Abstracts Archive - Page 2266 of 2607 - ACR Meeting Abstracts

Abstract Number: 2530 • 2013 ACR/ARHP Annual Meeting
Sustained Improvements In Health-Related Quality Of Life In Patients With Systemic Lupus Erythematosus following Epratuzumab Treament: Results from a Phase IIb Trial and Its Open-Label Extension
Vibeke Strand¹, Joan T. Merrill², Enkeleida Nikaï³, Brian Kilgallen⁴, Antoine Regnault⁵ and Caroline Gordon⁶, ¹Stanford University, Palo Alto, CA, ²Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³UCB Pharma, Brussels, Belgium, ⁴UCB Pharma, Raleigh, NC, ⁵Mapi HEOR & Strategic Market Access, Lyon, France, ⁶Rheumatology Research Group (East Wing), School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Epratuzumab is a monoclonal antibody targeting CD22. Improvements in health-related quality of life (HRQoL) with epratuzumab in patients with systemic lupus erythematosus (SLE) have…
Abstract Number: 2531 • 2013 ACR/ARHP Annual Meeting
Elevated Combined Serum Free Light Chains Are Associated With Active Disease In Systemic Lupus Erythematosus
Lakhvir Kaur Assi¹, Larissa Lisnevskaia², Emma Ross³, Richard G Hughes¹, Anisur Rahman⁴ and David A. Isenberg⁵, ¹Clinical R+D, The Binding Site Group Ltd, Birmingham, United Kingdom, ²Oshawa Clinic, Oshawa, ON, Canada, ³Centre for Rheumatology, University College London, London, United Kingdom, ⁴Centre for Rheumatology Research,Rayne Institute, 4th Floor, University College London, London, United Kingdom, ⁵Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom
Background/Purpose: Chronic and hyper-stimulated B cells are characteristics commonly found in patients with systemic lupus erythematosus (SLE). Due to the complexity and variability observed during…
Abstract Number: 2492 • 2013 ACR/ARHP Annual Meeting
Functionally Distinct ERAP1 Haplotype Combinations Distinguish Individuals With Ankylosing Spondylitis
Edward James¹, Emma Reeves¹, Alexandra Colebatch², Tim Elliott¹ and Christopher J. Edwards³, ¹Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom, ²Rheumatology, University Hospital Southampton, Southampton, United Kingdom, ³NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
Background/Purpose: The association of Ankylosing Spondylitis (AS) with HLA-B27 has been known for many years. Recent genetic linkage studies have identified polymorphisms within the aminopeptidase,…
Abstract Number: 2493 • 2013 ACR/ARHP Annual Meeting
Interleukin-17 Serum Levels Are Associated With Markers Of Systemic Inflammation In Patients With Active Ankylosing Spondylitis
Denis Poddubnyy¹, Alain Vicari², Hildrun Haibel¹, Jürgen Braun³, Martin Rudwaleit⁴ and Joachim Sieper¹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²EMD Serono, Geneva, Switzerland, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Endokrinologikum, Berlin, Germany
Background/Purpose: There is accumulating evidence that the Th17-signaling axis, particularly interleukin-17 (IL-17), plays an important role in the pathogenesis of ankylosing spondylitis (AS). Furthermore, biologics…
Abstract Number: 2494 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopaptidase 1 Variants In Antigen Presentaing Cells Affect HLA-B27 Free Heavy Chain Expression and Binding To NK-Cell Receptors
Nigil Haroon^1,2,3 and Zhenbo Zhang³, ¹Rheumatology, University Health Network, Toronto, ON, Canada, ²Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: ERAP1 and HLA-B27 are strongly associated with ankylosing spondylitis (AS). Using well-controlled tissue culture systems, we studied the effects of AS-associated ERAP1 variants on…
Abstract Number: 2495 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Protective Endoplasmic Reticulum Aminopeptidase 1 Variants Lead To Decreased Natural Killer Cell Conjugation and Activation
Hasan Abdullah¹, Zhenbo Zhang², Robert Inman³ and Nigil Haroon⁴, ¹IMS, University of Toronto, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto, ON, Canada, ³Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: Ankylosing Spondylitis (AS) is an inflammatory arthritis affecting the axial and peripheral joints. Human Leukocyte Antigen (HLA)-B27 and Endoplasmic Reticulum Aminopeptidase (ERAP) 1 genes…
Abstract Number: 2496 • 2013 ACR/ARHP Annual Meeting
HLA-B27 Influence On The Gut Microbiome
Robert D. Inman¹, Aifeng Lin², Phillip Sherman³ and Lee Pinnell⁴, ¹Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ²Medicine/Rheumatology, Toronto Western Research Institute and University Health Network, Toronto, ON, Canada, ³Pediatrics, Hospital for Sick Children, Toronto, ON, Canada, ⁴Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: The interrelationship between the gut microbiome and spondyloarthritis (SpA) has been highlighted by recent findings of (i) Subclinical bowel inflammation in SpA (ii) Antimicrobial…
Abstract Number: 2497 • 2013 ACR/ARHP Annual Meeting
Evidence Of a Microbial Signature In The Intestinal Microbiome In Ankylosing Spondylitis
Mary-Ellen Costello¹, Francesco Ciccia², Brooke Gardiner³, Mhairi Marshall³, Dana Willner⁴, Tony Kenna³, Giovanni Triolo² and Matthew A. Brown³, ¹Human Genetics Group, University of Queensland Diamantina Institute, Brisbane, Australia, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
Background/Purpose: Ankylosing spondylitis (AS) occurs in genetically predisposed individuals exposed to an unknown but likely ubiquitous environmental trigger. In both AS and Crohn’s disease (CD)…
Abstract Number: 2498 • 2013 ACR/ARHP Annual Meeting
ERAP2 Functional Knockout In Humans Does Not Alter ER Stress Or Evidence Of HLA-B27 Misfolding In Ankylosing Spondylitis
Philip Robinson¹, Yang Wang², Eugene Lau², Patricia Keith², Tony Kenna³ and Matthew A. Brown³, ¹Human Genetics Group, University of Queensland Diamantina Insititute, Brisbane, Australia, ²Human Genetics Group, University of Queensland Diamantina Institute, Brisbane, Australia, ³University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: SNPs in ERAP2 are strongly associated with ankylosing spondylitis (AS). One associated SNP is rs2248374 which changes the strength of the exon 10 donor…
Abstract Number: 2499 • 2013 ACR/ARHP Annual Meeting
Analysis Of Inflammatory Markers Within Facet Joints Of Patients Within Ankylosing Spondylitis
Uta Syrbe¹, Janine Bleil², Rene Maier³, Heiner Appel¹ and Joachim Sieper⁴, ¹Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ²Charité, Berlin, Germany, ³Charite, Berlin, Germany, ⁴Charitè Campus Benjamin Franklin, Berlin, Germany
Background/Purpose: Inflammation within sacroiliac joints and within the spine is a hallmark of ankylosing spondylitis (AS). Apart from nonsteroidal anti-rheumatic drug (NSAID) treatment, inhibition of…
Abstract Number: 2500 • 2013 ACR/ARHP Annual Meeting
Mast Cells Are a Major Source Of IL-17 In Synovium and Extra-Articular Tissues In Spondyloarthritis Related Diseases
T. Noordenbos¹, I. Gofita¹, M. Alsina², E.W.M. Vogels³, A. A. te Velde³, J. D. Cañete⁴, Dominique L. Baeten⁵ and N. Yeremenko¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain, ³Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre/University of Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain, ⁵Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: IL-17 plays a key role in the pathogenesis of spondyloarthritis (SpA) as demonstrated by a recent proof-of-concept trial with the anti-IL17A mAb secukinumab. The…
Abstract Number: 2501 • 2013 ACR/ARHP Annual Meeting
Validation Of Gene Expression Biomarkers Of Psoriatic Arthritis
Fatima Abji¹, Remy Pollock¹, Fawnda Pellett², Kun Liang³, Vinod Chandran² and Dafna D. Gladman², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a seronegative immune mediated arthritis that develops in about a third of patients with cutaneous psoriasis (PsC). The cellular pathways…
Abstract Number: 2502 • 2013 ACR/ARHP Annual Meeting
Contributions Of Skin and Joint Manifestations To The Parent-Of-Origin Effect In Psoriatic Disease
Remy Pollock¹, Arane Thavaneswaran², Vinod Chandran³, Art Petronis⁴, Al Amin P. Rahman⁵ and Dafna D. Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada, ⁵Medicine, Memorial University, St Johns, NE, Canada
Background/Purpose: Excessive paternal transmission has been previously documented in psoriatic disease. Our objective is to delineate the differential contributions of skin and joint manifestations to…
Abstract Number: 2503 • 2013 ACR/ARHP Annual Meeting
IL-17+ CD8+ T Cells Are Enriched In The Joints Of Patients With Psoriatic Arthritis and Correlate With Markers Of Disease Activity and Joint Damage Progression
Bina Menon^1,2, Nicola J. Gullick³, Hayley G. Evans⁴, Gina J. Walter⁴, Megha Rajasekhar⁴, Toby Garrood², Leonie S. Taams⁴ and Bruce W. Kirkham², ¹Centre for Cellular and Molecular Biology of Inflammation, King's College London, London, United Kingdom, ²Rheumatology, Guy's and St. Thomas' Foundation Hospital NHS Trust, London, United Kingdom, ³Rheumatology, King's College Hospital Foundation NHS Trust, London, United Kingdom, ⁴Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom
Background/Purpose: Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) have clear differences in clinical, radiological and genetic features, suggesting that the immunopathology of the conditions may…
Abstract Number: 2504 • 2013 ACR/ARHP Annual Meeting
Male Children With Higher SLE Disease Activity In An US Cohort
Lakshmi N. Moorthy¹, Elizabeth Roy², Margaret Peterson³, Afton L. Hassett⁴, Alexa B. Adams⁵, Laura V. Barinstein⁶, Elizabeth C. Chalom⁷, Karen Onel⁸, Linda Ray⁹, Jorge Lopez-Benitez¹⁰, Kathleen A. Haines¹¹, Philip Hashkes¹², Daniel J. Kingsbury¹³, Victoria Cartwright¹⁴, Nora G. Singer¹⁵, Ingrid Tomanova-Soltys¹⁶, Andreas Reiff¹⁷, Sandy D. Hong¹⁸ and Thomas J. A. Lehman¹⁹, ¹Pediatric Rheumatology, Robert Wood Johnson Medical School-Rutgers University, New Brunswick, NJ, ²RWJMS-UMDNJ, New Brunswick, NJ, ³Hospital for Special Surgery, New York, NY, ⁴Anesthesiology, University of Michigan, Ann Arbor, MI, ⁵Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Pediatric Rheumatology, Mount Sinai Med Ctr, New York, NY, ⁷Pediatrics, St. Barnabas Medical Center, Livingston, NJ, ⁸Pediatric Rheumatology, University of Chicago Hospitals, Chicago, IL, ⁹Pediatric Rheumatology, University of Mississippi Medical Center, Jackson, MS, ¹⁰Pediatric Rheumatology Program Centro Medico La Costa, Asuncion, Paraguay, ¹¹Department of Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ¹²Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, ¹³Randall Children's Hospital at Legacy Emanuel, Portland, OR, ¹⁴Legacy Emanuel Children's Hospital, Portland, OR, ¹⁵Medicine, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, ¹⁶Winthrop University Hospital, Mineola, NY, ¹⁷Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ¹⁸Pediatrics-Rheumatology, U of Iowa Children's Hosp, Iowa City, IA, ¹⁹Chief Div Ped Rheum PTD, Hospital for Special Surgery, New York, NY
Background/Purpose: Although systemic lupus erythematosus (SLE) is more common in females, males tend to have more severe disease. We compared age at SLE diagnosis, duration,…

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