ACR Meeting Abstracts

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  • Abstract Number: 346 • 2013 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis, a More Severe Disease Than Psoriatic Arthritis? A Comparison Of Disease Activity In Patients With Psoriatic Arthritis and Rheumatoid Arthritis From The Swedish Early Psoriatic Arthritis Registry (SwePsA) and The Swedish Rheumatology Registry For Early RA (SRR)

    Gerd-Marie Alenius1, Tomas Husmark2, Elke Theander3, Per Larsson4, Mats Geijer5, Annika Teleman6 and Ulla R. C. Lindqvist7, 1Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, 2Department of Rheumatology, Falu Hospital, Falun, Sweden, 3Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 4Dept of Rheumatology, Karolinska University Hospital, Stockholm, Sweden, 5Skåne University Hospital, Lund, Center for Medical Imaging and Physiology, Lund, Sweden, 6Department of Rheumatology, Spenshult Hospital, Oskarstrom, Sweden, 7Department of Medical Sciences, Rheumatology, University Hospital, Uppsala university, Uppsala, Sweden

    Background/Purpose: In clinical practise patients with psoriatic arthritis (PsA) seem to have milder disease expression compared with patients having rheumatoid arthritis (RA). Studies have, however,…
  • Abstract Number: 347 • 2013 ACR/ARHP Annual Meeting

    Factors Explaining The Discrepancy Between Patient and Physician Global Assessment Of Disease Activity In Psoriatic Arthritis

    Lihi Eder1, Arane Thavaneswaran1, Vinod Chandran2, Richard J. Cook3 and Dafna D. Gladman2, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada

    Background/Purpose: Patients and physicians often perceive the extent of disease activity differently. We aimed to assess the factors contributing to the variability in scoring of…
  • Abstract Number: 348 • 2013 ACR/ARHP Annual Meeting

    Laboratory Abnormalities In Patients With Psoriatic Arthritis Receiving Apremilast, An Oral Phosphodiesterase 4 Inhibitor: Pooled Safety Analysis Of Three Phase 3, Randomized, Controlled Trials

    Philip J. Mease1, Arthur Kavanaugh2, Adewale O. Adebajo3, Juan J. Gomez-Reino4, Jürgen Wollenhaupt5, Dafna D. Gladman6, Maurizio Cutolo7, Georg Schett8, Eric Lespessailles9, Kamal Shah10, ChiaChi Hu10, Randall M. Stevens10, Christopher J. Edwards11 and Charles A. Birbara12, 1Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, 2University of California San Diego, San Diego, CA, 3Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom, 4Hospital Clinico Universitario, Santiago, Spain, 5Schön Klinik Hamburg-Eilbek, Hamburg, Germany, 6University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 7University of Genova, Genova, Italy, 8Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 9University of Orléans, Orléans, France, 10Celgene Corporation, Warren, NJ, 11NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 12University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Apremilast (APR), an oral phosphodiesterase 4 inhibitor, works intracellularly to modulate inflammatory mediators. The PALACE 1, 2, and 3 trials compared the efficacy and…
  • Abstract Number: 349 • 2013 ACR/ARHP Annual Meeting

    Serum CTX-I Predicts Systemic Bone Loss At The Hip Over 1 Year In Patients With Early Psoriatic Arthritis

    Agnes Szentpetery1, Mark Kilbane2, Myra P. O'Keane2, Muhammad Haroon3, Phil Gallagher4, Susan van der Kamp5, Malachi McMenna6 and Oliver FitzGerald3, 1Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 2Metabolism Laboratory, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 3Department of Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 4Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, 5DXA Unit, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 6Department of Endocrinology & Metabolic Bone Disease, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: There is a growing interest in bone and cartilage biomarkers that could be used predicting and assessing changes in structural damage in inflammatory arthritis.…
  • Abstract Number: 350 • 2013 ACR/ARHP Annual Meeting

    Cortical Bone Density As Measured By Digital X-Ray Radiogrammetry Correlates with Radiographic Joint Damage In The Hands Within 1 Year In Psoriatic Arthritis

    Agnes Szentpetery1, Muhammad Haroon2, Phil Gallagher3, Eric J. Heffernan4 and Oliver FitzGerald2, 1Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 2Department of Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 3Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, 4Radiology, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Structural destruction in peripheral joints may occur over time in both PsA and RA. We previously reported that 47% of early PsA patients treated…
  • Abstract Number: 351 • 2013 ACR/ARHP Annual Meeting

    Psoriatic Arthritis Mutilans: Clinical and Radiographic Definitions. A Systematic Review

    Amir Haddad1, Mansour Somaily2, Sindhu R. Johnson3, Rouhi Fazelzad4, Amie T. Kron5, Cathy Chau6 and Vinod Chandran7, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Medicine, Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Toronto General Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, 4Health Sciences Libraries - Toronto General Hospital, University Health Network, Toronto, ON, Canada, 5Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, 6Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 7Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic Arthritis Mutilans (PAM) is the most severe form of psoriatic arthritis. Research on PAM has been impeded by the lack of an accepted…
  • Abstract Number: 352 • 2013 ACR/ARHP Annual Meeting

    Efficacy and Safety Of Vaccination Against seasonal 2012 Influenza Virus Among Patients With Psoriatic Arthritis and Psoriasis

    Arik Polackek1, Yuri Korobko1, Noa Madar-Balakirski1, Uri Arad2, David Levartovsky3, Ilana Kaufman4, Marina Anouk5, Irena Litinsky6, Ella Mendelson7, Daphna Paran8, Hagit Matz9, Dan Caspi10, Michal Mandelbaum11 and Ori Elkayam12, 1Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel, 2Department of Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Rheumatology, Tel Aviv Medical Ctr, Tel Aviv, Israel, 4Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel-aviv, Israel, 5Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel, 6Department of Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel, 7Central Virology Laboratory, Sheba Medical Center, Ramat Gan, Israel, 8Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv university, Tel Aviv, Israel, 9Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 10Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 11Central Virology Department, Sheba Medical Center, Tel Aviv, Israel, 12Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel- Aviv, Israel

    Background/Purpose: Patients with psoriatic arthritis (PsA) and psoriasis (Pso) are considered to be immunosuppressed and are therefore recommended to receive vaccination against seasonal influenza. However,…
  • Abstract Number: 353 • 2013 ACR/ARHP Annual Meeting

    Time Interval Between The Onset Of Psoriasis and The Onset Of Psoriatic Arthritis May Define Disease Subsets

    Arane Thavaneswaran1, Vinod Chandran2 and Dafna D. Gladman2, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic Arthritis (PsA) is a heterogeneous disease with widely varying clinical features and outcomes. Phenotypic heterogeneity may reflect genetic heterogeneity. We aimed to investigate…
  • Abstract Number: 354 • 2013 ACR/ARHP Annual Meeting

    Disease Burden Among Patients With Psoriatic Arthritis Who Have Experienced First Line Tumor Necrosis Factor Inhibitor Regimen Failure In The European Union

    Siva Narayanan1, Yao Lu2, Richard Hutchings2 and Amanda Baskett2, 1Evidence Generation, Value and Access Center, Ipsos Healthcare, Columbia, MD, 2Ipsos Healthcare, London, United Kingdom

    Background/Purpose: Data on second line biologic patients who have experienced 1st line tumor necrosis factor inhibitor (TNF) failure and associated disease burden among patients (pts)…
  • Abstract Number: 355 • 2013 ACR/ARHP Annual Meeting

    Response To Etanercept With Or Without Methotrexate Combination Therapy In Patients With Psoriatic Arthritis

    Bernard Combe1, Urs Kerkmann2, Fiona Brock3 and Gaia Gallo2, 1Hôpital Lapeyronie-Service d'Immuno-rhumatologie, Montpellier, France, 2Pfizer Europe, Rome, Italy, 3Quanticate, Hitchin, Hertfordshire, United Kingdom

    Background/Purpose:  Randomized controlled trials in psoriatic arthrtitis (PsA) have allowed treatment with TNF inhibitors (TNFi) as monotherapy as well as co-medication with methotrexate (MTX), but…
  • Abstract Number: 356 • 2013 ACR/ARHP Annual Meeting

    Outcomes Of Patients With Rheumatoid Arthritis and Comorbid Hyperlipidemia

    L Rosenblatt1, JR Curtis2, G Yang1 and T Hebden3, 1Bristol-Myers Squibb, Plainsboro, NJ, 2University of Alabama at Birmingham, Birmingham, AL, 3Formerly of Bristol-Myers Squibb, Plainsboro, NJ

    Background/Purpose: Patients (pts) with RA have an increased prevalence of cardiovascular disease (CVD). Whether due to comorbidity or related to RA medications, many pts with…
  • Abstract Number: 358 • 2013 ACR/ARHP Annual Meeting

    Inflammatory Burden Predicts Carotid Plaque Progression and Subsequent Cardiovascular Events In Rheumatoid Arthritis: The 2-Year Prospective Cohort Study

    Churl Hyun Im1, Sang Hoon Kwon2, Jeong Soo Eun1, Na Ri Kim1, Eon Jeong Nam1 and Young Mo Kang3, 1Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 2Internal medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 3Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea

    Background/Purpose: Rheumatoid arthritis (RA) patients have increased prevalence of carotid atherosclerosis, especially plaque formation, which has been associated with inflammatory burden in a previous study.…
  • Abstract Number: 359 • 2013 ACR/ARHP Annual Meeting

    Tocilizumab Treatment Increases Left Ventricular Ejection Fraction and Decreases Left Ventricular Mass Index In Rheumatoid Arthritis Patients Without Cardiac Symptoms : Assessment By Cardiac Magnetic Resonance Imaging At 3.0 Tesla

    Hitomi Kobayashi1,2, Isamu Yokoe3, Hiroshi Sato2, Yasuyuki Kobayashi4, Kihei Yoneyama5, Masaharu Hirano6 and Masami Takei7, 1Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 2Rheumatology, Itabashi Chuo Medical Center, Tokyo, Japan, 3Nihon University School of Medicine, Tokyo, Japan, 4Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, 5Cardiology, St.Marianna University School of Medicine, Kawasaki, Japan, 6Cardiology, Tokyo Medical Colleage, Tokyo, Japan, 7Division of Hematology and Rheumatology, NIhon University School of Medicine, Tokyo, Japan

    Background/Purpose: Left ventricular (LV) dysfunction in rheumatoid arthritis (RA) may result, at least in part, from inflammation that may be regional and global. Therefore, therapies…
  • Abstract Number: 320 • 2013 ACR/ARHP Annual Meeting

    Sustained Improvement In Health-Related Quality Of Life, Work Productivity, Employability, and Reduced Healthcare Resource Utilization Of Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Treated With Golimumab: 5-Year Results From 3 Phase III Studies

    Chenglong Han1, Arthur Kavanaugh2, Mark C. Genovese3, Benjamin Hsu4, Atul A. Deodhar5 and Elizabeth C. Hsia4, 1Janssen Global Services, LLC., Malvern, PA, 2University of California, San Diego, La Jolla, CA, 3Division of Rheumatology, Stanford University, Palo Alto, CA, 4Janssen Research & Development, LLC., Spring House, PA, 5Div of Arthritis & Rheum OP-09, Oregon Health & Science University, Portland, OR

    Background/Purpose: To summarize changes from baseline in health-related quality of life (HRQOL), impact of disease on work productivity, employability, and healthcare resource utilization among patients…
  • Abstract Number: 321 • 2013 ACR/ARHP Annual Meeting

    Evaluation and Comparison Of Performance Of Different Classification Criteria For Reactive Arthritis

    Mariana Benegas1, Rafael Chaparro1, Oscar L. Rillo2, Luciana Casalla1, Emilce Schneeberger3, Federico Ceccatto4, Sergio Paira5, Federico Zazzetti6, Juan C. Barreira7 and Emilio Busquiazzo8, 1Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 2Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 3Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Rheumatology, Hospital Jose María Cullen, Santa Fé, Argentina, 5Hospital Jose María Cullen, Santa Fé, Argentina, 6Rheumatology, Hospital Británico, Buenos Aires, Argentina, 7Rheumatology, British Hospital, Buenos Aires, Argentina, 8Rheumatology, Hospital del Milagro, Salta, Argentina

    Background/Purpose: Reactive Arthritis (Re.A) is an inflammatory joint disease that according to different records represents from 6% to 47% of the seronegative spondyloarthropathies (SS). These…
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