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  • Abstract Number: 503 • 2013 ACR/ARHP Annual Meeting

    Sjögren’s Syndrome In American Ethnic and Racial Minorities

    Ann Igoe1, Christopher J. Lessard2,3, Juan-Manuel Anaya4, Astrid Rasmussen2, Kiely Grundahl5, Biji T. Kurien6,7,8, Jacen S Maier-Moore9, Lida Radfar10, John A. Ice2, Glen D. Houston11, David M. Lewis12, Donald U. Stone13, Kimberly S. Hefner14, Kathy L. Sivils2,3 and R. Hal Scofield6,8,15, 1Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, oklahoma CIty, OK, 6Oklahoma Medical Research Foundation, Oklahoma City, OK, 7U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 8College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 9Medicine; Arthritis & Clinical Immunology, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Department of Veterans Affairs, Oklahoma City, OK 73104, Oklahoma City, OK, 10College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 11Collage of Denistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 12College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 13Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 14Hefner Eye Care and Optical Center, Oklahoma City, OK, 15US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: Examine the racial and ethnic make-up of a large cohort of Sjögren’s syndrome (SS) gathered in the USA compared to the make-up found among…
  • Abstract Number: 504 • 2013 ACR/ARHP Annual Meeting

    Raynaud’s Phenomenon and African American Race Are Independently Associated With Non-Hodgkin’s Lymphoma In Sjogrens Syndrome Patients: Findings From a United States National Study

    Bella Mehta1, Neville Jadeja2, Marjan Mujib3 and Petros V. Efthimiou4, 1Internal Medicine, Westchester Medical Center at New York Medical College, valhalla, NY, 2Internal Medicine, Jacobi Medical Center, New York, NY, 3Internal Medicine, New York Medical College, Valhalla, NY, 4Medicine/Rheumatology, LM&MHC/Weill Cornell MC, New York, NY

    Background/Purpose: , Higher incidence of lymphoma in sjogrens syndrome has been reported since more than 5 decades now. Non Hodgkin's Lymphoma (NHL) ranks as the…
  • Abstract Number: 505 • 2013 ACR/ARHP Annual Meeting

    Damage Accrual In a Single Centre Cohort Of Patients With Primary Sjögren’s Syndrome Followed Up For Over 10 Years

    Chiara Baldini1, Francesco Ferro1, Pasquale Pepe2, Nicoletta Luciano1, Francesca Sernissi1, Carlotta Cacciatore1, Daniela Martini1, Antonio Tavoni3, Marta Mosca4 and Stefano Bombardieri1, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2Institute of Clinical Physiology, National Research Council, Pisa, Italy, 3University of Pisa, Immunoallergology Unit, Pisa, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: 1) To describe  the progression and cumulative prevalence of damage accrued over the time in a single center cohort of patients with primary Sjögren’s…
  • Abstract Number: 506 • 2013 ACR/ARHP Annual Meeting

    Hospitalization In Patients With Primary Sjögren’s Syndrome

    Yemil Atisha-Fregoso1, Yahaira Rivera2 and Gabriela Hernandez-Molina2, 1Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: There is scant information on the frequency, main causes and associated risk factors of hospitalization in patients with primary Sjögren syndrome (PSS).We aimed to…
  • Abstract Number: 507 • 2013 ACR/ARHP Annual Meeting

    Level Of Agreement Of The AECG 2002 and ACR 2012 Classification Criteria For Sjögren’s Syndrome In The Brittany Cohort: Clues To Understand Discrepancies

    Divi Cornec1, Alain Saraux2, Jacques-Olivier Pers3, Sandrine Jousse-Joulin4, Yves Renaudineau3, Beatrice Cochener5, Thierry Marhadour6 and Valerie Devauchelle-Pensec7, 1Department of rheumatology, Brest Occidentale University, Brest, France, 2Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, 3Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, 4Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, 5Department of ophtalmology, Brest Occidentale University, Brest, France, 6Rheumatology, CHU de la Cavale Blanche, Brest, France, 7Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France

    Background/Purpose: New classification criteria for primary Sjögren’s syndrome (pSS) have been proposed in 2012 and approved by the ACR. They differ substantially from the currently…
  • Abstract Number: 508 • 2013 ACR/ARHP Annual Meeting

    Is Ultrasonography Of Salivary Gland a Validate Tool In Sjögren Syndrome? Study 1: Interobserver Reliability Between International Group Of Experts

    Sandrine Jousse-Joulin1, Vera Milic2, Elke Theander3, Malin V. Jonsson4, Wan-Fai Ng5, Chiara Baldini6, Marina Carotti7, Alan N. Baer8, Joel Fradin9, Pascale Rachele10, Hendrika Bootsma11, Jacqueline Brown12, Nicoletta Luciano6, S Bombardieri13, Roland Jonsson14, Salvatore De Vita15, Alojzija Hocevar16, Matija Tomsic17,18, Alain Saraux19, Emmanuel Nowak20, Alessandro Ciapetti Sr.21, Arjan Vissink22, John Rout23, Thomas Mandl24, Simon J. Bowman25 and Valerie Devauchelle-Pensec26, 1Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, 2rheumatology, belgrade university, belgrade, Serbia, 3Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 4Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, 5Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 6University of Pisa, Rheumatology Unit, Pisa, Italy, 7Rheumatology and radiology, Ospedali Riuniti, Ancona, Italy, 8Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 9Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 10radiology, university of Pisa, Pisa, Italy, 11Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 12dental division, Tower Wing Guy's hospital, london, United Kingdom, 13Department of Clinical and Experimental Medicine, Department of Rheumatology, University of Pisa, Pisa, Pisa, Italy, 14Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 15Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, 16Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 17Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia, 18Faculty of Medicine, Unversity Ljubljana, Ljubljana, Slovenia, 19Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, 20CIC, CHU Brest, Brest, France, 21Department of Rheumatology, Politechnic University of the Marche, Ancona, Ancona, Italy, 22Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 23Birmingham Dental Hospital, Birmingham, United Kingdom, 24Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden, 25Department of Rheumatology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, 26Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France

    Background/Purpose: Ultrasonography (US) of salivary glands is a relatively new test to diagnose primary Sjögren syndrome (pSS)1-6. In 2012, an international group of interest was…
  • Abstract Number: 509 • 2013 ACR/ARHP Annual Meeting

    A Novel Screening Tool Indicative Of Primary Sjogren’s Syndrome Versus Sicca Symptoms

    Gerard Dumancas1, Michael Brown2, Indra Adrianto1, Christopher J. Lessard1, Jennifer A. Kelly1, Kiely Grundahl3, Astrid Rasmussen1, R. Hal Scofield4, Courtney Montgomery5 and Kathy L. Sivils1,6, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, oklahoma CIty, OK, 4US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 5Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjogren's syndrome (SS) is a chronic, progressive disease characterized by dry eyes and dry mouth resulting from lymphocytic infiltration of the lacrimal and salivary…
  • Abstract Number: 510 • 2013 ACR/ARHP Annual Meeting

    Multicentric Analysis Of Inter and Intra Observer Reliabilities For Histopathological Abnormalities In Salivary Gland Biopsy In Primary Sjögren Syndrome

    Sebastian Costa1, Isabelle Quintin Roue2, Agnes Lesourd2, Sandrine Jousse-Joulin3, Pascale Marcorelles4, Eric Hachulla5, Vincent Goeb6, Marie-Christine Copin7, Jean-Marie Berthelot8, Jacques-Olivier Pers9, Olivier Vittecoq10, Emmanuel Nowak11, Alain Saraux12 and Valerie Devauchelle-Pensec13, 1anatomopathological department, Brest university hospital, Brest, France, 2anatomopathological department, Morvan hospital, Brest, France, 3Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, 4anatomopathological department, Brest university hospital, CHU Morvan, Brest, France, 5Internal Medicine, Lille CEDEX, France, 6Rheumatology, Amiens University Hospital, Amiens, France, 7anatomopathological department, Lille university, Lille, France, 8Rheumatology Unit, Nantes University Hospital, Nantes, France, 9Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, 10Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, 11CIC, CHU Brest, Brest, France, 12Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, 13Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France

    Background/Purpose: : Histopathologic evaluation of minor labial salivary gland (MLSG) is a major goal for the classification of patients with a primary Sjögren syndrome (pSS)…
  • Abstract Number: 511 • 2013 ACR/ARHP Annual Meeting

    Salivary Gland Lymphocyte Pattern Associated With Response To Belimumab In Primary sjogren’ssyndrome: Results Of The Beliss Study

    Raphaèle Seror1, Thierry Lazure2, Frederic Desmoulins3, Stephan Pavy4, Corinne Miceli-Richard5, Gabriel Baron6, Philippe Ravaud7 and Xavier Mariette8, 1Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 2Pathology, INSERM U1012 - Université Paris XI, Le Kremlin Bicêtre, France, 3Rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, Le Kremlin Bicetre, France, 4Rheumatology, Hopital Bicetre, Paris, France, 5Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, 6Hotel Dieu University Hospital Paris, Epidemiology, Paris, France, 7Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 8Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France

    Background/Purpose: To address the change in labial salivary gland (LSG) inflammation after Belimumab (biological treatment inhibiting soluble BAFF/BLyS) therapy in pSS patients and identify predictor…
  • Abstract Number: 512 • 2013 ACR/ARHP Annual Meeting

    The Significance Of Ectopic Germinal Center In Minor Salivary Gland Of Patients With Sjögren’s Syndrome

    Kyung-Eun Lee1, Dong-Jin Park1, Jeong-Won Lee2, Ji-Hyoun Kang2, Lihui Wen1, Tae-Jong Kim3, Yong-Wook Park1 and Shin-Seok Lee4, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Chonnam National University Medical School, Gwangju, South Korea, 3Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 4Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose: To investigate whether the presence of germinal center (GC) in minor salivary glands of patients with Sjögren’s syndrome (SS) is associated with different clinical…
  • Abstract Number: 513 • 2013 ACR/ARHP Annual Meeting

    Diagnostic Value Of Labial Minor Salivary Gland Biopsy For Primary Sjögren’s Syndrome

    Raquel Altoe1, Valeria Valim2, Maria Carmem S. Santos3, Erica V. Serrano1 and Samira T. Miyamoto4, 1Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, 2Clínica Médica - Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, 3Farmacologia, Universidade de Vila Velha, Vitória, Brazil, 4Educação Integrada em Saúde - Reumatologia, Universidade Federal do Espírito Santo, Vitoria, Brazil

    Background/Purpose: The presence of lymphocytic infiltrate with ≥ 1 focus score/4mm2 in minor salivary gland is a useful tool for the diagnosis of Sjögren's syndrome…
  • Abstract Number: 514 • 2013 ACR/ARHP Annual Meeting

    EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) Is Increased In Sjögren’s Syndrome Patient With Fibromyalgia

    Valeria Valim1, Samira T. Miyamoto2, Mauricio Paganotti3, Erica V. Serrano4 and Raquel Altoe4, 1Clínica Médica - Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, 2Educação Integrada em Saúde - Reumatologia, Universidade Federal do Espírito Santo, Vitoria, Brazil, 3Farmacologia, Universidade de Vila Velha, Vitória, Brazil, 4Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil

    Background/Purpose: The EULAR Sjögren’s Syndrome Patient Reported Index(ESSPRI) is a patient-reported index designed to assess the severity of patients’ symptoms such as dryness, pain and…
  • Abstract Number: 515 • 2013 ACR/ARHP Annual Meeting

    Does Multiplex Flow Immunoassay Underdetect SSA and SSB Antibodies? An Evaluation Of The Sjogren’s International Collaborative Clinical Alliance (SICCA) Cohort

    Alan N. Baer1, Laura Gutierrez2, Mara McAdams DeMarco3, Mi Y. Lam4, Livia Casciola-Rosen5, Stephen Shiboski6, Caroline Shiboski4 and Lindsey A. Criswell7, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Center Tower Ste 5300, Johns Hopkins University, Baltimore, MD, 3Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 4Orofacial Sciences, University of California San Francisco, San Francisco, CA, 5Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 6University of California, San Francisco, San Francisco, CA, 7Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA

    Background/Purpose:   Multiplex flow immunoassays (MFIA) are used by clinical laboratories to test for antibodies to extractable nuclear antigens. The use of blended Ro52 and…
  • Abstract Number: 516 • 2013 ACR/ARHP Annual Meeting

    Prevalence Of Seronegative Sjogren’s Syndrome: A Comparative Study From The Sjogren’s International Collaborative Clinical Alliance (SICCA) Cohort

    Alan N. Baer1, Laura Gutierrez2, Mara McAdams DeMarco3, Mi Y. Lam4, Livia Casciola-Rosen5, Stephen Shiboski6, Caroline Shiboski4 and Lindsey A. Criswell7, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Center Tower Ste 5300, Johns Hopkins University, Baltimore, MD, 3Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 4Orofacial Sciences, University of California San Francisco, San Francisco, CA, 5Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 6University of California, San Francisco, San Francisco, CA, 7Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA

    Background/Purpose:   Individuals with primary Sjogren’s syndrome (SS) may lack systemic autoantibodies. When defined by the absence of anti-SSA and –SSB antibodies, the reported range…
  • Abstract Number: 517 • 2013 ACR/ARHP Annual Meeting

    Antibody Responses To Oral Bacteria In Patients With Primary Sjögren’s Syndrome and Comparison With Rheumatoid Arthritis and Periodontitis

    Bozo Lugonja1, Michael Milward2, Diana Pearson3, Thomas Dietrich4, Iain Chapple5, John Hamburger6, Francesca Barone1, Saaeha Rauz7, Lorraine Yeo8, Ana Povedo-Gallego9, Geraint Williams7, Paola de Pablo1, Andrea Richards9, Christopher D. Buckley1, Dagmar Scheel-Toellner8 and Simon J. Bowman10, 1Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, 2Dept of Periodontology, University of Birmingham, Birmingham, United Kingdom, 3Dept of Periodontology, Birmingham Dental Hospital, Birmingham, United Kingdom, 4School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 5Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom, 6Dept of Oral Medicine, School of Dentistry, University of Birmingham, Birmingham, United Kingdom, 7Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom, 8Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, 9Dept of Oral Medicine, Birmingham Dental Hospital, Birmingham, United Kingdom, 10Department of Rheumatology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

    Background/Purpose: We set out to examine peripheral blood antibody ELISA responses to common oral bacteria in primary Sjögren’s syndrome (pSS) to identify potential bacterial triggers…
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