Abstracts Archive - Page 2256 of 2425 - ACR Meeting Abstracts

Abstract Number: 2490 • 2012 ACR/ARHP Annual Meeting
Herpes Zoster and Tofacitinib Therapy in Patients with Rheumatoid Arthritis
K. L. Winthrop¹, H. Valdez², E. Mortensen³, R. Chew⁴, S. Krishnaswami⁵, T. Kawabata⁵ and R. Riese⁴, ¹Division of Infectious Diseases, Oregon Health and Science University, Portland, OR, ²Pfizer Inc., New York, NY, ³Global Medical Affairs, Pfizer Inc., Collegeville, PA, ⁴Pfizer Inc., Groton, CT, ⁵Pfizer Inc, Groton, CT
Background/Purpose: Patients (pts) with RA are at increased risk for herpes zoster (HZ) i.e. ‘shingles'. Tofacitinib, a novel oral Janus kinase inhibitor investigated as a…
Abstract Number: 2491 • 2012 ACR/ARHP Annual Meeting
IL-17 Expression Is Low in Psoriatic Arthritis Synovium Compared to Expression in Matched Skin Lesions
Jennifer Belasco¹, Hiroshi Mitsui¹, Mayte Suarez-Farinas¹, James S. Louie², Nathan Wei³, Nicholas Gulati¹ and James G. Krueger¹, ¹Krueger Laboratory, The Rockefeller University, New York, NY, ²Rheumatology, UCLA School of Medicine, Los Angeles, CA, ³Arthritis Treatment Center, Frederick, MD
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory joint disease associated with psoriasis. It is known that treatment modalities are not equally effective for both skin…
Abstract Number: 2492 • 2012 ACR/ARHP Annual Meeting
Protective and Pathogenic Effects of the IL-23 Family of Cytokines in Spondyloarthropathy in SKG Mice
Helen Benham¹, Linda Rehaume¹, Merja Ruutu¹, Jared Velasco¹, Kristine Kikly², Geoffrey Strutton³, Michael McGuckin⁴ and Ranjeny Thomas¹, ¹Diamantina Institute, Diamantina Institute University of Queensland, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co., Indianapolis, ³Dept of Pathology, Department of Pathology, Princess Alexandra Hospital, Brisbane, Australia, ⁴Mater Medical Research Institute, Brisbane, Australia
Background/Purpose: , IL-23 is required for the expansion and maintenance of T cells and innate cells secreting IL-17 and IL-22. These cytokines are important for…
Abstract Number: 2493 • 2012 ACR/ARHP Annual Meeting
The Presence of HLA-B27 Shapes Gut Microbiome Composition in Rats
Mary H. Bach¹, Russell N. Van Gelder², Joel D. Taurog³ and James T. Rosenbaum⁴, ¹Rheumatology, University of Washington Medical Center, Seattle, WA, ²Ophthalmology, University of Washington Medical Center, Seattle, WA, ³Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ⁴Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR
Background/Purpose: The association of spondyloarthropathies (SpA) with HLA-B27 was first described in 1973. However, the mechanism remains unknown. The HLA-B27-human beta2 microglobulin (B27/hβ2m) transgenic (TG)…
Abstract Number: 2494 • 2012 ACR/ARHP Annual Meeting
Incidence and Severity of Spondyloarthritis and Crohn’s Ileitis Are Determined by Interaction Between the Microbiota and Genetic Susceptibility in Beta-Glucan-Treated SKG Mice
Ranjeny Thomas¹, Linda Rehaume¹, Daniel Aguirre de Cárcer², Stan Mondot², Jared Velasco¹, Helen Benham¹, Merja Ruutu¹, Mark Morrison² and Michael McGuckin³, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²CSIRO Livestock Industries, Brisbane, Australia, ³Mater Medical Research Institute, Brisbane, Australia
Background/Purpose: Spondyloarthritis and inflammatory bowel disease (IBD) or microscopic gut inflammation co-exist in many patients. These conditions share genetic associations in the IL23R signaling pathway.…
Abstract Number: 2495 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping of Candidate Genes Identifies 16 New Susceptibility Loci in Ankylosing Spondylitis
Adrian Cortes¹, Philip Robinson¹, International Spondyloarthritis Genetics Consortium² and Matthew A. Brown¹, ¹Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ²Brisbane, Australia
Background/Purpose: Ankylosing spondylitis (AS) is a highly heritable inflammatory arthritis common in both Asian and European populations. Thus far genes identified include the HLA-B*27 allele,…
Abstract Number: 2496 • 2012 ACR/ARHP Annual Meeting
Elevated Serum Level of the Vascular Endothelial Growth Factor Is Highly Predictive for New Syndesmophytes Formation in Patients with Ankylosing Spondylitis
Denis Poddubnyy¹, Kristina Conrad², Uta Syrbe², Hildrun Haibel³, Heiner Appel², Martin Rudwaleit⁴ and Joachim Sieper⁵, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ³Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ⁴Endokrinologikum Berlin, Berlin, Germany, ⁵Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: In the recent years several predictors of radiographic spinal progression/syndesmophyte formation in ankylosing spondylitis (AS) were identified: syndesmophytes at baseline (the strongest predictor so…
Abstract Number: 2497 • 2012 ACR/ARHP Annual Meeting
Altered Circulating Follicular Helper T Cell Phenotype and Subset Composition Are Associated with Disease Activity in Patients with Systemic Lupus Erythematosus
Hsi-en Ho¹, Jin Young Choi², Viviane M. Bunin², Sandra G. Pasoto³, Solange Carrasco⁴, Eduardo F. Borba⁵, Celio R. Goncalves⁶, Priscila R. Costa⁷, Esper G. Kallas⁷, Eloisa Bonfa⁶ and Joseph E. Craft², ¹Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ²Yale University School of Medicine, Internal Medicine, Section of Rheumatology, New Haven, CT, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁴University of São Paulo, São Paulo, Brazil, ⁵Rheumatology Division; University of São Paulo, São Paulo, Brazil, ⁶Universidade de São Paulo, Division of Rheumatology, Faculdade de Medicina, Sao Paulo, Brazil, ⁷Universidade de São Paulo, Division of Immunology, Faculdade de Medicina, Sao Paulo, Brazil
Background/Purpose: Autoreactive B cells in SLE undergo autoantigen selection, suggesting a requirement for germinal center follicular helper T (Tfh) cells in their maturation. However, evidence…
Abstract Number: 2498 • 2012 ACR/ARHP Annual Meeting
Biomarkers of Mitochondrial Dysfunction Correlate with Disease Activity in SLE
Zhi-Wei Lai¹, Tiffany Telarico², Robert Hanczko¹, Adam Bartos¹, Lisa Francis³, Hajra I. Tily⁴, Ricardo Garcia¹, Maha M. Dawood⁵, Jianghong Yu⁶, Ashwini Shadakshari⁶, Paul E. Phillips⁷ and Andras Perl⁸, ¹Medicine, SUNY, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Medicine/Rheumatology, SUNY upstate medical university, Syracuse, NY, ⁴SUNY, NY, ⁵Medicine/Rheumatology, SUNY Upstate, Syracuse, NY, ⁶Medicine/Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ⁷Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁸Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Systemic lupus erythematosus (SLE) patients’ T cells exhibit mitochondrial dysfunction, characterized by the persistent elevation of the mitochondrial transmembrane potential (Δψm) or mitochondrial hyperpolarization…
Abstract Number: 2499 • 2012 ACR/ARHP Annual Meeting
The Peroxisome-Proliferator Activated Receptor-γ Agonist Pioglitazone Modulates Aberrant T-Cell Responses in Systemic Lupus Erythematosus
Wenpu Zhao¹, Celine C. Berthier², Matthias Kretzler³ and Mariana J. Kaplan⁴, ¹University of Michigan Rheumatology, Ann Arbor, MI, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁴Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Previous studies indicate that PPAR-γ agonists, including pioglitazone (PIO), down-regulate autoimmune responses and renal inflammation in murine SLE. However, the mechanisms implicated in this process…
Abstract Number: 2500 • 2012 ACR/ARHP Annual Meeting
Podocyte Injury in Membranous and Proliferative Lupus Nephritis: Distinct Underlying Mechanisms?
Gabriela M. Rezende¹, Vilma S. T. Viana¹, Denise M. Malheiros², Elaine P. Leon³, Eduardo F. Borba¹, Neila AS Silva², Irene L. Noronha⁴, Cleonice Silva⁴ and Eloisa Bonfá⁵, ¹Internal Medicine, Division of Rheumatology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of AnatomoPathology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Internal Medicine, Division of Nephrology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Division of Rheumatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE) with proteinuria being the predominant common…
Abstract Number: 2501 • 2012 ACR/ARHP Annual Meeting
Mirorna Mir-150 Contributes to Chronic Kidney Injury in Lupus Nephritis by Increasing the Synthesis of Fibrotic Proteins Via Downregulation of SOCS1
Hua Zhou¹, Sarfaraz A. Hasni², Mayank Tandon³, Shyh-Ing Jang⁴, Howard A. Austin⁵, James E. Balow⁶, Ilias Alevizos³ and Gabor G. Illei³, ¹NIDCR/NIH, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁴Molecular Physiology and Therapeutics Branch, NIDCR/NIH, Bethesda, MD, ⁵Kidney Disease Section, NIDDK/NIH, Bethesda, MD, ⁶Clinical Director, NIDDK, NIDDK/NIH, Bethesda, MD
Background/Purpose: We have previously shown that renal expression of miR-150 correlates with chronicity index (CI) in lupus nephritis. Since fibrosis is a major histologic feature…
Abstract Number: 2502 • 2012 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap-Associated Protein Activation of the Inflammasome Is Enhanced in Lupus M1 Macrophages
J. Michelle Kahlenberg¹, Carolyne K. Smith², Carmelo Carmona-Rivera¹ and Mariana J. Kaplan³, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular traps (NETs) contain numerous bactericidal proteins and are an important defense mechanism against microorganisms. Clearance of NETs is impaired in a subset…
Abstract Number: 2503 • 2012 ACR/ARHP Annual Meeting
CD8+Foxp3-CD103+ Regulatory T Cells Generated Ex Vivo with TGF-β Suppress Autoimmunity Through IL-10-Dependet Mechanism
Ya Liu¹, An-Ping Xu², David A. Horwitz³ and Song G. Zheng⁴, ¹Medicine, USC Keck School of Medicine, Los Angeles, CA, ²Kidney disease and rheumatology, 2nd Affiliated Hospital of Sun Yat-sen University, ³Medicine-Rheumatology-Immun, Keck School of Medicine of USC, Los Angeles, CA, ⁴Medicine, Keck School of Medicine of USC, Los Angeles, CA
Background/Purpose: TGF-β is crucial for induction of CD4+Foxp3+ Tregs and maintenance of immunologic tolerance. It is, however, unclear if TGF-β also induces the similar CD8+…
Abstract Number: 2504 • 2012 ACR/ARHP Annual Meeting
SOCS1 Is One of the Key Molecules to Prevent the Plasticity of Regulatory T Cells and the Development of Autoimmunity
Reiko Takahashi¹, Kenji Itoh¹, Fumihiko Kimura¹ and Akihiko Yoshimura², ¹Division of Rheumatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan, ²Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Suppression of autoimmunity or inflamation by regulatory T cells (Tregs) is now well established, recently, natural Foxp3+T cells have been shown to be a…

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