Abstract Number: 580 • 2013 ACR/ARHP Annual Meeting
Lupus Nephritis Flares Precipitated By Switching From Mycophenolate Mofetil to Azathioprine in Pre-Pregnancy Planning
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that affects women of childbearing age. Lupus nephritis is a major cause of morbidity and…Abstract Number: 581 • 2013 ACR/ARHP Annual Meeting
Predictive Value Of The Autoantibody Triad Of Anti-Ro, Anti-Sm and Anti-RNP For The Future Development Of Lupus Nephritis
Background/Purpose: Autoantibody production against nuclear components is a characteristic feature of SLE. Autoantibody clustering may provide a valuable tool to differentiate between clinical subsets and…Abstract Number: 562 • 2013 ACR/ARHP Annual Meeting
The Knock-Out Of TWEAK Receptor/Fn14 Ameliorates Lupus Nephritis In MRL/Lpr Mice
Background/Purpose: Renal mesangial cells, podocytes, and tubular cells express Fn14, the sole confirmed receptor for the tumor necrosis factor (TNF)-family member cytokine TWEAK (TNF-like weak…Abstract Number: 563 • 2013 ACR/ARHP Annual Meeting
Hold The Rituximab: Neuropsychiatric Disease In Murine Lupus Is Not B-Cell Dependent
Background/Purpose: Neuropsychiatric disease is one of the earliest clinical manifestations in systemic lupus erythematosus (SLE). However, the mechanisms leading to neuropsychiatric SLE (NPSLE) are not…Abstract Number: 564 • 2013 ACR/ARHP Annual Meeting
Role of TLR3 and dsRNA Hyper-Responsiveness in the Generation of the Lupus-Like Phenotype of New Zealand Black Congenic Mice
Background/Purpose: New Zealand Black (NZB) mice develop a spontaneous lupus-like autoimmune disease, similar to human systemic lupus erythematosus. Genetic mapping studies have linked loci on…Abstract Number: 565 • 2013 ACR/ARHP Annual Meeting
Differential Efficacy Of Human Mesenchymal Stem Cells On Disease In Murine Lupus Based On Source Of Origin
Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that targets multiple organ systems. Current treatment options for SLE often cause non-specific immune suppression,…Abstract Number: 566 • 2013 ACR/ARHP Annual Meeting
A Human Monoclonal Antibody Against Domain I Of β2-Glycoprotein I prevents Clotting and Fetal Loss Induced By Polyclonal Anti-Phospholipid Antibodies In Animal Models
Background/Purpose: Anticoagulant, antiplatelet or immunosuppressive therapy are currently used to treat the clinical manifestations of the anti-phospholipid syndrome (APS). Side effects or recurrences in spite…Abstract Number: 567 • 2013 ACR/ARHP Annual Meeting
Contribution Of Marginal Zone B Cells To Autoimmunity In The B6.Sle1.Sle2.Sle3 Lupus Prone Mouse
Background/Purpose: We used the B6.Sle1.Sle2.Sle3 triple congenic (TC) mouse, which expresses three lupus susceptibility loci derived from NZM2410 onto the C57BL/6 (B6) background, to investigate…Abstract Number: 568 • 2013 ACR/ARHP Annual Meeting
Pneumococcal Polysaccharide Vaccination Regulates T and B Lymphocyte Cytokine Responses and Decreases Kidney Stat1 Levels In MRL/Lpr Mice In Vivo
Background/Purpose: Zwitterionic polysaccharides can activate CD4+ T cells after processing and presentation by antigen-presenting cells. The 23-valent capsular polysaccharide pneumococcal vaccine, PneumoVax, protects against invasive…Abstract Number: 569 • 2013 ACR/ARHP Annual Meeting
Hydroxycholorquine Is Cardioprotective In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury.-An Effect Mediated Through ERK Phosphorylation
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…Abstract Number: 570 • 2013 ACR/ARHP Annual Meeting
In Vivo Therapeutic Success Of Microrna-155 (miR-155) Antagomir In a Mouse Model Of Lupus Pulmonary Hemorrhage
Background/Purpose: MiR-155 is a typical pleiotropic miRNA that participates in various aspects of immunity. Previous in vitro studies indicated that it is both a pro-inflammatory and an anti-inflammatory…Abstract Number: 571 • 2013 ACR/ARHP Annual Meeting
Protective Effect Of Inducible Adeno-Associated Virus Mediated IL-2 Gene Therapy On Tissue Damages In Lupus-Prone Mice
Background/Purpose: IL-2 plays critical roles not only in immune responses but also in peripheral tolerance. Impairment of IL-2 production has been linked to the development…Abstract Number: 572 • 2013 ACR/ARHP Annual Meeting
Immunization With Hepatitis B Vaccine Accelerates SLE-Like Disease In An Animal Model
Background/Purpose: Hepatitis-B vaccine (HBVv) was proven to be successful and cost effective in preventing HBV infection and associated liver disease. However, in recent years concerns…Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting
Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…Abstract Number: 575 • 2013 ACR/ARHP Annual Meeting
Association Of Psoriasis and Psoriatic Arthritis With Systemic Lupus Erythematosus
Background/Purpose: There is a paucity of literature on the prevalence of psoriasis (Ps) and psoriatic arthritis (PsA) in patients with systemic lupus erythematosus (SLE). To…
ACR Meeting Abstracts