Abstracts Archive - Page 2239 of 2607 - ACR Meeting Abstracts

Abstract Number: 70 • 2013 ACR/ARHP Annual Meeting
Chondrocyte Hypertrophy, Measured By The Secretion Of Collagen Type X, Is Associated With Cartilage Degradation and Systemic Inflammation In Osteoarthritis
Yi He¹, Natasja Stæhr Gudman², Niels Ulrik Hansen¹, Jianxia Wang³, Di Su⁴, Qinlong Zheng⁴, Ole Simonsen⁵, Kristian Kjaer Petersen⁶, Moustapha Kassem⁷, Morten Asser Karsdal² and Anne C. Bay-Jensen⁸, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Cartilage biology and biomarkers, Nordic Bioscience China, Beijing, China, ⁴Nordic Bioscience China, Beijing, China, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁷Department of Endocrinology and Metabolism, Odense University Hospital and University of Southern, Odense, Denmark, ⁸Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. The hypertrophy-like changes, such as expression of hypertrophy…
Abstract Number: 71 • 2013 ACR/ARHP Annual Meeting
Subchondral Bone Turnover and Osteophyte Formation Are Key Aspects In The Progression Of Osteoarthritis and May Be Assessed and Predicted By a-CTX
Morten Asser Karsdal¹, Janet L. Huebner², Virginia Byers Kraus², Diana J. Leeming¹, Edward Coleman², Gary E. McDaniel³, Kim M. Huffman³, Kim Henriksen¹ and Anne C. Bay-jensen¹, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ³Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritic disease. It is characterized by pathological changes in both bone and cartilage turnover as well…
Abstract Number: 72 • 2013 ACR/ARHP Annual Meeting
Autophagy Changes During Aging: A Study In GFP-LC3 Mice
Beatriz Carames¹, William B. Kiosses², Merissa Olmer³ and Martin Lotz⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–A Coruña, SPAIN, A Coruña, Spain, ²The Scripps Research Institute, La Jolla, CA, ³The Sripps Research Institute, La Jolla, CA, ⁴The Scripps Research Institute, La Jolla, USA, La Jolla, CA
Background/Purpose: Aging is a main risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disorder. Aging-associated changes in autophagy, an essential cellular homeostasis mechanism, have…
Abstract Number: 73 • 2013 ACR/ARHP Annual Meeting
Fibrillin-1 Expression and Function Is Needed For Normal Joint Function and Mutations Leads To Osteoarthritis
Wasabha Ramanayake¹, Helen Jones¹, Isabel Orriss², Tim Arnett², Andrew Pitsillides³, Christopher P. Denton⁴, David J. Abraham⁴ and Blandine Poulet⁵, ¹Centre for Rheumatology and Connective tissue diseases, UCL Medical School, London, United Kingdom, ²Department of Cell and developmental biology, University College London, London, United Kingdom, ³Department of Comparative Biomedical Sciences, Royal Veterniary College, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁵Centre for Rheumarology and connective tissue diseases, UCL Medical School, London, United Kingdom
Background/Purpose: Osteoarthritis (OA) is a common degenerative disease leading to pain and disability in >6million british people. The TGFb signalling pathway has been shown to…
Abstract Number: 74 • 2013 ACR/ARHP Annual Meeting
Terminal Uridyltransferase Enzyme ZCCHC11 Regulates Interleukin-6 Expression In Primary Human Osteoarthritis Chondrocytes
Abdul Haseeb¹, Mohammad Shahidul Makki¹, Ahmad Arida² and Tariq M. Haqqi², ¹Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ²Anatomy & Neurobiology, North East Ohio Medical University, Rootstown, OH
Background/Purpose: Non-template addition of nucleotides on the 3’ termini of mRNAs acts as a mechanism that controls mRNA stability. ZCCHC11 is a member of the…
Abstract Number: 2918 • 2013 ACR/ARHP Annual Meeting
Survival After Lung Transplantation In Systemic Sclerosis. A Systematic Review
Irfan Y. Khan¹, Lianne G. Singer², Marc de Perrot³, John T. Granton⁴, Shaf Keshavjee³, Cathy Chau⁵, Amie T. Kron⁶ and Sindhu R. Johnson⁷, ¹Medicine, Pulmonary Hypertension Programme, University Health Network, University of Toronto, Toronto, ON, Canada, ²Medicine, Division of Respirology, University of Toronto; and Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, ³Medicine, Toronto Lung Transplant Program, Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, ON, Canada, ⁴Medicine, Toronto Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ⁵Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Medicine, Toronto Scleroderma Research Program, Toronto Western Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, ⁷Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Lung transplantation is a life-saving option for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) and interstitial lung disease (SSc-ILD) patients. Yet, there is risk…
Abstract Number: 2919 • 2013 ACR/ARHP Annual Meeting
The Clinical Utility Of Flow-Mediated Dilation In Systemic Sclerosis
Tracy M. Frech¹, Ashley Walker², Zachary Barrett-Okeefe², Russell Richardson², D. Walter Wray² and Anthony Donato², ¹Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, ²University of Utah, Salt Lake, UT
Background/Purpose: In systemic sclerosis (SSc, scleroderma) vasculopathy can result in the end-stage manifestation of a digital ulcer (DU). We hypothesized that bedside flow mediated dilatation…
Abstract Number: 2899 • 2013 ACR/ARHP Annual Meeting
Outcome Of Incidental Silent Strokes In Systemic Lupus Erythematosus
Jamal Mikdashi, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Silent strokes are brain infarcts that lack clinically overt stroke-like symptoms and fail to come to clinical attention. The prevalence of incidentally detected acute/subacute…
Abstract Number: 2898 • 2013 ACR/ARHP Annual Meeting
Atherosclerosis In Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis Of SLE Subgroups
Johanna Gustafsson¹, Kerstin Jensen-Urstad², Marie Herlitz-Lindberg², Sonia Möller¹, Susanne Pettersson¹, Iva Gunnarsson¹, Anders Larsson³ and Elisabet Svenungsson⁴, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, ³Department of Clinical Chemistry and Pharmacology, Akademiska Hospital, Uppsala, Sweden, ⁴Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Atherosclerosis is often assumed to be the main underlying cause of premature vascular events (VE) among patients with systemic lupus erythematosus (SLE) and accelerated…
Abstract Number: 2900 • 2013 ACR/ARHP Annual Meeting
Predictors Of Damage Accrual Over a 2 Year Period In a Large Multi-Racial/Ethnic Lupus Cohort
Megan E. B. Clowse¹, Jennifer M. Grossman², Joan T. Merrill³, Anca Askanase⁴, Olga Dvorkina⁵, Michael D. Lockshin⁶ and Cynthia Aranow⁷, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Rheumatology, New York University School of Medicine, New York, NY, ⁵Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁶Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁷The Feinstein Institute, Manhasset, NY
Background/Purpose: Clinical experience and some previous research suggest that patients with lupus who live in more socio-economically vulnerable conditions fair worse than other patients. We…
Abstract Number: 2901 • 2013 ACR/ARHP Annual Meeting
Standardized Incidence Ratios For Cancer After Renal Transplant In Systemic Lupus Erythematosus and Non-Systemic Lupus Erythematosus Recipients
Rosalind Ramsey-Goldman¹, Amarpali Brar², Moro Salifu², Ann E. Clarke³, Rahul M. Jindal⁴ and Sasha Bernatsky³, ¹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, SUNY Downstate, Brooklyn, NY, ³McGill University, Montreal, QC, Canada, ⁴Surgery, Uniformed Services University and George Washington University, Washington, DC
Background/Purpose: Differentiating between effects of drugs vs. disease activity on cancer risk in SLE is difficult. Because all renal transplant recipients are on similar immunomodulatory…
Abstract Number: 2902 • 2013 ACR/ARHP Annual Meeting
Key Roles For Interferon and Macrophage Activation In Progressive Lung Fibrosis Associated With Systemic Sclerosis
Romy Christmann¹, Giuseppina Stifano², Claudia Borges³, Carlos Carvalho⁴, Ronaldo Kairalla⁴, Edwin R. Parra⁵, Avrum Spira⁶, Robert W. Simms¹, Percival Sampaio-Barros⁷, Vera L. Capelozzi⁵ and Robert Lafyatis¹, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, ⁴Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁵Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁶Computational Biomedicine, Boston University School of Medicine, Boston, MA, ⁷Rheumatology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Background/Purpose: Interstitial lung disease associate with Systemic Sclerosis(SSc-ILD) is one of the leading causes of mortality. We analyzed the gene expression of lung tissue in…
Abstract Number: 2903 • 2013 ACR/ARHP Annual Meeting
Perturbed Response To Experimental Renal Injury In a TGFβ Dependent Mouse Model Of Scleroderma
Emma Derrett-Smith¹, Mark Neal², David J. Abraham³, Alan Salama⁴, Mark A. Little² and Christopher P. Denton³, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²UCL Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁴Centre for Nephrology, University College London, London, United Kingdom
Background/Purpose: Scleroderma renal pathology is predominantly vascular and fibrotic without major inflammatory features. Accelerated hypertension and rapidly progressive renal dysfunction are hallmarks of scleroderma renal…
Abstract Number: 2904 • 2013 ACR/ARHP Annual Meeting
Gadolinium-Based Compounds Induce NLRP3-Dependent IL-1β Production and Peritoneal Inflammation
Jonathan Kay^1,2, Lukas Bossaller³, Christian Schmidt-Lauber^1,4, Hani H. Abujudeh⁵, Gregory Vladimer³, Eicke Latz^3,6, Katherine A. Fitzgerald³, Ann Marshak-Rothstein¹ and Ellen M. Gravallese^1,7, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁴Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ⁵Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nephrogenic systemic fibrosis (NSF) is a progressive iatrogenic fibrosing disorder that develops in patients with chronic kidney disease following administration of gadolinium (Gd)-based contrast…
Abstract Number: 2905 • 2013 ACR/ARHP Annual Meeting
Demethylation of ITGAL (CD11a) regulatory sequences in CD4+T lymphocytes of Systemic Sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease epitomized numerous cellular and humoral immunological abnormalities. The immune system undoubtedly plays a pivotal…

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