Abstracts Archive - Page 2229 of 2425 - ACR Meeting Abstracts

Abstract Number: 314 • 2013 ACR/ARHP Annual Meeting
Impact Of Low Infliximab Dose Regimen On Treatment Response and Drug Survival In 462 Patients With Psoriatic Arthritis. Results From The Nationwide Registries Danbio and Icebio
Bente Glintborg^1,2, Bjorn Gudbjornsson^3,4, Niels Steen Krogh⁵, Emina Omerovic², Natalia Manilo⁶, Mette Holland-Fischer⁷, Hanne M. Lindegaard⁸, Anne Gitte Loft⁹, Henrik Nordin¹⁰, Laura Johnsen¹¹, Sussi Flejsborg Oeftiger¹², Annette Hansen¹³, Claus Rasmussen¹⁴, Gerdur Grondal¹⁵, Árni Jón Geirsson¹⁶ and Merete Lund Hetland^1,2,17, ¹The Danish Rheumatologic Database (DANBIO), Glostrup Hospital, Glostrup, Denmark, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, ³Department of Rheumatology, Center for Rheumatology Research (ICEBIO), Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland, ⁴Faculty of Medicine, University of Iceland, Reykjavik, Iceland, ⁵ZiteLab ApS, Copenhagen, Denmark, ⁶Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark, ⁷Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ⁸Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁹Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, ¹⁰Department of Infectious Diseases and Rheumatology, Rigshospitalet, Copenhagen, Denmark, ¹¹Department of Rheumatology, Helsingør and Hillerød Hospital, Hillerød, Denmark, ¹²Department of Rheumatology, Køge Hospital, Køge, East Timor, ¹³Department of Rheumatology, Gentofte University Hospital, Copenhagen, Denmark, ¹⁴Vendsyssel Teaching Hospital/Aalborg University, Hjoerring, Denmark, ¹⁵Department of Rheumatology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, ¹⁶Rheumatology, Department of Rheumatology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, ¹⁷Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark
Background/Purpose: International guidelines recommend that in psoriatic arthritis infliximab should be dosed with 5 mg/kg bodyweight every 8th week. Data on the use of lower…
Abstract Number: 315 • 2013 ACR/ARHP Annual Meeting
Long Term Outcomes In Psoriatic Arthritis 2; A Prospective Multicentre Observational Study Of Work Disability In Psoriatic Arthritis: First Report Of The Clinical and Socioeconomic Associations Of Work Disability In Psoriatic Arthritis
William Tillett¹, Gavin Shaddick², Ayman Askari³, Annie Cooper⁴, Paul Creamer⁵, Gavin Clunie⁶, Philip S. Helliwell⁷, Lesley Kay⁸, Eleanor Korendowych¹, Suzanne Lane⁹, Jonathon Packham¹⁰, Ragai Shaban¹¹, Lyn Williamson¹², Corinne deVries¹³ and Neil McHugh¹⁴, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Department of Mathematics, University of Bath, Bath, United Kingdom, ³Robert Jones and Agnes Hunt Hospital, Shrophire, United Kingdom, ⁴Rheumatology, Royal Hampshire County Hospital, Winchester, United Kingdom, ⁵Rheumatology, North Bristol NHS foundation trust, Bristol, United Kingdom, ⁶Rheumatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁷PsAID taskforce, EULAR, Zurich, Switzerland, ⁸Department of Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁹Rheumatology, Ipswich Hospital NHS Trust, Ipswich, United Kingdom, ¹⁰Rheumatology, Haywood Rheumatology Centre, Stoke-on-Trent, United Kingdom, ¹¹Rheumatology, Queen Alexandra Hospital, Portsmouth, United Kingdom, ¹²Rheumatology, Great Western Hospitals NHS Foundation Trust, Swindon, United Kingdom, ¹³Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ¹⁴Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that is associated with joint damage, impaired quality of life and high levels of work disability…
Abstract Number: 316 • 2013 ACR/ARHP Annual Meeting
Quantiferon-TB Test Can Be Usefull For Decision Of Anti-Tuberculosis Prophylaxis During Anti-TNF Treatment: Result Of Real Life
Umut Kalyoncu¹, Levent Kilic¹, Ahmet Cagkan Inkaya², Omer Karadag³, Sule Apras Bilgen⁴, Ali Akdogan⁴, Sedat Kiraz⁵ and Ihsan Ertenli³, ¹Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey, ²infectious disease, Hacettepe University, Faculty of Medicine, Ankara, Turkey, ³Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey, ⁵Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Anti-tumor necrosis factor (TNF) treatments may increase tuberculosis. Most of the national guidelines recommend tuberculin skin test (TST) for screening of latent tuberculosis. However,…
Abstract Number: 317 • 2013 ACR/ARHP Annual Meeting
Apremilast, An Oral Phosphodiesterase 4 Inhibitor, Is Associated With Long-Term (52-Week) Improvement In Tender and Swollen Joint Counts In Patients With Psoriatic Arthritis: Results From Three Phase 3, Randomized, Controlled Trials
Maurizio Cutolo¹, Philip J. Mease², Dafna D. Gladman³, Arthur Kavanaugh⁴, Adewale O. Adebajo⁵, Juan J. Gomez-Reino⁶, Jürgen Wollenhaupt⁷, Georg Schett⁸, Eric Lespessailles⁹, Kamal Shah¹⁰, ChiaChi Hu¹⁰, Randall M. Stevens¹⁰, Christopher J. Edwards¹¹ and Charles A. Birbara¹², ¹University of Genova, Genova, Italy, ²Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, ³University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴University of California San Diego, San Diego, CA, ⁵Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom, ⁶Hospital Clinico Universitario, Santiago, Spain, ⁷Schön Klinik Hamburg-Eilbek, Hamburg, Germany, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁹University of Orléans, Orléans, France, ¹⁰Celgene Corporation, Warren, NJ, ¹¹University of Southampton, Southampton, United Kingdom, ¹²University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Apremilast (APR), an oral phosphodiesterase 4 inhibitor, works intracellularly to modulate pro- and anti-inflammatory mediators. The PALACE 1, 2, and 3 trials compared the…
Abstract Number: 318 • 2013 ACR/ARHP Annual Meeting
Effect Of Brodalumab (AMG 827) On Pain and Physical Functioning In Patients With Psoriatic Arthritis
MC Genovese¹, Philip J. Mease², Hema Viswanathan³, Dina Chau³, JingYuan Feng³, Ngozi Erondu³ and Ajay Nirula³, ¹Stanford University, Palo Alto, CA, ²Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, ³Amgen Inc, Thousand Oaks, CA
Background/Purpose: Psoriatic arthritis (PsA) has a significant impact on health related quality of life (HRQoL). This analysis evaluated the efficacy of brodalumab, a human anti-IL-17…
Abstract Number: 319 • 2013 ACR/ARHP Annual Meeting
Secukinumab Shows Substantial Improvement In Both Psoriasis Symptoms and Physical Functioning In Moderate-To-Severe Plaque Psoriasis Patients With Psoriatic Arthritis: A Subanalysis Of a Phase 3, Multicenter, Double-Blind, Placebo-Controlled Study
Alice B. Gottlieb¹, Bardur Sigurgeirsson², Andrew Blauvelt³, Shephard Mpfofu⁴, Ruvie Martin⁵ and Charis Papavassilis⁴, ¹Tufts Medical Center, Boston, MA, ²University of Iceland, Kópavogur, Iceland, ³Oregon Health and Sciences University, Portland, OR, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Novartis Pharma AG, East Hanover, NJ
Background/Purpose: Since interleukin (IL)-17A has a potential role in the pathogenesis and chronic inflammation of psoriatic disease, with similar pathways impacting skin and joints, strategies…
Abstract Number: 288 • 2013 ACR/ARHP Annual Meeting
MRI Findings In Juvenile Spondyloarthopathy and Effects Of Treatment On Subsequent MRI
Clara Lin¹ and Diana Milojevic², ¹Pediatric Rheumatology, University of California-San Francisco, San Francisco, CA, ²Dept of Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: : The aim of our study was to describe pelvic MRI findings of juvenile spondyloarthopathy describe the treatment effects on subsequent MRIs in juvenile…
Abstract Number: 280 • 2013 ACR/ARHP Annual Meeting
Long-Term Safety and Efficacy Of Etanercept In Paediatric Subjects With Extended Oligoarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Or Psoriatic Arthritis
Tamas Constantin¹, Ivan Foeldvari², Jelena Vojinovic³, Gerd Horneff⁴, Ruben Burgos-Vargas⁵, Irina Nikishina⁶, Jonathan Akikusa⁷, Tadej Avcin⁸, Jeffrey Chaitow⁵, Elena Koskova⁹, Bernard Lauwerys¹⁰, Jack Bukowski¹¹, Chuanbo Zang¹², Joseph Wajdula¹², Deborah Woodworth¹², Bonnie Vlahos¹³, Alberto Martini¹⁴ and Nicolino Ruperto⁵, ¹Semmelweis University, Budapest, Hungary, ²Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ³Dept Pediatric Rheumatology, Clinical Center, School of Medicine University of Nis, Nis, Serbia, ⁴Department of Pediatrics, Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, ⁵PRINTO, Genoa, Italy, ⁶Pediatric Department, Scientific Research Institute of Rheumatology RAMS, Moskow, Moskow, Russia, ⁷Rheumatology, Royal Childrens Hospital, Parkville, Australia, ⁸The Ljubljana University Medical Centre, Pediatric Clinic, Ljubljana, Slovenia, ⁹National Institute of Rheumatic Diseases, Piestany, Slovakia, ¹⁰Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ¹¹Department of Specialty Care, Pfizer Inc, Collegeville, PA, ¹²Pfizer Inc., Collegeville, PA, ¹³Department of Specialty Care, Pfizer Inc., Collegeville, PA, ¹⁴Pediatria II, Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: Etanercept (ETN) is approved for the treatment of pediatric patients with the polyarticular subtype of juvenile idiopathic arthritis (JIA). In addition, based on the…
Abstract Number: 281 • 2013 ACR/ARHP Annual Meeting
GO-Kids Imaging Substudy: MRI Treatment Response To 30 Mg/m² 4-Weekly Subcutaneous injections Of Golimumab In Children With Polyarticular JIA – Preliminary Results Of The Open Label Portion
Nikolay Tzaribachev¹, Catrin Tzaribachev¹ and Bernd Koos², ¹Pediatric Rheumatology, PRI - Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, ²Clinic of Orthodontics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
GO-KIDS Imaging Substudy: MRI treatment response to 30 mg/m2 4-weekly subcutaneous injections of Golimumab in children with polyarticular JIA– preliminary results of the open label…
Abstract Number: 282 • 2013 ACR/ARHP Annual Meeting
Rates Of Flare-Free Survival In Juvenile Idiopathic Arthritis When Tapering Individual Components Of Tumor Necrosis Factor Inhibitor and Methotrexate Combination Therapy
Caroline Y Chang¹, Rika Meyer² and Andreas Reiff¹, ¹Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
Background/Purpose: Combination therapy of tumor necrosis factor inhibitors (TNFi) and methotrexate (MTX) is a well-established treatment that has dramatically changed outcomes in Juvenile Idiopathic Arthritis…
Abstract Number: 283 • 2013 ACR/ARHP Annual Meeting
Efficacy Of Biologic Treatments In Juvenile Idiopathic Arthritis With a Polyarticular Course: An Indirect Comparison
Laura Sawyer¹, Alex Diamantopoulos², Hermine Brunner³, Fabrizio De Benedetti⁴, Nicolino Ruperto⁵, Fred Dejonckheere⁶ and Caroline Keane⁷, ¹Symmetron Limited, London, United Kingdom, ²Symmetron Limited, Herts, United Kingdom, ³PRCSG, Cincinnati, OH, ⁴Division of Rheumatology, Department of Pediatric Medicine, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁵PRINTO, Genoa, Italy, ⁶F. Hoffmann-La Roche Ltd, Basel, Switzerland, ⁷Roche, Welwyn Garden City, United Kingdom
Background/Purpose: To date there are no head-to-head trials comparing the efficacy of biologic treatments for polyarticular-course JIA (pcJIA). The purpose of this study was to…
Abstract Number: 284 • 2013 ACR/ARHP Annual Meeting
What Is the Relative Priority of the ACR Pediatric Core Set Measures for Youth With Juvenile Idiopathic Arthritis and Their Parents?
Jaime Guzman¹, Oralia Gomez-Ramirez², Susanne M. Benseler³, Roberta A. Berard⁴, Rollin Brant⁵, Ciaran M. Duffy⁶, Roman Jurencak⁷, Kiem Oen⁸, Ross E. Petty⁹, Natalie J. Shiff¹⁰ and Lori B. Tucker¹¹, ¹Pediatric Rheum/Rm K4-122, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ²Anthropology, University of British Columbia, Vancouver, BC, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Children's Hospital of Western Ontario, London, ON, Canada, ⁵Statistics, University of British Columbia, Vancouver, BC, Canada, ⁶Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁷University of Ottawa, Ottawa, ON, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹Pediatric Rheumatology, BC Children's Hosptial, Vancouver, BC, Canada, ¹⁰Pediatric Rheumatology, University of Saskatchewan, Saskatoon, SK, Canada, ¹¹Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: The ACR has endorsed a core set of six measures to assess the course of JIA and the impact of treatment: active joint count,…
Abstract Number: 285 • 2013 ACR/ARHP Annual Meeting
Juvenile Idiopathic Arthritis Patients Demonstrate Alterations In HDL Functionality Without Accelerated Subclinical Atherosclerosis
Preethi Mani¹, Kiyoko Uno², Katherine Wolski³, Steven J. Spalding⁴, Stephen J. Nicholls⁵ and M. Elaine Husni⁶, ¹Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ²Cardiovascular medicine, Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, ⁴Pediatric Institute, Department of Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ⁵Clinical Research Heart & Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁶Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Previous literature supports an increase in cardiovascular (CV) morbidity and mortality in adults with inflammatory joint disease, however it is not known whether children with…
Abstract Number: 286 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Risk In Adults With Juvenile Idiopathic Arthritis
Elizabeth Coulson¹, Wan-Fai Ng², Philip N. Platt³ and H. E. Foster⁴, ¹Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ²Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ³Rheumatology, Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁴Paediatric Rheumatology, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom
Background/Purpose: Increased cardiovascular mortality and morbidity have been observed in adults with Rheumatoid Arthritis. The long-term risk of cardiovascular disease for individuals with Juvenile Idiopathic…
Abstract Number: 287 • 2013 ACR/ARHP Annual Meeting
Long-Term Evaluation Of Cardiac Function In Juvenile Idiopathic Arthritis Under Anti-Tumor Necrosis Factor Therapy
Alessandro C. Lianza¹, Nadia E. Aikawa², Julio C. B. Moraes³, Gabriela N. Leal⁴, Samira S. Morhy⁵, Eloisa Bonfa⁶ and Clovis A. Silva⁷, ¹Radiology, University of São Paulo, Sao Paulo, Brazil, ²Rheumatology, University of São Paulo, Sao Paulo, Brazil, ³Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Radiology Division, University of São Paulo, Sao Paulo, Brazil, ⁵Radiology Unit, University of São Paulo, Sao Paulo, Brazil, ⁶Rheumatology Division, University of São Paulo, Sao Paulo, Brazil, ⁷Children's Institute, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
Background/Purpose: Subclinical cardiac involvement was previously described in juvenile idiopathic arthritis (JIA) patients, however there is no data regarding echocardiography and cardiac biomarkers evaluations in…

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