Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting
Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)
Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…Abstract Number: 29 • 2013 ACR/ARHP Annual Meeting
A Novel CD27(-) B-Cell Subset Identified Based On Intracellular Characteristics Is Expanded In SLE
Background/Purpose: Several studies linked the emergence of autoimmunity to abnormalities of the B-cell receptor (BCR) due to disturbances of signaling molecules or its co-receptors. Therefore…Abstract Number: 31 • 2013 ACR/ARHP Annual Meeting
IgD- CD27- B Cells From Systemic Lupus Erythematous Patients Have Increased Expression Of Genes Involved In RNA Sensing and Toll-Like Receptor 3 Signaling Pathways
Background/Purpose: SLE patients have perturbations in B cell subsets including a large expansion of IgD-CD27- B cells (DN) in patients with active disease. Patients also…Abstract Number: 19 • 2013 ACR/ARHP Annual Meeting
Association Of Antiphospholipid Antibodied Detected In The Aphl ELISA With Clinical Manifestations Of The Antiphospholipid Syndrome In Two Lupus Cohorts
Background/Purpose: Antiphospholipid Syndrome (APS) is characterized by the presence of antibodies to phospholipid (aPL) and to β2glycoprotein I (β2GPI) in patients with thrombosis or pregnancy…Abstract Number: 20 • 2013 ACR/ARHP Annual Meeting
Complement Deposition On Platelets Is Associated To Venous Thrombosis In Systemic Lupus Erythematosus
Background/Purpose: Anti-phospholipid (aPL) antibodies are associated with development of venous thrombosis and stroke in the autoimmune disease systemic lupus erythematosus (SLE). The underlying mechanism for…Abstract Number: 21 • 2013 ACR/ARHP Annual Meeting
Factor Xa Reactive Antibodies In Patients With Systemic LUPUS Erythematosus and Antiphospholipid Syndrome Have Differential Effects Upon Coagulation Assays and Endothelial CELLS
Background/Purpose: Antiphospholipid antibodies have been shown to bind serine proteases (SP) involved in the coagulation cascade. Previously, we found that IgG anti-Factor(F)Xa antibody levels…Abstract Number: 22 • 2013 ACR/ARHP Annual Meeting
WHAT Is The Prevalence Of NON CRITERIA ANTIPHOSPHOLIPID ANTIBODIES IN Patients With Antiphospholipid Syndrome?
Background/Purpose: Increasing interest has focussed upon assays which are not currently included in the Antiphospholipid syndrome (APS) classification criteria to detect antibodies directed against other…Abstract Number: 24 • 2013 ACR/ARHP Annual Meeting
Plasma Cells In Acute Systemic Lupus Erythematosus Flares Are Characterized By a Highly Diversified Repertoire Accentuated By Clonal Expansions Of VH4-34 Antibodies
Background/Purpose :Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which faulty B cell tolerance promotes the generation of multiple autoantibodies of which anti-ds DNA,…Abstract Number: 26 • 2013 ACR/ARHP Annual Meeting
Autoantibodies Directed Against Cell Surface Components In Autoimmune Disease Patients: Proposal Of a Novel ELISA For The Detection Of Anti-Endothelial Cell Antibodies
Background/Purpose: Sera from patients with systemic vasculitis or inflammatory conditions have been reported to contain antibodies that bind to endothelial cells (EC), i.e., AECA (anti-endothelial…Abstract Number: 27 • 2013 ACR/ARHP Annual Meeting
Specificity Of Autoantibodies In Patients With Rheumatologic Inflammatory Syndrome Following Mineral Oil Injections Is Similar To Those In Mice With Adjuvant Mineral Oil-Induced Autoimmunity
Background/Purpose: Intraperitoneal injection of pristane or adjuvant mineral oil (incomplete Freund's adjuvant) in non-autoimmune strains of mice mainly induces autoantibodies to U1RNP and Su/argonaute2 (Ago2). …Abstract Number: 30 • 2013 ACR/ARHP Annual Meeting
Gene Expression Profiling Analysis Of Human B-Cell Subsets In Health and Systemic Lupus Erythematosus
Background/Purpose: SLE is an autoimmune disease, which exhibits multiple B cell abnormalities including expanded populations of plasmablasts and DN memory cells as well as a…Abstract Number: 32 • 2013 ACR/ARHP Annual Meeting
Understanding The Stimulatory Pathways Responsible For Naïve B Cell Activation In Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a recurrent autoimmune disease characterized by multiple B cell abnormalities, including the activation of naïve B cells. However, gaps…Abstract Number: 33 • 2013 ACR/ARHP Annual Meeting
B Cell Receptor Signaling As A Potential Clinical Parameter In Lupus
Background/Purpose: B cells are central to SLE. Signaling through the B cell receptor (BCR) controls critical processes at various stages of B cell development. Murine…Abstract Number: 34 • 2013 ACR/ARHP Annual Meeting
Dichotomous Responses Of Human Systemic Lupus Erythematosus B Cell Subsets To B Cell Receptor Stimulation
Background/Purpose: Autoantibody production is a hallmark of Systemic Lupus Erythematosus (SLE), supporting a central role for B cells in disease pathogenesis. Prior studies have demonstrated…Abstract Number: 35 • 2013 ACR/ARHP Annual Meeting
Defective Regulatory Function Of Granzyme B-Producing B Cells In Patients With Systemic Lupus Erythematosus
Background/Purpose: The efficacy of B-cell depletion therapy highlights a pathogenic role of B cells in autoimmune diseases. In certain conditions, elimination of B cells can…