Abstracts Archive - Page 2230 of 2425 - ACR Meeting Abstracts

Abstract Number: 289 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of The Cutoff Values For Disease Activity States Of The Three-Item Version Of The Juvenile Arthritis Disease Activity Score
Alessandro Consolaro¹, Sara Verazza¹, Maria C. Gallo¹, Giulia Bracciolini¹, Giorgia Negro¹, Alessia Frisina¹, Nicolino Ruperto², Alberto Martini^1,3 and Angelo Ravelli^1,3, ¹Pediatria II, Istituto Giannina Gaslini, Genova, Italy, ²PRINTO, Genoa, Italy, ³Department of Pediatrics, University of Genova, Genova, Italy
Background/Purpose: A new approach to the measurement of disease activity in juvenile idiopathic arthritis (JIA) is based on the Juvenile Arthritis Disease Activity Score (JADAS).…
Abstract Number: 290 • 2013 ACR/ARHP Annual Meeting
Children With JIA Show Distinct Patterns Of Improvement In Their Health-Related Quality Of Life During The First Year On Treatment: Growth Mixture Modeling Of a Prospective Cohort Of Newly Diagnosed Patients
Bin Huang¹, Chen Chen², Stacey Niehaus³, Hermine Brunner⁴, Rina Mina⁵ and Michael Seid⁶, ¹Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center/University of Cincinnati School of Medicine, Cincinnati, OH, ²Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Cincinnati Children's Hospital Medical Center/University of Cincinnati School of Medicine, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pulmonary, Cincinnati Children's Hospital Medical Center/University of Cincinnati School of Medicine, Cincinnati, OH
Background/Purpose: Health-related quality of life (HRQOL) is a key outcome in clinical care and research for children with JIA. Despite excellent clinical control and the…
Abstract Number: 292 • 2013 ACR/ARHP Annual Meeting
Body Surface Area-Based Dosing Approach Produced Comparable Golimumab Exposure Across Different Age Ranges After Subcutaneous Administration Of Golimumab In Pediatric Patients With Juvenile Idiopathic Arthritis
Jocelyn H. Leu¹, Alan M. Mendelsohn², Joyce Ford¹, Hugh M. Davis¹ and Zhenhua Xu¹, ¹Janssen Research & Development, LLC., Spring House, PA, ²Immunology, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: To evaluate the pharmacokinetics (PK) of body surface area (BSA)-adjusted dosing of SC golimumab 30 mg/m2 every 4 weeks (q4w) + methotrexate (MTX)…
Abstract Number: 293 • 2013 ACR/ARHP Annual Meeting
The Efficacy Of Etanercept In Patients With Juvenile Idiopathic Arthritis With Inadequate Response To Infliximab As a First TNF Inhibitor
Ekaterina Alekseeva^1,2, Tatyana Bzarova³, Anna Fetisova³, Tatyana Sleptsova³, Saniya Valieva³, Kseniya Isayeva³, Rina Denisova³, Elena Mitenko³, Evgeniya Chistyakova³ and Nikolay Taybulatov⁴, ¹PRINTO, Genoa, Italy, ²I.M.Sechenov First Moscow State Medical University, Moscow, Russia, ³Rheumatology, Scientific Center of Children's Health of RAMS, Moscow, Russia, ⁴Orthopedic, Scientific Center of Children's Health of RAMS, Moscow, Russia
Background/Purpose: Lack of efficacy of Methotrexate, primary and secondary resistance to biologics and their intolerance lead to juvenile idiopathic arthritis (JIA) of progression. Therefore, the problem of…
Abstract Number: 294 • 2013 ACR/ARHP Annual Meeting
Physical Activity In Children With Juvenile Idiopathic Arthritis (JIA): The LEAP (Linking Exercise, Activity and Pathophysiology in Childhood Arthritis) Study
Lori B. Tucker¹, Heather A. McKay², Leanne M. Ward³, Jaime Guzman¹, Adam Baxter-Jones⁴, Kiem Oen⁵, Alan M. Rosenberg⁶, Johannes Roth³, Elizabeth Stringer⁷, Rae SM Yeung⁸, Kristin M. Houghton⁹, Heather Macdonald¹⁰, Debbie Ehrmann Feldman¹¹, Ciaran M. Duffy¹² and LEAP Study Investigators¹³, ¹Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ²Family Practice and Orthoepedics, University of British Columbia, Vancouver, BC, Canada, ³University of Ottawa, Ottawa, ON, Canada, ⁴College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ⁷Department of Rheumatology, IWK Health Centre, Halifax, NS, Canada, ⁸Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁹University of British Columbia, Vancouver, BC, Canada, ¹⁰The University of British Columbia, Vancouver, BC, Canada, ¹¹Rehabilitation, Université de Montréal, Montreal, QC, Canada, ¹²Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹³BC Children's Hospital, Vancouver, BC, Canada
Background/Purpose: Although children with JIA have lower fitness levels than healthy peers, little is known about their level of habitual physical activity. The LEAP…
Abstract Number: 295 • 2013 ACR/ARHP Annual Meeting
Uveitis In The Nordic Juvenile Idiopathic Arthritis Cohort; High Incidence, Frequent Complications, and Gender Associated Risk Factors
Ellen Nordal^1,2, Lillemor Berntson³, Kristiina Aalto⁴, Suvi Peltoniemi⁵, Susan Nielsen⁶, Troels Herlin⁷, Anders Fasth⁸ and Marite Rygg^9,10, ¹Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway, ²Department of Clinical Medicine, University of Tromsø, Tromsø, Norway, ³Department of Pediatrics, Uppsala University Hospital, Uppsala, Sweden, ⁴Department of Pediatrics,, Helsinki University Children's Hospital, Helsinki, Finland, ⁵Department of Pediatrics, Helsinki University Children's Hospital, Helsinki, Finland, ⁶Pediatric Rheumatology Unit, Juliane Marie Centret, Rigshospitalet, Copenhagen, Denmark, ⁷Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, ⁸Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden, ⁹Department of Laboratory Medicine, Children's and Women's health, Norwegian University of Science and Technology, Trondheim, Norway, ¹⁰Department of Pediatrics, St Olav University Hospital, Trondheim, Norway
Background/Purpose: Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA). Both incidence and reported outcome varies, and population-based data are scarce. Early…
Abstract Number: 296 • 2013 ACR/ARHP Annual Meeting
Declines In Levels Of Disease Activity and Physical Disability In Children With Juvenile Idiopathic Arthritis Seen In Standard Clinical Care Over The Last 25 Years
Alessandro Consolaro¹, Stefano Lanni¹, Francesca Minoia¹, Sergio Davì¹, Sara Dalprà¹, Benedetta Schiappapietra¹, Rossana Pignataro¹, Cristina Ferrari¹, Alberto Martini^1,2 and Angelo Ravelli^3,4, ¹Pediatria II, Istituto Giannina Gaslini, Genova, Italy, ²Department of Pediatrics, University of Genova, Genova, Italy, ³PRINTO, Genoa, Italy, ⁴University of Genova, Genova, Italy
Background/Purpose: Over the last 3 decades there have been important advances in the management of juvenile idiopathic arthritis (JIA), which include the introduction of methotrexate…
Abstract Number: 297 • 2013 ACR/ARHP Annual Meeting
Plasma Nicotinamide Phosphoribosyltransferase Correlates With Markers Of Inflammation and May Predict Early Therapeutic Response To Low-Dose Methotrexate In Juvenile Idiopathic Arthritis
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, S.Q. Ye⁶, J.S. Leeder¹ and Mara L Becker⁷, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Medical Genetic Research, Children's Mercy Hospital, Kansas City, MO, ⁷Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Despite a poor understanding of its biochemical role in the inflammatory process, nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in a number of autoimmune…
Abstract Number: 298 • 2013 ACR/ARHP Annual Meeting
Preliminary Prospective Study Of Ultrasonography In Patients With Juvenile Idiopathic Arthritis In Clinical Remission: Subclinical Synovitis May Predict Flare?
Vanessa B Miotto e Silva¹, Sônia A.V. Mitraud², Rita NV Furtado³, Jamil Natour³ and Maria Teresa Terreri¹, ¹Pediatrics, Escola Paulista de Medicina/ Universidade Federal de São Paulo, São Paulo, Brazil, ²Radiology and Diagnostic Imaging, Escola Paulista de Medicina/ Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil, ³Internal Medicine, Escola Paulista de Medicina/ Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood and has variable prognosis, characterized by periods of activity and remission.…
Abstract Number: 299 • 2013 ACR/ARHP Annual Meeting
Phenotypic Cluster Analysis Of Juvenile Idiopathic Arthritis: Relationship To International Leagues Of Associations For Rheumatology Classification Criteria
Jay Mehta¹, Juan Lin², Norman T. Ilowite^3,4 and for The CARRA Registry Investigators⁵, ¹Pediatrics, Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY, ²Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, ³Pediatrics, Albert Einstein College of Medicine, Bronx, NY, ⁴Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ⁵Multiple Affiliations, Palo Alto, CA
Phenotypic cluster analysis of Juvenile Idiopathic Arthritis: relationship to ILAR classification criteriaBackground/Purpose: The ILAR classification of Juvenile Idiopathic Arthritis (JIA) delineated categories of childhood chronic…
Abstract Number: 268 • 2013 ACR/ARHP Annual Meeting
Inflammatory Bowel Disease In Juvenile Idiopathic Arthritis Patients Upon Biologics
Deborah Barthel¹ and Gerd Horneff², ¹Paediatrics, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, ²Department of Pediatrics, Centre of Pediatric Rheumatology, Sankt Augustin, Germany
Background/Purpose: Inflammatory bowel disease (IBD) is a matter of interest in patients with juvenile idiopathic arthritis (JIA) treated with biologics. Methods: Baseline demografics, clinical characteristics…
Abstract Number: 260 • 2013 ACR/ARHP Annual Meeting
Pain, Functional Impairment and Ultrasound Detected Changes In Patients With Erosive and Non-Erosive Hand Osteoarthritis
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka³ and Ladislav Senolt⁴, ¹Institute of Rheumatology, Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, 1st Medical Faculty, Charles University Prague, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…
Abstract Number: 261 • 2013 ACR/ARHP Annual Meeting
Concordance Of Hip Pain With Radiographic Hip Osteoarthritis In An Urban US Community: The Framingham Osteoarthritis Study
Kyu Chan Kim¹, David T. Felson², Katherine D. Linsenmeyer³, Ali Guermazi⁴, Steven C. Vlad⁵, Mary M. Clancy⁶ and Jingbo Niu⁷, ¹Internal Medicine and Rheumatology, Boston Medical Center, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Internal Medicine, Boston Medical Center, Boston, MA, ⁴Boston University, Boston, MA, ⁵Clinical Epidemiology, Boston University, Boston, MA, ⁶School of Medicine, Boston University, Boston, MA, ⁷Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: While it is well known that knee pain and radiographic knee osteoarthritis (OA) are often discordant, little is known of the concordance of hip…
Abstract Number: 262 • 2013 ACR/ARHP Annual Meeting
Is There a Role For Non-Mendelian Inheritance In Severe Osteoarthritis Of The Knee
Allen D. Sawitzke¹, Richard Pimentel², Jathine Wong², Helena Martinez³, Marta Herrero³, Josep Verges⁴ and Daniel O. Clegg⁵, ¹Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah, Salt Lake, UT, ³Pharmascience Division, Bioiberica S.A., Barcelona, Spain, ⁴Pharmacological Research Unit, Scientific Medical Department, Bioibérica, S.A., Barcelona, Spain, ⁵Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT
Background/Purpose: Although the etiopathogenesis of osteoarthritis of the knee remains largely unknown, it is clear that genetic risks are contributory. Traditional family, twin, case control…
Abstract Number: 263 • 2013 ACR/ARHP Annual Meeting
“Generalized Osteoarthritis”: A Systematic Review
Amanda E. Nelson¹, Michael W. Smith² and Yvonne M. Golightly³, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²Rheumatology, Saint Luke's Hospitals, Kansas City, MO, ³Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC
Background/Purpose: To perform a systematic review of definitions, risk factors, and outcomes in "generalized osteoarthritis" (GOA). Methods: We performed a systematic review of Medline literature…

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