Abstract Number: 2359 • 2012 ACR/ARHP Annual Meeting
Outcome of Aortic Involvement in GIANT CELL Arteritis (GCA) After 1-Year Follow-up: Prospective Study in 35 Patients Using Computed Tompography Angiography (CTA)
Background/Purpose: 65% of patients with newly diagnosed, biopsy-proven GCA showed radiologic finding of aortitis using CTA in a prospective study of 40 patients. By segments,…Abstract Number: 2360 • 2012 ACR/ARHP Annual Meeting
Prevalence, Management and Outcomes of PET Positive Large Vessel Vasculitis in Difficult to Treat PMR and GCA Patients
Background/Purpose: Management of PMR and GCA can be challenging in patients with persistently elevated inflammatory markers, prominent constitutional symptoms and inadequate steroid response. We undertook…Abstract Number: 2361 • 2012 ACR/ARHP Annual Meeting
Misdiagnosis of Giant Cell Arteritis Presenting As Fever of Unknown Origin
Background/Purpose: Giant cell arteritis (GCA) represents the most common primary vasculitis of the elderly, that usually involves large and medium sized arteries. The wide spectrum…Abstract Number: 2362 • 2012 ACR/ARHP Annual Meeting
Evaluation of Disease Activity Using FDG PET-CT in Patients with Large Vessel Vasculitis
Background/Purpose: 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computerized tomography (CT) [PET/CT] has been proposed as a useful tool to diagnose and monitor activity of large vessel…Abstract Number: 2363 • 2012 ACR/ARHP Annual Meeting
Assessment of Disease Activity in Large Vessel Vasculitis: Initial Results of an International Delphi Exercise
Background/Purpose: Assessment of disease activity in large vessel vasculitis (LVV) is challenging. The lack of specific, validated outcome measurements for both Takayasu’s (TAK) and giant…Abstract Number: 2364 • 2012 ACR/ARHP Annual Meeting
CROSS-Sectional Assessment of Damage in Takayasu Arteritis with A Validated Tool
Background/Purpose: Takayasu arteritis (TA) is a large vessel vasculitis with a chronic course, usually causing damage by the time of diagnosis. To our knowledge, there…Abstract Number: 2325 • 2012 ACR/ARHP Annual Meeting
PD-1 Signaling Promotes Suppressive Function of CD4+ Regulatory T Cells in (New Zealand Black x New Zealand White )F1 Lupus-Prone Mice in a Dose-Dependent Manner
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…Abstract Number: 2326 • 2012 ACR/ARHP Annual Meeting
Discovery of a Highly Potent, Selective Reversible Covalent Inhibitor of JAK3 Kinase
Background/Purpose: Targeting of the JAK-STAT pathway has been shown to be efficacious for treatment of patients with rheumatoid arthritis through the successful use of pan-JAK…Abstract Number: 2327 • 2012 ACR/ARHP Annual Meeting
CGEN-15001, a Novel Negative Costimulatory Fusion Protein Is Effective in the Collagen-Induced Arthritis Mouse Model of Rheumatoid Arthritis
Background/Purpose: CGEN-15001 is a recombinant Fc fusion protein consisting of the extracellular domain of CGEN-15001T, a protein predicted to be a member of the B7/CD28…Abstract Number: 2328 • 2012 ACR/ARHP Annual Meeting
A Novel Method for Quantitative and Functional Analysis of Autophagy Using Flow Cytometry in Activated Human Primary T Cells
Background/Purpose: Autophagy is an evolutionally conserved self-degradation system. In this process, an isolation membrane engulfs cytoplasmic materials and organelles to form an autophagosome. The autophagosome…Abstract Number: 2329 • 2012 ACR/ARHP Annual Meeting
Increase of CD4+CD25+FoxP3+ T Cell in Patients with Systemic Sclerosis Could Secret IL-17 with Dysfunction of Immunosuppression
Background/Purpose: Immune unbalance between Th17 and regulatory T cells (Treg) is a characteristic of systemic sclerosis (SSc). The functional heterogeneity and differentiation dynamics can be…Abstract Number: 2330 • 2012 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cells Are Inactivated by IFNα and Reduced in Systemic Lupus Erythematosus
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes which are restricted by the MHC-related molecule-1 (MR1) and express an invariant TCRα…Abstract Number: 2331 • 2012 ACR/ARHP Annual Meeting
The Effects of Anti–Tumor Necrosis Factor Agents On the Expansion of T Helper-Type 17 Cells Driven by Lipopolysaccharide-Stimulated Monocytes
Background/Purpose: T helper-type 17 (Th17) cells are proinflammatory CD4+ cells characterized by the production of Interleukin-17 (IL-17).There is evidence that IL-17 and other cytokines which…Abstract Number: 2332 • 2012 ACR/ARHP Annual Meeting
Suppression of PP2Ac Causes DNA Hypermethylation Through Enhanced Pmek/Perk Activity in T Cells
Background/Purpose: Although many reports have focused on the impaired MEK-ERK signaling pathway in T cells from systemic lupus erythematosus (SLE) patients which results in suppression…Abstract Number: 2333 • 2012 ACR/ARHP Annual Meeting
A Novel Subset of CD4 T Cells That Provides Help for Human Memory B Cell Responses
Background/Purpose: Follicular helper T (Tfh) cells provide help to B cells in germinal centers (GCs) of secondary lymphoid organs (SLOs) following primary antigen (Ag) challenge,…
ACR Meeting Abstracts