Abstracts Archive - Page 2213 of 2425 - ACR Meeting Abstracts

Abstract Number: 554 • 2013 ACR/ARHP Annual Meeting
Identification Of Stage Specific Genes Associated With Lupus Nephritis and Response To Remission induction In NZB/W Mice
Ramalingam Bethunaickan¹, Celine C. Berthier², Hong-dong Li³, Weijia Zhang⁴, Yuanfang Guan⁵, Matthias Kretzler⁶ and Anne Davidson⁷, ¹Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ⁴Mount Sinai School of Medicine, New York, NY, ⁵Department of Computational Medicine and Bioinformatics, Department of Medicine, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁷Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Our goal was to use transcriptome analysis to elucidate the molecular mechanisms involved in the immunopathogenesis of renal inflammation during the onset, remission and…
Abstract Number: 555 • 2013 ACR/ARHP Annual Meeting
Therapeutic Inhibition Of Anti-Apoptotic BCL-2 Family Proteins In a Murine Model Of Lupus Nephritis
Li Chun Wang¹, Stuart Perper², Danise Perron³, Edit Tarcsa⁴, Philip Bardwell³, Neelufar Mozaffarian⁵, Andrew Souers⁵, Steven Elmore⁶, Tariq Ghayur⁷ and Lisa Olson³, ¹Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²Pharmacology, AbbVie Bioresearch Center, Inc, Worcester, MA, ³Immunology, AbbVie Bioresearch Center, Inc, Worcester, MA, ⁴Immunology, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie, North Chicago, IL, ⁶AbbVie Inc, North Chicago, IL, ⁷AbbVie Bioresearch Center, Inc, Worcester, MA
Background/Purpose: Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed…
Abstract Number: 556 • 2013 ACR/ARHP Annual Meeting
Depletion Of The Gut Microbiota Prevents β₂-Glycoprotein I Antibody Production and Mortality In a Model Of Antiphospholipid Syndrome
Silvio M. Vieira¹, Andrew Yu¹, Odelya E. Pagovich¹, Eleni Tiniakou², John Sterpka¹ and Martin A. Kriegel^3,4, ¹Yale School of Medicine, New Haven, CT, ²Yale University School of Medicine, New Haven, CT, ³Immunobiology, Yale School of Medicine, New Haven, CT, ⁴Medicine/Division of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: Infectious triggers have been implicated in transient antiphospholipid antibody production in both mice and humans. The cause of persistent anti-β2-glycoprotein I (β2GPI) antibody production…
Abstract Number: 557 • 2013 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase 4 Ameliorates Th17 Related Autoimmune Disorder
Tomohiro Koga¹, Christian Hedrich¹, Masayuki Mizui², Nobuya Yoshida³, Linda Lieberman⁴, José C. Crispin¹ and George C. Tsokos⁵, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-17-producing T helper (Th17) cells have been causally linked to tissue inflammation in several autoimmune diseases including lupus and multiple sclerosis. Blockade of Th17…
Abstract Number: 558 • 2013 ACR/ARHP Annual Meeting
Fli-1 Regulates Immune Cell Infiltration Through Affecting Local Chemokine Expression and IL-6 Expression In The Kidney Of Lupus Prone Mice
Shuzo Sato¹, Sarah Williams², Eva Karam³ and Xian Zhang⁴, ¹Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Ralph H. Johnson VA Medical Center, Charleston, SC, ³Medicine, Medical University of South Carolina, Charleston, SC, ⁴Medicine, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: Fli-1 expression level, a member of the Ets family of transcription factors, is a mitigating factor in the development of nephritis in murine models…
Abstract Number: 559 • 2013 ACR/ARHP Annual Meeting
Effects Of In Vivo Treatment With Hydroxychloroquine On Endothelial Function In a Murine Model Of Systemic Lupus Erythematosus
Marta Mosca¹, Chiara Tani², Sabrina Vagnani³, Linda Carli^3,4, Rosaria Talarico⁵, Chiara Baldini⁵, Stefano Bombardieri³ and Agostino Virdis⁶, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴GenOMeC PhD, University of Siena, Siena, Italy, ⁵University of Pisa, Rheumatology Unit, Pisa, Italy, ⁶Department of Clinical and Experimental Medicine. University of Pisa, Hypertension Unit, University of Pisa, Pisa, Italy
Background/Purpose: Antimalarial drugs are a cornerstone of treatment of systemic lupus erythematosus (SLE). It has been suggested that antimalarial drugs may have a protective effect…
Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting
Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury
Lauren Bourke¹, James McCormick², Vera Ripoll³, Charis Pericleous⁴, Anna Radziszewska⁵, Anastasis Stephanou⁶ and Yiannis Ioannou⁷, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ⁵The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, ⁷Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 561 • 2013 ACR/ARHP Annual Meeting
Acyl-CoA Synthetase 1 Expression Is Increased In Murine Models Of Lupus As Well As In Human Systemic Lupus Erythematosus
Eyal Kedar¹, Shelley Barnhart², Keith B. Elkon³ and Karin Bornfeldt², ¹Rheumatology, University of Washington, Seattle, WA, ²Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, ³Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: The enzyme acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into their biologically active acyl-CoA derivatives. It is induced by lipopolysaccharide and cytokines (including…
Abstract Number: 531 • 2013 ACR/ARHP Annual Meeting
Influenza Infection Of MHC-I Transgenic Mice Reveals That Erap Is Necessary and Sufficient For Generation Of The B27-Specific Immunodominant Epitope
Ali Akram¹ and Robert Inman², ¹Institute of Medical Science and Department of Immunology, University of Toronto and University Health Network (UHN), Toronto, ON, Canada, ²Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Although HLA-B27 and ERAP are known to confer susceptibility to spondyloarthritis (SpA), the role of these elements in modulating host response to infection is…
Abstract Number: 534 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Gene Expression Profiling Of Psoriatic Arthritis Patient
Bidisha Dasgupta, Yauheniya Cherkas, Sarah Lamberth and Carrie Brodmerkel, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: Although PsA is heterogeneous and shows signs of rheumatoid arthritis (RA) and psoriasis (PsO), genetic studies indicate that PsA is a distinct disease with…
Abstract Number: 539 • 2013 ACR/ARHP Annual Meeting
Effects Of ERAP1 Knockdown On HLA Class I and HLA-B27 Expression In Human Monocytic U937 Cells
Tri M. Tran, Sohee Hong and Robert A. Colbert, NIAMS/NIH, Bethesda, MD
Background/Purpose: Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with susceptibility to ankylosing spondylitis in HLA-B27 (B27) positive individuals, implying a functional interaction…
Abstract Number: 521 • 2013 ACR/ARHP Annual Meeting
Respiratory Compromise In Patients With Primary Sjögren Syndrome
Evangelina Maria Miretti¹, Maria Haye Salinas², Francisco Caeiro¹, Anastasia Secco³, Antonio Catalan Pellet⁴, Paula Pucci⁵, Cecilia Asnal⁶, Catherine Crow⁷, Cristina Amitrano⁸, Alejandro Nitsche⁸, Silvia Papassidero⁹, Oscar L. Rillo¹⁰, Federico Zazzetti¹¹, Juan C. Barreira¹², Mariano Rivero¹², Damián Duartes Noé¹³, Hugo A. Laborde¹³, Natalia Tamborenea¹⁴, Eduardo Albiero¹⁵, Maria Renata Seisdedos¹⁶, Carla Gobbi¹⁷, Paula Alba¹⁸, Pablo Astesana¹⁹, Gabriela Salvatierra²⁰ and Veronica Saurit¹, ¹Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ²Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina, ³Rheumathology, Hospital Bernardino Rivadavia, Buenos aires, Argentina, ⁴Rheumatology, Hospital Rivadavia, Buenos Aires, Argentina, ⁵Rheumatology, Aleman Hospital, Argentina, buenos Aires, Argentina, ⁶Rheumatology, Argerich, Buenos Aires, Argentina, ⁷Rheumatology, Hospital Alemán, Buenos aires, Argentina, ⁸Rheumatology, Hospital Alemán, Buenos Aires, Argentina, ⁹Rheumatology, Hospital Tornú, Buenos Aires, Argentina, ¹⁰Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ¹¹Rheumatology, Hospital Británico, Buenos Aires, Argentina, ¹²Rheumatology, British Hospital, Buenos Aires, Argentina, ¹³Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina, ¹⁴Rheumatology, OMI, Buenos Aires, Argentina, ¹⁵Rheumatology, Sanatorio Allende de Córdoba, Córdoba, Argentina, ¹⁶Rheumatology, Rivadavia Hospital, Buenos Aires, Argentina, ¹⁷Rheumatology, Sanatorio Allende de Córdoba, Cordoba, Argentina, ¹⁸Rheumatology, Hospital Córdoba, Córdoba, Argentina, ¹⁹Sanatorio Allende, cordoba, Argentina, ²⁰Rheumatology, Centro de enfermedades Reumaticas, Santiago Del Estero, Argentina
Background/Purpose: Sjögren's syndrome (SS) is an autoimmune inflammatory disease that affects exocrine glands and may have extraglandular involvement. The respiratory compromise (RC) occurs in 19%…
Abstract Number: 522 • 2013 ACR/ARHP Annual Meeting
Abatacept Reduces Disease Activity In Early Primary Sjögren’s Syndrome:One Year Results From a Phase II Open-Label Study
PM Meiners¹, A Vissink², Fkl Spijkervet³, EA Haacke⁴, WH Abdulahad⁵, E Brouwer⁵, MG Huitema⁵, N Sillevis Smitt-Kamminga⁶, FGM Kroese⁷, S Arends⁵ and H Bootsma⁵, ¹Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁴Pathology, University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁶Opthalmology, University Medical Center Groningen, Groningen, Netherlands, ⁷Rheumatology and clinical immunology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Traditional DMARDs have limited effects in primary Sjögren's (pSS) patients. B cell depletion therapy with rituximab showed efficacy, but had some side-effects. T and…
Abstract Number: 523 • 2013 ACR/ARHP Annual Meeting
Association Between The Presence Of Amyloidosis In Patients With Ankylosing Spondylitis and Polymorphisms In Type 1/Type 2 Serum Amyloid A Protein Genes, Mediterranean Fever Genes
Gozde Yildirim Cetin¹, Eda Ganiyusufoglu², Dilek Solmaz³, Yonca Cagatay⁴, Sibel Yilmaz Oner⁵, Burak Erer⁶, Hasan Sabit Sagliker⁷, Ali Berkant Avci⁸, Servet Akar³, Omer Nuri Pamuk⁹, Metin Kilinc², Timucin Kasifoglu¹⁰, Haner Direskeneli⁵ and Mehmet Sayarlioglu¹¹, ¹Deparment of Rheumatology, Sutcu Imam University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey, ²Sutcu Imam University, School of Medicine, Department of Biochemistry Research Laboratory, Kahramanmaras, Turkey, ³Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, ⁴Department of Rheumatology, Bilim University Faculty of Medicine, Istanbul, Turkey, ⁵Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ⁶Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine,, Istanbul, Turkey, ⁷Sutcu Imam University, School of Medicine, Department of Internal Medicine, Kahramanmaras, Turkey, ⁸Antalya University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Antalya, Turkey, ⁹Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey, ¹⁰Rheumatology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey, ¹¹Rheumatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is a chronic autoinflammatory disease. The most severe complication of this disease is development of renal amyloidosis. The etiology of AS remains…
Abstract Number: 524 • 2013 ACR/ARHP Annual Meeting
Expansion Of DC-STAMP⁺ IL-17⁺ Cells In Bone Marrow From Psoriasis and Psoriatic Arthritis Patients
Yahui Grace Chiu¹, Edward M. Schwarz², Jamie Biear¹, Debbie Campbell³, Jennifer Hossler¹, Jennifer H. Anolik⁴, R. John Looney¹ and Christopher T. Ritchlin¹, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Allergy, Immunology and Rheumatology, Univerity of Rochester, Rochester, NY, ⁴Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Focal erosions in inflammatory arthritis are mediated by bone marrow (BM) derived osteoclasts (OC) that enter the joint as OC precursors (OCP) from peripheral…

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