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  • Abstract Number: 2628 • 2013 ACR/ARHP Annual Meeting

    Immunogenicity Of Infliximab Modulates Efficacy and Safety In Behcet’s Disease Patients With Uveitis

    Mitsuhiro Takeno1, Kayo Terauchi1, Yohei Kirino1,2, Ryusuke Yoshimi1, Nobuhisa Mizuki2, Etsuko Shibuya3 and Yoshiaki Ishigatsubo2, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Infliximab (IFX) suppresses ocular attacks in Behcet’s disease (BD) with uveitis, resulting in favorable long-term visual prognosis. However, some patients had ocular attacks which…
  • Abstract Number: 2629 • 2013 ACR/ARHP Annual Meeting

    Is Complete Remission a Realistic Target With Current Therapeutic Options in Behçet’s Disease ?

    Fatma Alibaz-Oner1, Gonca Mumcu2, Zeynep Kubilay3, Gülsen Ozen4, Gülce Celik3, Aslı Karadeniz3, Meryem Can5, Sibel Yılmaz Oner1, Nevsun Inanc6, Pamir Atagunduz7, Tülin Ergun8 and Haner Direskeneli1, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 3Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey, 4Rheumatology, Marmara University School of Medicine., Istanbul, Turkey, 5Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 6Marmara University School of Medicine, Istanbul, Turkey, 7Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 8Dermatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: The clinical course of Behcet’s disease (BD) as a multi-systemic disorder with a remitting-relapsing nature is unsufficiently explored. As complete remission should be aimed…
  • Abstract Number: 2630 • 2013 ACR/ARHP Annual Meeting

    Low Medication Adherence Is Observed In Behcet’s Disease

    Gonca Mumcu1, Ali Taze2, Esra Kula2, Semiha Yemez2, Silay Eksi2, Leyla Köksal3, Fatma Alibaz-Oner4, Sibel Yilmaz Oner4, Pamir Atagündüz4, Nevsun Inanc5, Tülin Ergun6 and Haner Direskeneli4, 1Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 2Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 3Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 4Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 5Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 6Dermatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Symptom-control with reduction of mortality and morbidityare the main treatment goalsin Behcet’s Disease (BD). However, similar to other chronic disorders,  increased unnecessary visits, hospitalisation…
  • Abstract Number: 2631 • 2013 ACR/ARHP Annual Meeting

    Fertility In Behçet’s Syndrome: Structured Interview In A Multidisciplinary Center

    Caner Saygin1, Didem Uzunaslan1, Gulen Hatemi2, Koray Tascilar1 and Hasan Yazici3, 1University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 2Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 3Cerrahpasa Medical Faculty University of Istanbul, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose: Behçet’s Syndrome (BS) follows an active course during the child-bearing years in both men and women. Whether fertility is decreased among the BS patients…
  • Abstract Number: 2632 • 2013 ACR/ARHP Annual Meeting

    Long Term Outcome Of Neuro-Behçet’s Disease

    Nicolas Noel1, Remy Bernard2, Bertrand Wechsler3, Matthieu Resche-Rigon2, Du Boutin4, Jean-Charles Piette5, Aurélie Drier6, Didier Dormont6, Patrice Cacoub4 and David Saadoun7, 1APHP, Hopital Bicêtre, Service de Médecine Interne et Immunologie Clinique, Le Kremlin Bicêtre, France, 2Biostatistics, Hopital Saint-Louis, Paris, France, 3Internal Medecine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 4Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 5Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 6Neuroradiology, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 7DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France

    Background/Purpose: Neurological involvement occurs in 5.3 to up to 59% of patients with Behçet’s disease (BD). Although the clinical and imaging features of neuro-Behçet’s disease…
  • Abstract Number: 2633 • 2013 ACR/ARHP Annual Meeting

    Clinical Spectrum Of Cutaneous Vasculitis

    Javier Loricera1, Vanesa Calvo-Río1, Francisco Ortiz-Sanjuan2, Héctor Fernández-Llaca3, Marcos A. González-López4, Lino Álvarez5, M. Carmen González-Vela6, Domingo González-Lamuño7, Cristina Mata2, Javier Rueda-Gotor8, Víctor M. Martínez-Taboada9, Miguel Angel González-Gay2 and Ricardo Blanco10, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 3Dermatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 4Dermatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 5Pediatrics, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 6Pathology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 7Pediatrics, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, 8Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 9Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV., Santander, Spain, 10Hospital Marques de Valdecilla, Santander, Spain

    Background/Purpose: Cutaneous vasculitis (CV) encompasses a large and heterogeneous set of syndromes characterized by inflammation of the skin vessels. The most common clinical manifestation is…
  • Abstract Number: 2634 • 2013 ACR/ARHP Annual Meeting

    Henoch-Schönlein Purpura: Clinical Spectrum Of The Disease In 417 Patients From A Single Center

    F. Ortiz-Sanjuán1, Vanesa Calvo-Río2, Javier Loricera1, C Mata1, L Martín Penagos3, L Alvarez4, M. Carmen González-Vela5, D González-Lamuño4, Javier Rueda-Gotor6, Héctor Fernández-Llaca7, Marcos A. González-López8, Susana Armesto9, M. Enriqueta Peiró2, M. Arias3, Miguel Angel Gonzalez-Gay1 and Ricardo Blanco10, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Nephrology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 4Pediatrics, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 5Pathology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 6Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 7Dermatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 8Dermatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 9Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 10Hospital Marques de Valdecilla, Santander, Spain

    Background/Purpose: The severity of clinical features and the outcome in the different series of Henoch-Schönlein Purpura (HSP) shows great variability, probably due to selection-bias. Our…
  • Abstract Number: 2595 • 2013 ACR/ARHP Annual Meeting

    Microvascular Abnormalities In Patients With Early Systemic Sclerosis: Less Severe Morphological Changes Compared To Patients With Definite Disease

    Cintia Camargo, Juliana Sekiyama, Maria I. Arismendi and Cristiane Kayser, Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil

    Background/Purpose: To analyze the morphological and functional abnormalities of the microcirculation through widefield nailfold capillaroscopy (NFC), videocapillaroscopy and cutaneous microvascular blood flow measurement before and…
  • Abstract Number: 2593 • 2013 ACR/ARHP Annual Meeting

    The Prognosis Of Scleroderma Renal Crisis In RNA-Polymerase III Antibody (ARA) Positive Compared To ARA Negative Patients

    Bernadette Lynch1, Henry Penn2, Jennifer Harvey3, Aine Burns4 and Christopher P. Denton5, 1Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, 2Northwick Park Hospital, Harrow, United Kingdom, 3Clinical Immunology, Royal Free Hospital, London, United Kingdom, 4Department of Nephrology, The Royal Free Hospital, London, United Kingdom, 5Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC) usually presenting with accelerated hypertension and acute kidney injury (AKI) is one of the most severe complications of Systemic Sclerosis…
  • Abstract Number: 2594 • 2013 ACR/ARHP Annual Meeting

    Stabilisation Of Microcirculation In Early Systemic Sclerosis Patients With Diffuse Skin Involvement Following Rituximab Treatment

    Vanessa Smith1, Carmen Pizzorni2, Valeria Riccieri3, Saskia Decuman4, Yves P. Piette1, Ellen Deschepper5, Filip De Keyser1 and Maurizio Cutolo6, 1Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 3Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy, 4Department of Internal Medicine, Ghent University, Ghent, Belgium, 5Biostatistics Unit, Department of Public Health, Ghent University, Ghent, Belgium, 6University of Genova, Genova, Italy

    Background/Purpose: Microangiopathy in systemic sclerosis is progressive over time [1, 2]. This study assesses microangiopathic evolution by nailfold videocapillarocopic (NVC) analysis after two treatment course…
  • Abstract Number: 2596 • 2013 ACR/ARHP Annual Meeting

    Association Between Nail Fold Capillaroscopy Abnormalities and Thermographic Assessment Of Peripheral Microvascular Dysfunction In An Unselected Cohort Of Patients Under Investigation For Symptoms Of Raynaud’s Phenomenon

    Bhavisha Vasta1, Marina Scolnik1,2, Darren Hart1, Jacqueline A. Shipley1, Sue Brown1, Eleanor Korendowych1, Neil J McHugh1,3 and John D. Pauling1,3, 1Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom

    Background/Purpose: Nail fold capillaroscopy (NC) and infrared thermography (IRT) allow objective assessment of digital microvascular abnormalities in patients with Raynaud’s phenomenon (RP) and have an…
  • Abstract Number: 2597 • 2013 ACR/ARHP Annual Meeting

    Acupressure For The Treatment Of Raynaud’s Phenomenon: A Pilot Randomized Controlled Trial

    Heather Gladue1, Richard E. Harris2, Veronica Berrocal3, Pei-Suen Tsou4, Gautam Edhayan5, Ray Ohara5 and Dinesh Khanna6, 1University of Michigan, Ann Arbor, MI, 2Anesthesiology, University of Michigan, Ann Arbor, MI, 3Department of Biostatistics- School of Public Health, University of Michigan, Ann Arbor, MI, 4Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 5University of Michigan Medical School, Ann Arbor, MI, 6Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Raynaud’s phenomenon (RP) affects approximately 10% of the US population. The high cost, lack of efficacy, and side effects of conventional medical therapies necessitates…
  • Abstract Number: 2598 • 2013 ACR/ARHP Annual Meeting

    Timing and Outcome Of Transition From Primary To Secondary Raynaud’s Phenomenon: A Capillaroscopic Based Study

    Alberto Sulli1, Giorgia Ferrari2, Elena Bernero2, Carmen Pizzorni2, Vanessa Smith3, Barbara Ruaro2 and Maurizio Cutolo4, 1Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 3Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 4Internal medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy

    Background/Purpose: Raynaud's phenomenon (RP) is classified as primary (PRP) or secondary (SRP) depending on its association with an underlying disease (1,2). PRP can evolve to…
  • Abstract Number: 2599 • 2013 ACR/ARHP Annual Meeting

    Safety and Effectiveness Of Mycophenolate In Systemic Sclerosis: A Systemic Review

    Mohammed Omair1, Abdulaziz Alahmadi2 and Sindhu R. Johnson3, 1Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, 2Medicine, Toronto Scleroderma Research Program, Division of Rheumatology, Mount Sinai Hospital, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada, 3Medicine, Toronto Western Hospital, Toronto General Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada

    Background/Purpose: Mycophenolate reduces chronic allograft nephropathy and interstitial fibrosis by inhibiting TGF-β, which is an important molecule in the pathogenesis of systemic sclerosis (SSc). The…
  • Abstract Number: 2600 • 2013 ACR/ARHP Annual Meeting

    Shear Wave Elastography:  A Novel Quantitative Approach For Evaluating Scleroderma Skin

    Ingeborg Sacksen1, Mark H. Wener2, P. Scott Pollock3 and Manjiri K. Dighe4, 1Rheumatology, University of Washington, Seattle, WA, 2Rheumatology & Lab Med, University of Washington, Seattle, WA, 3Internal Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 4Radiology, University of Washington, Seattle, WA

    Background/Purpose: Systemic sclerosis (SSc) is a multi-system disease with both visceral and cutaneous fibrosis. Dermal elasticity is reduced and stiffness increased due to excessive dermal…
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