Abstracts Archive - Page 2257 of 2607 - ACR Meeting Abstracts

Abstract Number: 2638 • 2013 ACR/ARHP Annual Meeting
Cryoglobulinemia Vasculitis With Or Without Associated Cryofibrinogenemia: A Different Phenotype?
Martin Michaud¹, Guillaume Moulis², Jacques Pourrat¹, Benedicte Puissant¹, Antoine Blancher¹ and Laurent Sailler³, ¹Toulouse University Hospital, University of Toulouse, Toulouse, France, ²Toulouse University Hospital, Clinical Pharmacology Department, University of Toulouse, UMR INSERM-UPS 1027, Toulouse, France, ³Department of Internal Medicine, Toulouse University Hospital, Toulouse, France
Background/Purpose: Cryoglobulin (CryoGl) and cryofibrinogen (CryoFg) are cryoproteins, both responsible for well-described systemic vasculitis. Nevertheless, cryoglobulinemia may be associated with cryofibrinogenemia. Such mixed cryoprotein vasculitis…
Abstract Number: 2639 • 2013 ACR/ARHP Annual Meeting
Long-Term Outcome of Monoclonal (type 1) Cryoglobulinemia
Antoine Néel¹, François Perrin¹, Olivier Decaux², Thomas Dejoie³, Maxime Halliez³, Béatrice Mahé⁴, Thierry Lamy⁵, Fadi Fakhouri⁶, Patrick Jego², Christian Agard¹, Cécile Vigneau⁷, Lucienne Guenet⁸, Bernard Grosbois⁹, Philippe Moreau⁴ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Department of Internal Medicine, Rennes University Hospital, Rennes, France, ³Biochemistry Laboratory, Nantes University Hospital, Nantes, France, ⁴Hematology, Nantes University Hospital, Nantes, France, ⁵Hematology, Rennes University Hospital, Rennes, France, ⁶Nephrology, Nantes University Hospital, Nantes, France, ⁷Nephrology, Rennes University Hospital, Rennes, France, ⁸Biochemistry Laboratory, Rennes University Hospital, Rennes, France, ⁹Internal Medicine Department, Rennes University Hospital, Rennes, France
Background/Purpose: To investigate long-term outcome of symptomatic type 1 cryoglobulinemia and its determinants. Methods: Retrospective analysis of a prospective cohort from 2 French university hospitals.…
Abstract Number: 2640 • 2013 ACR/ARHP Annual Meeting
VERY LONG-TERM Effects Of The “4 PLUS2 Infusion PROTOCOL” Of Rituximabalone In Patients With HCV-Associatedmixed Cryoglobulinemia With Diffusemembranoproliferative Glomerulonephritis,Severe Polyneuropathy and Necrotic Ulcersof Skin
Dario Roccatello¹, Savino Sciascia¹, Simone Baldovino² and Daniela Rossi¹, ¹Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, ²Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Torino, Italy
Background/Purpose: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitischaracterized by multiple organ involvement due to the vascular deposition ofIgMk/IgG cryoglobulins. B cells expansion usually triggered…
Abstract Number: 2641 • 2013 ACR/ARHP Annual Meeting
Earlier Admission To Specialized Care, Intensified Treatment and Improved Outcome In Patients With Autoimmune Connective Tissue Disorders and Vasculitides In Germany 2011 Compared To 1995
Dörte Huscher¹, Katinka Albrecht², Katja Thiele², Sascha Bischoff², Jutta G. Richter³, Ina Kötter⁴, Wolfgang Ochs⁵ and Angela Zink¹, ¹German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ⁴ZIRS, Centre for Interdisciplinary Rheumatology Stuttgart, Stuttgart, Germany, ⁵Rheumatologist in private practice, Bayreuth, Germany
Background/Purpose: Compared to rheumatoid arthritis and other arthritis-associated rheumatic diseases, autoimmune connective tissue disorders and vasculitides are still in the early stages of biological therapies.…
Abstract Number: 2642 • 2013 ACR/ARHP Annual Meeting
A Novel Genetic Basis For Systemic Vasculitis: Polyarteritis Nodosa Caused By Recessive Mutations In An Immune-Related Gene
Reeval Segel^1,2, Pnina Elkan-Navon³, Sarah B. Pierce⁴, Tom Walsh⁴, Judith Barash⁵, Shay Padeh⁶, Avraham Zlotogorski⁷, Yackov Berkun⁸, Isabel Voth⁹, Philip Hashkes¹⁰, Liora Harel¹¹, Eduard Ling¹², Fatos Yalcinkaya¹³, Ozgur Kasapcopur¹⁴, Paul F. Renbaum¹⁵, Ariella Weinberg-Shukron¹⁵, Barbara Schormair¹⁶, Mordechai Shohat¹⁷, Alan A. Rubinow¹⁸, Elon Pras¹⁹, Juliane Winkelmann²⁰, Mustafa Tekin²¹, Yair Anikster²², Mary-Claire King⁴ and Ephrat Levy-Lahad¹⁵, ¹Medical Genetics and Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, ²Hebrew University Medical School, Jerusalem, Israel, ³Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, ⁴Medical Genetics, University of Washington, Seattle, WA, ⁵Pediatric Day Care, Kaplan Medical Center, Rehovot, Israel, ⁶Pediatrics, Sheba Medical Center, Ramat Gan, Israel, ⁷Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, ⁸Pediatrics, Hadassah Medical Center, Mount Scopus, Jerusalem, Israel, ⁹Department of Neurology, Technische Universitat Munchen Klinikum rechts der Isar, Munich, Germany, ¹⁰Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, ¹¹Pediatric Rheumatology unit, Schneider Children's Medical Center, Tel Aviv University, Petach Tikvah, Israel, ¹²Rheumatology Unit, Soroka University Medical Center and Ben-Gurion University, Beer-Sheva, Beer Sheva, Israel, ¹³Pediatric Nephrology and Rheumatology, Ankara University, Ankara, Turkey, ¹⁴Ankara University, Ankara, Turkey, ¹⁵Medical Genetics, Shaare Zedek Medical Center, Jerusalem, Israel, ¹⁶Helmholtz Zentrum Munchen, Munich, Germany, ¹⁷Rafael Recanati medical genetics Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel, ¹⁸Hadassah Medical Center, Jerusalem, Israel, ¹⁹Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel, ²⁰Genetics, Stanford University, San Francisco, CA, ²¹Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, ²²Metabolic Disease Unit, Sheba Medical Center, Ramat Gan, Israel
Background/Purpose: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis. Disease pathogenesis and possible genetic factors are poorly understood. We identified familial, mostly pediatric PAN, in…
Abstract Number: 2643 • 2013 ACR/ARHP Annual Meeting
Midkine Is a Novel Prognostic Factor In Patients With Vasculitis Syndrome
Yoshie Kusunoki¹, Yutaka Okano¹, Natsuko Kusunoki², Natsuki Fujio², Mai Kawazoe², Emiko Shindo², Kotaro Shikano², Makoto Kaburaki², Sei Muraoka², Kanako Kitahara², Kaichi Kaneko², Nahoko Tanaka², Tatsuhiro Yamamoto², Kenji Takagi², Tomoko Hasunuma², Hirahito Endo² and Shinichi Kawai², ¹Center for Arthritis and Rheumatic Diseases, Kawasaki Municipal Kawasaki Hospital, Kanagawa, Japan, ²Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Midkine (MK) is a heparin-binding growth factor, promotes growth, survival, and migration of various cells. Recently several reports show that MK may also play…
Abstract Number: 2644 • 2013 ACR/ARHP Annual Meeting
Phase IB/Iia Study On Intravenous Administration Of Expanded Allogeneic Adipose-Derived Mesenchymal Stem Cells In Refractory Rheumatoid Arthritis Patients
JM Alvaro-Gracia¹, Juan A. Jover², Rosario Garcia-Vicuña³, Luis Carreño⁴, Alberto Alonso⁵, Sara Marsal⁶, Francisco J. Blanco⁷, Víctor M. Martínez-Taboada⁸, Peter C. Taylor⁹, Federico Díaz-González¹⁰ and Lydia Dorrego¹¹, ¹Unidad de Terapias Biológicas. Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, ²Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ³Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁴Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ⁵Hospital de Cruces, Bilbao, Spain, ⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁷INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV., Santander, Spain, ⁹NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ¹⁰Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ¹¹TiGenix, Tres Cantos, Spain
Background/Purpose: Expanded adipose-derived stem cells (eASCs) are shown to have immune-modulatory effects both in vitro and in animal models of arthritis. eASCs are currently under…
Abstract Number: 2645 • 2013 ACR/ARHP Annual Meeting
Pathological Roles Of The Anti-Oxidative Enzyme Peroxiredoxin 2 In Patients With Kawasaki Disease
Rie Karasawa¹, Toshiko Sato¹, Mayumi Tamaki¹, Mikiya Fujieda², Kazuhide Ohta³ and Kazuo Yudoh¹, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Department of Pediatrics, Kochi Medical School, Nankoku, Japan, ³Department of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan
Background/Purpose: Anti-endothelial cell antibodies (AECA) are autoantibodies that are detected frequently in vasculitis caused by, for example, Kawasaki disease (KD). However, AECA target molecules have…
Abstract Number: 2646 • 2013 ACR/ARHP Annual Meeting
Cost-Effectiveness Analysis Of Triple Therapy Versus Etanercept Plus Methotrexate In Early Aggressive Rheumatoid Arthritis: Analysis Based On The TEAR Trial
Hawre Jalal¹, Jeffrey R. Curtis², Stacey Cofield³, Larry W. Moreland⁴, James R. O'Dell⁵ and Kaleb Michaud⁶, ¹Health Polisy and Management, University of Minnesota, Minneapolis, MN, ²Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁶Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The long-term cost-effectiveness of triple therapy (methotrexate [MTX], sulfasalazine [SSZ], hydroxychloroquine [HCQ]) disease modifying anti-rheumatic drugs (DMARDs) compared to a combination of MTX and…
Abstract Number: 2647 • 2013 ACR/ARHP Annual Meeting
Recombinant Monoclonal Antibodies Derived From Single CD19+ Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones
Elisa Corsiero¹, Michele Bombardieri², Emanuela Carlotti¹, Hedda Wardemann³, William H. Robinson⁴ and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards citrullinated proteins. Around 40% of patients display synovial tertiary lymphoid structures (TLS) with functional…
Abstract Number: 2648 • 2013 ACR/ARHP Annual Meeting
Characterization Of Histidyl-tRNA Synthetase Specific Th Cell Response In Blood and Broncheoalveolar Lavage (BAL) Of Myositis Patients
Inka Albrecht¹, Eddie James², Maryam Fathi³, Maryam Dastmalchi⁴, Jessica Herrath¹, Vivianne Malmström⁵ and Ingrid E. Lundberg⁶, ¹Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ²Benaroya Research Institute, Seattle, WA, ³Karolinska Institutet, Department of Medicine , Respiratory Medicine Unit, Stockholm, Sweden, ⁴Department of Medicine, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Idiopathic inflammatory myopathy is a rare chronic inflammatory disease that is associated with the presence of autoantibodies pointing to a contribution of adaptive immune…
Abstract Number: 2649 • 2013 ACR/ARHP Annual Meeting
Rituximab For The Treatment Of IgG4-Related Disease: A Prospective Clinical Trial
Mollie Carruthers¹, Mark Topazian², Arezou Khosroshahi³, Thomas Witzig⁴, Judith Oakley⁵, Philip Hart⁶, Lauren Kelly⁵, Lori Bergstrom⁶, Suresh Chari⁶ and John Stone⁷, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Gastroenterology, Mayo Clinic, Rochester, MA, ³Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁴Hematology & Oncology, Mayo Clinic, Rochester, MN, ⁵Clinical Research Program, Massachusetts General Hospital, Boston, MA, ⁶Gastroenterology, Mayo Clinic, Rochester, MN, ⁷Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a multi-organ, fibro-inflammatory disorder. An open label pilot trial of rituximab (RTX) in IgG4-RD conducted at twocentershas enrolled 29 of…
Abstract Number: 2650 • 2013 ACR/ARHP Annual Meeting
Silent Ischemic Heart Disease In Patients With Primary Antiphospholipid Syndrome
Antonio R. Cabral¹, Gregoria Gómez-Hernández², Martha Morelos-Guzmán³, Tatiana Rodriguez-Reyna⁴, Carlos Alberto Núñez-Alvarez⁵ and Jorge Vazquez-Lamadrid³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ²Internal Medicine, Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ³Radiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴Immunology and Rheumatology, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Premature atherosclerosis in PAPS is still a matter of debate Patients and Methods: To determine the prevalence of ischemic heart disease in…
Abstract Number: 2651 • 2013 ACR/ARHP Annual Meeting
The Association Between Antiphospolipid Antibodies and Related Clinical Outcomes: A Critical Review Of The Literature
Cecilia B. Chighizola¹, Laura Andreoli², Alessandra Banzato³, Guilherme Ramires de Jesus⁴, Guillermo J. Pons-Estel⁵, Doruk Erkan⁶ and On Behalf of APS Action⁷, ¹Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, ²Rheumatology Unit, University of Brescia, Brescia, Italy, ³Department of Cardiac Thoracic and Vascular Sciences, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy, ⁴Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ⁵Servicio de Enfermedades Autoinmunes, Department of Autoimmune Diseases, Institut Clìnic de Medicina i Dermatologia, Hospital Clìnic, Barcelona, Spain, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷APS ACTION, New York, NY
Background/Purpose: AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) is an international network that has been created to design and conduct APS…
Abstract Number: 2652 • 2013 ACR/ARHP Annual Meeting
Ovarian Reserve In Women With Primary Antiphospholipid Syndrome
Lucas Yamakami¹, Paulo Serafini², Daniel B. Araujo³, Eloisa Bonfá⁴, Elaine P. Leon⁵, Edmund C. Baracat⁶ and Clovis A. Silva⁷, ¹Gynecology Department, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²MD; PhD, Sao Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil, ⁴Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁶Gynecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁷Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil
Background/Purpose: Aging, smoking, obesity and surgery have been found to influence the quantity and quality of primordial follicles in ovaries and, ultimately, the ovarian reserve.…

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