annual Meeting
An Assay Panel Combining Anticitrullinated Peptide Autoantibodies and Rheumatoid Factor Isotypes Has High Yield In The Diagnosis Of Rheumatoid Arthritis
Nirupa J. Patel¹, Ignacio Garcia-Valladares², Derren Barken³, Luis R. Espinoza⁴, Heena Sheth⁵ and Thierry Dervieux⁶, ¹Rheumatology, LSU Health Sciences Ctr, New Orleans, LA, ²Rheumatology, Guadalajara, Guadalajara, Mexico, ³Exagen Diagnostics, Vista, CA, ⁴Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA, ⁵Medicine, University of Pittsburgh, Pittsburgh, PA, ⁶Research and Development, Exagen Diagnostics, Vista, CA
Background/Purpose: We sought to establish the diagnostic performances of rheumatoid factor isotypes (IgM and IgA) and anti-citrullinated peptide antibodies (ACPAs: anti-mutated citrullinated vimentin [anti-MCV] and…
Abstract Number: 2265 • 2013 ACR/ARHP Annual Meeting
Switching From Immediate Release (IR) Prednisone To Delayed Release (DR) Prednisone Improves Patient Reported Outcomes In Rheumatoid Arthritis (RA) Patients On Conventional Disease-Modifying Antirheumatic Drugs (DMARDs)
Rieke Alten¹, Robert Holt², Amy Grahn³, Patricia Rice⁴, Jeffery Kent², Frank Buttgereit⁵ and Allan Gibofsky⁶, ¹Teaching Hospital of the Charité, University of Berlin, Berlin, Germany, ²Medical Affairs, Horizon Pharma, Inc, Deerfield, IL, ³Clinical Development, Horizon Pharma, Inc, Deerfield, IL, ⁴Statistics, CliniRx Research, Naperville, IL, ⁵Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁶Medicine and Public Health, Hospital for Special Surgery, New York, NY
Background/Purpose: A surge in nocturnal inflammatory cytokines causing morning stiffness (MS) is recognized as a therapeutic target in RA. MS has been underappreciated in…
Abstract Number: 2266 • 2013 ACR/ARHP Annual Meeting
Research On Factors Influenced For Bone Metabolic Markers In Rheumatoid Arthritis Patients From Prospective Cohort Study
Masahiro Tada¹, Tatsuya Koike², Tadashi Okano¹, Yuko Sugioka¹, Kenji Mamoto¹, Kentaro Inui³ and Hiroaki Nakamura¹, ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Rheumatosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ³Orhtopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) develop osteoporosis more frequently than healthy individuals. Bone resorption and formation are respectively increased and inhibited in patients with…
Abstract Number: 2267 • 2013 ACR/ARHP Annual Meeting
The Diagnostic Accuracy Of Rheumatoid Factor Testing In Primary Care
Anne Miller¹, Alison L Nightingale², Cormac J Sammon³, Tim Holt⁴, Kamal R Mahtani⁵, Neil McHugh⁶, Corinne S de Vries³ and Raashid A. Luqmani^1,7, ¹Rheumatology, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ²Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom, ⁴Primary Health Care Sciences, University of Oxford, Oxford, United Kingdom, ⁵Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom, ⁶Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁷Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: Studies of the diagnostic utility of rheumatoid factor (RF) testing for rheumatoid arthritis (RA) conducted in early arthritis clinics in secondary care have reported…
Abstract Number: 2268 • 2013 ACR/ARHP Annual Meeting
Patient-Reported Outcome Measures For Rheumatoid Arthritis: Minimal Important Differences Review
Helen Kitchen¹, Brian Bekker Hansen², Linda Abetz¹, Lise Højbjerre² and Martin Strandberg-Larsen², ¹Endpoint Development & Outcomes Assessment, Adelphi Values Ltd, Cheshire, United Kingdom, ²Health Economics & HTA, Novo Nordisk A/S, Søborg, Denmark
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disease, affecting around 1.3 million people in the US. A patient-centred focus is increasingly advocated by healthcare…
Abstract Number: 2269 • 2013 ACR/ARHP Annual Meeting
Patient Reported Pain: A Predictor Of Outcomes In Rheumatoid Arthritis From The Consortium Of Rheumatology Researchers Of North America Registry
Dimitrios A. Pappas¹, Chitra K. Karki², Chin Lee³, George W. Reed⁴, Ping He⁵ and Sarah Al Sawah³, ¹Columbia University, New York, NY, ²Corrona, LLC., Southborough, MA, ³Eli Lilly and Company, Indianapolis, IN, ⁴CORRONA, Inc., Southborough, MA, ⁵UMASS Medical School, Worcester, MA
Background/Purpose: Pain is a hallmark of rheumatoid arthritis (RA). The extent to which patient reported pain in RA is related to patterns of biologic treatment…
Abstract Number: 2230 • 2013 ACR/ARHP Annual Meeting
Specific Angiotensin Type II Receptor Stimulation Attenuates Collagen-Induced Arthritis Via Enhancement Of FoxP3 Regulatory T Cells
Bettina Sehnert¹, Veronica Valero-Esquitino², Georg Schett³, Ulrika Muscha Steckelings² and Reinhard E. Voll⁴, ¹Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency,, University Hospital Freiburg, Freiburg, Germany, ²Center for Cardiovascular Research, Medical Faculty Berlin, Berlin, Germany, ³Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany
Background/Purpose: The renin-angiotensin system (RAS) is known to play an important role in inflammation, fibrosis, and end-organ damage. Moreover, AT2R signalling exerts anti-inflammatory and anti-apoptotic…
Abstract Number: 2231 • 2013 ACR/ARHP Annual Meeting
The Actin-Crosslinking Protein Lasp-1 Regulates Synovial Fibroblast Migration and Cartilage Destruction In Arthritis
Denise Beckmann¹, Jan Hillen², Marianne Heitzmann², Catherine S. Chew³, Stefan Butz⁴, Dietmar Vestweber⁵, Hermann Pavenstädt⁶, Thomas Pap⁷ and Adelheid Korb-Pap², ¹1nstitute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ³Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ⁴Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁶Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany, ⁷Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Lasp-1 localizes at focal adhesions along stress fibres and leading edges of migrating cells and regulates the metastatic dissemination of tumors. Although rheumatoid arthritis…
Abstract Number: 2232 • 2013 ACR/ARHP Annual Meeting
Neutralization of Angiopoietin-2 Enhances the Efficacy of Anti-Tumor Necrosis Factor-Alpha Treatment in a Mouse Model of Rheumatoid Arthritis by Decreasing Cellular Infiltration into the Joint and Protecting Bone
Brian Naiman, Sean Turman, William Iverson, Ronald Herbst, Tomas Mustelin and Jane Connor, Respiration, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: It has recently been established that >75% of patients on methotrexate and a biologic do not achieve complete remission based on the new definition…
Abstract Number: 2233 • 2013 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis peptidylarginine Deiminase Exacerbates Collagen-Induced Arthritis In C57BL/6 mice
Saba Alzabin^1,2, Anne-Marie Quirke², Elena B. Lugli², Muslima Choudhury^2,3, Peter J. Charles⁴, Richard O. Williams⁵ and Patrick Venables⁶, ¹Epistem Ltd., Manchester, United Kingdom, ²University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Kennedy Institute of Rheumatology, London, United Kingdom, ⁴Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁵Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, ⁶Kennedy Institute of Rheumatology, Oxford, United Kingdom
Background/Purpose: There is increasing molecular and epidemiological evidence linking Porphyromonas gingivalis to RA. P. gingivalis is unique amongst periodontal pathogens in possessing a citrullinating enzyme…
Abstract Number: 2234 • 2013 ACR/ARHP Annual Meeting
Targeting Therapy Of Citrullinated Antigen-Specific B Cells Ameliorates Collagen-Induced Arthritis
Kazuya Michishita¹, Kimito Kawahata¹, Takeyuki Kanzaki², Lisa Akahira¹, Toshiki Eri¹ and Kazuhiko Yamamoto³, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, ³Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: The clinical benefit of B-cell depletion therapy in rheumatoid arthritis(RA) is a well-known fact, but problems such as relapse of tuberculosis and reactivation of…
Abstract Number: 2235 • 2013 ACR/ARHP Annual Meeting
Fas Signaling In Macrophages Promotes Chronicity In K/BxN Serum Transfer Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, Carla M. Cuda³, J.-P. Jin⁴, Harris R. Perlman⁵ and Richard M. Pope⁶, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ³Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Physiology, Wayne State University, Detroit, MI, ⁵Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: A non-apoptotic role for Fas signaling has been implicated in the regulation of inflammation and innate immunity. These studies were performed to elucidate the…
Abstract Number: 2236 • 2013 ACR/ARHP Annual Meeting
Articular Inflammation Is Protected By Fat-1 During The Acute Phase Of Arthritis In Mice
Sang-Il Lee¹, Yun-Hong Cheon², Ji-Min Kim³ and Won Seok Lee², ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ²Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea
Background/Purpose: Omega-3 polyunsaturated fatty acids (n-3 PUFA) are well known to exert anti-inflammatory effects. The Fat-1 transgenic (Fat-1 TG) mice are capable of producing n-3…
Abstract Number: 2237 • 2013 ACR/ARHP Annual Meeting
Assessment Of Wage and Salary Growth In Patients With Rheumatoid Arthritis (RA)
Martin J. Bergman¹, Gourab De², Arijit X. Ganguli³, James Signorovitch⁴ and Yanjun Bao⁵, ¹Taylor Hospital, Ridley Park, PA, ²Analysis Group, Inc., New York, NY, ³AbbVie, Inc., North Chicago, IL, ⁴Analysis Group, Inc., Boston, MA, ⁵AbbVie Inc., North Chicago, IL
Background/Purpose: RA negatively impacts patients' work outcomes. Treatment with tumor necrosis factor inhibitors (anti-TNFs) has been associated with improved work productivity and stability in RA.…

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