Abstracts Archive - Page 2279 of 2607 - ACR Meeting Abstracts

Abstract Number: 2324 • 2013 ACR/ARHP Annual Meeting
Persistence On Biologics Is Associated With Concomitant Methotrexate Use Among Rheumatoid Arthritis Patient
Jie Zhang¹, Fenglong Xie², Elizabeth S. Delzell³, Huifeng Yun³, James Lewis⁴, Kevin Haynes⁵, Lang Chen⁶ and Jeffrey R. Curtis⁷, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴Medicine, University of Pennsylvania, Philadelphia, PA, ⁵Clinical Epidemiology and Biostatistics, University of Pennsylvania., Philadelphia, PA, ⁶Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL
Persistence on Biologics is Associated with Concomitant Methotrexate Use among Rheumatoid Arthritis Patient Background/Purpose: Concomitant methotrexate (MTX) is associated with improved treatment efficacy in randomized controlled…
Abstract Number: 2325 • 2013 ACR/ARHP Annual Meeting
Final 5-Year Safety and Efficacy Results Of a Phase 3, Randomized, Placebo-Controlled Trial Of Golimumab In Patients With Active Rheumatoid Arthritis Despite Previous Anti-Tumor Necrosis Factor Therapy
Josef S. Smolen¹, Jonathan Kay², Robert Landewé³, Eric L. Matteson⁴, Norman B. Gaylis⁵, Jürgen Wollenhaupt⁶, Frederick T. Murphy⁷, Chenglong Han⁸, Timothy A. Gathany⁸, Stephen Xu⁹, Yiying Zhou¹⁰, Elizabeth C. Hsia⁹ and Mittie K. Doyle⁹, ¹Division of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ²Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ³Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Arthritis & Rheumatic Disease Specialties, Aventura, FL, ⁶Schön Klinik Hamburg-Eilbek, Hamburg, Germany, ⁷Altoona Ctr for Clinical Research, Duncansville, PA, ⁸Janssen Global Services, LLC., Malvern, PA, ⁹Janssen Research & Development, LLC., Spring House, PA, ¹⁰Biostatistics, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: GO-AFTER was the first multicenter, randomized, placebo (PBO)-controlled trial of the safety/efficacy of an anti-TNFα agent, GLM, in pts with active RA despite prior…
Abstract Number: 2326 • 2013 ACR/ARHP Annual Meeting
Head-To-Head Comparison Of Subcutaneous Abatacept Versus Adalimumab On Background Methotrexate In RA: Blinded Two Year Results From The Ample (Abatacept Versus Adalimumab Comparison in Biologic-Naive RA Subjectswith Background Methotrexate) study
Michael E. Weinblatt¹, Michael H Schiff², Robert Valente³, Désirée M. van der Heijde⁴, Gustavo Citera⁵, Ayanbola Elegbe⁶, Michael A Maldonado⁶ and Roy Fleischmann⁷, ¹Division of Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, ²University of Colorado, Denver, CO, ³Arthritis Center of Nebraska, Lincoln, NE, ⁴Dept of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁶Bristol-Myers Squibb, Princeton, NJ, ⁷University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: AMPLE (Abatacept Versus Adalimumab Comparison in Biologic-Naive RA Subjects with Background Methotrexate) is the first 2 year, active comparator study in RA patients utilizing…
Abstract Number: 2327 • 2013 ACR/ARHP Annual Meeting
Dose Reduction Of Tocilizumab In Rheumatoid Arthritis Patients With Low Disease Activity Is Feasible
Noortje van Herwaarden¹, Susan Herfkens-Hol¹, Aatke van der Maas¹, Bart J.F. van Den Bemt², Ronald F. van Vollenhoven³, Johannes W.J. Bijlsma⁴ and Alfons A. den Broeder¹, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Pharmacy, Sint Maartenskliniek, Nijmegen, Netherlands, ³Karolinska Institute, Stockholm, Sweden, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Tocilizumab, at a registered dose of 8mg/kg, has proven to be effective in the treatment of rheumatoid arthritis. Clinical trial data show that a…
Abstract Number: 2328 • 2013 ACR/ARHP Annual Meeting
Tofacitinib, An Oral Janus Kinase Inhibitor, In The Treatment Of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy Up To 5 Years
Jürgen Wollenhaupt¹, Joel Silverfield², Eun Bong Lee³, Susan P. Wood⁴, Ketti K. Terry⁴, Hiroyuki Nakamura⁵, Yukako Ohno⁵, David Gruben⁴, Birgitta Benda⁶, Lisy Wang⁴ and Richard Riese⁴, ¹Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ²Healthpoint Medical Group, Tampa, FL, ³Seoul National University, Seoul, South Korea, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Japan Inc, Tokyo, Japan, ⁶Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is a novel, oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). Here we report tofacitinib safety, tolerability, and durability of response…
Abstract Number: 2329 • 2013 ACR/ARHP Annual Meeting
Improvements In Physical Function Correlate With Improvements In Health Related Quality Of Life: Reported Outcomes In Rheumatoid Arthritis Patients Treated With Tofacitinib: Results From 3 Randomized Phase 3 Trials
V. Strand¹, R. E. Alten², C. I. Nduaka³, R. Riese³, D. Gruben³, S. H. Zwillich³, J. Andrews³ and G. Wallenstein³, ¹Adjunct, Division of Immunology / Rheumatology, Stanford University, Palo Alto, CA, ²Department of Internal Medicine II, Schlosspark-Klinik, University Medicine, Berlin, Germany, ³Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is a novel, oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). RA affects all domains of health-related quality of…
Abstract Number: 2330 • 2013 ACR/ARHP Annual Meeting
Relationship Between Lymphocyte Count and Risk Of Infection In Rheumatoid Arthritis Patients Treated With Tofacitinib
R. F. van Vollenhoven¹, R. Riese², S. Krishnaswami², T. Kawabata², C. Fosser², S. Rottinghaus², M. Lamba² and S. H. Zwillich², ¹Clinical Trials Unit Department of Rheumatology, The Karolinska Institute, Stockholm, Sweden, ²Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is a novel oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). Cytokines involved in lymphocyte development, function and homeostasis…
Abstract Number: 2290 • 2013 ACR/ARHP Annual Meeting
Global Metabolite Profiling Of Synovial Fluids From Different Forms Of Inflammatory Arthritis For The Identification Of Putative Biomarker In Rheumatoid Arthritis
Jiwon Hwang¹, Joong Kyong Ahn², Jaejoon Lee¹, Inyoung Kim¹, Seulkee Lee¹, Chan Hong Jeon³, Eun-Mi Koh¹ and Hoon-Suk Cha¹, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
Background/Purpose: Metabolomics is the study of unique chemical fingerprints of specific cellular processes. Metabolite profiling is recently applied in identifying biomarkers in medical research including…
Abstract Number: 2291 • 2013 ACR/ARHP Annual Meeting
Only Rheumatoid Factor-Positive Subset Of Anti-Citrullinated Peptide/Protein Antibody-Negative Rheumatoid Arthritis Seroconverts To Anti-Citrullinated Peptide/Protein Antibody-Positive
Ryosuke Hiwa¹, Koichiro Ohmura¹, Shuichiro Nakabo¹, Chikashi Terao², Ran Nakashima¹, Yoshitaka Imura³, Naoichiro Yukawa⁴, Hajime Yoshifuji¹, Motomu Hashimoto⁵, Moritoshi Furu⁶, Hiromu Ito⁶, Takao Fujii⁶ and Tsuneyo Mimori^1,6, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: 216 (17.3%) out of 1,246 RA patients were negative for ACPA. In 149 cases of the ACPA-negative RA whose ACPA were measured more than…
Abstract Number: 2292 • 2013 ACR/ARHP Annual Meeting
Factors Affecting The Discrepancy Between Physician and Patient Global Assessment Of Disease Activity In Early and Established Rheumatoid Arthritis Patients- Results From The Ontario Best Practices Initiative
Pooneh Akhavan¹, Binu Jacob², Edward C. Keystone^3,4, Xiuying Li⁵, J. Carter Thorne⁶ and Claire Bombardier⁷, ¹Medicine, Early Rheumatoid Arthritis Program, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ²University Health Network, Toronto General Research Institute, Toronto, ON, Canada, ³Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada, ⁴University of Toronto/Mount Sinai Hospital, Toronto, ON, Canada, ⁵Clinical Decision Making and Health Care, University Health Network, Toronto, ON, Canada, ⁶Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Discrepancy between patient (PGA) and physician (MDGA) global assessments in Rheumatoid Arthritis (RA) can adversely affect therapeutic decisions. The pattern of PGA and MDGA,…
Abstract Number: 2293 • 2013 ACR/ARHP Annual Meeting
Anti-Citrullinated Peptide/Protein Antibody Specificities and Subclinical Synovitis In Palindromic Rheumatism: Towards a Better Understanding Of The Relationship With Rheumatoid Arthritis
Sonia Cabrera-Villalba¹, Julio Ramirez¹, Georgina Salvador², Virginia Ruiz-Esquide³, M. Victoria Hernández⁴, José Inciarte⁵, Celia Saura¹, J. D. Cañete¹ and Raimon Sanmarti³, ¹Rheumatology, Hospital Clinic, Barcelona, Spain, ²Rheumatology Unit., Hospital Mutua de Terrassa. Barcelona, Barcelona, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Arthritis Unit, Department of Rheumatology, Hospital Clinic, Barcelona, Barcelona, Spain, ⁵Arthritis Unit. Rheumatology Service, Hospital Clinic of Barcelona, Barcelona, Spain
Background/Purpose: Palindromic rheumatism (PR) may evolve to rheumatoid arthritis (RA), especially in anti-citrullinated peptide/protein antibody (ACPA) positive patients, although many do not evolve to RA…
Abstract Number: 2294 • 2013 ACR/ARHP Annual Meeting
The Role Of Patient Global Disease Activity Score In The Definition Of American College Of Rheumatology/European League Against Rheumatism Remission In Very Early Rheumatoid Arthritis From The Norwegian Very Early Arthritis Clinic
Maria Dahl Mjaavatten¹, Anne Julsrud Haugen², Halvor Nygaard³, Olav Bjørneboe⁴, Patrik Stolt⁵, Cathrine Thunem⁶ and Tore Kristian Kvien^1,7, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Østfold Hospital Trust, Fredrikstad, Norway, ³Dept. of Rheumatology, Revmatismesykehuset Lillehammer, Lillehammer, Norway, ⁴Dept. of Rheumatology, Martina Hansens Hospital, Sandvika, Norway, ⁵Dept. of Rheumatology, Innlandet Hospital Trust, Brumunddal, Norway, ⁶Dept. of Rheumatology, Betanien Hospital, Skien, Norway, ⁷Faculty of Medicine, University of Oslo, Oslo, Norway
Background/Purpose: In the ACR/EULAR criteria remission can be defined in two ways, either by fulfilment of 4 Boolean criteria or by a Simplified Disease Activity…
Abstract Number: 2295 • 2013 ACR/ARHP Annual Meeting
Mortality In Early Rheumatoid Arthritis Comparing Lithuania and Finland. A 13-Year Follow Up
Tuulikki Sokka¹, Sigita Stropuviene², Hannu Kautiainen³, Tuomas Rannio⁴ and Jolanta Dadoniene², ¹Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, ²Vilnius Univ, Vilnius, Lithuania, ³Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland, ⁴Jyvaskyla Central Hospital, Jyväskylä, Finland
Background/Purpose: Life span of patients with rheumatoid arthritis (RA) is reduced by 3-10 years compared to non-RA population. Only recent reports indicate improvements in survival…
Abstract Number: 2296 • 2013 ACR/ARHP Annual Meeting
Are SDAI50 and DAS28 Response Measures Comparable In Early Rheumatoid Arthritis Patients?
Mohammed Omair¹, Edward C. Keystone², Juan Xiong³, Gilles Boire⁴, Janet E. Pope⁵, J. Carter Thorne⁶, Carol A. Hitchon⁷, Boulos Haraoui⁸, Diane Tin⁹, Deborah Weber³, Vivian P. Bykerk² and Pooneh Akhavan², ¹Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, ²Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, ³Mount Sinai Hospital, Toronto, ON, Canada, ⁴Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵St Joseph Health Care, London, ON, Canada, ⁶Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁸Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada
Background/Purpose: An essential element of treat to target strategy is adjusting therapy in the absence of achieving a target response by 12 wk. A DDAS28…
Abstract Number: 2297 • 2013 ACR/ARHP Annual Meeting
Evaluating Depression Questionnaires In German Rheumatoid Arthritis Patients – Preliminary Results From a Validation Study
Matthias Englbrecht¹, Rieke Alten², Martin Aringer³, Christoph G. Baerwald⁴, Harald Burkhardt⁵, Nancy Eby⁶, Gerhard Fliedner⁷, Bettina Gauger⁸, Ulf Henkemeier⁹, Michael Hofmann¹⁰, Stefan Kleinert¹¹, Christian Kneitz¹², Christoph Pohl¹³, Georg Schett¹, Marc Schmalzing¹⁴, Anne-Kathrin Tausche¹⁵, Hans Peter Tony¹⁶ and Joerg Wendler¹⁷, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Teaching Hospital of the Charité, University of Berlin, Berlin, Germany, ³Rheumatology, Medicine III, University Clinical Center Technical University of Dresden, Dresden, Germany, ⁴Rheumatology, University Hospital, Leipzig, Germany, ⁵CIRI /Div. of Rheumatology, Goethe-University, Frankfurt/Main, Germany, ⁶Biostatistics, AMS-Advanced Medical Services, Mannheim, Germany, ⁷Praxis Osnabrück, Germany, Germany, Osnabrück, Germany, ⁸Roche Pharma AG, Grenzach, Germany, ⁹University Hospital Frankfurt, Frankfurt, Germany, ¹⁰Chugai Pharma, Frankfurt, Germany, ¹¹Rheumatology/Clinical Immunology,, University Hospital Würzburg, Würzburg, Germany, ¹²Internal Medicine II, Hospital Südstadt, Rostock, Germany, ¹³Rheumatology,Clinical Immunolo, Schlosspark Klinik, Berlin, Germany, ¹⁴Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany, ¹⁵Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ¹⁶Rheumatology/Immunology, University of Würzburg, Würzburg, Germany, ¹⁷Schwerpunktpraxis Rheumatologie, Erlangen, Germany
Background/Purpose: To date, only a few studies have discussed the prevalence of depression in RA patients in Germany and depression questionnaires have not been validated…

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