Abstracts Archive - Page 2237 of 2607 - ACR Meeting Abstracts

Abstract Number: 150 • 2013 ACR/ARHP Annual Meeting
A Subset Of Osteoarthritis Individuals Has Elevated IL-6 Pathway Activation Associated With Worse Symptoms
Michael Kuziora¹, Zheng Liu², Brandon W. Higgs², Philip Brohawn², Kim Lehmann², Fernanda Pilataxi², Katie Streicher², Lydia Greenlees¹, Meina Liang³, Rozanne Lee⁴, Amy Schneider⁴, Raffaella Faggioni⁴, Yihong Yao² and Koustubh Ranade², ¹Translational Science, MedImmune, LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³Dmpk, MedImmune, LLC, Hayward, CA, ⁴DMPK, MedImmune, LLC, Hayward, CA
Background/Purpose: Elevated levels of the pro-inflammatory cytokine IL-6 have been found in the affected joint of patients with osteoarthritis (OA), although the prevalence of OA…
Abstract Number: 151 • 2013 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence The Cartilage Integrity In Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Ignacio Rego-Pérez¹, Angel Soto-Hermida², Mercedes Fernández-Moreno², Sonia Pértega-Díaz³, Juan Fernández-Tajes², María Eugenia Vázquez-Mosquera², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^4,5,6, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain, ⁶CIBER-BBN-ISCIII, Madrid, Spain
Background/Purpose: Magnetic resonance imaging (MRI) is ideally suited for detect structural changes and degradation in cartilage against the limitations of radiographic common methods. Changes in…
Abstract Number: 152 • 2013 ACR/ARHP Annual Meeting
The Uncoupling mtDNA Haplogroup T Associates With Better Radiographic Progression Of Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Angel Soto-Hermida¹, Ignacio Rego-Pérez², Mercedes Fernández-Moreno¹, Sonia Pértega-Díaz³, Juan Fernández-Tajes¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Sara Relaño-Fernández¹, Natividad Oreiro-Villar¹, Carlos Fernández-López¹ and Francisco J. Blanco^1,4,5, ¹INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: The Osteoarthritis Initiative (OAI) is a multicentre study focused on identifying and evaluating risk factors of knee osteoarthritis (OA). Previous studies carried out by…
Abstract Number: 153 • 2013 ACR/ARHP Annual Meeting
Identification Of Autoimmune Disease Risk Alleles That Are Under Recent Selection In The Sea Island Gullah African Americans
Carl D. Langefeld¹, Satria Sajuthi¹, Jasmin Divers¹, Yiqi Huang², Uma Nayak³, Wei-Min Chen³, Kelly J. Hunt⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁶, Jyotika K. Fernandes⁷, Ida J. Spruill⁷, W. Timothy Garvey⁸, Michèle M. Sale² and Paula S. Ramos⁵, ¹Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ³Public Health Sciences, University of Virginia, Charlottesville, VA, ⁴Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁷Medical University of South Carolina, Charleston, SC, ⁸Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The reasons for the ethnic disparities in rheumatic and autoimmune diseases (AIDs) are largely unknown. Given the increasing evidence of selection at loci associated…
Abstract Number: 154 • 2013 ACR/ARHP Annual Meeting
Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina
Paula S. Ramos¹, Nathan Titus², Satria Sajuthi³, Jasmin Divers³, Yiqi Huang⁴, Uma Nayak⁵, Wei-Min Chen⁵, Kelly J. Hunt⁶, Diane L. Kamen⁷, Gary S. Gilkeson⁷, Jyotika K. Fernandes⁸, Ida J. Spruill⁸, W. Timothy Garvey⁹, Michèle M. Sale⁴ and Carl D. Langefeld³, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁵Public Health Sciences, University of Virginia, Charlottesville, VA, ⁶Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁷Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁸Medical University of South Carolina, Charleston, SC, ⁹Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Most autoimmune diseases (ADs) are more prevalent in specific ethnic groups. We hypothesize that one reason for the ethnic disparity may be an effect…
Abstract Number: 155 • 2013 ACR/ARHP Annual Meeting
Exome Sequencing For Identification Of Potential Causal Variants For Diffuse Cutaneous Systemic Sclerosis
Angel CY Mak¹, M Kari Connolly², Tamiko Katsumoto^3,4, Paul Wolters⁵, Clare Cleveland^3,4, Blanca M Herrera¹, Paul LF Tang¹, Simi Mathauda¹, Richard Lao¹, Pui-Yan Kwok^1,2 and Lindsey A. Criswell^3,4, ¹University of California, San Francisco, Institute for Human Genetics, San Francisco, CA, ²University of California, San Francisco, Department of Dermatology, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁴University of California, San Francisco, Department of Medicine, San Francisco, CA, ⁵University of California, San Francisco, Department of Medicine, Pulmonary Division, San Francisco, CA
Background/Purpose: Scleroderma is a genetically complex autoimmune disease with substantial phenotypic heterogeneity. Previous genome-wide association studies (GWAS) have identified a large number of gene regions…
Abstract Number: 156 • 2013 ACR/ARHP Annual Meeting
Cartilage Peptide Profiling: Identifying Novel OA Biomarkers For Early Disease Detection
Valentina Calamia¹, Lucía Lourido¹, Diego López¹, Jesus Mateos¹, Patricia Fernández-Puente¹, Carolina Fernández-Costa², Beatriz Rocha², Cristina Ruiz-Romero³ and Francisco J. Blanco¹, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain
Background/Purpose: Cartilage secretome contains a complex matrix of proteolytically derived peptides that may provide useful information of the biological events occurring in the articular joint…
Abstract Number: 157 • 2013 ACR/ARHP Annual Meeting
Application Of a Multiplex Gene Polymorphism Assay For Variants Associated With Rheumatoid Arthritis Susceptibility: Results Of 168 Single Nucleotide Polymorphisms In The Optima Study
Jeffrey F. Waring¹, Viswanath Devanarayan², Kenneth Idler¹, Feng Hong², Josef S. Smolen³, Arthur Kavanaugh⁴, Hartmut Kupper⁵, Hendrik Schulze-Koops⁶ and Alla Skapenko⁷, ¹AbbVie Inc., North Chicago, IL, ²AbbVie Bioresearch Center, Worchester, MA, ³Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁴University of California San Diego, La Jolla, CA, ⁵AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁶Division of Rheumatology, University of Munich, Munich, Germany, ⁷Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Genetic factors have been identified that may be associated with the development and severity of rheumatoid arthritis (RA), disease progression, or response to treatment.…
Abstract Number: 158 • 2013 ACR/ARHP Annual Meeting
The Use Of “Autoantigenomics” To Rapidly Identify Targets Of Human Autoantibodies
Wei-Hong Yang¹, Emily G. Bloch², Daniel F. Berenson³, Rita L. Galdos³, Pankaj Arora⁴, Connie Wu² and Donald B. Bloch⁵, ¹Rheumatology, allergy and immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ³The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁴3the Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁵Rheumatology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Background/Purpose: The messenger RNA (mRNA) processing body (P-body) is a cellular structure that regulates the stability of cytoplasmic mRNA. Approximately 5% of patients with the…
Abstract Number: 159 • 2013 ACR/ARHP Annual Meeting
Transcriptomic Blood Markers and Molecular Stratification In Sarcoidosis
Robert Su¹, Michael Li², Nirav Bhakta², Misha Agarwal², Prescott Woodruff² and Laura Koth², ¹Rheumatology, University of California San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA
Background/Purpose: Sarcoidosis is a heterogeneous disease with diverse manifestations and varied clinical courses. Currently there are no reliable non-invasive biomarkers of disease activity or severity.…
Abstract Number: 120 • 2013 ACR/ARHP Annual Meeting
The Symptom Severity In Korean Patients With Fibromyalgia Is Associated With Socioeconomic Status, But Not With Obesity
Dong-Jin Park¹, Shin-Seok Lee², Seong-Ho Kim³, Seong-Su Nah⁴, Ji Hyun Lee⁵, Seong-Kyu Kim⁶, Yeon-Ah Lee⁷, Seung-Jae Hong⁷, Hyun-Sook Kim⁸, Hye-Soon Lee⁹, Hyoun Ah Kim¹⁰, Chung-Il Joung¹¹ and Sang-Hyon Kim¹², ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ³Internal Medicine, Division of Rheumatology, Inje University College of Medicine, Haeundae Paik Hospital, Busan, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, South Korea, ⁶Catholic University of Daegu School of Medicine, Daegu, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, ⁸Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University of Korea, Seoul, South Korea, ⁹Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ¹⁰Ajou University Hospital, Suwon, South Korea, ¹¹Department of Internal Medicine, Konyang university hospital, Daejeon, South Korea, ¹²Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea
Background/Purpose: Fibromyalgia (FM) is a chronic pain disorder characterized by widespread pain, tenderness, and various associated symptoms including sleep disturbances, chronic fatigue, depression, and other…
Abstract Number: 121 • 2013 ACR/ARHP Annual Meeting
Comparative Burden Of Chronic Widespread Pain and Fibromyalgia In The US Population
Caroline Schaefer¹, Rachael Mann², Elizabeth T. Masters³, Joseph C. Cappelleri⁴, Shoshana Daniel⁵, Gergana Zlateva³, Heather McElroy⁶, Arthi B. Chandran³, Edgar H. Adams¹, Annlouise R. Assaf⁴, Michael McNett⁷, Philip Mease⁸, Stuart L. Silverman⁹ and Roland Staud¹⁰, ¹Covance Market Access Services Inc., Gaithersburg, MD, ²Covance Market Access Services Inc., San Diego, CA, ³Pfizer Inc., New York, NY, ⁴Pfizer Inc., Groton, CT, ⁵Covance Market Access Services Inc., Conshohocken, PA, ⁶Covance Market Access Services, Sydney, Australia, ⁷Aurora Pain Program, Milwaukee, WI, ⁸Director, Rheumatology Research, Swedish Medical Center, Seattle, WA, ⁹Cedars-Sinai Medical Center, UCLA Center of Excellence, Los Angeles, CA, ¹⁰Dept Med/Rheum/Clin Immun Div, University of Florida, Gainesville, FL
Background/Purpose: Few data exist on the comparative burden of chronic widespread pain (CWP) and fibromyalgia (FM) in the general population. Methods: 8,382 nationally representative participants…
Abstract Number: 122 • 2013 ACR/ARHP Annual Meeting
Rheumatologists Lack Confidence in Their Knowledge of Cannabinoid Molecules and Use in the Management of Rheumatic Disease Patients: Analysis of a Needs Assessment
Mary-Ann Fitzcharles¹, Peter A. Ste-Marie², Daniel J. Clauw³, Shahin Jamal⁴, Jacob Karsh⁵, Sharon Leclercq⁶, Jason J. McDougall⁷, Yoram Shir², Kamran Shojania⁸ and Zach Walsh⁹, ¹Rheumatology & Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, ²Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, ³Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁴Department of Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Ottawa Hosp Riverside, Ottawa, ON, Canada, ⁶Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁷Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada, ⁸Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁹Department of Psychology, University of British Columbia, Kelowna, BC, Canada
Background/Purpose: The pharmacologic treatment of chronic rheumatic pain is often sub-optimal, leading patients to seek alternate treatments. Although herbal cannabis (marihuana) has had medicinal use…
Abstract Number: 123 • 2013 ACR/ARHP Annual Meeting
Association Of Rheumatic Diseases With Symptom Severity, Quality Of Life, and Treatment Outcome In Patients With Fibromyalgia
Juan Jiao^1,2, John M. Davis III³, Ann Vincent⁴, Connie A. Luedtke⁵, Stephen Cha⁶ and Terry H. Oh⁷, ¹Rheumatology, Guang'anmen Hospital , China Academy of Chinese Medical Sciences, Beijing, China, ²Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴General Internal Medicine, Mayo Clinic, Rochester, MN, ⁵Department of Nursing, Mayo Clinic, Rochester, MN, ⁶Health Sciences Research, Mayo Clinic, Rochester, MN, ⁷Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN
Background/Purpose: Fibromyalgia is often associated with various comorbid conditions. A high prevalence of fibromyalgia in patients with rheumatic diseases has been reported. Previous studies showed…
Abstract Number: 124 • 2013 ACR/ARHP Annual Meeting
Disability In Fibromyalgia Is Associated With Greater Self-Reported Symptoms and Functional Impairment
Emmanouil Rampakakis^1,2, Mary-Ann Fitzcharles³, Peter A. Ste-Marie⁴, John S. Sampalis^1,2 and Yoram Shir⁴, ¹JSS Medical Research, Montreal, QC, Canada, ²Jewish General Hospital, McGill University, Montreal, QC, Canada, ³Rheumatology & Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, ⁴Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: It is intuitive that disablement due to illness should be reflected in illness severity. When illness measurement is based on subjective report only, without…

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