Abstract Number: 543 • 2013 ACR/ARHP Annual Meeting
Inhibiting TWEAK (TNF-like weak inducer of apoptosis) Signaling Improves Blood Brain Barrier Integrity and Protects From Neuronal Damage In Murine Neuropsychiatric Lupus
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by involvement of multiple organs, including the central nervous system. While neuropsychiatric involvement in…Abstract Number: 544 • 2013 ACR/ARHP Annual Meeting
Ultraviolet-B Induced Plasmacytoid Dendritic Cell Migration and Type 1 Interferon Signaling In The Skin
Background/Purpose: Plasmacytoid dendritic cells (pDCs) are highly specialized cells of the innate immune system that secrete very high levels of interferon alpha (IFN-a) following nucleic…Abstract Number: 546 • 2013 ACR/ARHP Annual Meeting
The Survival Of Gr1+CD11b+ cells Is Differentially Regulated In Male and Female Lupus-Prone Mice
Background/Purpose: Systemic Lupus Erythematosis (SLE) is a multisystem autoimmune disease that develops far more frequently in females than in males (9:1 ratio). The (NZBxNZW)F1 lupus-prone…Abstract Number: 547 • 2013 ACR/ARHP Annual Meeting
Anti Ribosomal P Antibodies Accelerate Lupus Glomerulonephritis and Induce Lupus Nephritis In Naive Mice
Background/Purpose: Circulating anti-phosphoribosomal protein antibodies (anti-Ribos.P) were found to be associated with lupus nephritis. We have assessed the direct role of anti-Ribos.P in the development…Abstract Number: 548 • 2013 ACR/ARHP Annual Meeting
Characterizing The Role Of The Granulocyte Colony Stimulating Factor Pathway In a Mouse Model Of Systemic Lupus Erythematosus
Background/Purpose: Originally considered primarily a B cell disorder, lupus pathogenicity has recently been linked to enhanced functions of neutrophils. The genetic analysis of the lupus…Abstract Number: 549 • 2013 ACR/ARHP Annual Meeting
Augmented Megakaryopoiesis Supports Accumulation Of Plasma Cells In Lupus-Prone Mice
Background/Purpose: Autoantibodies - secreted by short- and long-lived plasma cells in bone marrow and spleen - trigger the immune response, and immune complex deposits in…Abstract Number: 550 • 2013 ACR/ARHP Annual Meeting
Neutrophil Gelatinase Associated Lipocalin (NGAL/Lipocalin-2) Regulates the Onset Of Serum Autoantibodies In Pristane Induced Lupus
Background/Purpose: NGAL (lipocalin-2), a member of the lipocalin superfamily, is expressed by a variety of cells including neutrophils, hepatocytes, alveolar epithelial cells and renal resident…Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting
Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females
Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…Abstract Number: 552 • 2013 ACR/ARHP Annual Meeting
Inhibitor Of Differentiation 3, A Transcription Factor Regulates Susceptibility To Kidney Disease
Background/Purpose: Responses of renal cells to pathogenic stimuli play an important role in dictating susceptibility to kidney disease. Inhibitor of differentiation 3, ID3, is a…Abstract Number: 553 • 2013 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Deficiency Protects Against Development Of Cognitive Impairment In Murine Lupus
Background/Purpose: Up to 80% of SLE patients have cognitive defects or affective disorders. The mechanism of CNS injury responsible for cognitive impairment is unknown. Anti-dsDNA…Abstract Number: 554 • 2013 ACR/ARHP Annual Meeting
Identification Of Stage Specific Genes Associated With Lupus Nephritis and Response To Remission induction In NZB/W Mice
Background/Purpose: Our goal was to use transcriptome analysis to elucidate the molecular mechanisms involved in the immunopathogenesis of renal inflammation during the onset, remission and…Abstract Number: 555 • 2013 ACR/ARHP Annual Meeting
Therapeutic Inhibition Of Anti-Apoptotic BCL-2 Family Proteins In a Murine Model Of Lupus Nephritis
Background/Purpose: Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed…Abstract Number: 556 • 2013 ACR/ARHP Annual Meeting
Depletion Of The Gut Microbiota Prevents β2-Glycoprotein I Antibody Production and Mortality In a Model Of Antiphospholipid Syndrome
Background/Purpose: Infectious triggers have been implicated in transient antiphospholipid antibody production in both mice and humans. The cause of persistent anti-β2-glycoprotein I (β2GPI) antibody production…Abstract Number: 557 • 2013 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase 4 Ameliorates Th17 Related Autoimmune Disorder
Background/Purpose: IL-17-producing T helper (Th17) cells have been causally linked to tissue inflammation in several autoimmune diseases including lupus and multiple sclerosis. Blockade of Th17…Abstract Number: 558 • 2013 ACR/ARHP Annual Meeting
Fli-1 Regulates Immune Cell Infiltration Through Affecting Local Chemokine Expression and IL-6 Expression In The Kidney Of Lupus Prone Mice
Background/Purpose: Fli-1 expression level, a member of the Ets family of transcription factors, is a mitigating factor in the development of nephritis in murine models…