Abstract Number: 559 • 2013 ACR/ARHP Annual Meeting
Effects Of In Vivo Treatment With Hydroxychloroquine On Endothelial Function In a Murine Model Of Systemic Lupus Erythematosus
Background/Purpose: Antimalarial drugs are a cornerstone of treatment of systemic lupus erythematosus (SLE). It has been suggested that antimalarial drugs may have a protective effect…Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting
Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…Abstract Number: 561 • 2013 ACR/ARHP Annual Meeting
Acyl-CoA Synthetase 1 Expression Is Increased In Murine Models Of Lupus As Well As In Human Systemic Lupus Erythematosus
Background/Purpose: The enzyme acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into their biologically active acyl-CoA derivatives. It is induced by lipopolysaccharide and cytokines (including…Abstract Number: 531 • 2013 ACR/ARHP Annual Meeting
Influenza Infection Of MHC-I Transgenic Mice Reveals That Erap Is Necessary and Sufficient For Generation Of The B27-Specific Immunodominant Epitope
Background/Purpose: Although HLA-B27 and ERAP are known to confer susceptibility to spondyloarthritis (SpA), the role of these elements in modulating host response to infection is…Abstract Number: 534 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Gene Expression Profiling Of Psoriatic Arthritis Patient
Background/Purpose: Although PsA is heterogeneous and shows signs of rheumatoid arthritis (RA) and psoriasis (PsO), genetic studies indicate that PsA is a distinct disease with…Abstract Number: 539 • 2013 ACR/ARHP Annual Meeting
Effects Of ERAP1 Knockdown On HLA Class I and HLA-B27 Expression In Human Monocytic U937 Cells
Background/Purpose: Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with susceptibility to ankylosing spondylitis in HLA-B27 (B27) positive individuals, implying a functional interaction…Abstract Number: 521 • 2013 ACR/ARHP Annual Meeting
Respiratory Compromise In Patients With Primary Sjögren Syndrome
Background/Purpose: Sjögren's syndrome (SS) is an autoimmune inflammatory disease that affects exocrine glands and may have extraglandular involvement. The respiratory compromise (RC) occurs in 19%…Abstract Number: 522 • 2013 ACR/ARHP Annual Meeting
Abatacept Reduces Disease Activity In Early Primary Sjögren’s Syndrome:One Year Results From a Phase II Open-Label Study
Background/Purpose: Traditional DMARDs have limited effects in primary Sjögren's (pSS) patients. B cell depletion therapy with rituximab showed efficacy, but had some side-effects. T and…Abstract Number: 523 • 2013 ACR/ARHP Annual Meeting
Association Between The Presence Of Amyloidosis In Patients With Ankylosing Spondylitis and Polymorphisms In Type 1/Type 2 Serum Amyloid A Protein Genes, Mediterranean Fever Genes
Background/Purpose: Ankylosing spondylitis (AS) is a chronic autoinflammatory disease. The most severe complication of this disease is development of renal amyloidosis. The etiology of AS remains…Abstract Number: 524 • 2013 ACR/ARHP Annual Meeting
Expansion Of DC-STAMP+ IL-17+ Cells In Bone Marrow From Psoriasis and Psoriatic Arthritis Patients
Background/Purpose: Focal erosions in inflammatory arthritis are mediated by bone marrow (BM) derived osteoclasts (OC) that enter the joint as OC precursors (OCP) from peripheral…Abstract Number: 525 • 2013 ACR/ARHP Annual Meeting
Evidence For Enhanced Induction Of Unfolded Protein Response Target Genes In Peripheral Blood Mononuclear Cells From Spondyloarthritis Patients
Background/Purpose: Spondyloarthritis (SpA) is an immune-mediated inflammatory disease strongly associated with HLA-B27 (B27). In a transgenic rat model where B27 causes SpA-like disease, CD8 T…Abstract Number: 526 • 2013 ACR/ARHP Annual Meeting
Endochondral Bone Formation and Advanced Enthesitis Are Key Features Of Proteoglycan Induced Spondylitis Mouse Model Of Ankylosing Spondylitis
Background/Purpose: Transition from an initial inflammatory phase to the disabling osteoproliferative phase in ankylosing spondylitis (AS) is very poorly understood. Elucidation of the mechanisms underlying…Abstract Number: 527 • 2013 ACR/ARHP Annual Meeting
Presence Of Gastrointestinal Symptoms and Autoantibodies In Patients With Spondyloarthritis In A Colombian Population
Background/Purpose: The frequency of gastrointestinal (GI) involvement in spondyloarthritis (SpA) ranges from 21% to 30% and 5% to 10% are associated with inflammatory bowel disease…Abstract Number: 528 • 2013 ACR/ARHP Annual Meeting
Upregulated Th17 and Innate Pathways Are More Characteristic Of The Skin Than The Synovium In Psoriatic Arthritis
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory joint disease associated with psoriasis. There is little understanding of the relative levels of cytokines and chemokines between…Abstract Number: 529 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis and Dysfunctional Dkk
Background/Purpose: Ankylosing Spondylitis (AS) is characterized by inflammation of the spine and entheses followed by formation of syndesmophytes. Wnt pathway is a regulator of bone…