Abstracts Archive - Page 2268 of 2607 - ACR Meeting Abstracts

Abstract Number: 2479 • 2013 ACR/ARHP Annual Meeting
Adalimumab Significantly Reduces Inflammation In Active Ankylosing Spondylitis: An Ultrasound Study
Zaiying Hu¹, Manlong Xu², Zetao Liao³, Zhiming Lin⁴ and Jieruo Gu⁵, ¹Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²THIRD AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSIT, Guangzho, China, ³Rheumatology, The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, ⁴Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ⁵Medicine, Third Affiliated Hospital of Sun Yat-sen University, GuangZhou, China
Background/Purpose: To evaluate the feasibility of using power Doppler ultrasound (PDUS) to detect inflammation in sacroiliac joints and entheses after adalimumab (a TNF-alpha antagonist) treatment…
Abstract Number: 2480 • 2013 ACR/ARHP Annual Meeting
Predicting Progression Of Non-Radiographic Axial Spondyloarthritis
Nigil Haroon^1,2,3, Lianne S. Gensler⁴, Dinny Wallis⁵, Ammepa Anton¹, Grace Yoon⁶ and Robert D. Inman⁷, ¹Rheumatology, University Health Network, Toronto, ON, Canada, ²Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁶Medicine/Rheumatology, UCSF, San Franciscao, CA, ⁷Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: A proportion of patients with non-radiographic axial spondyloarthritis (NR-AxSpA) progress to AS but the predictors of progression have not been well established. We studied…
Abstract Number: 2481 • 2013 ACR/ARHP Annual Meeting
External Validation Of The Spondyloarthritis Radiography Online Reference Module For Training Readers To Score The Modified Stoke Ankylosing Spondylitis Score
Praveena Chiowchanwisawakit¹, Susanne Juhl Pedersen² and Walter P. Maksymowych³, ¹Mahidol University, Bangkok, Thailand, ²Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ³Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) is commonly used to assess disease severity and progression in patients with AS; however, the reliability…
Abstract Number: 2482 • 2013 ACR/ARHP Annual Meeting
Which Contextual Factors Have An Important Influence On Work Outcome In Patients With Ankylosing Spondylitis. A Systematic Literature Review
Jose Dionisio Castillo-Ortiz^1,2, Carmen Stolwijk³ and Annelies Boonen¹, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ²Unidad de Investigacion en Enfermedades Cronico-Degenerativas, Guadalajara, Mexico, ³School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands
Background/Purpose: It is increasingly recognized that contextual factors (either environmental or personal) play a role in the magnitude in which the disease influences work participation.…
Abstract Number: 2483 • 2013 ACR/ARHP Annual Meeting
Periarticular Bone Gain In Early Psoriatic Arthritis But Not In Rheumatoid Arthritis Following Anti-Rheumatic Treatment As Measured By Digital X-Ray Radiogrammetry
Agnes Szentpetery¹, Muhammad Haroon², Phil Gallagher³, Eric J. Heffernan⁴ and Oliver FitzGerald², ¹Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Department of Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ³Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, ⁴Radiology, St. Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Hand bone loss is an early feature in both RA and PsA, but there is less data available on periarticular bone gain, in particular…
Abstract Number: 2484 • 2013 ACR/ARHP Annual Meeting
Immunogenicity Of TNFα Blockers In Patients With Psoriatic Arthritis
Michael Zisapel Zisapel¹, Noa Madar-Balakirsi², Hagit Padova³, Irena Wigler⁴, Daphna Paran⁵, Uri Arad⁴, Dan Caspi⁶ and Ori Elkayam⁷, ¹Rheumatology, Tel Aviv Medical Centet, Tel Aviv, Israel, ²Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel, ³Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Department of Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁵Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv university, Tel Aviv, Israel, ⁶Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel- Aviv, Israel
Background/Purpose: TNFα blockers have been shown to produce immunogenecity in patients with rheumatoid arthritis, spondyloarthrritis and inflammatory bowel diseases. Data on the induction of anti-drug…
Abstract Number: 2485 • 2013 ACR/ARHP Annual Meeting
High Incidence Of Disease Recurrence After Discontinuation Of Disease Modifying Anti-Rheumatic Drug Treatment In Patients With Psoriatic Arthritis In Remission
Elizabeth Araujo¹, Stephanie Finzel¹, Dominik A. Schreiber², Matthias Englbrecht¹, Axel J. Hueber³, Francesca Faustini³, Juergen Rech³ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: In the era of modern anti-rheumatic therapy, it is now possible to contemplate the idea of clinical remission in patients with psoriatic arthritis (PsA).…
Abstract Number: 2486 • 2013 ACR/ARHP Annual Meeting
Clinical Performance Of 4 Methods For Detecting Latent Tuberculosis Infection (LTbI) In Patients With Active Chronic Inflammatory Arthritis Taking TNFα Blockers
Carina M F Gomes¹, Maria Teresa Terreri², Maria Isabel Pinto³, Karen Oseki³, Fernanda Spina⁴ and Marcelo M. Pinheiro⁵, ¹Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Pediatrics, Universidade Federal de São Paulo / UNIFESP, Sao Paulo, Brazil, ³Pediatrics, Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁴Rheumatology Division, Universidade Federal de São Paulo Unifesp/EPM, Brazil, Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁵Brazilian Registry of Spondyloarthritis, São Paulo, Brazil
Background/Purpose: About 5% of the Brazilian population has some chronic inflammatory arthropathy (CIA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PA) and juvenile…
Abstract Number: 2487 • 2013 ACR/ARHP Annual Meeting
Role Of IL-33 In The Development Of Premature Atherosclerosis In Psoriatic Arthritis Patients
Priscilla Ching-han Wong¹, Qing Shang², Cheuk-Man Yu² and Lai Shan Tam², ¹Medicine and Therapeutics, Prince of Wales hospital, New Territories, Hong Kong, ²Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Interleukin 33 (IL-33) is a newly identified member of the IL-1 cytokine family. It involves in T-cell mediated immune responses through the activation of…
Abstract Number: 2488 • 2013 ACR/ARHP Annual Meeting
Elevated Serum Anti-Flagellin Antibodies Implicate Subclinical Bowel Inflammation in Ankylosing Spondylitis
Dinny Wallis¹, Arundip Asaduzzaman¹, Michael H. Weisman², Nigil Haroon¹, Ammepa Anton³, Dermot P. B. McGovern⁴, Stephan R. Targan⁵ and Robert D. Inman⁶, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA, ³Rheumatology, University Health Network, Toronto, ON, Canada, ⁴Department of Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitisBackground/Purpose: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share genetic and clinical features. IBD…
Abstract Number: 2489 • 2013 ACR/ARHP Annual Meeting
Spondyloarthritis-Associated Polymorphisms Of ERAP1 Are Correlated With Gene Expression, Protein Level and Enzymatic Activity Of The Amino-Peptidase
Félicie Costantino¹, Alice Talpin², Irini Evnouchidou³, Amir Kadi², Roula Said-Nahal⁴, Ariane Leboime⁵, Nelly Bonilla⁶, Franck Letourneur⁶, Tifenn Leturcq², Zeyna Ka², Peter van Endert³, Henri-Jean Garchon^2,7, Gilles Chiocchia^8,9 and Maxime A. Breban^2,7, ¹INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ²Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ³INSERM U1013 - Université Paris Descartes - Sorbonne Paris Cité, Paris, France, ⁴Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁵Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁶INSERM U1016, Cochin Institute, Paris, France, ⁷Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁸Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France, ⁹Université Versailles-Saint Quentin, Montigny le Bretonneux, France
Background/Purpose: Endoplasmic reticulum aminopeptidase 1 (ERAP1) exerts a central role in antigen presentation making it an attractive candidate gene for inflammatory diseases. Several polymorphisms in…
Abstract Number: 2491 • 2013 ACR/ARHP Annual Meeting
Serum Levels Of Novel Noggin- and Sclerostin-Immune Complexes Are Elevated In Ankylosing Spondylitis
Florence W. Tsui¹, Hing Wo Tsui² and Robert D. Inman³, ¹Genetics and Development / Immunology, Toronto Western Research Institute UHN and University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute UHN, Toronto, ON, Canada, ³Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: Unravelling the basis of joint inflammation and ankylosis represents a major challenge in ankylosing spondylitis (AS) research. As noggin (NOG) and sclerostin (SOST) have…
Abstract Number: 2451 • 2013 ACR/ARHP Annual Meeting
Work Instability Scores In Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis Are Equal and Higher Than In Psoriatic Arthritis
Sherry Rohekar¹, Robert D. Inman² and Dafna D. Gladman³, ¹Rheumatology, St. Joseph's Hospital, London, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Clinical subsets of spondyloarthitis (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA) may be associated with significant impact on work performance and…
Abstract Number: 2452 • 2013 ACR/ARHP Annual Meeting
Effects Of Smoking In Patients With Axial Spondyloarthritis – Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis – Receiving Anti-TNF therapy
Ozlem Pehlivan, Yasemin Yalcinkaya, Nihat Huseyinsinoglu, Nilufer Alpay Kanitez, Burak Erer, Sevil Kamali, Murat Inanç, Orhan Aral, Ahmet Gul and Lale Ocal, Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is a systemic disease characterized by sacroiliitis and inflammatory back pain. The radiological findings of AS appear late causing delay in…
Abstract Number: 2453 • 2013 ACR/ARHP Annual Meeting
Identification Of Determinants Of The Functional Outcome In Patients With Early Axial Spondyloarthritis: Results From The German Spondyloarthritis Inception Cohort
Denis Poddubnyy¹, Hildrun Haibel¹, Joachim Listing², Jürgen Braun³, Martin Rudwaleit⁴ and Joachim Sieper¹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²German Rheumatism Research Center, Berlin, Germany, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Endokrinologikum, Berlin, Germany
Background/Purpose: In cross-sectional studies it has been shown already that functional status in ankylosing spondylitis (AS), which represents probably the most important long-term outcome in…

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