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  • Abstract Number: 2653 • 2013 ACR/ARHP Annual Meeting

    Low Vitamin D Is Associated With Increased Risk of Venous Thrombosis in Systemic Lupus Erythematosus, Regardless of Lupus Anticoagulant Status

    Michelle Petri and Hong Fang, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Vitamin D deficiency is common in SLE. Vitamin D deficiency is also associated with activation of Tissue Factor. In cross-sectional studies, vitamin D deficiency…
  • Abstract Number: 2654 • 2013 ACR/ARHP Annual Meeting

    IgG Antibodies Directed Against Domain I Of ß2-Glycoprotein I Are Significant Predictors Of Thromboembolic Events In Patients With Antiphospholipid Antibodies. A Prospective Cohort Study

    Stephane Zuily1, Bas de Laat2, Francis Guillemin3, Pierre Kaminsky4, Hilde Kelchtermans5, Roger Albesa6, Gary L. Norman6, Anne-Christine Rat7, Philip de Groot8, Thomas Lecompte9, Veronique Regnault10 and Denis Wahl1, 1CHU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy, F-54000, France; Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France, Nancy, France, 2Biochemistry, CARIM, Maastricht University, The Netherlands; Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands; Synapse BV, Maastricht, The Netherlands; Sanquin Research, Amsterdam, The Netherlands, Maastricht, Netherlands, 3CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, 4Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Orphan disease unit, Nancy, F-54000, France;, Nancy, France, 5Biochemistry, CARIM, Maastricht University, The Netherlands; Synapse BV, Maastricht, The Netherlands, Maastricht, Netherlands, 6Research, INOVA Diagnostics, San Diego, CA, 7Université de Lorraine, Nancy, F-54000, France; Inserm, CIC-EC CIE6, Nancy, F-54000, France; CHU de Nancy, Clinical Epidemiology and Evaluation Department, Nancy, F-54000, France; CHU de Nancy, Rheumatology department, Nancy, France, 8Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands, Utrecht, Netherlands, 9Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Haematology Laboratory, Nancy, F-54000, France; Division of Haematology, HUG, Geneva, Switzerland (current address), Geneva, Switzerland, 10Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Contrat d’interface, Nancy, F-54000, France, Nancy, France

    AbstractBackground/Purpose : Our objective was to prospectively determine the prognostic significance of laboratory variables regarding thrombotic events during follow-up, including novel assays IgG antibodies directed…
  • Abstract Number: 2615 • 2013 ACR/ARHP Annual Meeting

    Serum Beta 2 Microglobulin and Its Association With Disease Activity in Patients With Behcet’s Disease

    Meltem Alkan Melikoglu1 and Mehmet Melikoglu2, 1Rheumatology, Ataturk University Faculty of Medicine, Erzurum, Turkey, 2Dermatology, Health Ministry Erzurum Regional Training and Research Hospital, Dermatology, Erzurum, Turkey

    Background/Purpose: β2-microglobulin (β2M) is a low-molecular weight protein, that is a constant component of human leukocyte antigen (HLA), which is secreted from all nucleated cells.…
  • Abstract Number: 2616 • 2013 ACR/ARHP Annual Meeting

    Ischemia-Modified Albumin : A Novel Marker of Vascular Involvement in Behcet’s Disease ?

    Erhan Capkin1, Murat Karkucak2, Mehmet Kola3, Adem Karaca2, süleyman Caner Karahan4, Aysegul Sumer4, Arzu Aydin Capkin5, Ferhat Gokmen2 and Refik Ali Sari6, 1rheumatolgy, trabzon, Turkey, 2rheumatology, trabzon, Turkey, 3oftalmology, trabzon, Turkey, 4biochemistry, trabzon, Turkey, 5dermatology, trabzon, Turkey, 6immunology and allergy, trabzon, Turkey

    Background/Purpose: The etiology and pathogenesis of Behçet’s disease (BD) are not yet well understood, but immunoregulatory abnormalities have been proposed as pathogenic mechanisms. Ischemia-modified albumin…
  • Abstract Number: 2617 • 2013 ACR/ARHP Annual Meeting

    Clinical Features Of 127 Patients With Behcet’s Disease In Japan

    Keisuke Nishimura1, Jun Saegusa2, Sho Sendo3, Yoshinori Kogata1, Goichi Kageyama1, Seiji Kawano1, Shunichi Kumagai4 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 4Center of rheumatic diseases, Shinko hospital, Kobe, Japan

    Background/Purpose: Behcet’s disease (BD) is characterized by recurrent oral aphthae and any of several systemic manifestations including genital ulcer, ocular disease, skin lesions, gastrointestinal involvement,…
  • Abstract Number: 2618 • 2013 ACR/ARHP Annual Meeting

    Bipolar Disorders May Represent a Primary Feature Of Behçet’s Disease

    Rosaria Talarico1, Laura Palagini2, Elena Elefante3, Claudia Ferrari4, Chiara Stagnaro3, Chiara Baldini3, Chiari Tani3, Marta Mosca4 and Stefano Bombardieri3, 1Rheumatology Unit, Pisa, Italy, 2University of Pisa, Psychiatry Unit, Department of Neuroscience, Pisa, Italy, 3University of Pisa, Rheumatology Unit, Pisa, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Frequency of psychiatric disorders in BD is a debated issue: while some experts attribute their presence to the chronicity of the illness, others think…
  • Abstract Number: 2619 • 2013 ACR/ARHP Annual Meeting

    Suicidal Ideation Among Patients With Behcet’s Syndrome

    Didem Uzunaslan1, Caner Saygin1, Gulen Hatemi2, Koray Tascilar1, Hasan Yazici3 and Vedat Hamuryudan4, 1University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 2Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 3Cerrahpasa Medical Faculty University of Istanbul, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 4Division of Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose:  An increased frequency of depression has been reported in Behcet’s syndrome (BS). While an increased suicidal ideation has been reported in other chronic rheumatologic conditions, this…
  • Abstract Number: 2620 • 2013 ACR/ARHP Annual Meeting

    Development Of De Novo Major Involvement During The Follow-Up In Behçet’s Disease

    Claudia Ferrari1, Rosaria Talarico2, Chiara Stagnaro3, Anna d'Ascanio4, Chiara Tani3, Chiara Baldini3, Marta Mosca1 and Stefano Bombardieri3, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Rheumatology Unit, Pisa, Italy, 3University of Pisa, Rheumatology Unit, Pisa, Italy, 4Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy

    Background/Purpose: Behçet’s disease (BD) is globally characterized by a variable spectrum of disease profile: while prevalent muco-cutaneous lesions and arthritis represent the only clinical features…
  • Abstract Number: 2621 • 2013 ACR/ARHP Annual Meeting

    Venous Claudication Is A Severe and Frequent Symptom In BEHCET’S Syndrome

    SerdaL Ugurlu1, Emire Seyahi1, Veysel Oktay2, Zerrin Yigit2, Serdar Kucukoglu2 and Hasan Yazici1, 1Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Department of Cardiology, Cardiology Institute, University of Istanbul, Istanbul, Turkey

    Background/Purpose: In a previous cross-sectional questionnaire survey, we had shown that intermittent claudication was significantly more common among BS patients when compared to healthy controls,…
  • Abstract Number: 2622 • 2013 ACR/ARHP Annual Meeting

    Comparison Of Different Methods Of Skin Pathergy Test In Patients With Behçet’s Syndrome

    Aysegul Lacin1, Cigdem Atan Uzun1, Zafer Gunendi2 and Feride Gogus1, 1Physical Medicine and Rehabilitation, Division of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, 2Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Skin pathergy test (SPT) has a diagnostic value in Behçet’s syndrome (BS). There are different descriptions of the test which may effect its positivity rate.…
  • Abstract Number: 2623 • 2013 ACR/ARHP Annual Meeting

    A CT Evaluation Of Pulmonary and Cardiac Lesions In BEHÇET’S Syndrome Patients Without Pulmonary Symptoms

    Emire Seyahi1, Deniz Cebi Olgun2, SerdaL Ugurlu1, Idil Hanci3, Reona Takahashi4 and Hasan Yazici1, 1Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Department of Radiology,, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Department of Neurology, Krankrenhaus Nordwest, Frankfurt am Main, Frankfurt, Germany, 4Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose:  In Behçet’s syndrome (BS) patients with symptomatic pulmonary artery involvement (PAI) varying and multiple pulmonary parenchymal and cardiac lesions can be seen in thorax CT…
  • Abstract Number: 2624 • 2013 ACR/ARHP Annual Meeting

    Evaluation of Asymptomatic Venous Disease By Venous Doppler Ultrasonography in Patients With Behcet’s Disease

    Fatma Alibaz-Oner1, Emrah Karatay2, Ihsan Nuri Akpinar2, Tülin Ergun3 and Haner Direskeneli1, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Radiology, Marmara University, School of Medicine, Istanbul, Turkey, 3Dermatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: One of the major causes of mortality and morbidity in Behcet’s disease (BD), especially in young males of Mediterranean origin, is vascular involvement. A…
  • Abstract Number: 2625 • 2013 ACR/ARHP Annual Meeting

    Biologic Therapy In Refractory Uveitis Of Behcet’s Syndrome: Switching and Dose Modification. Multicenter Study Of 124 Patients

    F. Ortiz-Sanjuán1, Vanesa Calvo-Río2, Ricardo Blanco3, Emma Beltrán4, Juan Sánchez-Bursón5, Marina Mesquida6, Alfredo M. Adan6, M Hernandez Grafella7, E Valls Pascual8, L Martínez-Costa9, A Sellas-Fernàndez10, Miguel Cordero-Coma11, Manuel Diaz-llopis12, David Salom12, Jl García Serrano13, Norberto Ortego13, JM Herreras14, Alejandro Fonollosa15, A Aparicio16, O Maíz17, A Blanco18, I Torre19, Cruz Fernández-Espartero20, V Jovani21, D Peitado-Lopez22, Esperanza Pato23, J Cruz24, J. Carlos Fernandez-Cid25, Elena Aurrecoechea26, M García27, M Caracuel28, Carlos Montilla29, A Atanes30, F Francisco31, S Insua32, S González-Suárez33, A Sánchez-Andrade34, F Gamero35, Luis Linares36, F Romero-Bueno37, J García38, AJ García González39, Raquel Almodovar40, E Minguez41, C Carrasco Cubero42, Alejandro Olivé Marqués43, J Vázquez44, O Ruiz Moreno45, F Jimenez-Zorzo45, J Manero45, Javier Loricera2 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Marques de Valdecilla, Santander, Spain, 4Rheumatology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, 5Hospital de Valme. Sevilla, Sevilla, Spain, 6Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, 7Ophthalmology, Hospital General Universitario, Valencia, Valencia, Spain, 8Rheumatology, Hospital Peset Valencia, Valencia, Spain, 9Ophthalmology, Hospital Peset Valencia, Valencia, Spain, 10Rheumatology, Hospital Val d´Hebron. Barcelona, Barcelona, Spain, 11Departament of Ophthalmology, Hospital de León, León, Spain, 12Department of Ophthalmology, Hospital Universitario La Fe de Valencia, Valencia, Spain, 13Hospital San Cecilio. Granada, Granada, Spain, 14Hospital Universitario, IOBA. Valladolid, Valladolid, Spain, 15Ophtalmology Service, Hospital de Cruces. Bilbao, Baracaldo, Spain, 16Rheumatology., Hospital de Toledo., Toledo, Spain, 17Rheumatology, Hospital Donosti San Sebastian, San Sebastián, Spain, 18Ophthalmology., Hospital Donosti San Sebastian, San Sebastián, Spain, 19Rheumatology., Hospital Basurto. Bilbao, Bilbao, Spain, 20Servicio de Reumatología, Hospital Universitario de Móstoles. Madrid, Madrid, Spain, 21Rheumatology., Hospital General de Alicante., Alicante, Spain, 22Rheumatology, Hospital Universitario La Paz Madrid, Madrid, Spain, 23Rheumatology, Hospital Clínico San Carlos. Madrid, Madrid, Spain, 24Rheumatology, Hospital de Pontevedra, Pontevedra, Spain, 25Departament of Ophthalmology, Hospital de Pontevedra, Pontevedra, Spain, 26Rheumatology, Hospital Sierrallana. Torrelavega, Torrelavega, Spain, 27Rheumatology., Hospital La Princesa. Madrid, Madrid, Spain, 28Rheumatology., Hospital de Córdoba., Córdoba, Spain, 29Rheumatology Service, Hospital Universitario de Salamanca, Salamanca, Spain, 30Rheumatology., HUCA La Coruña., A Coruña, Spain, 31Rheumatology., Hospital Doctor Negrín Canarias., Canarias, Spain, 32Rheumatology., Hospital Universitario Santiago de Compostela, Santiago de Compostela, Spain, 33Rheumatology., Hospital Cabueñes, Gijón, Gijón, Spain, 34Rheumatology., Hospital Lucus Augusti Lugo, Lugo, Spain, 35Rheumatology., Hospital San Pedro Alcantara Caceres, Caceres, Spain, 36Rheumatology, Hospital Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 37Rheumatology., Fundación Jimenez Díaz. Madrid, Madrid, Spain, 38Rheumatology, Hospital 12 de Octubre. Madrid, Madrid, Spain, 39Rheumatology., Hospital 12 de Octubre. Madrid, Madrid, Spain, 40Rheumatology Unit, Hospital Universitario Fundación Alcorcón. Madrid, Alcorcon. Madrid, Spain, 41Ophthalmology, Hospital Clínico de Zaragoza, Zaragoza, Spain, 42Rheumatology., Hospital de Mérida, Mérida, Spain, 43Hospital Germans Trias i Pujol. Badalona, Barcelona, Spain, 44Rheumatology, Hospital de Ferrol. A Coruña, A Coruña, Spain, 45Hospital Universitario Miguel Servet. Zaragoza, Zaragoza, Spain

    Background/Purpose: Several situations can be observed in patients undergoing biologic therapy in uveitis associated to Behçet´s syndrome (BS): a) Patients are switched to another therapy…
  • Abstract Number: 2626 • 2013 ACR/ARHP Annual Meeting

    Infliximab For Sight-Threatening and Refractory Uveitis Of Behcet’s Syndrome

    Vedat Hamuryudan1, Gulen Hatemi2, Yilmaz Ozyazgan2, Didar Ucar2, Sebahattin Yurdakul2, Emire Seyahi2, Koray Tascilar2, Serdal Ugurlu2 and Hasan Yazici3, 1Division of Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 2Cerrahpasa Medical Faculty University of Istanbul, Behcet's Syndrome Research Center, Cerrahpasa Medical Faculty University of Istanbul, Istanbul, Turkey, 3Cerrahpasa Medical Faculty University of Istanbul, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose: Uncontrolled studies suggest a beneficial effect of infliximab in the treatment of severe uveitis of BS. The majority of these studies had short observation…
  • Abstract Number: 2627 • 2013 ACR/ARHP Annual Meeting

    Prognostic Factors Of Visual Function In The Treatment With Infliximab For Uveitis Of Behçet’s Disease

    Akihiko Nakabayashi1, Toru Hirano2, Yoshihiro Hishitani2, Keisuke Hagihara3, Kei Nakai4, Kouji Nishida4 and Atsushi Kumanogoh2, 1Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, 2Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, 3Department of Kampo Medicine, Osaka University Graduate School of Medicine, Suita, Japan, 4Department of Ophthalmology, Osaka University Graduate School of Medicine, suita, Japan

    Background/Purpose: Infliximab, a chimeric monoclonal antibody against TNF-a, is expected to improve prognosis of visual function in patients with severe and refractory uveitis of Behçet's…
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