Abstracts Archive - Page 2272 of 2607 - ACR Meeting Abstracts

Abstract Number: 2419 • 2013 ACR/ARHP Annual Meeting
CDK6 Transcripts Expression Control By The Synoviocyte Proliferation Gene, SPACIA1
Rie Komatsu¹, Ryoji Fujii¹, Tomoo Sato¹, Yoshihisa Yamano¹, Kazuo Yudoh², Moroe Beppu³, Kusuki Nishioka⁴ and Toshihiro Nakajima^3,4,5, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ²Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ³St. Marianna University School of Medicine, Kanagawa, Japan, ⁴Tokyo Medical University, Tokyo, Japan, ⁵Misato Marine Hospital, Kohchi, Japan
SPACIA1ASFs) and . In the present study we investigated the mechanisms involved in the SPACIA1-related regulation of CDK6 gene expression in vitro.ASFs: Among the key…
Abstract Number: 2420 • 2013 ACR/ARHP Annual Meeting
Pleiotropic Roles Of Fcγ Receptors Upregulated On Circulating Monocytes In Rheumatoid Arthritis Patients
Masako Tsukamoto¹, Katsuya Suzuki², Keiko Yoshimoto², Hideto Kameda² and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: We have previously demonstrated that Fc gamma receptor(FcgR)II) and CD64(FcgRI) molecules on CD14+ cells were measured by flow cytometry. FcgR IIIa, anti-CD16 antibody(1D3) which…
Abstract Number: 2421 • 2013 ACR/ARHP Annual Meeting
Association Between Physical Work Load and Rheumatoid Arthritis, Results From The EIRA Case Control Study
Annmarie Wesley¹, Henrik Källberg², Camilla Bengtsson², Eva Skillgate¹, Johan Rönnelid³, Mohammed Mullazehi⁴, Lars Klareskog⁵, Lars Alfredsson², Saedis Saevarsdottir⁶ and Sara Wedren^7,8, ¹Institute of Enviornmental Medicine, Karolinska Insitutet, Stockholm, Sweden, ²Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Uppsala University, Uppsala, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁷Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁸Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The association between occupation and RA has previously been investigated where occupations associated with a physical work load (quarry workers, construction workers, assistant nurses,…
Abstract Number: 2422 • 2013 ACR/ARHP Annual Meeting
Anti-P. Gingivalis antibody Is Correlated With Severity Of Periodontitis But Not With Rheumatoid Arthritis Disease Activity In RA
Joo Youn Lee¹, In Ah Choi², Jin-Hee Kim³, Kyung-Hwa Kim⁴, Hye Jin Oh⁵, Myeong Jae Yoon⁶, Eun Young Lee², Eun Bong Lee², Yong-Moo Lee³ and Young Wook Song^1,2, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ³Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, ⁴Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea, ⁵Seoul National University, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: Periodontitis (PD) has been suggested to be one of risk factors for rheumatoid arthritis (RA). Porphyromonas gingivalis (P. ginvivalis, Pg) is a gram-negative anaerobic…
Abstract Number: 2423 • 2013 ACR/ARHP Annual Meeting
Mir-27b As Biomarker and Regulator Of IL-6R Pathway In Resistant Rheumatoid Arthritis Monocyte
Marina Frleta¹, Ashleigh-Ann Rainey², Derek S. Gilchrist³, Lynn Crawford³, Derek Baxter³, Mariola Kurowska-Stolarska⁴ and Iain B. McInnes², ¹Institute of infection, immunity and inflammation, University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ³Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Whereas molecular mechanisms mediating treatment responses to biologic DMARDS in Rheumatoid Arthritis (RA) are emerging, those pathways that subserve treatment resistance are poorly explored.…
Abstract Number: 2424 • 2013 ACR/ARHP Annual Meeting
Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts
Sarah Hawtree¹, Munitta Muthana¹, Sarah Aynsley¹, J. Mark Wilkinson² and Anthony G. Wilson³, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, ³Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS).…
Abstract Number: 2425 • 2013 ACR/ARHP Annual Meeting
Impaired TNFá Production By Dendritic Cells From Rheumatoid Arthritis Patients Upon Contact With Porphyromonas Gingivalis
Kim CM Santegoets^1,2, Mark H. Wenink^1,2, Wim B van den Berg³ and Timothy RDJ Radstake^2,4, ¹Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA) and the severity of periodontitis can affect the level of arthritis. Porphyromonas…
Abstract Number: 2426 • 2013 ACR/ARHP Annual Meeting
Signaling Abnormalities In Neutrophil Granulocytes Of Rheumatoid Arthritis Patients Are Associated With Increased Extracellular Trap Formation and Provide a Basis For The Induction Of Anti-Citrullinated Peptide Antibodies
Chanchal Sur Chowdhury¹, Stavros Giaglis^2,3, Ulrich A. Walker⁴, Andreas Buser⁵, Paul Hasler² and Sinuhe Hahn⁶, ¹Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, ²Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ⁵Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, ⁶Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Rheumatoid arthritis (RA) is often associated with anti-citrullinated peptide antibodies (ACPAs) in the serum. While ACPAs have been associated with increased inflammation, joint destruction…
Abstract Number: 2427 • 2013 ACR/ARHP Annual Meeting
Enhanced Expression Of mRNA For Triggering Receptor Expressed On Myeloid Cells 1 In CD34+ Cells Of The Bone Marrow In Rheumatoid Arthritis
Tatsuo Nagai¹, Tetsuya Tomita², Hideki Yoshikawa² and Shunsei Hirohata³, ¹Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ²Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ³Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: We previously showed that bone marrow (BM) CD34+ cells from rheumatoid arthritis (RA) patients have abnormal capacities to respond to tumor necrosis factor alpha…
Abstract Number: 2428 • 2013 ACR/ARHP Annual Meeting
Suppression Of Tumor Necrosis Factor Receptor Associated Factor (TRAF) 6 Attenuates The Proinflammatory Effect Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Lang Jing Zhu¹, Jing Jing Zhou¹, Chan Juan Zou², Dong Hui Zheng¹, Xiu Ning Wei¹, Jian Da Ma¹, Ying Qian Mo¹ and Lie Dai¹, ¹Division of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, ²Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic inﬂammatory synovitis, leading to invasion of synovial tissue into the adjacent cartilage matrix…
Abstract Number: 2429 • 2013 ACR/ARHP Annual Meeting
Enhanced Responsiveness To Stimulation and Increased Extrusion Of Extracellular Traps By Rheumatoid Arthritis Neutrophil Granulocytes and of Healthy Control Neutrophils to Serum and Synovial Fluid From Rheumatoid Arthritis Patients
Stavros Giaglis^1,2, Chanchal Sur Chowdhury³, Ulrich A. Walker⁴, Andreas Buser⁵, Sinuhe Hahn⁶ and Paul Hasler¹, ¹Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ⁵Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, ⁶Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Polymorphonuclear granulocytes (PMNs) are the most abundant immune cell population in the synovial fluid in the joints of patients with rheumatoid arthritis (RA) and…
Abstract Number: 2430 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis as An Etiological Clue To The Development Of Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis
Nastya Kharlamova¹, Natalia Sherina¹, Anne-Marie Quirke², Kaja Eriksson³, Lena Israelsson⁴, Jan Potempa⁵, Patrick Venables⁶, Tulay Yucel-Lindberg³ and Karin Lundberg⁷, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Department of Dentistry, Karolinska Institutet, Stockholm, Sweden, ⁴Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Microbiology Department, Jagiellonian University, Krakow, Poland, ⁶Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the production of autoantibodies to citrullinated proteins (ACPA). Citrullinated proteins are generated by the actions of peptidyl arginine…
Abstract Number: 2395 • 2013 ACR/ARHP Annual Meeting
Plasma Short-Talin Is a New Rheumatoid Arthritis Monitoring Biomarker Independent Of The Inflammatory Markers
Kensei Tsuzaka, Masako Takao and Jiro Nishida, Dept of Internal Medicine, Ichikawa General Hospital,TDC, Ichikawa, Chiba, Japan
Methods: ). Sixteen (31.4 %) of these 51 patients were untreated, and 18 patients (35.3%) were treated with biologics DMARD at the time of collecting…
Abstract Number: 2391 • 2013 ACR/ARHP Annual Meeting
Pathogenic Pro-Inflammatory Cytokine Production Induced By Synovial Fluid From RA Patients Is Related To Levels Of Endogenous TLR4 Ligands and Is Blocked By a Novel Therapeutic Anti-Human TLR4 Monoclonal Antibody, NI-0101
Limin Shang¹, Greg Elson¹, Jeremy Sokolove², Iain B. McInnes³, James Reilly⁴, Eric Hatterer¹, Marie Kosco-Vilbois⁵, Walter Ferlin⁵, Emmanuel Monnet⁵ and Cristina de Min⁶, ¹NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵NovImmune S.A., Geneva, Switzerland, ⁶Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland
Background/Purpose: Deregulation of Toll-Like Receptor 4 (TLR4) signaling is thought to play a role in the pathogenesis of certain autoimmune diseases. In rheumatoid arthritis (RA),…
Abstract Number: 2392 • 2013 ACR/ARHP Annual Meeting
Impact Of CT-P13 and Originator Infliximab Treatment On Quality Of Life Derived From The Health Assessment Questionnaire (HAQ) and Short-Form 36 (SF-36) From a Randomized, Double-Blind Trial In Patients With Active RA
Dae-Hyun Yoo¹, Andriy Yagensky², Antoaneta Toncheva³, Osca Ruiz Santacruz⁴, Fidencio Cons Molina⁵, Yunju Bae⁶, Taek Kwon⁶, SinHye Kim⁶, Peter Lacouture⁷, Teresa Kok⁸ and Won Park⁹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Lutsk City Hospital, Lutsk, Ukraine, ³National Multiprofile Transport Hospital, Sofia, Bulgaria, ⁴Centro Integral de Reumatología e Inmunología - CIREI S.A.S, Bogotá, Colombia, ⁵Centro de Investigacion en Artritis y Osteoporosis, Mexicali, Mexico, ⁶Celltrion Inc., Incheon, South Korea, ⁷Hospira Inc, Lake forest, IL, ⁸Hospira Inc., Lake Forest, IL, ⁹Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea
Background/Purpose: Quality of life and functionality are important outcome metrics in understanding the value of therapeutic interventions in RA. Biological products have become an established…

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