Abstract Number: 55 • 2013 ACR/ARHP Annual Meeting
Glucocorticoid Receptor Modulator Compound A Does Not Induce Leptin In Human Osteoarthritic Synovial Fibroblasts and In Dedifferentiated Chondrocytes
Background/Purpose: Leptin is generally considered detrimental in osteoarthritis (OA) as it can induce IL-8 in synovial fibroblasts (SF) and matrix metalloproteinases in chondrocytes. We recently…Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting
Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor. One of OA's main hallmarks is degradation of…Abstract Number: 57 • 2013 ACR/ARHP Annual Meeting
Role Of Procatabolic Cytokines In Dysregulation Of O-Linked N-Acetylglucosamine Modified Proteins In Human Osteoarthritic Chondrocytes
Background/Purpose: Nuclear and cytoplasmic protein glycosylation by the addition of O-linked N-Acetylglucosamine (O-GlcNAc) to serine and threonine residues is a widespread post-translational modification that has…Abstract Number: 23 • 2013 ACR/ARHP Annual Meeting
Seizures In Systemic Lupus Erythematosus Are Not An Inflammatory Manifestation Of Lupus Anticoagulant
Background/Purpose: About 50% of SLE patients make an antiphospholipid antibody and 10% develop classic antiphospholipid syndrome. Seizures are one of the components of the SLICC…Abstract Number: 25 • 2013 ACR/ARHP Annual Meeting
SLE Flares Are Characterized By Generalized Polyclonal Expansions Of Antibody Secreting Cells Without Preference For Autoimmune Responses
Background/Purpose: Increased circulating antibody secreting cells (ASC), including both CD138- plasmablasts and CD138+ plasma cells (PB/PC), correlate with SLE activity and are prominent during Lupus…Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting
Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)
Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…Abstract Number: 29 • 2013 ACR/ARHP Annual Meeting
A Novel CD27(-) B-Cell Subset Identified Based On Intracellular Characteristics Is Expanded In SLE
Background/Purpose: Several studies linked the emergence of autoimmunity to abnormalities of the B-cell receptor (BCR) due to disturbances of signaling molecules or its co-receptors. Therefore…Abstract Number: 31 • 2013 ACR/ARHP Annual Meeting
IgD- CD27- B Cells From Systemic Lupus Erythematous Patients Have Increased Expression Of Genes Involved In RNA Sensing and Toll-Like Receptor 3 Signaling Pathways
Background/Purpose: SLE patients have perturbations in B cell subsets including a large expansion of IgD-CD27- B cells (DN) in patients with active disease. Patients also…Abstract Number: 19 • 2013 ACR/ARHP Annual Meeting
Association Of Antiphospholipid Antibodied Detected In The Aphl ELISA With Clinical Manifestations Of The Antiphospholipid Syndrome In Two Lupus Cohorts
Background/Purpose: Antiphospholipid Syndrome (APS) is characterized by the presence of antibodies to phospholipid (aPL) and to β2glycoprotein I (β2GPI) in patients with thrombosis or pregnancy…Abstract Number: 20 • 2013 ACR/ARHP Annual Meeting
Complement Deposition On Platelets Is Associated To Venous Thrombosis In Systemic Lupus Erythematosus
Background/Purpose: Anti-phospholipid (aPL) antibodies are associated with development of venous thrombosis and stroke in the autoimmune disease systemic lupus erythematosus (SLE). The underlying mechanism for…Abstract Number: 21 • 2013 ACR/ARHP Annual Meeting
Factor Xa Reactive Antibodies In Patients With Systemic LUPUS Erythematosus and Antiphospholipid Syndrome Have Differential Effects Upon Coagulation Assays and Endothelial CELLS
Background/Purpose: Antiphospholipid antibodies have been shown to bind serine proteases (SP) involved in the coagulation cascade. Previously, we found that IgG anti-Factor(F)Xa antibody levels…Abstract Number: 22 • 2013 ACR/ARHP Annual Meeting
WHAT Is The Prevalence Of NON CRITERIA ANTIPHOSPHOLIPID ANTIBODIES IN Patients With Antiphospholipid Syndrome?
Background/Purpose: Increasing interest has focussed upon assays which are not currently included in the Antiphospholipid syndrome (APS) classification criteria to detect antibodies directed against other…Abstract Number: 24 • 2013 ACR/ARHP Annual Meeting
Plasma Cells In Acute Systemic Lupus Erythematosus Flares Are Characterized By a Highly Diversified Repertoire Accentuated By Clonal Expansions Of VH4-34 Antibodies
Background/Purpose :Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which faulty B cell tolerance promotes the generation of multiple autoantibodies of which anti-ds DNA,…Abstract Number: 26 • 2013 ACR/ARHP Annual Meeting
Autoantibodies Directed Against Cell Surface Components In Autoimmune Disease Patients: Proposal Of a Novel ELISA For The Detection Of Anti-Endothelial Cell Antibodies
Background/Purpose: Sera from patients with systemic vasculitis or inflammatory conditions have been reported to contain antibodies that bind to endothelial cells (EC), i.e., AECA (anti-endothelial…Abstract Number: 27 • 2013 ACR/ARHP Annual Meeting
Specificity Of Autoantibodies In Patients With Rheumatologic Inflammatory Syndrome Following Mineral Oil Injections Is Similar To Those In Mice With Adjuvant Mineral Oil-Induced Autoimmunity
Background/Purpose: Intraperitoneal injection of pristane or adjuvant mineral oil (incomplete Freund's adjuvant) in non-autoimmune strains of mice mainly induces autoantibodies to U1RNP and Su/argonaute2 (Ago2). …
ACR Meeting Abstracts