Abstracts Archive - Page 2211 of 2607 - ACR Meeting Abstracts

Abstract Number: 333 • 2014 ACR/ARHP Annual Meeting
Deletion of the Prolactin Receptor Aggravates the Course of Antigen-Induced Arthritis
Norma Adan, Maria G. Ledesma-Colunga, Ana L. Reyes-Lopez, Fernando Lopez-Barrera, Gonzalo Martinez de la Escalera and Carmen Clapp, Institute of Neurobiology, National University of Mexico (UNAM), Queretaro, Mexico
Background/Purpose: Prolactin (PRL), the hormone essential for lactation, may protect against joint damage in rheumatoid arthritis. PRL frequently increases in the circulation of patients with…
Abstract Number: 332 • 2014 ACR/ARHP Annual Meeting
Improvement of the Stability of RNA Aptamers Against Interleukin-17A
Natsuki Otaki¹, Asako Sasaki¹, Shinsuke Hiramoto¹, Masakazu Nagamine¹, Shigeyuki Mori¹, Tomoyoshi Kayo¹, Kuniyoshi Hota¹, Masayuki Takahashi¹, Kazuhiko Haruta² and Yoshikazu Nakamura^3,4, ¹Zenyaku Kogyo Co., Ltd., Tokyo, Japan, ²2-33-7 Oizumi, Nerima, Zenyaku Kogyo Co., Ltd., Tokyo, Japan, ³Division of RNA Medical Science, The Institute of Medical Science, The University Of Tokyo, Tokyo, Japan, ⁴RIBOMIC Inc., Tokyo, Japan
Background/Purpose Aptamers are RNA or DNA oligonucleotides selected for their capacity to specifically bind and inhibit the function of a target protein. The effect is…
Abstract Number: 330 • 2014 ACR/ARHP Annual Meeting
Prolactin Reduces Bone Erosion in Adjuvant-Induced Arthritis
Maria G. Ledesma-Colunga, Norma Adan, Ana L. Reyes-Lopez, Fernando Lopez-Barrera, Gonzalo Martinez de la Escalera and Carmen Clapp, Institute of Neurobiology, National University of Mexico (UNAM), Queretaro, Mexico
Background/Purpose Bone erosion is an important feature of rheumatoid arthritis (RA) that frequently results in lifelong crippling. The receptor activator of NFkB ligand (RANKL)/osteoprotegerin (OPG)/RANK…
Abstract Number: 329 • 2014 ACR/ARHP Annual Meeting
A Novel, Small Molecule Cyclin-Dependent Kinase 4/6 Inhibitor As the New Option for Treatment of Rheumatoid Arthritis
Hiroshi Takahashi¹, Tsuyoshi Mizuno¹, Toshimichi Nakamura¹, Yuri Sakai¹, Yumiko Muroga¹, Kyohei Horie¹, Naoki Hase¹, Hitoshi Kohsaka² and Tsuyoshi Kimura¹, ¹Teijin Pharma Limited, Hino,Tokyo, Japan, ²Department of Rheumatology, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose The pathogenesis of rheumatoid arthritis (RA) is characterized by infiltration of immune cells to the synovial tissues and their hyperplasia. Therapeutic strategies to inhibit…
Abstract Number: 328 • 2014 ACR/ARHP Annual Meeting
Etanercept, Abatacept and Anakinra Treatment Ameliorates Inflammation and Pain in a Novel Mono-Arthritic Multi-Flare Model of Streptococcal Cell Wall Induced Arthritis: Further Characterization in a Rodent Model of Collagen Induced Arthritis
Kalyan Chakravarthy¹, Robert Faltus¹, Anwar Murtaza¹ and Milenko Cicmil², ¹Pharmacology, Merck Research Laboratories, Boston, MA, ²Merck Research Laboratories, Boston, MA
Background/Purpose: We developed a novel mono-arthritic multi-flare Rat Streptococcal Cell Wall (SCW) model which captures certain aspects of disease with flares and remission of inflammation…
Abstract Number: 327 • 2014 ACR/ARHP Annual Meeting
AMPK Activation in Inflammatory Arthritis
Monica Guma¹, Yun Wang² and Ru Liu-Bryan², ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²UCSD/VAMC, La Jolla, CA
Background/Purpose: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular energy homeostasis. It is a central regulator of both…
Abstract Number: 326 • 2014 ACR/ARHP Annual Meeting
IL-1 Receptor Antagonis (IL-1Ra)-Fc Ameliorate Autoimmune Arthritis By Regulation of the Th17 Cells/Treg Balance and Arthrogenic Cytokine Activation
Hong Ki Min¹, Sung Hwan Park², Mi-La Cho³, Ji Hyeon Ju¹, Seung-Ki Kwok⁴, Seon-Yeong Lee³, Seung Min Jung¹, Kyung-Su Park⁵ and Jennifer Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, St. Mary’s hospital, The Catholic University of Korea, Seoul, South Korea, ⁵Internal Medicine, St. Vincent Hospital, SuWon Gyeonggi-do, South Korea
Background/Purpose: : IL-1ß signalling has critical role on pathogenesis of various inflammatory arthritis including rheumatoid arthritis (RA). We aimed to investigate the therapeutic effects of…
Abstract Number: 325 • 2014 ACR/ARHP Annual Meeting
Tadalafil Decreases Joint Inflammation in TNF-Tg Mice By Restoring Passive Lymphatic Transport
Echoe M. Bouta¹, Igor Kuzin², Ronald Wood³, Christopher T. Ritchlin⁴, Andrea Bottaro² and Edward M. Schwarz⁵, ¹University of Rochester, Rochester, NY, ²Cooper Medical School, Camden, NJ, ³Department of Urology, University of Rochester Medical Center, Rochester, NY, ⁴Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with enigmatic episodic flares. Using longitudinal imaging, we recently demonstrated that arthritic knee flare in…
Abstract Number: 324 • 2014 ACR/ARHP Annual Meeting
Regulation of TNF-α-Mediated Activation of Rheumatoid Synovial Fibroblasts By Transcription Factor Snail
Chrong-Reen Wang^1,2, Shih-Yao Chen³, Ai-Li Shiau⁴, I-Ming Jou^5,6, Ming-Fei Liu^1,2 and Chao-Liang Wu³, ¹Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁵Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, ⁶Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan
Background/Purpose: Transcription factor Snail plays active roles in various biological functions and is involved in many disease states. We hypothesized that this molecule regulates TNF-α-mediated…
Abstract Number: 323 • 2014 ACR/ARHP Annual Meeting
Anti-Inflammatory Marine Compound, Lyy-B2, Ameliorates Rheumatoid Arthritis through Inhibition of Osteoclast Differentiation
Yen-You Lin¹, Hsin-Pai Lee^1,2, Shi-Ying Huang¹, Han-Chun Hung³, Chien-Wei Feng³, Chun-Hong Chen³, Jui-Hsin Su^4,5, Ping-Jyun Sung^4,5, Jyh-Horng Sheu^1,3, Yen-Hsuan Jean² and Zhi-Hong Wen^1,3, ¹Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung, Taiwan, ²Section of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung, Taiwan, ³Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung, Taiwan, ⁴Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung, Taiwan, ⁵Taiwan Coral Research Center, National Museum of Marine Biology & Aquarium, Pingtung, Taiwan
Background/Purpose: Osteoclasts are multinucleated giant cells of macrophage/monocyte lineage, and are believed to play major roles in joint destruction caused by rheumatoid arthritis (RA). Nuclear…
Abstract Number: 322 • 2014 ACR/ARHP Annual Meeting
Superior Therapeutic Efficacy of a Novel Oral Small Molecule Retinoic Acid Receptor-Related Orphan Receptor Gamma T [Rorgt] Inverse Agonist Inv-17: A Promising Safe & Efficacious Treatment for Rheumatoid Arthritis
Anderson Gaweco^1,2, Samantha Palmer¹, Rambon Shamilov¹, Caroline Stremnitzer¹, Katie Matthews¹, Michael Fisher¹, William Windsor¹, James Blinn¹, Ellen M. Ginzler³ and Jefferson Tilley¹, ¹Innovimmune Biotherapeutics, Brooklyn, NY, ²SUNY-Downstate Medical Center, Brooklyn, NY, ³Rheumatology, SUNY-Downstate Medical Center, Brooklyn, NY
Background/Purpose: T helper 17 [TH17] cells and its production of TH17 cytokines IL-17A and IL-17F play a critical role in the pathogenesis of RA and…
Abstract Number: 321 • 2014 ACR/ARHP Annual Meeting
Mutations of Familial Hemophagocytic Lymphohistiocytosis (FHL) Related Genes and Abnormalities of Cytotoxicity function tests in Patients with Macrophage Activation Syndrome (MAS) Occurring in Systemic Juvenile Idiopathic Arthritis (sJIA)
Claudia Bracaglia¹, Elena Sieni², Martina Da Ros², Carmela De Fusco³, Concetta Micalizzi⁴, Valentina Cetica², Benedetta Ciambotti², Maria Luisa Coniglio², Antonella Insalaco⁵, Fabrizio De Benedetti Sr.¹ and Maurizio Arico' Sr.⁶, ¹Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, ²Department of Pediatric Hematology-Oncology, Meyer Children’s Hospital, Florence, Italy, ³Department of Pediatric Hematology-Oncology, Pausillipon Children’s Hospital, Naple, Italy, ⁴Department of Pediatric Hematology-Oncology, G. Gaslini Children' s Hospital, Genoa, Italy, ⁵Department of Pediatric Medicine,, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, ⁶Istituto Toscano Tumori (I.T.T.), Florence, Italy
Background/Purpose: MAS is a severe complication of rheumatic diseases, mostly sJIA. Clinical and laboratory features are similar to those of FHL resulting from mutations in…
Abstract Number: 320 • 2014 ACR/ARHP Annual Meeting
Autoantibodies in Juvenile Systemic Sclerosis
Katharine Moore^1,2, J. Lee Nelson^3,4, Marvin J. Fritzler⁵, Marisa S. Klein-Gitelman⁶, Ann M. Reed⁷, Tzielan C. Lee⁸ and Anne M. Stevens^1,9, ¹Pediatrics, University of Washington, Seattle, WA, ²Pediatric Rheumatology, Seattle Children's Hospital, Seattle, WA, ³University of Washington, Seattle, WA, ⁴Fred Hutchinson Cancer Research Center, Seattle, WA, ⁵Mitogen Advanced Diagnostics Laboratory, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ⁶Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁷Rheumatology, Mayo Clinic, Rochester, MN, ⁸Pediatric Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁹Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: There are no known biomarkers for organ involvement, response to therapy, or prognosis in juvenile systemic sclerosis (jSSc). In adults with systemic sclerosis, a…
Abstract Number: 319 • 2014 ACR/ARHP Annual Meeting
Systemic Juvenile Idiopathic Arthritis and Exposure to Fine Particulate Air Pollution
Andrew S. Zeft¹, Sampath Prahalad², Rayfel Schneider³, Alexei Grom⁴, Fatma Dedeoglu⁵, Pamela F. Weiss⁶, Carter Mix⁷ and C. Arden Pope⁸, ¹Pediatrics, Rheumatology, The Cleveland Clinic, Cleveland, OH, ²Emory University, Atlanta, GA, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵on behalf of CARRAnet Investigators, Palo Alto, CA, ⁶Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Brigham Young University, Provo, UT, ⁸Economics, Brigham Young University, Provo, UT
Background/Purpose: Environmental factors are understood to play a pathogenic role in the etiology of Systemic Onset Juvenile Idiopathic Arthritis (SJIA). Fine particulate matter (aerodynamic diameter…
Abstract Number: 338 • 2014 ACR/ARHP Annual Meeting
Bombina Variegate peptide8/Prokineticin 2: A Novel Arthritis-Inducible Chemokine
Haruyasu Ito, Ken Yoshida, Kentaro Noda and Daitaro Kurosaka, Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Background/Purpose Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the joint destruction. Chemokines play important roles as monocyte and neutrophil recruiters in RA.…

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