ACR Meeting Abstracts

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  • Abstract Number: 338 • 2013 ACR/ARHP Annual Meeting

    Tailored Approach To Early Psoriatic Arthritis Patients: Ultrasonographic Predictors For Structural Joint Damage

    Yasser El Miedany1, Maha El Gaafary2, Sally Youssef3 and Annie Nasr4, 1Rheumatology, Medway Hospital, Gillingham, United Kingdom, 2Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt, 3Rheumatology & Rehabilitation, Ain Shams University, Cairo, Egypt, 4Radiology, Ain Shams University, Cairo, Egypt

    Background/Purpose:  To evaluate the use of musculoskeletal US as a predictor for inflammatory structural progression in psoriatic patients Methods: Measures of association (OR) were tested,…
  • Abstract Number: 339 • 2013 ACR/ARHP Annual Meeting

    The Association Between Obesity and Radiographic Progression Of Joint Damage Among Patients With Psoriatic Arthritis

    Lihi Eder1, Arane Thavaneswaran1, Vinod Chandran2, Richard J. Cook3 and Dafna D. Gladman2, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada

    Background/Purpose: The prevalence of obesity among patients with psoriatic arthritis (PsA) is increased compared to the general population. Obese patients with PsA tend to respond…
  • Abstract Number: 300 • 2013 ACR/ARHP Annual Meeting

    Higher Disease Activity In Psoriatic Arthritis Is Associated With Elevated Total Cholesterol and Triglycerides

    Monalyn Labitigan1, Asha Shrestha1, George W. Reed2,3, Robert P. Magner4, Nicole Jordan5, Joel M. Kremer6, Jeffrey D. Greenberg7, Asena Bahce-Altuntas5 and Anna R. Broder1, 1Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 2CORRONA, Inc., Southborough, MA, 3Orthopedics, University of Massachusetts Medical School, Worcester, MA, 4University of Massachusetts Medical School, Worcester, MA, 5Department of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 6Center for Rheumatology, Albany Medical College, Albany, NY, 7Departments of Medicine (Rheum Div) and Hospital for Joint Diseases, New York Hospital for Joint Diseases, New York, NY

    Background/Purpose: Psoriatic Arthritis (PsA) is linked to both obesity and an increased cardiovascular risk.  However, the relationship between PsA disease activity and lipids, a major cardiovascular…
  • Abstract Number: 301 • 2013 ACR/ARHP Annual Meeting

    Arthritis and Nail Involvement In Patients With Plaque-Type Psoriasis

    Odirlei Andre Monticielo1, Karen Regina Rosso Schons2, Cristiane Faccin Knob2, Walter Neumaier2, Maristela de Oliveira Beck2 and André Avelino Costa Beber2, 1Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, 2Universidade Federal de Santa Maria, Santa Maria, Brazil

    Background/Purpose: Psoriasis is a chronic disease that presents in individuals of all ages, affecting skin, nails and joints. Nail changes are estimated to be present…
  • Abstract Number: 302 • 2013 ACR/ARHP Annual Meeting

    Maintenance Of Efficacy and Safety Of Ustekinumab In Patients With Active Psoriatic Arthritis Despite Prior Conventional Nonbiologic and Anti-TNF Biologic Therapy:  1‑year Results Of a Phase 3, Multicenter, Double-Blind, Placebo-Controlled Trial

    Christopher T. Ritchlin1, Iain B. McInnes2, Arthur Kavanaugh3, Lluis Puig4, Proton Rahman5, Carrie Brodmerkel6, Shu Li6, Yaung-Kaung Shen6, Mittie K. Doyle6, Alan M. Mendelsohn7 and Alice B. Gottlieb8, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 3University of California, San Diego, La Jolla, CA, 4Universitat Autònoma de Barcelona, Barcelona, Spain, 5Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 6Janssen Research & Development, LLC., Spring House, PA, 7Immunology, Janssen Research & Development, LLC., Spring House, PA, 8Tufts Medical Center, Boston, MA

    Background/Purpose: Ustekinumab (UST) has demonstrated substantial efficacy and an acceptable safety profile, and is approved for use, in treating moderate-to-severe psoriasis. UST has also demonstrated…
  • Abstract Number: 303 • 2013 ACR/ARHP Annual Meeting

    Risk Of Cardiovascular Events In Patients With Psoriatic Arthritis, Psoriasis, and Rheumatoid Arthritis: A General Population-Based Cohort Study

    Alexis Ogdie1, Yiding Yu2, Kevin Haynes3, Samantha Maliha4, Thorvardur Love5,6, Andrea Troxel7, Sean Hennessy8, David Margolis9, Stephen Kimmel10, Nehal N. Mehta11, Hyon Choi12,13 and Joel Gelfand14, 1Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, 2Medicine, Brigham and Women's Hospital, Boston, MA, 3Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 4University of Pennsylvania, Philadelphia, PA, 5Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 6Landspitali University Hospital, Reykjavik, Iceland, 7Biostatistics and Epidemiology, University of Pennsylvania., Philadelphia, PA, 8Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 9Dermatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, 10Cardiology and Epidemiology, University of Pennsylvania, Philadelphia, PA, 11National Heart Lung Blood Institute, Cardiovascular and Pulmonary Division, NHLBI, National Institutes of Health, Bethesda, MD, 12Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 13Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, 14Dermatology and Epidemiology, University of Pennsylvania., Philadelphia, PA

    Risk of Cardiovascular Events in Patients with Psoriatic Arthritis, Psoriasis, and Rheumatoid Arthritis: A general population-based cohort studyBackground/Purpose: Psoriatic arthritis (PsA), psoriasis, and rheumatoid arthritis…
  • Abstract Number: 304 • 2013 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibodies In Patients With Psoriatic Arthritis: Clinical Relevance

    Doquyen H. Huynh1, Carol Etzel2, Vanessa Cox3, J. M. Kremer4, Jeffrey D. Greenberg5 and Arthur Kavanaugh6, 1Rheumatology, UC San Diego School of Medicine, San Diego, CA, 2CORRONA, Inc, Southborough, MA, 3General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, 4Albany Medical College and The Center for Rheumatology, Albany, NY, 5Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, 6University of California San Diego, San Diego, CA

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) have been considered a relatively specific marker for rheumatoid arthritis (RA), and may play a role in its pathogenesis. In…
  • Abstract Number: 305 • 2013 ACR/ARHP Annual Meeting

    Incidence of Herpes Zoster in Patients with Psoriatic Arthritis

    Devy Zisman1,2, Haim Bitterman1,3, Ilan Feldhamer4, Doron Comanesther4, Erez Battat4, Sari Greenberg-Dotan4, Sarit Cohen5 and Arnon-Dov Cohen4, 1Technion, The Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel, 2Rheumatology Unit, Carmel Medical Center, Haifa, Israel, 3Chief Physician's Office, Clalit Health Services, Haifa, Israel, 4Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel, 5Carmel Medical Center, Haifa, Israel

    Background/Purpose: To assess the incidence of Herpes Zoster (HZ) in patients with psoriatic arthritis (PsA) and its relation to treatment regimen:Traditional disease-modifying anti-rheumatic drugs (c-DMARDs)…
  • Abstract Number: 306 • 2013 ACR/ARHP Annual Meeting

    Responsiveness To Change Of a Global Ultrasound Assessment Score In Psoriatic Arthritis Patients

    Maria Laura Acosta Felquer1, Santiago Ruta1, Javier Rosa2, David A. Navarta3, Carla Saucedo1, Ricardo Garcia-Monaco4, Mirtha Sabelli2 and Enrique R. Soriano5, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Radiology and Imagenology Department, Hospital italiano de Buenos Aires, Buenos Aires, Argentina, 5Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina

    Background/Purpose: Psoriatic arthritis (PsA) manifests clinically in several ways, including arthritis, enthesitis, and dactylitis,.  Assessment of disease activity in PsA should ideally record each feature.…
  • Abstract Number: 307 • 2013 ACR/ARHP Annual Meeting

    Abnormal Imaging and Increased Osteoclast Precursors In a Psoriasis Cohort Are Associated with New Onset of Psoriatic Arthritis

    Ralf G. Thiele1, Yahui Grace Chiu1, Francisco A. Tausk2, Bethany A. Marston1, Gregory Dieudonne3, Vaseem Chengazi3, Michelle Smith1, Sharon Moorehead1, Rick Barrett1 and Christopher T. Ritchlin1, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Dermatology, University of Rochester, Rochester, NY, 3Radiology, University of Rochester, Rochester, NY

    Background/Purpose: Psoriasis (Ps) precedes joint inflammation by about 10 years in patients who develop psoriatic arthritis (PsA). Several studies have documented abnormal musculoskeletal imaging findings…
  • Abstract Number: 308 • 2013 ACR/ARHP Annual Meeting

    Cross-Cultural Adaptation, Validation and Reliability Of The Brazilian Version Of The Psoriatic Arthritis Screening Evaluation Tool

    Roberto Ranza1, Claudia G Schainberg2, Sueli Carneiro3, Gladys Martins4, Jose Joaquim Rodrigues5, Jamille Carneiro6, Ricardo Romiti7, Thiago B. M. Barros8, Ana Luiza Sampaio9, Amanda Pedreira9, Carolina Z Costa10, Rogerio MC Pinto11, M. Elaine Husni12 and Abrar A. Qureshi13, 1Universidade Federal de Uberlandia, Uberlandia MG, Brazil, 2Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 3Brazilian Registry of Spondyloarthritis, São Paulo, Brazil, 4Dermatologia Hospital Universitario Universidade de Brasilia, Brasilia, Brazil, 5Dermatologia, Universidade Federal de Uberlandia, Uberlandia, Brazil, 6Reumatologia, Universidade de Brasilia, Brasilia, Brazil, 7Dermatologia Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 8Rheumatology, Reumatologia Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 9Dermatologia Hospital Universitário e Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 10Reumatologia, Reumatologia, Universidade Federal de Uberlandia, Uberlandia, Brazil, 11Matematica, Matematica, Universidade Federal de Uberlandia, Uberlandia, Brazil, 12Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH, 13Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Psoriatic Arthritis (PsA) remains an under-diagnosed disease among patients with psoriasis (PsO). Dermatologists are not routinely trained to detect musculoskeletal manifestations hence arthritis, enthesitis…
  • Abstract Number: 309 • 2013 ACR/ARHP Annual Meeting

    Diagnostic Delay Of Even More Than 6 Months Contributes To Poor Radiographic and Functional Outcome In Psoriatic Arthritis

    Muhammad Haroon1, Phil Gallagher2 and Oliver FitzGerald1, 1Department of Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 2Rheumatology, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Diagnostic delay in Psoriatic Arthritis (PsA) is not uncommon with a recent study of psoriasis patients attending a dermatology clinic showing that 29% of…
  • Abstract Number: 310 • 2013 ACR/ARHP Annual Meeting

    Long-Term Safety and Tolerability Of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, In Patients With Psoriatic Arthritis: Pooled Safety Analysis Of Three Phase 3, Randomized, Controlled Trials

    Philip J. Mease1, Arthur Kavanaugh2, Dafna D. Gladman3, Adewale O. Adebajo4, Juan J. Gomez-Reino5, Jürgen Wollenhaupt6, Maurizio Cutolo7, Georg Schett8, Eric Lespessailles9, Kamal Shah10, ChiaChi Hu10, Randall M. Stevens10, Christopher J. Edwards11 and Charles A. Birbara12, 1Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, 2University of California San Diego, San Diego, CA, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom, 5Rheumatology, Hospital Clinico Universitario, Santiago, Spain, 6Schön Klinik Hamburg Eilbek, Hamburg, Germany, 7University of Genova, Genova, Italy, 8Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 9University of Orléans, Orléans, France, 10Celgene Corporation, Warren, NJ, 11University of Southampton, Southampton, United Kingdom, 12University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Apremilast (APR), an oral phosphodiesterase 4 inhibitor, works intracellularly to modulate inflammatory mediators. PALACE 1, 2, and 3 compared the efficacy and safety of…
  • Abstract Number: 311 • 2013 ACR/ARHP Annual Meeting

    Long-Term (52-Week) Results Of a Phase 3, Randomized, Controlled Trial Of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, In Patients With Psoriatic Arthritis and Current Skin Involvement (PALACE 3)

    Christopher J. Edwards1, Francisco J. Blanco2, Jeffrey Crowley3, ChiaChi Hu4, Randall M. Stevens4 and Charles A. Birbara5, 1University of Southampton, Southampton, United Kingdom, 2INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 3Bakersfield Dermatology, Bakersfield, CA, 4Celgene Corporation, Warren, NJ, 5University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Apremilast (APR), an oral phosphodiesterase 4 inhibitor, works intracellularly to modulate inflammatory mediators. PALACE 3 compared the efficacy/safety of APR with placebo (PBO) in…
  • Abstract Number: 313 • 2013 ACR/ARHP Annual Meeting

    The DC-STAMP+IL17A+ Cell Subset Is Elevated In Psoriatic Arthritis (PsA) Patients and Declines Following Anti-TNFi Therapy

    Yahui Grace Chiu1, Edward M. Schwarz2, Hua He3, Francisco A. Tausk4, Sharon Moorehead5, Michelle Smith5 and Christopher T. Ritchlin5, 1Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Biostatistics and Computational Biology, University of Rochester, Rochester, NY, 4Dermatology, University of Rochester, Rochester, NY, 5Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Approximately 25% of psoriasis (Ps) patients develop psoriatic arthritis (PsA), a potentially destructive joint disease, within 10 years of Ps onset. Although early diagnosis…
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