Abstracts Archive - Page 2253 of 2425 - ACR Meeting Abstracts

Abstract Number: 2565 • 2012 ACR/ARHP Annual Meeting
Prevalence of Anti-Neutrophil Cytoplasmic Antibodies in Infective Endocarditis: An Analysis of 109 Cases
Alfred Mahr¹, Frédéric Batteux², Sarah Tubiana³, Michel Wolff⁴, Claire Goulvestre², Thomas Papo⁵, François Vrtovsnik⁶, Isabelle Klein⁷, Bernard Iung⁸ and Xavier Duval⁹, ¹Internal Medicine, Hospital Saint-Louis, Paris, France, ²Laboratoire d'Immunologie, Hospital Cochin, Paris, France, ³Clinical Investigation, Hospital Bichat, Paris, France, ⁴Intensive Care Unit, Hospital Bichat, Paris, France, ⁵Internal Medicine, University Paris-7, INSERM U699, APHP, Bichat Hospital, Paris, France, ⁶Nephrology, Hospital Bichat, Paris, France, ⁷Radiology, University Paris-7, APHP, Bichat Hospital, Paris, France, ⁸Cardiology, Hospital Bichat, Paris, France, ⁹Infectious Diseases, Hospital Bichat, Paris, France
Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCAs), particularly those directed against proteinase 3 (anti-PR3) or myeloperoxydase (anti-MPO), are considered a highly specific hallmark of ANCA-associated vasculitis. Thus,…
Abstract Number: 2526 • 2012 ACR/ARHP Annual Meeting
Bruton′s Tyrosine Kinase and Calreticulin: A Novel Interaction with Implications for Inflammatory and Autoimmune Disease
Jennifer C. Byrne¹, Joan Ní Gabhann¹, Kevin Stacey¹, Barbara M. Coffey¹, Eoghan M. McCarthy², Warren Thomas³, Eamonn Molloy⁴, Grainne M. Kearns⁵ and Caroline Jefferies¹, ¹Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin, Ireland, ³Molecular Medicine, Royal College of Surgeons in Ireland, Dublin 9, Ireland, ⁴Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁵Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Bruton’s Tyrosine Kinase (Btk) regulates innate immune responses downstream of multiple Toll-like receptors (TLRs), including TLR7. Given the role of TLR7 in driving type…
Abstract Number: 2527 • 2012 ACR/ARHP Annual Meeting
Prozone Phenomenon Leads to Low IgG4 Concentrations in IgG4-Related Disease
Arezou Khosroshahi¹, Lynn A. Cheryk², Mollie Carruthers¹, Judith A. Edwards², Donald B. Bloch³ and John H. Stone¹, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Mayo Medical Laboratories, Mayo Medical Laboratories, Andover, ³Rheumatology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is frequently associated with elevations in serum IgG4 concentration. However, the frequency of serum IgG4 elevation varies in published series from…
Abstract Number: 2528 • 2012 ACR/ARHP Annual Meeting
Hypertrophic Pachymeningitis: IgG4-Related Disease Is A Common Etiology
Zachary S. Wallace¹, Mollie Carruthers², Arezou Khosroshahi², Robert Carruthers³, Shweta Shinagare⁴, Anat Stemmer-Rachamimov⁴, Vikram Deshpande⁴ and John H. Stone², ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Rheumatology, Massachusetts General Hospital, Boston, MA, ³Department of Neurology, Massachusetts General Hospital, Boston, MA, ⁴Pathology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result…
Abstract Number: 2529 • 2012 ACR/ARHP Annual Meeting
Molecular Mechanism of IgG4 Class Switch Recombination in IgG4-Related Disease
Hiroto Tsuboi¹, Mana Iizuka¹, Hiromitsu Asashima¹, Sayaka Tsuzuki¹, Yuya Kondo¹, Akihiko Tanaka², Masafumi Moriyama², Isao Matsumoto¹, Seiji Nakamura² and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a new disease entity characterized by high serum IgG4 levels, IgG4-positive plasmacytic infiltration and fibrosis in various organs. Although the…
Abstract Number: 2530 • 2012 ACR/ARHP Annual Meeting
Anti-Ribosomal P Antibodies in a Large Cohort of Autoimmune Hepatitis with No Evidence of Lupus: A Common Underlying Mechanism Targeting Liver?
Ana Luisa Calich¹, Vilma S. T. Viana¹, Eduardo L. Cançado², Débora R. Terrabuio², Francisco Tustumi¹, Elaine P. Leon¹, Clovis Artur Silva³, Eduardo F. Borba Neto¹ and Eloisa Bonfa¹, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Gastroenterology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: Anti-ribosomal P proteins antibody (anti-rib P) is a highly specific marker for systemic lupus erythematosus (SLE) and it is associated with liver involvement in…
Abstract Number: 2531 • 2012 ACR/ARHP Annual Meeting
The Relapsing Polychondritis Disease Activity Index: International Development and Initial Validation of the First Disease Activity Score for Relapsing Polychondritis
Laurent Arnaud¹, Hervé Devilliers², Stanford L. Peng³, Zahir Amoura⁴ and the RPDAI study group⁵, ¹Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ²Internal medicine, CHU Dijon, Dijon, France, ³Department of Rheumatology, Virginia Mason Medical Center, Seattle, WA, ⁴Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ⁵Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, Paris
Background/Purpose: Relapsing polychondritis (RP) is a rare multi-systemic disorder characterized by recurrent, destructive, inflammatory lesions of the auricular, nasal, and laryngo-tracheo-bronchial cartilages. Additional clinical features…
Abstract Number: 2532 • 2012 ACR/ARHP Annual Meeting
Whole Transcriptome Analysis in Relapsing Polychondritis: A Single-Center Analysis of 35 Patients
Laurent Arnaud¹, Alexis Mathian², Bruno Faivre³, Karim Dorgham³, Julien Haroche², Nathalie Costedoat-Chalumeau¹, Jean-Charles Piette², Guy Gorochov⁴ and Zahir Amoura¹, ¹Internal Medicine, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ²Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ³Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France, ⁴Inserm UMRS945, Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France
Background/Purpose: Relapsing polychondritis (RP) is a severe and episodic inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose, and laryngotracheobronchial tree. Other affected…
Abstract Number: 2533 • 2012 ACR/ARHP Annual Meeting
Weight Loss Is Associated with Structure Modification in Subjects with Radiographic Osteoarthritis of the Knee: Data From the Osteoarthritis Initiative
Marc C. Hochberg¹, Danuta I. Bujak², Jeffrey W. Duryea³, Knachelle Favors⁴ and John D. Sorkin⁴, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²School of Medicine, University of Maryland, Baltimore, MD, ³Dept of Radiology, Brigham & Women, Boston, MA, ⁴VA Maryland Health Care System, Baltimore, MD
Background/Purpose: Obesity is a risk factor for the development and progression of knee osteoarthritis (OA) and weight loss is recommended as part of the management…
Abstract Number: 2534 • 2012 ACR/ARHP Annual Meeting
The Intensive Diet and Exercise for Arthritis Trial (IDEA): 18-Month Radiographic and MRI Outcomes
David J. Hunter¹, D. Beavers², Felix Eckstein³, Ali Guermazi⁴, Richard F. Loeser⁵, Barbara J. Nicklas⁶, Shannon Mihalko⁷, Gary D. Miller⁷, Mary Lyles⁸, Paul DeVita⁹, Claudine Legault¹⁰, J. Jeffery Carr¹¹, Jeff D. Williamson⁸ and Stephen P. Messier⁷, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Wake Forest University, Winston Salem, NC, ³Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁴Radiology, Boston University, Boston, MA, ⁵Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ⁶Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, ⁷Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, ⁸Center on Aging, Wake Forest University School of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, ⁹Department of Exercise and Sport Science, East Carolina University, Greenville, NC, ¹⁰Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, ¹¹Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC
Background/Purpose: Dietary induced weight loss is a proven non-pharmacologic intervention for osteoarthritis. Based upon current literature it is unclear if weight loss modifies structural progression.…
Abstract Number: 2535 • 2012 ACR/ARHP Annual Meeting
Childhood Physical Fitness Predicts Adulthood Knee Cartilage Volume and Bone Area: A 25-Year Cohort Study
Benny Samuel Eathakkattu Antony¹, Graeme Jones¹, Alison Venn², Leigh Blizzard³, Flavia Cicuttini⁴, Lyn March⁵, Terry Dwyer⁶ and Changhai Ding⁷, ¹Musculoskeletal, Menzies Research Institute Tasmania, Hobart, Australia, ²Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ³Biostatistics, Hobart, Australia, ⁴Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Melbourne, Australia, ⁵University of Sydney, Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards - Sydney, Australia, ⁶Director, Murdoch Children's Research Institute, Melbourne, Australia, ⁷Musculoskeletal and Epidemilogy, Menzies research institute & Monash University, Hobart, Australia
Background/Purpose: Physical activity interventions are often advised for management of osteoarthritis patients, despite contradictory findings regarding its effect on knee structure. In particular, there is…
Abstract Number: 2536 • 2012 ACR/ARHP Annual Meeting
The Effects of Intensive Diet and Exercise On Bone Density in Older Adults with Knee Osteoarthritis: The Intensive Diet and Exercise for Arthritis (IDEA) Trial
Nicole R. Walton¹, Richard F. Loeser², Daniel Beavers³, Barbara J. Nicklas⁴, Mary Lyles⁵ and Stephen P. Messier⁶, ¹Rheumatology, Wake Forest University School of Medicine, Winston Salem, NC, ²Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, ⁴Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, ⁵Center on Aging, Wake Forest University School of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, ⁶Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC
Background/Purpose: Previous studies on the effects of weight loss and exercise on bone mass show conflicting results and there are no studies of older adults…
Abstract Number: 2537 • 2012 ACR/ARHP Annual Meeting
Cross-Sectional and Longitudinal Associations Between Circulating Leptin and Knee Cartilage Thickness in Older Adults
Oliver Stannus¹, Yuelong Cao², Benny Samuel Eathakkattu Antony¹, Graeme Jones³ and Changhai Ding⁴, ¹Musculoskeletal, Menzies Research Institute Tasmania, Hobart, Australia, ²Musculoskeletal, Orthopaedics, Menzies Research Institute Tasmania, Research Institute of Orthopaedics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,, Hobart, Australia, ³Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ⁴Musculoskeletal and Epidemilogy, Menzies research institute & Monash University, Hobart, Australia
Background/Purpose: To investigate cross-sectional and longitudinal associations between serum leptin levels and knee cartilage thickness in older adults. Methods: A prospective cohort of 163 randomly…
Abstract Number: 2538 • 2012 ACR/ARHP Annual Meeting
The Association of Fat Mass and Skeletal Muscle Mass with Clinical and Structural Knee Osteoarthritis: The Netherlands Epidemiology of Obesity Study
A. Willemien Visser¹, Marieke Loef¹, Martin den Heijer², Monique Reijnierse³, Frits R. Rosendaal² and Margreet Kloppenburg⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Body mass index (BMI) is an important risk factor for knee osteoarthritis (OA), but BMI depends only upon height and weight and gives no…
Abstract Number: 2539 • 2012 ACR/ARHP Annual Meeting
Fine-Specificity of Anti-Citrullinated Peptide Auto-Antibodies: Associations with Cardiac Structure and Function in Rheumatoid Arthritis
Laura Geraldino-Pardilla¹, Jon T. Giles², Jeremy Sokolove³, William H. Robinson⁴ and Joan M. Bathon⁵, ¹Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁵Columbia University, New York, NY
Background/Purpose: Despite advancements in rheumatoid arthritis (RA) treatment, standardized mortality rates remain up to 3 times higher than in the general population. Cardiovascular disease (CVD)…

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