Abstracts Archive - Page 2264 of 2425 - ACR Meeting Abstracts

Abstract Number: 2369 • 2012 ACR/ARHP Annual Meeting
Aspects of Innate Immunity in Behçet´s Disease: A Model of Autoinflammatory Disease?
Sandro F. Perazzio¹, Paulo Vitor Soeiro Pereira², Alexandre Wagner S. de Souza³, Antonio Condino-Neto² and Luis Eduardo C. Andrade⁴, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: Behçet's disease (BD) is a systemic vasculitis of unknown etiopathogenesis. Increased neutrophil activation has been previously shown in BD patients and it is unclear…
Abstract Number: 2370 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Study Identifies Significant Epigenetic Changes Across the Genome and in Multiple HLA Loci in Behcet’s Disease
Haner Direskeneli¹, Patrick S. Coit², Filiz Ture-Ozdemir¹, Fatma Alibaz-Oner¹, Guher Saruhan-Direskeneli³, Matlock A. Jeffries⁴ and Amr H. Sawalha², ¹Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Medicine, University of Oklahoma and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Behcet’s disease (BD) is a systemic vasculitis of poorly understood etiology. Herein, we study the DNA methylome in BD for the first time and…
Abstract Number: 2371 • 2012 ACR/ARHP Annual Meeting
The Unmet Need in Behcet’s Disease: Most Patients Are Not in Complete Remission in the Long-Term Follow-up
Fatma Alibaz-Oner¹, Gonca Mumcu², Gülsen Ozen³, Zeynep Kubilay⁴, Meryem Can¹, Sibel Yýlmaz Oner¹, Tülin Ergun⁵ and Haner Direskeneli¹, ¹Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ²Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, ³Rheumatology, Marmara University School of Medicine., Istanbul, Turkey, ⁴Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey, ⁵Dermatology, Marmara University School of Medicine, Istanbul, Turkey
Background/Purpose: The nature of Behcet’s disease (BD) as a multi-systemic disorder with a remitting-relapsing course is unsufficiently explored. As complete remission should be aimed in…
Abstract Number: 2372 • 2012 ACR/ARHP Annual Meeting
Efficacy of Quantitative Analysis of Brainstem Atrophy On Magnetic Resonance Imaging for Diagnosis of Chronic Progressive Neuro-Behçet’s Disease
Hirotoshi Kikuchi¹, Maki Takayama², Yoshitaka Kimura², Kurumi Asako², Hajime Kono², Yasuo Ono¹ and Shunsei Hirohata³, ¹Department of Microbiology and Immunology, Teikyo University Shool of Medicine, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose : CNS involvement in Behçet's disease, usually called neuro-Behçet's disease (NB), can be classified into acute NB (ANB) and chronic progressive NB (CPNB) based…
Abstract Number: 2373 • 2012 ACR/ARHP Annual Meeting
The Clinical Course of the Acute Deep Vein Thrombosis of the Legs in Behçet’s Syndrome
Yesim Ozguler¹, Melike Melikoglu², Firat Cetinkaya³, Serdal Ugurlu⁴, Emire Seyahi⁵, Koray Tascilar⁶ and Hasan Yazici⁷, ¹Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey, ²Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ³Radiology, Colormed Radiology Center, Istanbul, Turkey, ⁴Rheumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey, ⁵Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁶University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁷Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: 15-50% of patients with Behçet’s syndrome have vascular involvement (BS). Deep vein thrombosis is the most common form with lower extremity deep vein thrombosis…
Abstract Number: 2374 • 2012 ACR/ARHP Annual Meeting
Characteristics, Treatment and Outcome of Gastrointestinal Involvement in Behcet’s Syndrome: Experience in A Dedicated Center
Ibrahim Hatemi¹, Gulen Hatemi², Yusuf Erzin¹, Aykut Ferhat Celik¹ and Hasan Yazici³, ¹Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Gastroenterology, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: Gastrointestinal involvement can be a severe complication resulting in perforation and massive bleeding. Controlled data regarding treatment is lacking and long term prognosis is…
Abstract Number: 2375 • 2012 ACR/ARHP Annual Meeting
WHAT Affects the Quality of Life in Patients with BEHCET’S Disease?
Mehmet Melikoglu¹ and Meltem Alkan Melikoglu², ¹Dermatology, Health Ministry Erzurum Regional Training and Research Hospital, Dermatology, Erzurum, Turkey, ²Rheumatology, Ataturk University Faculty of Medicine, Erzurum, Turkey
Background/Purpose: The aim of this study was to evaluate the possible associations between quality of life (QoL) and sociodemographic features, disease characteristics and the Behcet’s…
Abstract Number: 2376 • 2012 ACR/ARHP Annual Meeting
Behcet’s Disease: Combination of Pulse Cyclophosphamide, Azathioprine, and Prednisolone for the Treatment of Retinal Vasculitis; Longitudinal Study On 10 Years
Fereydoun Davatchi¹, Farhad Shahram², Bahar Sadeghi Abdollahi², Hormoz Shams², Abdolhadi Nadji², Massoomeh Akhlaghi², Tahereh Faezi² and Farimah Ashofteh², ¹Rheumatology Research Ctr and Department of Rheumatology, Shariati Hospital-Tehran Univ, Tehran, Iran, ²Rheumatology, Behcet's Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Background/Purpose: Ocular lesions of Behcet’s Disease (BD), need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents…
Abstract Number: 2377 • 2012 ACR/ARHP Annual Meeting
Impaired Endothelial Function in Patients with Takayasu’s Arteritis
Fatma Alibaz-Oner¹, Selen Yurdakul², Yelda Tayyareci³, Saide Aytekin⁴ and Haner Direskeneli¹, ¹Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ²Cardiology, Bilim University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey, ³Cardiology, ISTANBUL FLORENCE NIGHTINGALE HOSPITAL, Istanbul, Turkey, ⁴Cardiology, Istanbul Florence Nightingale Hospital, Cardiology, Istanbul, Turkey
Background/Purpose: Takayasu’ s arteritis (TAK) is a chronic, inflammatory, large-vessel vasculitis. In the present study we aimed to evaluate vascular endothelial function in patients with…
Abstract Number: 2378 • 2012 ACR/ARHP Annual Meeting
Evaluation of the EULAR/ACR 2012 Classification Criteria for Polymyalgia Rheumatica: Comparison of the New Algorithms with and without Ultrasound to the Formerly Used Criteria
Sandra Balser¹, Wolfgang Hartung², Emmanuelle LeBras¹, Boris P. Ehrenstein², Martina Müller³ and Martin Fleck², ¹Rheumatology & Clinical Immunology, Asklepios Klinikum Bad Abbach, Bad Abbach, Germany, ²Rheumatology & Clinical Immunology, Asklepios Clinic Bad Abbach, Bad Abbach, Germany, ³Clinic for Internal Medicine I, University Clinic Regensburg, Regensburg
Background/Purpose: The purpose of this study was to compare the sensitivity of the algorithms with and without ultrasound of the EULAR/ACR 2012 Classification Criteria for Polymyalgia…
Abstract Number: 2379 • 2012 ACR/ARHP Annual Meeting
Successful Treatment of Churg-Strauss Syndrome with Rituximab
Christin Dubrau¹, Fabian Arndt², Wolfgang L. Gross and Frank Moosig⁴, ¹Departement of Rheumatology and Clinical Immunology, University Hospital Schleswig-Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany, ²Departement of rheumatology and clinical immunology, University Hospital Schleswig Holstein and Klinikum Bad Bramstedt, Bad Bramstedt, Germany, ³Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany
Background/Purpose: Rituximab has recently been shown to be equipotent to cyclophosphamide for induction of remission in generalized ANCA-associated vasculitis. A substantial number of observational pro-…
Abstract Number: 2380 • 2012 ACR/ARHP Annual Meeting
High Frequency of Ferritin Autoantibodies in Takayasu Arteritis
Niklas T. Baerlecken¹, Katherina Große², Frank Moosig³, Wolfgang L. Gross⁴, Reinhold E. Schmidt¹ and Torsten Witte⁵, ¹Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany, ²Department of Immunology and Rheumatology, Student, Hannover, Germany, ³University of Luebeck, Stormarnzing 156, Bad Bramstedt, Germany, ⁴Dept of Clinical Rheumatology, Medical University at Lubeck, Lubeck, Germany, ⁵Hannover Medical School, Hanover, Germany
Background/Purpose: Takayasu arteritis (TA) may be difficult to diagnose since diagnostic biomarkers have not been established so far. In a previous study, we could show…
Abstract Number: 2381 • 2012 ACR/ARHP Annual Meeting
Serum Level of IL-33 and Soluble ST2 and Their Association with Disease Activity in Patients with Behcet’s Disease
Dae-Jun Kim¹, Jae-Ho Lee¹, Ji Hyeon Ju¹, Sung-Hwan Park², Ho-Youn Kim¹ and Seung-Ki Kwok¹, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ²Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: Interleukin-33 (IL-33) is a new member of the IL-1 family of cytokines which signals via receptor, ST2(IL-33R), and has an important role in Neutrophil…
Abstract Number: 2382 • 2012 ACR/ARHP Annual Meeting
Plasma Fibrinogen is an Accurate Marker of Disease Activity in Patients with Polymyalgia Rheumatica
E.M. McCarthy¹, Paul A. MacMullan¹, S. Al-Mudhaffer¹, Anne M. Madigan¹, S. Donnelly¹, C. J. McCarthy¹, Dermot Kenny², Eamonn Molloy³ and G M. McCarthy¹, ¹Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ²Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland, ³Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Accurate determination of disease activity in polymyalgia rheumatica(PMR) is challenging due to the subjective nature of symptoms and concurrent musculoskeletal complaints in an elderly…
Abstract Number: 2383 • 2012 ACR/ARHP Annual Meeting
Rituximab As Induction and Maintenance Therapies for ANCA-Associated Vasculitis: A Multicenter Retrospective Study On 80 Patients
Pierre Charles¹, Antoine Néel², Nathalie Tieulié³, Arnaud Hot⁴, Grégory Pugnet⁵, Olivier Decaux⁶, Isabelle Marie⁷, Mehdi Khellaf⁸, Jean-Emmanuel Kahn⁹, Alexandre Karras¹⁰, Jean-Marc Ziza¹¹, Christophe Deligny¹², Colas Tchérakian¹³ and Loic Guillevin¹⁴, ¹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ²Internal Medicine, Nantes University Hospital, Nantes, France, ³CHU Nice, Nice, France, ⁴Internal Medicine, Edouard Herriot University Hospital, Lyon, France, ⁵Department of Internal Medicine, Toulouse University Hospital, University of Toulouse, INSERM UMR 1027, Toulouse, France, ⁶Department of Internal Medicine, Rennes University Hospital, Rennes, France, ⁷Service de médecine interne, CHU de Rouen, Rouen, France., Rouen, France, ⁸Internal Medicine, Service de médecine interne, Université Paris Est Créteil, AP-HP, Hôpital Mondor Créteil, France, Creteil, France, ⁹Internal Medicine, Foch Hospital, Suresnes, France, ¹⁰Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, ¹¹Rheumatology, Croix Saint Simon Hospital, Paris, France, ¹²Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ¹³Service de pneumologie, hôpital Foch, Suresnes, France, ¹⁴Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Rituximab has been shown to induce remission of ANCA-associated vasculitis (AAV). Our study was undertaken to 1) describe the clinical response of AAV to…

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