Abstracts Archive - Page 2273 of 2607 - ACR Meeting Abstracts

Abstract Number: 2393 • 2013 ACR/ARHP Annual Meeting
Involvement Of Transitional T Follicular Like Helper Cells Bearing Triple Phenotypes Of Tfh/Th1/Th17 In The Pathogenesis Of Rheumatoid Arthritis
Shingo Nakayamada¹, Satoshi Kubo², Naoki Yunoue², Maiko Yoshikawa², Shunsuke Fukuyo², Kazuyoshi Saito² and Yoshiya Tanaka², ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: T follicular helper (Tfh) cells are a new subset of T helper cells that regulate B cell function and promote autoantibody production. We previously…
Abstract Number: 2394 • 2013 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Smoking Is Not Primarily Associated With Anti-Citrullinated Protein Antibodies, But With The Presence Of Multiple Autoantibodies
Ammar Muhammad¹, Tineke van Wesemael², Yuta Kochi³, Maria Mjaavatten⁴, Kirsten Wevers-de-Boer¹, Cornelia F. Allaart¹, Leendert A. Trouw¹, Akari Suzuki³, Kazuhiko Yamamoto⁵, Annette H.M. van der Helm-van Mil¹, Tom W.J. Huizinga¹, René E.M. Toes¹ and Diane van der Woude¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: Smoking is associated with the presence of several autoantibodies in various autoimmune diseases. In rheumatoid arthritis (RA), smoking has been described to be specifically…
Abstract Number: 2396 • 2013 ACR/ARHP Annual Meeting
PI3Kdelta Regulates Invadosome Formation and Invasiveness Of Fibroblast-Like Synoviocyte In Rheumatoid Arthritis
Beatrix Bartok¹ and G. S. Firestein², ¹Rheumatology, UCSD School of Medicine, La Jolla, CA, ²Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the intimal lining are major effectors of cartilage damage in rheumatoid arthritis (RA). PI3Kdelta, a member of the Class IA…
Abstract Number: 2397 • 2013 ACR/ARHP Annual Meeting
To Which Extent May The Familial Risk Of Rheumatoid Arthritis Be Explained By Established Risk Factors?
Xia Jiang¹, Thomas Frisell², Johan Askling³, Lars Klareskog⁴, Lars Alfredsson¹ and Henrik Källberg¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a complex inflammatory disease known to aggregate within families, implicating the crucial role of shared genetic and/or environmental factors in…
Abstract Number: 2398 • 2013 ACR/ARHP Annual Meeting
Redox Mediated Angiogenesis In The Hypoxic Joint Of Inflammatory Arthritis
Monika Biniecka¹, Chin Teck Ng¹, Emese Balogh¹, Douglas J. Veale² and Ursula Fearon³, ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ³Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: To investigate whether in vivo synovial hypoxia and TNF blocking therapy determine expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase (Nox2) - a key source of…
Abstract Number: 2399 • 2013 ACR/ARHP Annual Meeting
Altered Histone Methylation Is Associated With IL-6 Dependent Matrix Metalloproteinases Gene Transcriptional Activation In Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^1,2, Kojiro Sato¹, Kazuhiro Yokota¹, Fumihiko Miyoshi¹, Yu F. Asanuma³, Yuji Akiyama¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which causes progressive joint destruction. In spite of the modern medications including biologic reagents, it…
Abstract Number: 2400 • 2013 ACR/ARHP Annual Meeting
Targeted Exon Resequencing For Korean Rheumatoid Arthritis
So-Young Bang¹, Kwangwoo Kim², Young-Ji Na², Jaemoon Lee³, Youngho Park⁴, Sun Young Lee⁵, Adnan Ahmad Ansari⁵, Chan-Bum Choi⁶, Yoon-Kyoung Sung², Tae-Hwan Kim⁷, Jae-Bum Jun⁸, Dae-Hyun Yoo⁸, Junghee Jung⁹, Hwanseok Rhee¹⁰, Jong-Young Lee¹¹, Bok-Ghee Han¹², Sung-Min Ahn¹³, Sungho Won³, Hye-Soon Lee¹⁴ and Sang-Cheol Bae⁸, ¹Hanyang University Guri Hospital, Guri, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Department of Applied Statistics, Chung-Ang University, Seoul, South Korea, ⁴Chung-Ang University, Seoul, South Korea, ⁵Gachon University, Incheon, South Korea, ⁶Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁸Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁹Bioinfomatics Center, Macrogen Inc, Seoul, South Korea, ¹⁰Bioinfomatics Center, Macrogen Inc, Seoul, South Korea, ¹¹Center for Genome Science, Korea National Institute of Health, Osong, South Korea, ¹²Korea National Institute of Health, Osong, South Korea, ¹³Deapartment of Translational Medicine, Gachon University, Incheon, South Korea, ¹⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disorder with heritability estimated at 65% characterized by arthritis and autoantibodies formation against citrullinated peptides (ACPA). Although…
Abstract Number: 2401 • 2013 ACR/ARHP Annual Meeting
Disease Activity (DAS-28CRP) In Rheumatoid Arthritis Correlates With Synovial Expression Of Tumor-Associated and IL-6-Dependent Genes
Bernard Lauwerys¹, Julie Ducreux², Adrien Nzeusseu Toukap¹, Valérie Badot³, Frédéric A. Houssiau² and Patrick Durez¹, ¹Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ³Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Background/Purpose: The molecular mechanisms that regulate disease activity in rheumatoid arthritis (RA) are unknown. Using high-throughput transcriptomic data sets generated in knee synovial biopsies from…
Abstract Number: 2402 • 2013 ACR/ARHP Annual Meeting
Association Between Life Events and Rheumatoid Arthritis, Results From The EIRA Case Control Study
Annmarie Wesley¹, Camilla Camilla Bengtsson¹, Marie Holmqvist², Töres Theorell³, Saedis Saevarsdottir⁴, Eva Skillgate¹, Lars Klareskog⁵, Lars Alfredsson⁶ and Sara Wedrén⁷, ¹Institute of Enviornmental Medicine, Karolinska Insitutet, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Public Health Sciences, Karolinska Insitutet, Stockholm, Sweden, ⁴Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Institute of Enviornmental Medicine/Cardiovascular epidemiology, Karolinska Insitutet, Stockholm, Sweden, ⁷Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The association between life events and rheumatoid arthritis (RA) has previously been studied with contradicting results. No previous study have investigated the impact of…
Abstract Number: 2403 • 2013 ACR/ARHP Annual Meeting
The Incidence Of Factor V Leiden A1691G, Methylene Tetrahydrofolate Reductase C677T, and Prothrombin G20210A Mutation In Patients With Rheumatoid Arthritis
Taskin Senturk¹, Zahit Bolaman², Sabri Batun³, Irfan Yavasoglu⁴ and Gurhan Kadikoylu², ¹Adnan Menderes University, Department of Rheumatology, Professor, Aydin, Turkey, ²Adnan Menderes University, Department of Hematology, Professor, Aydin, Turkey, ³Dicle University, Department of Hematology, Professor, Diyarbakır, Turkey, ⁴Adnan Menderes University, Department of Hematology, Associated Professor, Aydin, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic and inflammatory disease. Thromboembolic phenomenas are more frequent in patients with RA than healthy individuals and several…
Abstract Number: 2404 • 2013 ACR/ARHP Annual Meeting
CXCL13-Producing CD4 T-Cells In Rheumatoid Synovitis Are a Distinct Subset
Shio Kobayashi¹, Koichi Murata², Hideyuki Shibuya², Masahiro Ishikawa², Moritoshi Furu³, Hiromu Ito³, Shuichi Matsuda², Takeshi Watanabe⁴ and Hiroyuki Yoshitomi⁵, ¹Center for Innovation in Immunoregulative Technology ant Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Innovation Center for Immunoregulation Technologies and Drugs, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Ectopic lymphoid structures are frequently formed in synovial tissues of patients with rheumatoid arthritis (RA). Several reports suggested that CD4 T-cells have a crucial…
Abstract Number: 2405 • 2013 ACR/ARHP Annual Meeting
Respiratory Diseases As Risk Factors For Rheumatoid Arthritis
Marie Holmqvist¹, Johan Askling¹, Lars Alfredsson², Camilla Bengtsson², Fredrik Nyberg³ and Göran Tornling⁴, ¹Karolinska Institutet, Stockholm, Sweden, ²Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³AstraZeneca R&D, Mölndal, Sweden, ⁴Respiratory Medicine Unit, Department of Medicine Solna and CMM, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: The etiology of rheumatoid arthritis (RA) is only partly understood. In addition to smoking, other airway exposures, e.g. silica dust and traffic pollution, have…
Abstract Number: 2406 • 2013 ACR/ARHP Annual Meeting
The Relationship Between Anti-Citrullinated Protein Antibodies and Radiographic Damage In African-Americans With Rheumatoid Arthritis
Maria I. Danila¹, Richard J. Reynolds², Stella Aslibekyan³, Ashutosh Tamhane³, Laura B. Hughes⁴, Jeremy Sokolove⁵, William H. Robinson⁶, Doyt L. Conn⁷, Beth L. Jonas⁸, Leigh F. Callahan⁹, Larry W. Moreland¹⁰, Richard D. Brasington¹¹, Edwin A. Smith¹², Ted R. Mikuls¹³, Désirée van der Heijde¹⁴ and S. Louis Bridges Jr.¹⁵, ¹Med/Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ²Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Med Div of Clin Imm & Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁵VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ⁸Thurston Arthritis Research Ct, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁹Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC, ¹⁰Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, ¹²Dept of Med Div of Rheum, Med Univ of South Carolina, Charleston, SC, ¹³Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁵Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Joint erosions and joint space narrowing may lead to impaired functional status and disability in rheumatoid arthritis (RA). Autoantibodies to citrullinated proteins (ACPA) are present in…
Abstract Number: 2407 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Related Autoantibodies In The Lung Evolve Over Time In Subjects At Elevated Risk For Future Rheumatoid Arthritis
M. Kristen Demoruelle¹, Patrick R. Wood², Michael H. Weisman³, Mark C. Parish¹, Isabel F. Pedraza⁴, Jill M. Norris⁵, V. Michael Holers⁶ and Kevin D. Deane¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Internal Medicine, University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Epidemiology, Colorado School of Public Health, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Recent data from our group have demonstrated that RA-related autoantibodies (Abs), including anti-CCP and RF, are detectable in sputum from subjects with early Classified…
Abstract Number: 2408 • 2013 ACR/ARHP Annual Meeting
Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models
Yvonne NW Kam¹, Andrew Filer², Christopher D. Buckley³, Costantino Pitzalis⁴ and Michele Bombardieri⁵, ¹William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, QMUL, London, United Kingdom, ²Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ³Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the formation of synovial niches of autoreactive B cells which are favored by the autocrine production of B…

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