Abstracts Archive - Page 2236 of 2607 - ACR Meeting Abstracts

Abstract Number: 175 • 2013 ACR/ARHP Annual Meeting
Dynamics Of The Inflammatory Response In Rheumatoid Arthritis Patients Following Traumatic Injury: Insights From In Vivo,In Silico, and Single Nucleotide Polymorphism Studies
Rajaie Namas¹, Rami Namas², Harpreet Sagar³, Felix Fernandez-Madrid³, Timothy Billiar² and Yoram Vodovotz⁴, ¹Rheumatology, Wayne State University/ Henry Ford Health System, Detroit, MI, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, ⁴Surgery, Immunology, Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Both traumatic injury/hemorrhagic shock (T/HS) and rheumatoid arthritis (RA) are inflammatory diseases that are major sources of morbidity worldwide. We hypothesize that RA modifies…
Abstract Number: 176 • 2013 ACR/ARHP Annual Meeting
Identification Of Major Histocompatibility Complex Class II Alleles Associated With Systemic Sclerosis Through Imputation Strategy
Jose Ezequiel Martin¹, Carmen P. Simeón², Norberto Ortego-Centeno³, Patricia Carreira⁴, Miguel A. Gonzalez-Gay^5,6, Nicolas Hunzelmann⁷, Shervin Assassi⁸, Filemon K. Tan⁸, Frank C. Arnett⁸, Xiaodong Zhou⁸, T.R.D.J. Radstake^9,10, Maureen D. Mayes¹¹, Paul de Bakker^12,13, Javier Martin^1,14 and B. P. C. Koeleman¹³, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, ³Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁴Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Department of Dermatology, University of Cologne, Cologne, Germany, ⁸Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁹Laboratory for Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ¹⁰Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹¹University of Texas Health Science Center at Houston, Houston, TX, ¹²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹³Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁴Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain
Background/Purpose: Different alleles of MHC class II molecules have been associated either with risk to systemic sclerosis (SSc) or its subphenotypes. Due to the high…
Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting
Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis
Sebastien Viatte¹, Paul Martin², Andrew Brass³, Mark Lunt⁴, Anne Barton⁵ and Stephen Eyre⁵, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³School of Computer Science, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…
Abstract Number: 178 • 2013 ACR/ARHP Annual Meeting
Fc-Gamma Receptor Genetic Variation In Kawasaki Disease
Carline E. Tacke^1,2, Willemijn B. Breunis^3,4, Long T. Hoang¹, Eileen Png¹, Judy Geissler⁵, Sietse Nagelkerke⁴, Justine Ellis^6,7, Sonia Davila⁸, Chiea Chuen Khor⁸, Michael Levin⁹, David Burgner^10,11, Chisato Shimizu¹², Jane C. Burns¹², Martin L. Hibberd¹ and Taco W. Kuijpers^4,13, ¹Infectious Diseases, Genome Institute of Singapore, Singapore, Singapore, ²Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands, ³Pediatric rheumatology and immunology, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands, ⁴Blood cell research, Sanquin Resarch and Landsteiner Laboratory (AMC), Amsterdam, Netherlands, ⁵Sanquin Resarch and Landsteiner Laboratory (AMC), Amsterdam, Netherlands, ⁶Murdoch Childrens Research Institute, Parkville, Australia, ⁷Department of Paediatrics, The University of Melbourne, Parkville, Australia, ⁸Human Genetics, Genome Institute of Singapore, Singapore, Singapore, ⁹Department of Pediatrics, Imperial College London, London, United Kingdom, ¹⁰The royal Children's Hospital, Murdoch Childrens Research Institute, Parkville, Australia, ¹¹Department of Paediatrics, The University of Melbourne, Melbourne, Australia, ¹²Pediatrics, UC San Diego, School of Medicine, La Jolla, CA, ¹³Pediatric Rheumatology and Immunology, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands
Abstract on behalf of the International Kawasaki Disease Genetics Consortium. Background/Purpose: Kawasaki disease (KD) is a pediatric vasculitis of unknown etiology with a substantial genetic…
Abstract Number: 179 • 2013 ACR/ARHP Annual Meeting
The Association Between Single Nucleotide Polymorphism ABCG2 rs2231142 and Hyperuricemia: A Case-Control Study
Bingqing Zhang¹, Weigang Fang², Yun Zhang^3,4, Shufen Liu³, Yuanjie Li³ and Xuejun Zeng², ¹Peking Union Medical College, Beijing, China, ²Medicine, Peking Union Medical College Hospital, Beijing, China, ³Peking Union Medical College Hospital, Beijing, China, ⁴Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
Background/Purpose: The prevalence of hyperuricemia and gout in China increased markedly in the past decades. Genome-wide association studies in Caucasian population have identified multiple…
Abstract Number: 140 • 2013 ACR/ARHP Annual Meeting
Fibromyalgia and Pregnancy: Challenges Of The Savella^® (Milnacipran) Pregnancy Registry
Damien Hirsch¹, Denise Leclair¹, Robert H. Palmer¹, Vikki Brown², Susan Sinclair Roberts^2,3 and Janice McLean², ¹Forest Research Institute, Inc., Jersey City, NJ, ²INC Research, LLC, Wilmington, NC, ³University of North Carolina Wilmington, Wilmington, NC
Background/Purpose: During pregnancy, women with fibromyalgia (FM) often experience worsening of symptoms, which include widespread pain, fatigue, sleep disturbances, cognitive difficulties, and reduced daily functioning.…
Abstract Number: 141 • 2013 ACR/ARHP Annual Meeting
Skin Disease and Fibromyalgia: Dermatologic Diagnoses Encountered In a Series Of 845 Patients With Fibromyalgia At Mayo Clinic In 2008
Valerie Laniosz¹, David Wetter² and Desiree Godar², ¹Dermatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN
Background/Purpose: To determine the common dermatological diagnoses and skin-related complaints in a cohort of patients with fibromyalgia seen in a tertiary referral center. Methods: A…
Abstract Number: 142 • 2013 ACR/ARHP Annual Meeting
Home Tender Point Measurement In Fibromyalgia Patients
Robert S. Katz¹, Hannah Bond² and Jessica L. Polyak², ¹Rush Medical College, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: To determine whether: 1) patients with the fibromyalgia syndrome (FMS) can accurately evaluate their own tender points, similar to self-administered testing for other purposes…
Abstract Number: 143 • 2013 ACR/ARHP Annual Meeting
Rapid Infrared Microscopy (IRMS) For Differential Diagnosis Of Fibromyalgia and Other Central Sensitivity Syndromes
Kevin V. Hackshaw¹, Luis Rodriguez-Saona², Irving L. Rosenberg³, Marcal Plans² and C.A. Tony Buffington⁴, ¹Immunology/Rheumatology, The Ohio State University, Columbus, OH, ²Food Sciences, The Ohio State University, Columbus, OH, ³Immunology/ Rheumatology, The Ohio State University, Columbus, OH, ⁴Veterinary Biological Sciences, The Ohio State University, Columbus, OH
Background/Purpose: Background/Purpose: The aim of this study was to investigate the ability of a rapid blood-spot-based method for diagnosis of Fibromyalgia (FM) using mid-infrared microspectroscopy (IRMS)…
Abstract Number: 144 • 2013 ACR/ARHP Annual Meeting
Cytokines, Oxidative Stress Markers and Brain-Derived Neurotrophic Factor In Fibromyalgia Syndrome
Aline Ranzolin^1,2, Claudio Antônio da C. Neto³, Bruna Maria Ascoli⁴, Bianca Wollenhaupt-Aguiar⁵, Angela Luzia B. Pinto Duarte³, Markus Bredemeier⁶, Flávio Kapczinski⁴ and Ricardo M. Xavier⁷, ¹Rheumatology, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ²Programa de Pós-Graduação em Ciências Médicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ³Faculdade de Medicina, Universidade Federal de Pernambuco - Hospital das Clínicas de Pernambuco, Recife, Brazil, ⁴Programa de Pós-Graduação em Ciências Médicas da Universidade Federal do Rio Grande do Sul: Psiquiatria, Porto Alegre, Brazil, ⁵Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁶Rheumatology, Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição, Porto Alegre, Brazil, ⁷Rheumatology Division, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Background/Purpose: The pathophysiology of Fibromyalgia Syndrome (FMS) is incompletely understood. An imbalance of pro- and anti-inflammatory cytokines is assumed to play a role in the…
Abstract Number: 145 • 2013 ACR/ARHP Annual Meeting
Autonomic Nervous System “Decomplexification” In Fibromyalgia. A Proof Of Concept Study Looking At The Fractality Of Heart Rhythms
Manuel Martinez-Lavin¹, Claudia Lerma², Laura Aline Martinez-Martinez³, Oscar Infante² and Angelica Vargas³, ¹Chief Rheumatology, National Institute of Cardiology, Mexico City, Mexico, ²National Institute of Cardiology, Mexico City, Mexico, ³Rheumatology, National Institute of Cardiology, Mexico City, Mexico
Background/Purpose: Prevailing linear-reductionist medical model seems unable to explain complex diseases like fibromyalgia (FM) and similar maladies. As consequence of this divorce, some physicians disparage…
Abstract Number: 146 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity Locus Cia4 Is An Early Regulator of IL-6, IL-1β, and NFκB activators’ Expression in Pristane-Induced Arthritis
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Cia4 is a quantitative trait locus on rat chromosome 7 that regulates disease severity and joint damage in three models of rheumatoid arthritis including…
Abstract Number: 147 • 2013 ACR/ARHP Annual Meeting
Modular Analysis Of In Peripheral Blood Gene Expression In Rheumatoid Arthritis Captures Reproducible Gene Expression Changes In TNF Responders
Mark Curran¹, Michaela Oswald², Sarah Lamberth¹, Carrie Brodmerkel¹, Zhenya Cherkas¹ and Peter K. Gregersen³, ¹Janssen Research & Development, LLC., Spring House, PA, ²Laboratory of Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY, ³Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: The use of whole blood gene expression to predict and follow the response to TNF inhibition therapy in RA has been challenging due to…
Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting
Microarray Analysis Of Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology
Arjen B. Blom¹, Peter L. van Lent², Martijn H. van den Bosch¹, Hans Cats³, Frank H.J. van den Hoogen⁴, Peter M. van der Kraan⁵ and Wim B. van den Berg⁶, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
Abstract Number: 149 • 2013 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis Of Neutrophils From Patients With Microscopic Polyangiitis and Granulomatosis With Polyangiitis
Teisuke Uchida¹, Kohei Nagai², Toshiyuki Sato³, Nobuko Iizuka³, Mitsumi Arito³, Yukiko Takakuwa⁴, Hiromasa Nakano⁴, Seido Ooka⁴, Manae Kurokawa³, Naoya Suematsu³, Kazuki Okamoto³, Shoichi Ozaki⁵ and Tomohiro Kato³, ¹Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, kawasaki, Japan, ²Department of Genetic Engineering, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan, ³Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ⁴Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which neutrophils are thought to be involved in their…

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