Abstracts Archive - Page 2243 of 2607 - ACR Meeting Abstracts

Abstract Number: 2871 • 2013 ACR/ARHP Annual Meeting
Validation Of The FLARE Self-Report Questionnaire For Assessing FLARE Out Of The Clinical Visit In Rheumatoid Arthritis
Jacques Morel¹, Jean-Marie Berthelot², Arnaud L. Constantin³, Michel De Bandt⁴, Philippe Gaudin⁵, Olivier Vittecoq⁶, Jean Francis Maillefert⁷, Olivier Meyer⁸, Thao Pham⁹, Alain Saraux¹⁰, Elisabeth Solau Gervais¹¹, Elisabeth Spitz¹², Daniel Wendling¹³, Francis Guillemin¹⁴ and Bruno Fautrel¹⁵, ¹Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ²Rheumatology Unit, Nantes University Hospital, Nantes, France, ³Rheumatology, Purpan University Hospital, Toulouse, France, ⁴Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ⁵Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, ⁶Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, ⁷University Hospital, Department of Rheumatology, Dijon, France, ⁸Rheumatology, Bichat University Hospital, Paris, France, ⁹Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ¹⁰Rhumatologie, CHU de la Cavale Blanche, Brest Cedex, France, ¹¹Departement of Rheumatology, CHU de Poitiers, Poitiers, France, ¹²UFR Sciences Humaines et Arts, APEMAC-EA4360, Metz, France, ¹³Rheumatology, University Hospital, Besancon, France, ¹⁴CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ¹⁵Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France
Background/Purpose: Defining flare in rheumatoid arthritis (RA) raises a complex issue related to the difference in perception or concept of flare between patients or health…
Abstract Number: 2872 • 2013 ACR/ARHP Annual Meeting
Long Noncoding RNA Nron Regulates The Cytoplasmic-Nuclear Shuttling and Activity Of NFAT5 In Rheumatoid Arthritis Synovial Fibroblast
Kunihiko Umekita¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴, Steffen Gay¹ and Mojca Frank Bertoncelj⁵, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) are critical regulators of gene expression and of major biological processes, such as cell migration, proliferation and invasion. The lncRNA…
Abstract Number: 2873 • 2013 ACR/ARHP Annual Meeting
The Ion Channel TRPV2 Is New Suppressor of Arthritis Severity and Joint Damage
Teresina Laragione^1,2, Max Brenner^1,2, Christine Beeton³ and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY, ³Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic disease associated with increased risk of developing disability. Disease remission is still rarely achieved and better…
Abstract Number: 2874 • 2013 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts
Munitta Muthana¹, Holly Davies², Sachin Khetan³, Gbadebo Adeleke Adeleke⁴, Sarah Hawtree¹ and Anthony G. Wilson⁵, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, Sheffield, United Kingdom, ³Infection and immunity, Dr, Sheffield, United Kingdom, ⁴Infection and Immunity, Dr, Sheffield, United Kingdom, ⁵Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first intron of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility…
Abstract Number: 2875 • 2013 ACR/ARHP Annual Meeting
Metabolic Profiles of Synovial Fibroblasts
Sabrina Kapoor¹, Andrew Filer², Christopher D. Buckley³, Karim Raza⁴ and Stephen Young⁵, ¹Rheumatology, University of Birmingham, Birmingham, United Kingdom, ²Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ³Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁴Centre for Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom, ⁵Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Synovial fibroblasts play a key role in the persistence of inflammation and joint destruction in rheumatoid arthritis (RA). Cell function and proliferation are highly…
Abstract Number: 2876 • 2013 ACR/ARHP Annual Meeting
Key Rheumatoid Arthritis-Associated Pathogenic Pathways Revealed By Integrative Analysis Of RA Omics Datasets
John Whitaker¹, Wei Wang² and Gary S. Firestein³, ¹Chemistry, UCSD School of Medicine, La Jolla, CA, ²Chemistry, UCSD, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Genome-wide analysis of RA has independently evaluated DNA sequence variation, differential RNA expression, and differential DNA methylation. Each approach alone implicates promising pathways…
Abstract Number: 2877 • 2013 ACR/ARHP Annual Meeting
Potential Of Integrating Human Genetics and Electronic Medical Records For Drug Discovery: The Example Of TYK2 and Rheumatoid Arthritis
Dorothee Diogo¹, Katherine P. Liao², Robert S. Fulton³, Robert R. Graham⁴, Jing Cui⁵, Jeffrey D. Greenberg⁶, Stephen Eyre⁷, John Bowes⁸, Annette T. Lee⁹, Dimitrios A. Pappas¹⁰, Joel M. Kremer¹¹, Anne Barton⁷, Marieke J.H. Coenen¹², Xavier Mariette¹³, Corrine Richard-Miceli¹⁴, Helena Canhão¹⁵, João E. Fonseca¹⁶, Niek de Vries¹⁷, Fina Kurreeman¹⁸, Ted R. Mikuls¹⁹, Yukinori Okada¹, Isaac Kohane²⁰, Joshua C. Denny²¹, Jane Worthington²², Soumya Raychaudhuri¹, Timothy W. Behrens²³, Michael F. Seldin²⁴, Peter K. Gregersen²⁵, Elaine R. Mardis³ and Robert M. Plenge²⁶, ¹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³The Genome Institute, Washington University School of Medicine, Saint Louis, MO, ⁴ITGR Human Genetics, Genentech, Inc., South San Francisco, CA, ⁵Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶NYU Hospital for Joint Diseases, New York, NY, ⁷Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁸Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁹Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰Department of Medicine, Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ¹¹Center for Rheumatology, Albany Medical College, Albany, NY, ¹²Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹³Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ¹⁴Hôpital Bicêtre, Université Paris-sud, Paris, France, ¹⁵Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisboa, Portugal, ¹⁶Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ¹⁷Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ¹⁸Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²⁰on behalf of i2b2 ; Brigham and Women's Hospital, Boston, MA, ²¹Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, ²²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²³Genentech, Inc, South San Francisco, CA, ²⁴Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, ²⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Human genetics has the potential to identify promising drug targets for complex traits such as rheumatoid arthritis (RA). Genes with a series of disease-associated…
Abstract Number: 2837 • 2013 ACR/ARHP Annual Meeting
Higher Disease Activity Leads To More Damage In The Early Phases Of Ankylosing Spondylitis: 12-Year Data From The OASIS Cohort
Sofia Ramiro¹, A.M. van Tubergen², Désirée van der Heijde³, Carmen Stolwijk⁴, Maxime Dougados⁵, Filip Van den Bosch⁶ and Robert Landewé⁷, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: For years, it was unclear if inflammation and radiographic progression were related in ankylosing spondylitis (AS), but studies were only of short follow-up and…
Abstract Number: 2838 • 2013 ACR/ARHP Annual Meeting
Relationship Between Active Inflammatory Lesions In The Spine and Sacroiliac Joints and Development Of Fatty Lesions On Whole-Body MRI In Patients With Early Axial Spondyloarthritis- Long-Term Data Of The Esther Trial
In-Ho Song¹, Kay-Geert A. Hermann², Hildrun Haibel³, Christian Althoff⁴, Denis Poddubnyy³, Joachim Listing⁵, Anja Weiss⁶, Ekkehard Lange⁷, Bruce Freundlich⁸, Martin Rudwaleit⁹ and Joachim Sieper¹⁰, ¹Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ²Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Radiology, Charite Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ⁵German Rheumatism Research Center, Berlin, Germany, ⁶German Rheumatism Research Centre, Berlin, Germany, ⁷BU Specialty Care, Pfizer Pharma AG, Berlin, Germany, ⁸University of Pennsylvania, Philadelphia, PA, ⁹Endokrinologikum, Berlin, Germany, ¹⁰Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin-Franklin, Berlin, Germany
Background/Purpose : In patients with early axial spondyloarthritis (SpA) with evidence of active inflammation on magnetic resonance imaging (MRI) in the spine and/or sacroiliac (SI-)joints…
Abstract Number: 2839 • 2013 ACR/ARHP Annual Meeting
Effects Of Treatment On Spinal Fat Lesions As Assessed By MRI With The Fat Spondyloarthritis Spine Score
Susanne Juhl Pedersen¹, Zheng Zhao², Stephanie Wichuk³, Robert GW Lambert⁴ and Walter P. Maksymowych³, ¹Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Fat lesions develop after resolution of inflammation in the spine (1), and have also been shown to predict development of new syndesmophytes (2). Consequently,…
Abstract Number: 2840 • 2013 ACR/ARHP Annual Meeting
Predictors Of Spinal Mobility Progression In A Multi-ethnic Cohort Of Patients With Ankylosing Spondylitis
Roozbeh Sharif¹, Trisha M. Parekh², Lianne S. Gensler³, MinJae Lee⁴, Mohammad Rahbar⁵, Laura A. Diekman⁶, Michael H. Weisman⁷, Michael M. Ward⁸, Shervin Assassi⁹ and John D. Reveille⁹, ¹Graduate School of Biomedical Science, University of Texas Medical Branch, Galveston, TX, ²Internal Medicine, University of Texas Medical Branch, Galveston, TX, ³Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, ⁵The University of Texas Health Science Center at Houston, Houston, TX, ⁶Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: Clinicians utilize several different clinical measurements (metrology) in patients with Ankylosing Spondylitis (AS) to assess the spinal mobility. We aimed to examine the pattern…
Abstract Number: 2841 • 2013 ACR/ARHP Annual Meeting
Inflammation and Structural Progression In The Sacroiliac Joints Of Patients With Axial Spa Treated With Adalimumab Or Placebo As Assessed By The Berlin and The Spondyloarthritis Research Consortium Of Canada MRI Methods
Susanne Juhl Pedersen¹, Denis Poddubnyy², Inge Juul Sørensen³, Anne Gitte Loft⁴, Jens Skjødt Hindrup⁵, Gorm Thamsborg⁶, Karsten Asmussen⁷, Elka Kluger⁸, Jesper Nørregaard⁹, Torben Grube Christensen¹⁰, Anne G. Jurik¹¹, J.M. Møller¹², Thomas Skjødt¹³, Dorrit Mikkelsen¹⁴ and Mikkel Østergaard¹⁵, ¹Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Department of Rheumatology, Hvidovre Hospital, Copenhagen, Denmark, ⁴Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, ⁵Dep. of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁶Dep. of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ⁷Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ⁸King Christian 10th Rheumatism Hospital at Gråsten, Graasten, Denmark, ⁹Dep of Rheumatology, Hørsholm Hospital, Hørsholm, Denmark, ¹⁰MD, Slagelse, Denmark, ¹¹Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, ¹²Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, ¹³Dep. of Radiology, Vejle Hospital, Vejle, Denmark, ¹⁴Dep. of Radiology, Aabenraa Hospital, Aabenraa, Denmark, ¹⁵Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: To investigate changes in inflammation and structural progression in the sacroiliac joints (SIJs) in patients with axial spondyloarthritis (SpA) during treatment with adalimumab and…
Abstract Number: 2842 • 2013 ACR/ARHP Annual Meeting
Cochrane Systematic Review Of Self-Management Education Programs For People With Osteoarthritis
Féline P.B. Kroon¹, Lennart R.A. van der Burg¹, Rachelle Buchbinder², Richard H. Osborne³ and Veronica Pitt⁴, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Monash Department of Clinical Epidemiology at Cabrini Hospital, Department of Epidemiology and Preventive Medicine, Monash University, Malvern, Victoria, Australia, ³Public Health Innovation, Deakin University, Melbourne, Australia, ⁴National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, Australia
Background/Purpose: We performed a Cochrane systematic review to determine the effectiveness of self-management education programs (SMPs) for people with osteoarthritis (OA). Methods: Published randomised controlled…
Abstract Number: 2843 • 2013 ACR/ARHP Annual Meeting
An Education Needs Assessment: Findings From Surveys Of Patients and Caregivers
Elizabeth M. Badley^1,2, Monique A. Gignac^2,3,4, Lynn Moore⁵, Christina H. Chan⁶, Xingshan Cao⁷ and Julie Bowring⁸, ¹Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ³Institute for Work and Health, Toronto, ON, Canada, ⁴Divison of Health Care & Outcomes Research, University Health Network, Toronto, ON, Canada, ⁵Programs and Services, The Arthritis Society, Toronto, ON, Canada, ⁶Division of Healthcare Outcomes and Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁷Divison of Health Care & Outcomes Research, Arthritis Community Research and Evaluation Unit , Toronto Western Research Institute, Toronto, ON, Canada, ⁸Arthritis Community Research and Evaluation Unit, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Getting trustworthy information to patients with arthritis is a challenge facing health professionals and organizations concerned with arthritis. This study examined the perceptions of…
Abstract Number: 2844 • 2013 ACR/ARHP Annual Meeting
The assessment of education requirements for patients with rheumatoidarthritis, based on the Polish version of the Educational Needs AssessmentTool (Pol-ENAT)
Matylda Sierakowska¹, Malgorzata Klepacka², Stanislaw Sierakowski³, Justyna Sierakowska⁴, Piotr Leszczynski⁵, Maria Majdan⁶, Marzena Olesinska⁷, Wojciech Romanowski⁸, Małgorzata Bykowska-Sochacka⁹, Slawomir Jeka¹⁰, Mwidimi Nondosi¹¹ and Elzbieta Krajewska-Kulak¹, ¹Department of Integrated Medical Care, Medical University of Bialystok, Bialystok, Poland, ²Department of Nephrology, Medical University of Bialystok, Bialystok, Poland, ³Department of Rheumatology and Internal Diseases, Medical University in Bialystok, Bialystok, Poland, ⁴Department of English Literature, University of Bialystok, Bialystok, Poland, ⁵Department of Rheumatology and Rehabilitation, Municipal Hospital in PoznaÅ„, Medical University in Poznan and J. Strus, Poznan, Poland, ⁶Department of Rheumatology and Connective Tissue Diseases, Medical University in Lublin, Lublin, Poland, ⁷Department of Connective Tissue Disease, Institute of Rheumatology, Warsaw, Poland, ⁸Poznań Centre of Rheumatology in Srem, Srem, Poland, ⁹9Dr. Jadwiga Titz-Kosko Regional Hospital for Rheumatic Diseases in Sopot, Sopot, Poland, ¹⁰Clinic of Rheumatology and Connective Tissue Diseases University Hospital No 2 in Bydgoszcz Collegium Medicum UMK in Torun, Bydgoszcz, Poland, ¹¹Academic & Clinical Unit for Musculoskeletal Nursing, University of Leeds, Leeds, United Kingdom
Background/Purpose: Chronic rheumatic diseases lead to large deficits in physical, mental and social functioning. Only an early diagnosis, followed by the implementation of comprehensive and…

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