Abstracts Archive - Page 2283 of 2425 - ACR Meeting Abstracts

Abstract Number: 2090 • 2012 ACR/ARHP Annual Meeting
Orchestrating the Orchestrators: Blockade of Flt3L Signaling-Dependent Dendritic Cells Protects Against Collagen Induced Arthritis
Maria I. Martins Ramos¹, Karpus O.N. Karpus², Pleun Broekstra², Saïda Aarrass³, Paul P. Tak⁴ and Maria C. Lebre³, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Clinical Immunology and Rheumatology & Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Autoimmune diseases often result from inappropriate or unregulated activation of autoreactive T cells. The induction and maintenance of T cell tolerance to tissue antigens…
Abstract Number: 2091 • 2012 ACR/ARHP Annual Meeting
The Effect of Pretreatment with Capsaicin On Measurement of Arthritis Pain by Dynamic Weight Bearing and Evoked Pain Responses in an Acute Murine Arthritis Model
Hollis E. Krug¹, Christopher W. Dorman², Sandra Frizelle² and Maren L. Mahowald³, ¹Medicine, VA Health Care System, Minneapolis, MN, ²Research, Minneapolis VA Health Care System, Minneapolis, MN, ³Medicine, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, MN

Background/Purpose: Murine models are important to study arthritis pain and new analgesics, however measuring pain in mice is challenging. The Dynamic Weight Bearing (DWB) device…
Abstract Number: 2092 • 2012 ACR/ARHP Annual Meeting
No Significant Effect of Hepatitis B Virus Infection On Disease Activity, Synovitis or Joint Destruction in Rheumatoid Arthritis
Chan Juan Zou, Yan Hua Li, Ying Qian Mo, Lang Jing Zhu, Dong Hui Zheng, Jian Da Ma, Xia Ouyang and Lie Dai, Division of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: The prevalence of chronic hepatitis B virus (HBV) infection is high in China. 4% patients with HBV infection can present with polyarthritis and positive…
Abstract Number: 2093 • 2012 ACR/ARHP Annual Meeting
Rates of Opportunistic Infections Among Rheumatoid Arthritis Patients Switching Biologic Therapy
John Baddley¹, Shuo Yang², Klye Brizendine³, Scott DuVall⁴, Kevin L. Winthrop⁵, Mary J. Burton⁶, Nivedita M. Patkar⁷, Elizabeth S. Delzell⁸, Monika M. Safford⁹, Jasvinder A. Singh¹⁰, Iris E. Navarro¹¹, Grant W. Cannon¹², Ted R. Mikuls¹³, Lang Chen¹¹, Kenneth G. Saag¹⁴, Kimberly Alexander¹⁵, Pavel Napalkov¹⁵, Aaron Kamauu¹⁶ and Jeffrey R. Curtis¹⁷, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Infectious Disease, Birmingham, AL, ⁴VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ⁵Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ⁶VA Hospital, Jackson, MS, ⁷Immunology/Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, ⁸Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁹Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁰Department of Medicine, University of Alabama, Tuscaloosa, AL, ¹¹Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹²Division of Rheumatology, George E. Wahlen VA Medical Center, Salt Lake City, UT, ¹³Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁴Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ¹⁵Epidemiology, Genentech, Inc., South San Francisco, CA, ¹⁶Anolinx, Bountiful, UT, ¹⁷Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL
Background/Purpose: The incidence of opportunistic infections (OIs) in patients on biologics is low, but may approach several cases per 100 person-years (PY). Data on risks…
Abstract Number: 2094 • 2012 ACR/ARHP Annual Meeting
Reactivation of Hepatitis B Virus in Autoimmune Disease Patients Receiving Immunosuppressive Agents
Daisuke Kobayashi¹, Satoshi Ito¹, Megumi Unno¹, Ichiei Narita² and Akira Murasawa¹, ¹Niigata Rheumatic Center, Niigata, Japan, ²Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Background/Purpose: Reactivation of resolved hepatitis B in patients undergoing immunosuppressive therapy is now considered to be a complication of major clinical importance. Because this is…
Abstract Number: 2095 • 2012 ACR/ARHP Annual Meeting
Identifying Arthralgia Patients At Risk for Rheumatoid Arthritis in the Rotterdam Early Arthritis Cohort
M. van der Veer¹, D. van Zeben², A.E.A.M. Weel³, P.J. Barendregt³, A.H. Gerards⁴, Johanna M.W. Hazes⁵ and Jolanda J. Luime⁵, ¹Department of Rheumatology, ErasmusMC, Rotterdam, Netherlands, ²Department of Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, ³Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ⁴Department of Rheumatology, Vlietland Hospital, Schiedam, Netherlands, ⁵Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Patients with rheumatoid arthritis (RA) frequently have a high disease burden and erosions at first presentation because of the insidious nature of the disease.…
Abstract Number: 2096 • 2012 ACR/ARHP Annual Meeting
A Prediction Rule for the Progression to Rheumatoid Arthritis Applied in a Mexican Mestizo Cohort with Undifferentiated Arthritis
Ana Arana Guajardo, Lorena Pérez Barbosa, David Vega Morales, Janett Riega Torres, Roberto Negrete López, Jacqueline Rodríguez Amado, Jorge Esquivel Valerio, Cassandra Skinner Taylor, Diana Flores Alvarado, Dionicio Galarza Delgado, Miguel Villarreal Alarcon and Mario Garza Elizondo, Rheumatology, Hospital Universitario, UANL, Monterrey, Mexico
Background/Purpose: A high proportion of patients who present with recent-onset arthritis have undifferentiated arthritis (UA), as these patients do not fulfill the classification criteria for…
Abstract Number: 2097 • 2012 ACR/ARHP Annual Meeting
Adiponectin Is Associated with Pro-Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives (FDRs) of Patients with Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kevin D. Deane², Lezlie A. Derber³, Gary O. Zerbe⁴, Dana M. Dabelea¹, Jeremy Sokolove⁵, William H. Robinson⁶, V. Michael Holers⁷ and Jill M. Norris⁸, ¹Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: While adiponectin is generally considered an anti-inflammatory adipokine, it has also been shown to participate in active RA in inflammatory, matrix-destructive and fibrotic processes…
Abstract Number: 2098 • 2012 ACR/ARHP Annual Meeting
Patient Report Outcomes Variance Between Centers Is Much Lower Than Physician and Laboratory Assessed Measures of Rheumatoid Arthritis Activity: Results From a Multinational Study
Nasim A. Khan¹, Horace Spencer², Tuulikki Sokka³ and QUEST-RA⁴, ¹Rheumatology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, ²University of Arkansas for Medical Sciences, Little Rock, AR, ³Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, ⁴Jyväskylä
Background/Purpose: Clinical trials and epidemiological rheumatoid arthritis (RA) studies often recruit patients from multiple centers. We studied the proportion of variance in the American…
Abstract Number: 2099 • 2012 ACR/ARHP Annual Meeting
Patient Self-Assessments and Selected Patient Reported Outcomes May Reliably Identify Rheumatoid Disease Flare in Early Rheumatoid Arthritis Patients
Vivian P. Bykerk¹, Clifton O. Bingham III², Ernest Choy³, Juan Xiong⁴, Gilles Boire⁵, Carol A. Hitchon⁶, Janet E. Pope⁷, J. Carter Thorne⁸, Boulos Haraoui⁹, Edward Keystone¹⁰ and Susan J. Bartlett¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ¹⁰University of Toronto, Toronto, ON, Canada, ¹¹Clinical Epidemiology, McGill University, Montreal, QC, Canada
Background/Purpose: Significant RA worsening or flare may predict poorer outcomes and signal a need for treatment reassessment. However, there is little agreement about how to…
Abstract Number: 2100 • 2012 ACR/ARHP Annual Meeting
Relative, Reliability-Adjusted Diagnostic Test Accuracy of Erosion Detection Between Magnetic Resonance Imaging and Radiography in Rheumatoid Arthritis
Ruben Tavares¹, Naveen Parasu², Karen Finlay², Erik Jurriaans², Hao Wu¹, Karen A. Beattie³, Maggie Larche⁴, Lawrence E. Hart⁵, William G. Bensen⁶, Raja S. Bobba⁴, Alfred A. Cividino³, Colin E. Webber⁷, Jean-Eric Tarride⁸ and Jonathan D. Adachi⁹, ¹McMaster University, Hamilton, ON, Canada, ²Radiology, Hamilton Health Sciences, Hamilton, ON, Canada, ³Medicine, McMaster University, Hamilton, ON, Canada, ⁴Rheumatology, McMaster University, Hamilton, ON, Canada, ⁵Medicine (Rheumatology), St. Joseph's Health Care, Hamilton, ON, Canada, ⁶Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, ⁷Department of Nuclear Medicine, Hamilton Health Sciences, Hamilton, ON, Canada, ⁸Clinical Epidemiology and Biostatistics (CE&B) and Economics, Programs for Assessment of Technology in Health (PATH) Research Institute, Hamilton, ON, Canada, ⁹St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: In rheumatoid arthritis (RA), erosion detection on radiography (X-ray) compared to magnetic resonance imaging (MRI) is characterized by low sensitivity and high specificity. This…
Abstract Number: 2061 • 2012 ACR/ARHP Annual Meeting
Physician Variation in Documentation of Rheumatoid Arthritis Quality Measures and Evaluation of Relationship with Radiographic Progression
Sonali Desai¹, Jinoos Yazdany², Nancy A. Shadick³, Siri Lillegraven⁴, Chih-Chin Liu⁵, Michelle A. Frits⁶, Tabatha Norton⁷, Jonathan S. Coblyn⁸, Michael Weinblatt⁵ and Daniel H. Solomon⁹, ¹Medicine/ Rheumatology, Boston, MA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ⁶Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁹Division of Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Documentation of quality measures (QMs) in rheumatoid arthritis (RA) has been proposed as a way to demonstrate quality of care, but data linking appropriate…
Abstract Number: 2062 • 2012 ACR/ARHP Annual Meeting
Increasing Pneumococcal Vaccination for Immunosuppressed Patients: A Cluster Quality Improvement Trial
Sonali Desai¹, Lara Szent-gyorgyi², Alexander Turchin³, Bing Lu⁴, Anna A. Bogdanova², Michael Weinblatt⁵, Jonathan S. Coblyn⁶, Jeffrey O. Greenberg², Allen Kachalia² and Daniel H. Solomon⁷, ¹Medicine/ Rheumatology, Boston, MA, ²Medicine, Boston, MA, ³Endocrinology, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Division of Rheumatology, Brigham and Women's Hospital, Boston, MA
Increasing Pneumococcal Vaccination for Immunosuppressed Patients: A Cluster Quality Improvement TrialBackground/Purpose: It is important for patients on immunosuppressive medications to receive pneumococcal vaccination. Prior…
Abstract Number: 2063 • 2012 ACR/ARHP Annual Meeting
Detection of Inflammatory Arthritis and Musculoskeletal Conditions in a First Nations Community: Results of an Onsite Screening Program
Cheryl Barnabe¹, Carrissa Low Horn², Margaret Kargard², Stephen Mintsioulis², Sharon Leclercq³, Dianne P. Mosher⁴, Hani S. El-Gabalawy⁵, Tyler White² and Marvin J. Fritzler⁶, ¹Medicine, Community Health Sciences, University of Calgary, Calgary, AB, Canada, ²Siksika Health Services, Siksika, AB, Canada, ³Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁴Med, University of Calgary, Calgary, AB, Canada, ⁵Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ⁶Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: RA and SLE are more severe and at least twice as prevalent in the First Nations population of Canada compared to the Caucasian population.…
Abstract Number: 2064 • 2012 ACR/ARHP Annual Meeting
Regular Measure of Disease Activity During the Routine Care of Rheumatoid Arthritis Patients Involves Some Extra Work but Positive Results
Lissiane K. N. Guedes¹, Ana Cristina Medeiros Ribeiro², Karina Rossi Bonfiglioli³, Diogo Domiciano¹, Carolina Reither Vizioli¹, Gilmara Franco da Cunha¹, Andressa Silva Abreu¹, Filipi M. Mello¹, Ana Luiza de Aguiar Foelkel⁴, Celio R. Gonçalves¹ and Ieda Laurindo¹, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: According to treat to target recommendations the use of validated composite measures of disease activity, which include joint assessments, is needed in routine clinical…

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