Abstract Number: 2591 • 2013 ACR/ARHP Annual Meeting
Scleroderma Renal Crisis and Pulmonary Arterial Hypertension Are Very Rare In The Same Patient
Background/Purpose: Systemic Sclerosis (SSc) is associated with occlusive vasculopathy resulting in digital ischaemia, telangiectasia, scleroderma renal crisis (SRC) and pulmonary arterial hypertension (PAH). SRC and…Abstract Number: 2592 • 2013 ACR/ARHP Annual Meeting
Clinical Significance Of Endothelial Vasodilator Function Evaluated By Endopat In Patients With Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Evidence has…Abstract Number: 2559 • 2013 ACR/ARHP Annual Meeting
Effect Of NOX4 Overexpression On The Levels Of Micro RNAs Relevant To Systemic Sclerosis Fibrotic Process
Background/Purpose: Systemic sclerosis (SSc) is characterized by the excessive deposition of collagen and other connective tissue components in skin and multiple internal organs. Although transforming…Abstract Number: 2562 • 2013 ACR/ARHP Annual Meeting
Inhibition Of SOX9 Phosphorylation Abrogates The Increased Expression Of Profibrotic Genes In Systemic Sclerosis Dermal Fibroblasts
Background/Purpose: SOX9, a high mobility group transcription factor is a master regulator of chondrogenesis and plays a crucial role in the regulation of chondrocyte gene…Abstract Number: 2564 • 2013 ACR/ARHP Annual Meeting
Functional Activation Of The TRPV1 and TRPV2 Non-Selective Cation Channels Potentiates TGF-β1-Induced Endothelial-To-Mesenchymal Transition In Murine Pulmonary Endothelial Cells Suggest a Potential Role Of Trpv Channels In The Pathogenesis Of Systemic Sclerosis
Background/Purpose: Transient receptor potential (Trp) cation channel, subfamily V (TRPV) members can impact a diverse range of vascular functions, including vascular tone, vascular permeability, mechanosensing,…Abstract Number: 2565 • 2013 ACR/ARHP Annual Meeting
Synergistic Effects Of Endothelin-1 On Transforming Growth Factor-β1 (TGF-β1) Induced Endothelial-To-Mesenchymal Transition. A Novel Mechanism For The Fibrogenic Effects Of Endothelin
Background/Purpose: The process of endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in the generation of activated myofibroblasts, cells that play a pivotal role in…Abstract Number: 2567 • 2013 ACR/ARHP Annual Meeting
Cadherin-11 Regulates Pulmonary Fibrosis In Bleomycin-Induced Lung Injury
Background/Purpose: Pulmonary fibrosis (PF) is the leading cause of death in systemic sclerosis. Pathologically, PF is characterized by an aberrant wound healing repair mechanism leading…Abstract Number: 2552 • 2013 ACR/ARHP Annual Meeting
Predictive Significance Of ANTI-Prothrombin Antibodies For Second and Third Trimester Obstetric Complications In Patients With Systemic LUPUS Erythematosus and ANTI-Phospholipid Syndrome
Background/Purpose: Anti-prothrombin antibodies (aPT) either alone or in association with other anti-phospholipid antibodies have been associated with an increased risk of thrombosis as well as…Abstract Number: 2553 • 2013 ACR/ARHP Annual Meeting
The Clinical Value Of Testing For Aphl, a New ELISA Kit With a Unique Phospholipid Mixture In Patients With Systemic Lupus Erythematosus (SLE)
Background/Purpose: Antibodies directed to APhL (a mixture of phospholipids) have been reported to predict APS more reliably than aCL tests. We designed this study to…Abstract Number: 2554 • 2013 ACR/ARHP Annual Meeting
In Vitro Fertilization In Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Series Of 82 Cycles
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) undergoing in vitro fertilization (IVF) are at increased risk of both hormone-associated flare and…Abstract Number: 2555 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Questionnaire To Screen For The Presence Of Autoimmune Disease
Background/Purpose: Healthy family members of patients with systemic autoimmune rheumatic diseases (SARDs) are at higher risk of developing autoimmune disease than the general population. …Abstract Number: 2556 • 2013 ACR/ARHP Annual Meeting
Concordance Of Indirect Immunofluorescence and Multiplex Immunoassay For Measurement Of Antinuclear Antibodies
Background/Purpose: The indirect immunofluorescence assay (IIF) is the gold standard for ANA testing. However, many laboratories now use multiplex assay as an ANA screening test.…Abstract Number: 2557 • 2013 ACR/ARHP Annual Meeting
Fluctuations In sVCAM-1 and Adiponectin Mirror Fluctuations In Disease Activity In Lupus, But Cannot Be Use To Accurately Predict Impending Changes In Disease State
Background/Purpose: Previous reports have identified a number of pro-inflammatory cyto/chemokines as candidate activity-specific SLE biomarkers. In our preliminary studies we found that out of a…Abstract Number: 2558 • 2013 ACR/ARHP Annual Meeting
Bone Morphogenic Protein Receptor 2 (BMPR2) Gene Mutations Are Associated To The Development Of Isolated Pulmonary Arterial Hypertension (PAH) In Systemic Sclerosis (SSc) Patients
Background/Purpose: Isolated pulmonary arterial hypertension (PAH) secondary to Systemic Sclerosis (SSc) is a severe life-threatening complication. Several pathogenic pathways have been implicated in its development.…Abstract Number: 2560 • 2013 ACR/ARHP Annual Meeting
Analysis Of Global Gene Expression Of Pulmonary Endothelial Cells From Caveolin-1 Knock-Out Mice
Background/Purpose: Caveolin-1 (Cav-1) deficiency has recently been shown to participate in the pathogenesis of tissue fibrosis in Systemic Sclerosis (SSc). Although the mechanisms involved have…
ACR Meeting Abstracts