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  • Abstract Number: 2540 • 2012 ACR/ARHP Annual Meeting

    Prescription of Tumour Necrosis Factor α Antagonists Is Strongly Associated with a Reduction in Hospital Admissions and in Musculoskeletal Surgical Procedures for Rheumatoid Arthritis Based On a 16 Year Analysis of Nationwide Data

    Leonard C. Harty1, Gary O'Toole2, Kathleen Bennett3 and Oliver M. FitzGerald4, 1Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, 2Department of Orthopaedic Surgery, St. Vincent's University Hospital, Dublin, Ireland, 3Trinity Centre for Health Sciences, Department of Pharmacology & Therapeutics, Dublin, Ireland, 4Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Comorbidities, joint destruction leading to orthopaedic intervention and physical disability are predictable outcomes of uncontrolled Rheumatoid Arthritis (RA). Synthetic DMARDS have a slow mechanism…
  • Abstract Number: 2541 • 2012 ACR/ARHP Annual Meeting

    High Risk of Intensive Care Unit Admission in Rheumatoid Arthritis Patients: A Population Based Study

    Christine Peschken1, Carol A. Hitchon2, Allan Garland3, Charles N. Bernstein3, Randy Fransoo4 and Ruth Ann Marrie3, 1Medicine & Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, 4Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Comorbidity in Rheumatoid arthritis (RA) has been a focus of intensive research in recent years, but little is known about the incidence of critical…
  • Abstract Number: 2542 • 2012 ACR/ARHP Annual Meeting

    The Association Between Inflammatory Markers and Hyperlipidemia and the Risk of Myocardial Infarction in Patients with Rheumatoid Arthritis

    Jie Zhang1, Lang Chen2, Elizabeth S. Delzell3, Paul M. Muntner3, William B. Hillegass4, Monika M. Safford5, Iris E. Navarro2 and Jeffrey R. Curtis6, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 4Preventative Medicine, Birmingham, AL, 5Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL

    Title: The Association between Inflammatory Markers and Hyperlipidemia and the Risk of Myocardial Infarction in Patients with Rheumatoid Arthritis Background/Purpose: Patients with rheumatoid arthritis (RA)…
  • Abstract Number: 2543 • 2012 ACR/ARHP Annual Meeting

    Hospitalized Bacterial Infections Among U.S. Veterans with Rheumatoid Arthritis Initiating TNF Antagonist and Newer Biologic Agents

    Jeffrey R. Curtis1, Shuo Yang2, Nivedita M. Patkar3, Lang Chen4, Jasvinder A. Singh5, Grant W. Cannon6, Ted R. Mikuls7, Elizabeth S. Delzell8, Kenneth G. Saag9, Monika M. Safford10, Scott DuVall11, Kimberly Alexander12, Pavel Napalkov12, Aaron Kamauu13 and John Baddley14, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Immunology/Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, 4Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Department of Medicine, University of Alabama, Tuscaloosa, AL, 6Division of Rheumatology, George E. Wahlen VA Medical Center, Salt Lake City, UT, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 9Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, 10Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, 11VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, 12Epidemiology, Genentech, Inc., South San Francisco, CA, 13Anolinx, Bountiful, UT, 14Medicine, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Risks of hospitalized infections for newer biologic agents have not been well characterized compared to risks for anti-TNF therapy. Purpose: To compare the risk…
  • Abstract Number: 2544 • 2012 ACR/ARHP Annual Meeting

    Widening Gap Between Cardiovascular Specific Mortality in Patients with Inflammatory Polyarthritis Compared to the General Population?

    Alexander J. Warner1, Jh Humphreys2, Mark Lunt3, Tarnya Marshall4, Deborah P. M. Symmons5 and Suzanne Verstappen6, 1Manchester Academic Health Sciences Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 2Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, 3Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, 5Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 6Arthritis Research UK Epidemiology Unit,, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

    Background/Purpose: Cardiovascular (CVD) mortality rates are raised in patients with inflammatory polyarthritis (IP) but have been shown to be falling in the general population. This…
  • Abstract Number: 2545 • 2012 ACR/ARHP Annual Meeting

    A Randomized, Double-Blind, Parallel Group Study of the Safety and Efficacy of Tocilizumab SC Versus Tocilizumab IV, in Combination with Traditional Dmards in Patients with Moderate to Severe RA

    G. R. Burmester1, Andrea Rubbert-Roth2, Alain G. Cantagrel3, Stephen Hall4, Piotr Leszczynski5, Daniel Feldman6, Madura J. Rangaraj7, Georgia Roane8, Charles L. Ludivico9, Francesco Ramirez10 and Min Bao11, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Klinikum der Universität zu Köln, Köln, Germany, 3Dept of Rheumatology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France, 4Cabrini Medical Centre, Malvern, Australia, 5Dept. of Rheumatology and Clinical Immunology, J. Strus Poznan Municipal Hospital, Poznan University of Medical Sciences, Poznan, Poland, 6Rheumatology, Universidade Federal de de São Paulo, Sao Paulo, Brazil, 7Arthritis & Diabetes Clinic, Inc., Monroe, LA, 8Rheumatology Associates of South Carolina, Charleston, SC, 9East Penn Rheumatology Assoc, Bethlehem, PA, 10Roche Products Limited, Welwyn, United Kingdom, 11Genentech, South San Francisco, CA

    Background/Purpose: The objective of this study was to compare the efficacy and safety of tocilizumab (TCZ) subcutaneous (SC) and TCZ intravenous (IV) regimen in patients…
  • Abstract Number: 2506 • 2012 ACR/ARHP Annual Meeting

    Expression of Helios Facilitates Distinction Between FoxP3+ Treg and FoxP3+ Activated T Conventional Cells in Patients with Systemic Lupus Erythematosus

    Amit Golding1, Sarfaraz A. Hasni2, Gabor G. Illei3 and Ethan M. Shevach4, 1Medicine/Rheumatology and Clinical Immunology, Baltimore VA and University of Maryland School of Medicine, Baltimore, MD, 2Rheumatology, National Institutes of Health, Bethesda, MD, 3Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, 4Laboratory of Immunology, NIAID/NIH, Bethesda, MD

    Background/Purpose: FoxP3 is not a reliable marker for distinguishing regulatory T (Treg) cells in humans due to the fact that FoxP3 may be up-regulated in…
  • Abstract Number: 2507 • 2012 ACR/ARHP Annual Meeting

    Activated Cullin-Ring Ubiquitin Ligases (CRLs) Dampen T Cell Signaling and Inactivation of Crls Arrests the Progression of Inflammatory Arthritis

    Leonard L. Dragone1, Lisa K. Peterson2, Allison Berger3 and Samantha F. Friend2, 1Dept of Pediatrics, National Jewish Health, Denver, CO, 2Pediatrics, National Jewish Health, Denver, CO, 3Department of Millennium Pharmaceuticals, Millennium Pharmaceuticals, Inc, Cambridge, MA

    Background/Purpose: The role of Cullin-Ring ubiquitin ligase (CRL) activity in regulating T cell function is largely unexplored. Thus, we sought to determine if cullin neddylation…
  • Abstract Number: 2508 • 2012 ACR/ARHP Annual Meeting

    miR142-3p Interfers with T Cell Proliferation by Targeting the Expression of Garp in Patients with Rheumatoid Arthritis

    Qihui Zhou1, Sonja Haupt1, Johannes Thomas Kreuzer1, Hendrik Schulze-Koops1 and Alla Skapenko2, 1Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is a systematic chronic inflammatory disorder, characterized by severe joint destruction.  Regulatory T cells (Tregs) have been implicated to be important…
  • Abstract Number: 2509 • 2012 ACR/ARHP Annual Meeting

    Cost-Effectiveness of Training Rural Providers to Perform Joint Injections

    Michael J. Battistone1, Richard E. Nelson2, William D. Ashworth3, Andrea Barker3, Marissa Grotzke4, Timothy A. Huhtala5, Robert Z. Tashjian6 and Grant W. Cannon1, 1Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 2Division of Epidemiology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 3General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, 4Division of Endocrinology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 5Division of General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, 6Division of Orthopaedics, Salt Lake City VA and University of Utah, Salt Lake City, UT

    Background/Purpose: Community based outpatient clinics (CBOCs) have been established by the Department of Veteran Affairs (VA) to provide primary care services to veterans living in…
  • Abstract Number: 2510 • 2012 ACR/ARHP Annual Meeting

    Patient and Provider Factors Associated with Compliance with Rheumatoid Arthritis Treatment Recommendations

    Leslie R. Harrold1, George W. Reed2, Katherine C. Saunders3, Ying Shan1, Tanya Spruill4 and Jeffrey D. Greenberg5, 1Dept of Medicine, UMass Medical School, Worcester, MA, 2University of Massachusetts Medical School, Worcester, MA, 3Corrona, LLC., Southborough, MA, 4Center for Healthful Behavior Change, Department of Population Health, NYU School of Medicine, New York, NY, 5New York Hospital for Joint Disease, New York, NY

    Background/Purpose:  Only approximately 50% of rheumatoid arthritis (RA) patient with active disease receive care consistent with the American College of Rheumatology (ACR) recommendations for the…
  • Abstract Number: 2511 • 2012 ACR/ARHP Annual Meeting

    Potential Barriers That Limit Access to Rheumatologists Among Patients with Early Rheumatoid Arthritis in a Universal Access Health Care System

    Jessica Widdifield1, J. Michael Paterson2, Sasha Bernatsky3, Karen Tu2, Nadia Gunraj2, Noah Ivers1, Debra Butt2, R. Liisa Jaakkimainen4, J. Carter Thorne5, Vandana Ahluwalia6 and Claire Bombardier7, 1University of Toronto, Toronto, ON, Canada, 2Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, 3Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada, 4Preventive Med and Biostatisti, University of Toronto, Toronto, ON, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6William Osler Health Center, Brampton, ON, Canada, 7Rheumatology, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Current guidelines for the optimal care of rheumatoid arthritis (RA) recommend prompt referral to a rheumatologist. In the province of Ontario, Canada all 13…
  • Abstract Number: 2512 • 2012 ACR/ARHP Annual Meeting

    Changes in Bone Marrow Lesion Volume Relate to Changes in Knee Pain. Data From the Osteoarthritis Initiative

    Jeffrey B. Driban1, Lori Lyn Price2, Grace H. Lo3, Jincheng Pang4, Eric Miller4, Charles Eaton5, John A. Lynch6 and Timothy E. McAlindon7, 1Rheumatology, Tufts Medical Center, Boston, MA, 2Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, 3Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, 4Department of Electrical and Computer Engineering, Tufts University, Medford, MA, 5Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, 6Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, 7Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Changes in bone marrow lesions (BMLs), common magnetic resonance (MR) imaging findings in osteoarthritis (OA), are predictive of OA progression. However, it is unclear…
  • Abstract Number: 2513 • 2012 ACR/ARHP Annual Meeting

    Association of Arthritis and Joint Pain with Accelerometer-Measured Physical Activity in Adults Aged 50 and Older in the United States: Findings From the National Health and Nutrition Examination Survey (2003-2004)

    Kathryn Remmes Martin1, Dane Van Domelen1, Matthew Pantell1, Ming-yang Hung1, Tamara B. Harris1 and Kushang Patel2, 1Laboratory of Epidemiology, Demography, and Biometry, NIA/NIH, Bethesda, MD, 2Center for Pain Research on Impact, Measurement & Effectiveness, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA

    Background/Purpose: To compare the prevalence of meeting current public health physical activity (PA) guidelines by arthritis and knee/hip joint pain status, and to examine the…
  • Abstract Number: 2514 • 2012 ACR/ARHP Annual Meeting

    Racial/Ethnic Trends in Incidence and Prevalence of Rheumatoid Arthritis in a Large Multi-Ethnic Managed Care Population

    Aniket A. Kawatkar1, Cecilia Portugal1, Li-Hao Chu2 and Rajan Iyer3, 1Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 2Department of Research and Evaluation,, Kaiser Permanente Southern California, Pasadena, 3Department of Research and Evaluation,, Kaiser Permanente Southern California, Pasadena, CA

    Background/Purpose: As epidemiologic studies throughout the world have shown significant variations, we sought to characterize racial differences in longitudinal epidemiologic trends of adult rheumatoid arthritis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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