Abstract Number: 2334 • 2012 ACR/ARHP Annual Meeting
T-Cell Cross Reactivity with Citrullinated Antigen and P. Gingivalis Membrane Antigen Following Infection with P. Gingavalis and/or Injection of Citrullinated Mouse Type II Collagen in DBA/1J Mice
Background/Purpose: Recently, periodontal disease (PD) has been associated with the risk and progression of RA. Patients with RA complicated by PD have been shown to…Abstract Number: 2335 • 2012 ACR/ARHP Annual Meeting
Increased TSLP Expression in Joints of Rheumatoid Arthritis Patients Causes Increased Activation of Intra-Articular Myeloid Dendritic Cells with Enhanced Th1 and Th17 Cell Activity
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Administration of TSLP…Abstract Number: 2336 • 2012 ACR/ARHP Annual Meeting
Elevated Frequency of Synovial Interleukin-21+ CD4+ T Cells Co-Expressing Tumor Necrosis Factor-a in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial tissue in multiple joints. The inflammatory process in RA is regulated by several cytokines,…Abstract Number: 2337 • 2012 ACR/ARHP Annual Meeting
Therapeutic Promotion of CD8 CTL by CpG Oligodeoxynucleotides (ODN) in an Induced Model of Lupus
Background/Purpose: In addition to TcR signaling and costimulation, CD8 T cells require a third signal to mature into effector cytotoxic T lymphocytes (CTL). In pathogen…Abstract Number: 2338 • 2012 ACR/ARHP Annual Meeting
1,25(OH)2D3 Modulates the Migration Pattern of Th17 Cells From Patients with Rheumatoid Arthritis
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, T-helper-17 (Th17) cells have been implicated to play…Abstract Number: 2339 • 2012 ACR/ARHP Annual Meeting
Lowering Fli1 Levels Decreases the Levels of Lipid Mediators in the Kidneys and T Cells of MRL/Lpr Lupus Prone Mice
Background/Purpose: The Ets factor Fli1 is implicated as a key modulator of lupus disease expression. Over-expressing Fli1 in healthy mice, results in the development of…Abstract Number: 2340 • 2012 ACR/ARHP Annual Meeting
A Numeric Expansion of Invariant Natural Killer T Cells Protects Against the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Background/Purpose: Previous studies from our lab have shown that the introgression of a NZB chromosome 1 (c1) interval extending from 135 to179 Mb onto the…Abstract Number: 2341 • 2012 ACR/ARHP Annual Meeting
Exacerbation of Collagen-Induced Arthritis by an Anti-CD3 Antibody Targeting Aminoterminal-Deficient CD3ε
Background/Purpose: We have previously characterized naturally occurring forms of CD3e that lack the aminoterminal region (DNH2-CD3e) and are bound with high avidity by the YCD3-1…Abstract Number: 2342 • 2012 ACR/ARHP Annual Meeting
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…Abstract Number: 2343 • 2012 ACR/ARHP Annual Meeting
The Therapeutic Antibody Tregalizumab (BT-061) Induces Activation of Regulatory T Cells by Engaging a Unique CD4 Mediated Signaling That Strongly Differs From Signaling Events Induced by Standard Anti-CD4 Antibodies
Background/Purpose: The humanized CD4 specific monoclonal antibody (mAb) tregalizumab is currently being tested in phase II clinical trials in Rheumatoid Arthritis. In contrast to other…Abstract Number: 2344 • 2012 ACR/ARHP Annual Meeting
Transcriptional Regulation of Garp Expression
Background/Purpose: Regulatory T cells (Tregs) contribute to immune tolerance and play a pivotal role in the prevention of autoimmune diseases such as rheumatoid arthritis (RA).…Abstract Number: 2303 • 2012 ACR/ARHP Annual Meeting
Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study
Background/Purpose: Systemic sclerosis or scleroderma (SSc) is a complex autoimmune disorder that affects the connective tissue causing fibrosis in the skin and different internal organs.…Abstract Number: 2304 • 2012 ACR/ARHP Annual Meeting
Differential Association of IRAK1 and MECP2 with Specific Systemic Sclerosis Phenotypes
Background/Purpose: Systemic sclerosis (SSc) is a fibrotic autoimmune disease that represents a clear example of a sex biased immune disorder. The X-chromosome gene IRAK1 has…Abstract Number: 2306 • 2012 ACR/ARHP Annual Meeting
Intratracheal Instillation of Omniscan in an Adenine-Induced Model of Chronic Renal Failure: A New Model of Nephrogenic Systemic Fibrosis
Background/Purpose: Nephrogenic Systemic Fibrosis (NSF), a generalized progressive fibrotic disorder, occurs in some patients with renal insufficiency exposed to various gadolinium based contrast agents (GdBCA). …Abstract Number: 2307 • 2012 ACR/ARHP Annual Meeting
Role of Endosomal and Cell Membrane Toll-Like Receptors in Keratinocyte Activation by Systemic Sclerosis Autoantibodies
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune rare connective tissue disorder of unknown aetiology, heterogeneous clinical manifestations and an often progressive course which includes skin…
ACR Meeting Abstracts