Abstracts Archive - Page 2212 of 2425 - ACR Meeting Abstracts

Abstract Number: 576 • 2013 ACR/ARHP Annual Meeting
Monitoring Of Opportunistic Virus Infections In Systemic Lupus Erythematosus
Lorenzo Cavagna¹, Sandra Calarota², Eva Scorletti³, Roberto Caporali⁴, Francesca Rovida⁵, Carlomaurizio Montecucco¹ and Fausto Baldanti⁵, ¹Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ²Molecular Virology Unit, Virology and Microbiology Department, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy, ³Division of Rheumatology, University and IRCCS Foundation Policlinico S. Matteo, Pavia, Italy, ⁴Division of Rheumatology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy, ⁵Molecular Virology Unit, Virology and Microbiology Department, IRCCS Foundation Policlinico S. Matteo,, Pavia, Italy
Background/Purpose: due to disease characteristics and treatment approaches, systemic lupus erythematosus (SLE) patients are at high risk of opportunistic virus infections, as for example Epstein…
Abstract Number: 577 • 2013 ACR/ARHP Annual Meeting
Is An Excess Risk Of Attention Deficit Hyperactivity Disorder In Children Born To Women With SLE Mediated By In Utero Drug Exposures? Preliminary Data From The O S L E R Cohort
Evelyne Vinet¹, Susan Scott², Christian A. Pineau³, Lawrence Joseph⁴, Ann E. Clarke⁵, Eric Fombonne⁶, Robert W. Platt⁴ and Sasha Bernatsky⁷, ¹McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, ⁶Oregon Health and Sciences University, Portland, OR, ⁷Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada
Background/Purpose: Women with SLE display autoantibodies (e.g. anti-N-methyl-D-aspartate receptor antibodies) and cytokines (e.g. interleukin-6), which, in animal models, alter fetal brain development and induce behavioural…
Abstract Number: 578 • 2013 ACR/ARHP Annual Meeting
Ultrasonographic Findings and Inter-Observer Reliability In Danish Patients With Systemic Lupus Erythematosus – a Comparison With Clinical Examination Of Wrist and Hand Joints
Lene Dreyer¹, Søren Jacobsen², Lars Juul³ and Lene Terslev⁴, ¹Internal Medicine - Rheumatology Section, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, ²Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ³Department of Rheumatology, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, ⁴Copenhagen University Hospital at Glostrup, Copenhagen, Denmark
Background/Purpose: Patients with systemic lupus erythematosus (SLE) frequently encounter problems of musculoskeletal origin including arthralgia, tenosynovitis and arthritis in varying degrees of severity. Some patients…
Abstract Number: 545 • 2013 ACR/ARHP Annual Meeting
Preferential Infiltration Of Double-Negative (DN) T Cells Into The Glomeruli Of NZM 2328 Lupus Mice
Ning Yu, Shunhua Guo, William Stohl and Chaim O. Jacob, Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: Lupus nephritis affects at least 50% of patients with SLE and is a major cause of morbidity. The pathologic picture of lupus nephritis is…
Abstract Number: 542 • 2013 ACR/ARHP Annual Meeting
Evidence For Involvement Of C5a Receptor in Human and Murine Lupus Nephritis
Constanze Hess¹, Ditte Tornehave², Peter Helding Kvist², Yvonne Sundström³, Louise Berg³, Iva Gunnarsson⁴, Søren Jacobsen⁵, Claus Haase¹ and Lars Hornum¹, ¹Department of Immunopharmacology, Novo Nordisk A/S, Måløv, Denmark, ²Department of Histology, Novo Nordisk A/S, Måløv, Denmark, ³Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Background/Purpose: The complement system plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Apart from the activation of the early components of…
Abstract Number: 543 • 2013 ACR/ARHP Annual Meeting
Inhibiting TWEAK (TNF-like weak inducer of apoptosis) Signaling Improves Blood Brain Barrier Integrity and Protects From Neuronal Damage In Murine Neuropsychiatric Lupus
Jing Wen¹, Jessica Doerner², Ariel Stock¹, Jennifer Michaelson³, Linda Burkly³, Maria Gulinello¹ and Chaim Putterman⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ³Biogen Idec, Cambridge, MA, ⁴The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by involvement of multiple organs, including the central nervous system. While neuropsychiatric involvement in…
Abstract Number: 544 • 2013 ACR/ARHP Annual Meeting
Ultraviolet-B Induced Plasmacytoid Dendritic Cell Migration and Type 1 Interferon Signaling In The Skin
Clayton Sontheimer¹, Thomas H. Teal², Nalini Agrawal², Denny Liggitt³ and Keith B. Elkon⁴, ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Comparative Medicine, University of Washington, Seattle, WA, ⁴Department of Medicine & Immunology, University of Washington, Seattle, WA
Background/Purpose: Plasmacytoid dendritic cells (pDCs) are highly specialized cells of the innate immune system that secrete very high levels of interferon alpha (IFN-a) following nucleic…
Abstract Number: 546 • 2013 ACR/ARHP Annual Meeting
The Survival Of Gr1⁺CD11b⁺cells Is Differentially Regulated In Male and Female Lupus-Prone Mice
Elena Gonzalez^1,2, Trine Jorgensen² and Abhishek Trigunaite², ¹Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, ²Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Systemic Lupus Erythematosis (SLE) is a multisystem autoimmune disease that develops far more frequently in females than in males (9:1 ratio). The (NZBxNZW)F1 lupus-prone…
Abstract Number: 547 • 2013 ACR/ARHP Annual Meeting
Anti Ribosomal P Antibodies Accelerate Lupus Glomerulonephritis and Induce Lupus Nephritis In Naive Mice
Dana Ben-Ami Shor¹, Miri Blank², Sandra Reuter³, Torsten Matthias⁴, Alexander Volkov⁵, Iris Barshack⁶ and Yehuda Shoenfeld⁷, ¹Zabludowicz Center for Autoimmune Diseases, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Sackler Faculty of Medicine,Tel Aviv University, Tel-Aviv, Tel-Aviv, Israel, ³AIRA e.V., AESKU.KIPP Institute, Wendelsheim, Germany, ⁴AESKU.Diagnostics GmbH & Co. KG, Wendelsheim, Germany, ⁵Institute of Pathology, Sheba Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Tel-Aviv, Israel, ⁶Institute of Pathology, Sheba Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel, ⁷Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel
Background/Purpose: Circulating anti-phosphoribosomal protein antibodies (anti-Ribos.P) were found to be associated with lupus nephritis. We have assessed the direct role of anti-Ribos.P in the development…
Abstract Number: 548 • 2013 ACR/ARHP Annual Meeting
Characterizing The Role Of The Granulocyte Colony Stimulating Factor Pathway In a Mouse Model Of Systemic Lupus Erythematosus
Laurence Morel¹ and Ramya Sivakumar², ¹Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL, ²Pathology, University of Florida, Gainesville, FL
Background/Purpose: Originally considered primarily a B cell disorder, lupus pathogenicity has recently been linked to enhanced functions of neutrophils. The genetic analysis of the lupus…
Abstract Number: 549 • 2013 ACR/ARHP Annual Meeting
Augmented Megakaryopoiesis Supports Accumulation Of Plasma Cells In Lupus-Prone Mice
Oliver Winter¹, Niels-Peter Becker², Stephanie Musiol², Katrin Moser³, Falk Hiepe⁴ and Rudolf A. Manz⁵, ¹Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ²Charité - University Medicine Berlin, Berlin, Germany, ³German Arthritis Research Center (DRFZ Berlin), Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ⁵Institute for Systemic Inflammation Research (ISEF), University of Lübeck, Lübeck, Germany
Background/Purpose: Autoantibodies - secreted by short- and long-lived plasma cells in bone marrow and spleen - trigger the immune response, and immune complex deposits in…
Abstract Number: 550 • 2013 ACR/ARHP Annual Meeting
Neutrophil Gelatinase Associated Lipocalin (NGAL/Lipocalin-2) Regulates the Onset Of Serum Autoantibodies In Pristane Induced Lupus
Rahul Pawar¹, Beatrice Goilav², Yumin Xia¹, Haoyang Zuang³, Leal Herlitz⁴, Westley H. Reeves⁵ and Chaim Putterman⁶, ¹Albert Einstein College of Medicine, Bronx, NY, ²Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ³University of Florida, Gainesville, FL, ⁴The Department of Pathology, Columbia University Medical Center, New York, NY, ⁵Medicine, University of Florida, Gainesville, FL, ⁶The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: NGAL (lipocalin-2), a member of the lipocalin superfamily, is expressed by a variety of cells including neutrophils, hepatocytes, alveolar epithelial cells and renal resident…
Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting
Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…
Abstract Number: 552 • 2013 ACR/ARHP Annual Meeting
Inhibitor Of Differentiation 3, A Transcription Factor Regulates Susceptibility To Kidney Disease
Dominika Nackiewicz¹, Ani Manichaikul², Barbara Szczerba³, Paromita Dey³, Stephen Rich², Coleen McNamara⁴, Umesh Deshmukh¹ and Harini Bagavant³, ¹Medicine, University of Virginia, Charlottesville, VA, ²Center for Public Genomics, University of Virginia, Charlottesville, VA, ³Department of Medicine, University of Virginia, Charlottesville, VA, ⁴University of Virginia, Charlottesville, VA
Background/Purpose: Responses of renal cells to pathogenic stimuli play an important role in dictating susceptibility to kidney disease. Inhibitor of differentiation 3, ID3, is a…
Abstract Number: 553 • 2013 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Deficiency Protects Against Development Of Cognitive Impairment In Murine Lupus
Melissa A. Cunningham¹, Jena Wirth¹, Heather A. Boger², Ann-Charlotte Granholm-Bentley³ and Gary S. Gilkeson⁴, ¹Med/Rheumatology, MUSC, Charleston, SC, ²Neuroscience, Medical University of SC, Charleston, SC, ³Neuroscience, MUSC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Up to 80% of SLE patients have cognitive defects or affective disorders. The mechanism of CNS injury responsible for cognitive impairment is unknown. Anti-dsDNA…

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