Abstracts Archive - Page 2246 of 2425 - ACR Meeting Abstracts

Abstract Number: L13 • 2013 ACR/ARHP Annual Meeting
Serum 14-3-3η Marks RA Development in Arthralgia and Radiographic Progression in Early RA Patients
D. van Schaardenburg¹, Marian van Beers-Tas², Karin Britsemmer², Mairead Murphy³, Walter P. Maksymowych⁴, Maarten Boers⁵ and Anthony Marotta⁶, ¹Jan van Breemen Research Institute, Amsterdam, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁶Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: The focus of RA management is increasingly towards early detection and treatment. While newly-diagnosed patients will benefit from treatment decisions based on more robust…
• 2013 ACR/ARHP Annual Meeting
2012 Lee C. Howley, Sr. Prize for Arthritis Research Introductory Talk
George C. Tsokos, Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Abstract Number: 2687 • 2012 ACR/ARHP Annual Meeting
Modular Microarray Analysis Fails to Reveal a Significant Biological Effect of Vitamin D3 Treatment in Patients Participating in a Double-Blind Randomized Placebo-Controlled Trial of the Effect of Vitamin D3 On the Interferon Signature in Patients with Systemic Lupus Erythematosus
Michaela Oswald¹, Cynthia Aranow², Diane L. Kamen³, Meggan C. Mackay⁴, Ellen A. Goldmuntz⁵, Betty Diamond⁶, Peter K. Gregersen⁷ and ALE02 Study Team⁸, ¹Laboratory of Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY, ²Feinstein Institute for Medical Research, Manhasset, NY, ³Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ⁴Autoimmune & Musculoskeletal Disease, The Feinstein Institute, Manhasset, NY, ⁵DAIT, NIAID/NIH, Bethesda, MD, ⁶Autoimmune & Musculoskeletal, Feinstein Institute Med Rsch, Manhasset, NY, ⁷Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁸NIAID/NIH Rm 6807, Bethesda, MD
Background/Purpose: Vitamin D modulates the immune response. Exposing normal PBMCs to activating SLE sera induces an interferon signature which can be inhibited by preexposure of…
Abstract Number: 2689 • 2012 ACR/ARHP Annual Meeting
Quality of Sleep, Physical Activity and Fatigue in Patients with Rheumatoid Arthritis. A Cross-Sectional Study
Katrine Loeppenthin¹, Bente Appel Esbensen¹, Poul Jennum², Mikkel Østergaard³, Tanja Thomsen¹ and Julie Midtgaard⁴, ¹Nursing and Health Science Research Unit, DK-2600 Glostrup, Denmark, ²Danish Centre for Sleep Medicine, Department of Clinical Neurophysiology, DK-2600 Glostrup, Denmark, ³Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁴Health Care Research Centre, Copenhagen, Denmark
Background/Purpose: Sleep disturbances and fatigue are frequently experienced (40-70 %) in patients with rheumatoid arthritis (RA) and contribute to decreased quality of life and adverse…
Abstract Number: 2690 • 2012 ACR/ARHP Annual Meeting
Assessment of Sleep Quality in Patients with Rheumatoid Arthritis
Ulku Ucar and Mehmet Tuncay Duruöz, PMR Department, Rheumatology Division, Celal Bayar University Medical School, Manisa, Turkey
Background/Purpose: Rheumatoid arthritis is a chronic inflammatory disease affecting mainly diartrodial synovial joints. Fatigue and sleep disturbances are commonly seen symptoms in RA patients which…
Abstract Number: 2692 • 2012 ACR/ARHP Annual Meeting
Diet and Other Lifestyle Related Factors and the Risk of Developing Rheumatoid Arthritis
Björn Sundström¹, Ingegerd Johansson² and Solbritt Rantapää Dahlqvist³, ¹Department of Public Health & Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, ²Department of Odontology, Cariology, Umeå Universitet, Umeå, Sweden, ³Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden
Background/Purpose: There is a growing interest in the role of lifestyle in developing chronic diseases, such as rheumatoid arthritis (RA). Our aim was to investigate…
Abstract Number: 2693 • 2012 ACR/ARHP Annual Meeting
Factors Associated with Person-Perceived Disability in Adults Aged 18+ with Rheumatoid Arthritis
Yeliz Greenhill¹, Alison Hammond² and Sarah Tyson¹, ¹Centre for Health Sciences Research, University of Salford, Manchester, United Kingdom, ²Centre for Health Sciences Research, University of Salford, Greater Manchester, United Kingdom
Background/Purpose: Rheumatoid Arthritis (RA) is associated with high risk of disability (1). Loss of independence is negatively correlated with the person’s health and wellbeing (2).…
Abstract Number: 2694 • 2012 ACR/ARHP Annual Meeting
Examination of a Multidimensional Model of Disability and Role Functioning in Patients with Rheumatoid Arthritis
Sarah R. Ormseth¹, Taylor Draper², M. Custodio³, Michael H. Weisman⁴, M.R. Irwin⁵ and Perry M. Nicassio⁵, ¹Cousins Center for PNI, University of California, Los Angeles, Los Angeles, CA, ²Psychology, Loma Linda University, Loma Linda, CA, ³UCLA, Los Angeles, CA, ⁴Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Cousins Center for PNI, UCLA, Los Angeles, CA
Background/Purpose: Disability and impairments in role functioning are common obstacles for many patients with RA. A combination of disease-related and psychosocial factors may contribute to…
Abstract Number: 2670 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Study On the Severity of Joint Destruction in Autoantibody Positive Rheumatoid Arthritis Identifies a Role for Sperm Associated Antigen 16
Rachel Knevel¹, Kerstin Klein², Klaartje Somers³, Caroline Ospelt⁴, Jeanine J. Houwing-Duistermaat⁵, Jessica van Nies⁶, Diederik P.C. de Rooy⁶, Laura de Bock⁷, Joris Schonkeren⁸, Gerrie Stoeken-Rijsbergen⁶, Jenna Kiridly⁹, Luis Rodriguez-Rodriguez⁹, Quinta Helmer⁵, Piet Sinissen³, Tom W. J. Huizinga¹, René E.M. Toes¹, Steffen Gay¹⁰, Peter K. Gregersen¹¹, Veerle Somers⁷ and Annette H.M. van der Helm - van Mil⁸, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP),, Zurich, Switzerland, ³Hasselt University, Biomedical Research Institute, Diepenbeek, Belgium, ⁴Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland, ⁵Department of Medical Statistics and Bioinformatics, Leiden, Netherlands, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷Hasselt University, Biomedical Research Institute, Belgium, ⁸Leiden University Medical Center, Leiden, Netherlands, ⁹Feinstein Institute for Medical Research and North Shore–Long Island Jewish Health System, Manhasset, New York, ¹⁰Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹¹Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Recent genome-wide association studies (GWAs) have identified >30 SNPs predisposing to Rheumatoid Arthritis (RA). These variants are helpful in unraveling the pathogenesis of RA.…
Abstract Number: 2658 • 2012 ACR/ARHP Annual Meeting
Correlation Between Mefv Genotype and Interleukin (IL)1β secretion and Role of the nlr Family Pyrin Domain Containing 3 (Nlrp3) Inflammasome in Patients with Familial Mediterranean Fever (FMF)
Alessia Omenetti¹, Sonia Carta², Delfino Laura², Alberto Martini³, Anna Rubartelli⁴ and Marco Gattorno¹, ¹Pediatrics II Unit G Gaslini Institute, Genoa, Italy, ²Cell Biology, lST-San Martino, Genoa, Italy, ³Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, ⁴lST-San Martino, Genoa, Italy, Genoa, Italy
Background/Purpose: Familial Mediterranean Fever (FMF) is an autoinflammatory disease due to mutations of MEFV gene which encodes for Pyrin. FMF does not behave as a…
Abstract Number: 2659 • 2012 ACR/ARHP Annual Meeting
An Expanded Repertoire of Anti-Citrullinated Peptide Antibodies Is Associated with Interstitial Lung Disease in Rheumatoid Arthritis
Jon T. Giles¹, Sonye Danoff², Jeremy Sokolove³, Robert Winchester⁴, Dimitrios A. Pappas⁵, Catriona Cramb⁶, Geoffrey Connors⁷, Stanley S. Siegelman⁸, William H. Robinson⁹ and Joan M. Bathon⁵, ¹Medicine, Columbia University, New York, NY, ²Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, ³Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁴Dept of Medicine & Pathology, Columbia University, New York, NY, ⁵Columbia University, New York, NY, ⁶VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁷Division of Pulmonary and Critical Care Medicine, Yale University, New Haven, CT, ⁸Department of Radiology, Johns Hopkins University, Baltimore, MD, ⁹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Interstitial lung disease (ILD) is an outcome with high morbidity and mortality in rheumatoid arthritis (RA). Citrullinated proteins are observed in these lung tissues;…
Abstract Number: 2660 • 2012 ACR/ARHP Annual Meeting
Progressive Radiographic Joint Damage in Established Rheumatoid Arthritis: Common and Strongly Associated with Seropositivity
Siri Lillegraven¹, Nancy A. Shadick², Zarif Jabbar-Lopez³, Anna Potapov³, Michelle A. Frits⁴, Christine K. Iannaccone⁴, Espen A. Haavardsholm¹, Tore K. Kvien⁵, Michael Weinblatt² and Daniel H. Solomon⁶, ¹Diakonhjemmet Hospital, Oslo, Norway, ²Brigham and Women's Hospital, Boston, MA, ³Harvard School of Public Health, Boston, MA, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Division of Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: During the last decade, rheumatoid arthritis (RA) research has mainly focused on early disease, as it has become apparent that early and aggressive treatment…
Abstract Number: 2661 • 2012 ACR/ARHP Annual Meeting
Disease Activity Score 28-Joint Count: Are Erythrocyte Sedimentation Rate and C-Reactive Protein Versions Comparable?
Roy Fleischmann¹, Désirée van der Heijde², Andrew S. Koenig³, Ronald Pedersen³, Annette Szumski⁴, Lisa Marshall⁵ and Eustratios Bananis⁴, ¹Southwestern Medical Center at Dallas, University of Texas, Dallas, TX, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Specialty Care, Pfizer Inc, Collegeville, PA, ⁴Specialty Care, Pfizer Inc., Collegeville, PA, ⁵Pfizer Inc., Collegeville, PA
Background/Purpose: Frequently DAS28-CRP is utilized instead of DAS28-ESR to assess rheumatoid arthritis (RA) disease activity; however, values for remission and low disease activity (LDA) for…
Abstract Number: 2633 • 2012 ACR/ARHP Annual Meeting
Independence At Home: Real or Perceived
Hazel L. Breland, Health Professions, Division of Occupational Therapy, Medical University of South Carolina, Charleston, SC
Background/Purpose: Rheumatic conditions are more prevalent among women than men and increase with age. Over 4 million African Americans affected are by rheumatic conditions and…
Abstract Number: 2634 • 2012 ACR/ARHP Annual Meeting
Physical Disability, Perceived Dependence and Depression in Older Women with Osteoarthriti
Kisoo Park¹, Monique A. Gignac² and E. M. Badley³, ¹Preventive Medicine and Institute of health science, Gyeongsang National University, Jinju, South Korea, ²Divison of Health Care & Outcomes Research, Arthritis Community Research and Evaluation Unit , Toronto Western Research Institute and University of Toronto, Toronto, ON, Canada, ³Division of Health Care and Outcomes Research,Toronto Western Research Institute; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: Older women with osteoarthritis (OA) often report difficulty with tasks and needing to rely on others for assistance. In addition, depressed mood has been…

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