Abstracts Archive - Page 2257 of 2425 - ACR Meeting Abstracts

Abstract Number: 2505 • 2012 ACR/ARHP Annual Meeting
Involvment of CD4⁺ FoxP3⁺ Regulatory T Cells in Interleukin-6 Receptor Targeted Treatment in Murine Arthritis and Rheumatoid Arthritis
Allan Thiolat¹, Jerome Biton¹, Luca Semerano¹, Yves-Marie Pers², Pierre Portales², Delphine Lemeiter¹, Patrice Decker¹, Christian Jorgensen², Pascale Louis-Plence², Natacha Bessis³ and Marie-Christophe Boissier⁴, ¹EA4222, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, 93009, France, Bobigny, France, ²Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ⁴INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: Studies have demonstrated the clinical efficacy of tocilizumab, a humanized anti-IL-6 receptor (R) antibody (Ab), in patients with rheumatoid arthritis (RA). The rational for…
Abstract Number: 2466 • 2012 ACR/ARHP Annual Meeting
Pregnancy Outcome in Women Treated with Adalimumab for the Treatment of Rheumatoid Arthritis: The OTIS Autoimmune Diseases in Pregnancy Project
Christina D. Chambers¹, Diana L. Johnson², Yunjun Luo¹, Janina L. Jimenez¹, Nicole Mirrasoul¹, Elizabeth Salas¹, Kenneth Lyons Jones² and OTIS Research Group³, ¹Pediatrics, University of California, San Diego, La Jolla, CA, ²University of California San Diego Department of Pediatrics, La Jolla, CA, ³Pediatrics, La Jolla
Background/Purpose: The fully human, anti-tumor necrosis factor monoclonal antibody, adalimumab (ADA), is approved for the treatment of rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile…
Abstract Number: 2467 • 2012 ACR/ARHP Annual Meeting
Tissue Lesions in Osteoarthritis Initiative Participants with Normal X-Rays and Risk Factors for Incident Cartilage Damage
Leena Sharma¹, Ali Guermazi², Orit Almagor¹, Michel Crema², Dorothy D. Dunlop³, Frank Roemer⁴, Marc C. Hochberg⁵, Charles Eaton⁶, Joan M. Bathon⁷, Rebecca D. Jackson⁸, W.J. Mysiw⁸, C. Kent Kwoh⁹, Michael C. Nevitt¹⁰ and Joan S. Chmiel¹, ¹Northwestern University, Chicago, IL, ²Boston University, Boston, MA, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵Department of Medicine, University of Maryland, Baltimore, MD, ⁶Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁷Columbia University, New York, NY, ⁸Ohio State University, Columbus, OH, ⁹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: Understanding factors underlying initial development of knee OA is crucial to effective prevention strategy design. Our goals were to: 1) determine extent of tissue…
Abstract Number: 2468 • 2012 ACR/ARHP Annual Meeting
Incident Symptomatic Hip Osteoarthritis Is Associated with Differences in Hip Shape by Active Shape Modeling: The Johnston County Osteoarthritis Project
Amanda E. Nelson¹, Felix Liu², John A. Lynch³, Jordan B. Renner⁴, Todd A. Schwartz⁵, Nancy E. Lane⁶ and Joanne M. Jordan⁷, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²University of California at San Francisco, San Francisco, CA, ³Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁴University of North Carolina Department of Radiology, Chapel Hill, NC, ⁵Biostatistics, University of North Carolina Gillings School of Global Public Health, Dept of Biostatistics, Chapel Hill, NC, ⁶Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: We investigated hip shape by active shape modeling (ASM) as a potential predictor of incident radiographic and symptomatic hip OA (rHOA and srHOA) in…
Abstract Number: 2469 • 2012 ACR/ARHP Annual Meeting
A Virtual Knee Joint Replacement Clinical Endpoint Based On Longitudinal Trends and Thresholds in Koos Knee Pain and Function in Osteoarthritis Initiative Participants
Robert M. Boudreau¹, David J. Hunter², Zhijie Wang³, Frank Roemer⁴, Felix Eckstein⁵, Michael J. Hannon³, Ali Guermazi⁶ and C. Kent Kwoh⁷, ¹Epidemiology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁶Boston University, Boston, MA, ⁷School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes, but has limitations as an endpoint in OA intervention trials. A definition…
Abstract Number: 2470 • 2012 ACR/ARHP Annual Meeting
Does Structural Progression of Knee Osteoarthritis Measured with Magnetic Resonance Imaging or Radiography Predict Knee Replacement? – Data From the Osteoarthritis Initiative
Felix Eckstein¹, C. Kent Kwoh², Robert M. Boudreau³, Zhijie Wang⁴, Michael J. Hannon⁴, Wolfgang Wirth¹, Ali Guermazi⁵, Frank Roemer⁶, Michael C. Nevitt⁷, Markus R. John⁸, Leena Sharma⁹, Jeffrey W. Duryea¹⁰, David J. Hunter¹¹ and Osteoarthritis Initiative Investigators¹², ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Radiology, Boston University, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Northwestern University, Chicago, IL, ¹⁰Dept of Radiology, Brigham & Women, Boston, MA, ¹¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ¹²San Francisco
Background/Purpose: Imaging biomarkers that predict relevant clinical endpoints, such as knee replacement (KR), are valuable tools for knee osteoarthritis prognosis. Currently, measurement of minimum radiographic…
Abstract Number: 2471 • 2012 ACR/ARHP Annual Meeting
Oral Glucosamine Sulphate for the Prevention of Knee Osteoarthritis in Overweight Females; The First Ever Preventive Randomized Controlled Trial
Jos Runhaar¹, Marienke van Middelkoop¹, Max Reijman², Edwin Oei³, Dammis Vroegindeweij⁴, Gerjo van Osch², Bart Koes¹ and Sita Bierma-Zeinstra⁵, ¹General Practice, Erasmus MC, Rotterdam, Netherlands, ²Orthopaedics, Erasmus MC, Rotterdam, Netherlands, ³Radiology, Erasmus MC, Rotterdam, Netherlands, ⁴Radiology, Maasstad Hospital, Rotterdam, Netherlands, ⁵Orthopaedics and General Practice, Erasmus MC, Rotterdam, Netherlands
Background/Purpose: Previous studies showed the largest effects of glucosamine on osteoarthritis (OA) symptoms of the knee joint and when used in an early phase of…
Abstract Number: 2472 • 2012 ACR/ARHP Annual Meeting
A Randomized, Multicentre, Double Blind, Placebo-Controlled Trial of Anti TNF Alpha (adalimumab) in Refractory Hand Osteoarthritis: The Dora Study
Xavier Chevalier¹, Philippe Ravaud², Emmanuel Maheu³, Gabriel Baron⁴, Amandine Rialland⁵, Philippe Vergnaud⁶, Christian Roux⁷, Yves Maugars⁸, Denis Mulleman⁹, Bernard Combe¹⁰, Daniel Wendling¹¹, Pierre Laforgue¹², Damien Loeuille¹³, Violaine Foltz¹⁴ and Pascal Richette¹⁵, ¹Department of Rheumatology Hopital Henri Mondor, Créteil, France, ²Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ³Rheumatology, AP-HP, St Antoine Hospital, Paris, France, ⁴Hotel Dieu University Hospital Paris, Epidemiology, Paris, France, ⁵Unité de recherche clinique Henri Mondor, Créteil, France, ⁶CCRB Synarc Lyon, Lyon, France, ⁷Rheuamtology, CHU L' Archet University Nice, Nice, France, ⁸Rheumatology, Nantes University Hospital, Nantes, France, ⁹CHU Trousseau Tours, Tours, France, ¹⁰CHU Lapeyronie, Montpellier, France, ¹¹Service de Rhumatologie, Minjoz University Hospital, Besancon, France, ¹²CHU la conception Marseille, Marseille, France, ¹³Rheumatology, CHU Brabois, Vandoeuvre les Nancy, France, ¹⁴APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, ¹⁵Lariboisière Hospital, Paris, France
Background/Purpose: Hand osteoarthritis (HOA) is a frequent painful polyarticular disease which often does not respond to any classical therapeutics. TNF a is involved in the…
Abstract Number: 2473 • 2012 ACR/ARHP Annual Meeting
A Randomized Trial in New Onset Juvenile Dermatomyositis: Prednisone Versus Prednisone Plus Cyclosporine Versus Prednisone Plus Methotrexate
Nicolino Ruperto¹, Angela Pistorio², Sheila Oliveira³, Rubén J. Cuttica⁴, Angelo Ravelli¹, Michel Fischbach⁵, Stefan Hagelberg¹, Tadej Avcin⁶, Emanuel Cheuret¹, Fabrizia Corona⁷, Gerard Couillault¹, Frank Dressler¹, Valeria Gerloni¹, Gary Sterba Sr.¹, Francesco Zulian¹, Maria Teresa Apaz¹, Adriana Cespedes-Cruz¹, Rolando Cimaz¹, Fabrizio De Benedetti⁸, Pierre Quartier¹, Ricardo Russo¹, Nico Wulffraat¹, Simona Angioloni¹ and Alberto Martini⁹, ¹Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy, ²PRINTO, Genoa, Italy, ³Istituto Giannina Gaslini, Pediatria II, Reumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Center, Genoa, Italy, Genova, Italy, ⁴Hospital de Niños Pedro de Elizalde - University of Buenos Aires, Buenes Aires, Argentina, ⁵Pediatric Rheumatology International Trials Organization (PRINTO)-Istituto Gaslini, Genova, Italy, ⁶The Ljubljana University Medical Centre, Pediatric Clinic, Ljubljana, Slovenia, ⁷Reumatologia Pediatrica, Paediatric Department University of Milano, Milano, Italy, ⁸IRCCS Ospedale Pediatrico Bambino Gesú, Rome, Italy, ⁹Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH
Background/Purpose: Data regarding the safety and efficacy of treatment regimens for juvenile dermatomyositis(JDM) tends to be from anecdotal, small, uncontrolled, non-randomized case series. This randomized…
Abstract Number: 2474 • 2012 ACR/ARHP Annual Meeting
Urine Biomarkers Distinguish Between Proliferative and Membranous Lupus Nephritis in Childhood Onset Systemic Lupus Erythematosus
Rina Mina¹, Michael Bennett², Lining Qi³, Shannen Nelson⁴, Jessica Hummel⁵, Pavel Shiyanov³, John Schlager³, Prasad Devarajan² and Hermine Brunner⁶, ¹Rheumatology, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, ²Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³US Air Force Research Lab, Wright-Patterson Air Force Base, OH, ⁴Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: The ISN/RPS Morphologic Classification of Lupus Nephritis (LN) reports on histological features that differentiate among various forms of LN, most notably between proliferative and…
Abstract Number: 2475 • 2012 ACR/ARHP Annual Meeting
Cancer in Pediatric-Onset Systemic Lupus: What Is the Role of Disease Duration and Other Factors on Risk?
Sasha Bernatsky¹, Ann E. Clarke¹, Jeremy Labrecque², Emily von Scheven³, Laura E. Schanberg⁴, Earl D. Silverman⁵, Hermine Brunner⁶, Kathleen A. Haines⁷, Randy Q. Cron⁸, Kathleen M. O'Neil⁹, Kiem Oen¹⁰, Alan M. Rosenberg¹¹, Ciaran M. Duffy¹², Jennifer LF Lee¹³, Mruganka Kale¹³, Elizabeth M. Turnbull¹⁴ and Rosalind Ramsey-Goldman¹⁵, ¹Clinical Epidemiology, McGill University, Montreal, QC, Canada, ²Clinical Epidemiology, Research Institute of the McGill Univ. Health Ctre, Montreal, QC, Canada, ³Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴Pediatrics, Duke University Medical Center, Durham, NC, ⁵PRSCG, Cincinnati, OH, ⁶Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Department of Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁸Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁹Division of Pediatric Rheum, Okla Univ Health Science Ctr, Oklahoma City, OK, ¹⁰Pediatrics, Children's Hospital of Winnipeg and University of Manitoba, Winnipeg, MB, Canada, ¹¹Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ¹²Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹³Clinical Epidemiology Rheum, RI McGill Univ Health Ctr, Montreal, QC, Canada, ¹⁴Research Institute of the McGill Univ. Health Ctre, Montreal, QC, Canada, ¹⁵Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Compared to adults with SLE, relatively little is known about cancer risk in pediatric-onset SLE. We assessed cancer incidence in a multi-centre pediatric-onset SLE…
Abstract Number: 2476 • 2012 ACR/ARHP Annual Meeting
Role of Whole-Body Magnetic Resonance Imaging in the Assessment of Disease Activity in Juvenile Dermatomyositis. A Pilot Study.
Clara Malattia¹, Annalisa Madeo², Silvia Pederzoli¹, Anna Providenti³, Marta Mazzoni², Agnese Beltramo², Alessandro Consolaro⁴, Stefania Viola⁵, Antonella Buoncompagni⁶ and A. Martini², ¹PRINTO, Genoa, Italy, ²Istituto G Gaslini, Pediatria II, Reumatologia, Genova, Italy, ³Istituto G Gaslini, Genova, UO Fisioterapia, Genova, Italy, ⁴Pediatria II, Istituto Giannina Gaslini, Genova, Italy, ⁵Istituto G. Gaslini, Istituto Giannina Gaslini, Genova, Italy, ⁶Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: Musculoskeletal MRI represents a valuable non-invasive technique for dectecting muscle inflammation in idiopathic inflammatory myopathies (IIM). So far, all MRI studies in juvenile dermatomyositis…
Abstract Number: 2477 • 2012 ACR/ARHP Annual Meeting
The Comparison of Childhood Polyarteritis Nodosa and Cutaneous Polyarteritis Nodosa and a New Set of Diagnostic Criteria for Cut-Polyarteritis Nodosa
Erkan Demirkaya¹, Seza Ozen¹, Turker Turker¹, Rubén J. Cuttica², Paul Brogan¹, Pierre Quartier¹, Jordi Anton³, Nuray Aktay Ayaz⁴, Stella Maris Garay⁵, Graciela Espada¹, Raju Khubchandani⁶, Francesco Zulian¹, Arvind Bagga¹, Alexandre Belot¹, Clovis Artur Silva¹, Sulaiman Al-Mayouf¹, Amparo Ibanez Estrella¹, Sheila Oliveira⁷, Cengizhan Acikel¹, Claudia Saad-Magalhães¹, Alberto Martini⁸ and Nicolino Ruperto¹, ¹Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy, ²Hospital de Niños Pedro de Elizalde - University of Buenos Aires, Buenes Aires, Argentina, ³Rheumatology, Hospital Sant Joan de Deu, Barcelona, Spain, ⁴Bakırkoy Maternity and Childrens Education and Research Hospital, Istanbul, Turkey, ⁵PRINTO, Genoa, Italy, ⁶Rheumatology, Jaslok Hospital and Research Center, Mumbai, India, ⁷Istituto Giannina Gaslini, Pediatria II, Reumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Center, Genoa, Italy, Genova, Italy, ⁸Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH
AbstractBackground/Purpose: Systemic polyarteritis nodosa (PAN) is a predominantly medium size vasculitis characterized by non granulomatous necrotizing vasculitis. We aimed to evaluate clinical, laboratory and imaging…
Abstract Number: 2478 • 2012 ACR/ARHP Annual Meeting
Identification of Disease-Specific Neuroimaging Phenotypes in Childhood Inflammatory Brain Diseases
Tania Cellucci¹, Pascal N. Tyrrell², Shehla Sheikh³, Suzanne Laughlin⁴ and Susanne M. Benseler³, ¹Pediatrics/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Cardiology/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Magnetic resonance imaging (MRI) is a key diagnostic modality of childhood inflammatory brain diseases (IBrainD). While overlapping clinical features contribute to significant diagnostic uncertainty,…
Abstract Number: 2479 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Does Not Increase Risk of Short Term Total Knee Replacement (TKR) Adverse Events (AE)
Zachary J. LoVerde¹, Lisa A. Mandl², Beverly K. Johnson², Mark P. Figgie³, Friedrich Boettner⁴ and Susan M. Goodman², ¹New York Medical College, Valhalla, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY
Background/Purpose: TKR is commonly performed for rheumatoid arthritis (RA) and osteoarthritis (OA). Historically, RA patients were at higher risk of post-operative AEs. The purpose of…

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