ACR Meeting Abstracts

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  • Abstract Number: 613 • 2013 ACR/ARHP Annual Meeting

    The Influence Of Cumulative Dose Of Corticosteroids On The Presence Of Carotid Atherosclerosis In Patients With Longstanding Systemic Lupus Erythematosus

    Maria Rubino1, Ellie Aghdassi2, Sun Makosso-Kallyth3, Stacey Morrison4, Lihi Eder5 and Paul R. Fortin6,7, 1Internal Medicine, Université Laval, Quebéc, QC, Canada, 2University Health Network Research Institute and Department of Public Health, University of Toronto, Toronto, ON, Canada, 3Centre de Recherche CHU de Québec, Québec, QC, Canada, 4Div Rheumatology Rm MP-10-304, The Toronto Western Hospital, Toronto, ON, Canada, 5Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Rheumatology, Division of Rheumatology, Université Laval, Québec, QC, Canada, 7Rheumatology, Laval University, Division of Rheumatology, Centre de Recherche du CHU de Québec and Department of Medicine, Quebec City, QC, Canada

    Background/Purpose: The purpose of this study is to determine the relationship between cumulative corticosteroid dose (CCD) with presence of carotid plaques (CP), total plaque area…
  • Abstract Number: 615 • 2013 ACR/ARHP Annual Meeting

    Relationship Between 25-Hydroxyvitamin D [25(OH)D] and Risk For Cardiovascular Events In Systemic Lupus Erythematosus Over 11 Years In An Inception Cohort

    Apinya Lertratanakul1, Peggy Wu2, Alan Dyer1, Dafna D. Gladman3, Murray B. Urowitz3, Paul R. Fortin4, Dominique Ibanez3, Rosalind Ramsey-Goldman5 and for the Systemic Lupus International Collaborating Clinics (SLICC)6, 1Northwestern University, Chicago, IL, 2Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Medicine, Centre de Recherche du Chu de Québec et Université Laval, Quebec City, QC, Canada, 5Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Toronto Western Hospital, Division of Rheumatology, University of Toronto, Toronto Western Hospital (Coordinating Center), Toronto, ON, Canada

    Background/Purpose: 25(OH)D deficiency has been associated with increased cardiovascular disease (CVD) in the general population. We investigated the relationship between 25(OH)D and CVD events in…
  • Abstract Number: 616 • 2013 ACR/ARHP Annual Meeting

    Trends Of Mortality Associated To Systemic Lupus Erythematosus At The Nation Level: A Multiple Cause-Of-Death Analysis In France

    Laurent Chiche Sr.1, Guillemette Thomas2, Albetine Aouba3, Julien Mancini4, Gabrielle Sarlon5, Noémie Jourde6, Eric Jougla3 and Jean-Robert Harle2, 1Internal Medicine, CHU Marseille, Marseille, France, 2Internal Medicine, APHM, Marseille, France, 3inserm CépiDc, paris, France, 4public health, APHM, Marseille, France, 5APHM, marseille, France, 6APHM, Marseille, France

    Background/Purpose: The overall mortality rate of Systemic Lupus Erythematosus (SLE) has improved significantly over the past 50 years but is still high as compared with…
  • Abstract Number: 617 • 2013 ACR/ARHP Annual Meeting

    The Potentiality Of Multi-Target Therapy With Cyclophosphamide and Tacrolimus For Lupus Nephritis

    Ryota Sakai, Akiko Shibata, Kentaro Chino, Tsuneo Kondo, Ayumi Okuyama, Eiko Nishi, Hirofumi Takei, Hayato Nagasawa and Koichi Amano, Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan

    Background/Purpose: Multi-target therapy for lupus nephritis (LN) had first reported by Bao et al. 2008 regarding the treatment of mixed diffuse proliferative and membranous LN using…
  • Abstract Number: 618 • 2013 ACR/ARHP Annual Meeting

    Active Renal Disease Is Associated With The Presence Of The Metabolic Syndrome (MetS) In Peruvian Patients With Systemic Lupus Erythematosus (SLE)

    Manuel F. Ugarte-Gil1,2, Rocio V. Gamboa-Cardenas3, Mariela Medina-Chinchon1, Francisco Zevallos-Miranda1, Karim E. Diaz-Deza3, J. Mariano Cucho-Venegas1, Zoila Rodriguez-Bellido1,4, Jose L. Alfaro-Lozano1, Risto A. Perich-Campos1,4, Erika Noriega3, Hugo Torrealva1 and Cesar A. Pastor-Asurza1,4, 1Rheumatology, Hospital Guillermo Almenara, EsSalud, Lima, Peru, 2Universidad Cientifica del Sur, Lima, Peru, 3Rheumatology, Hospital Almenara, Lima, Peru, 4Universidad Nacional Mayor de San Marcos, Lima, Peru

    Background/Purpose: The MetS prevalence is increased in SLE patients, in particular in those of Hispanic origin and it is associated with a higher risk for…
  • Abstract Number: 619 • 2013 ACR/ARHP Annual Meeting

    Survival and Prognostic Factors In Patients With Connective Tissue Disease Associated Pulmonary Arterial Hypertension: Results From Korean Nationwide Registry

    Kwi Young Kang1, Chan Hong Jeon2, Sung Jae Choi3, Seung-Ki Kwok4, Seong-Kyu Kim5, Hyoun-Ah Kim6, Eon Jeong Nam7, Yong-Beom Park8, Kichul Shin9, Jaejoon Lee10, Chang-Hoon Lee11, Chan-Bum Choi12, Shin-Seok Lee13 and Dae-Hyun Yoo14, 1Rheumatology, Internal Medicine, Catholic University of Korea, Incheon St. Mary's Hospital, Seoul, South Korea, 2Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, 3Rheumatology, Korea University Medical Center, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, 5Catholic University of Daegu School of Medicine, Daegu, South Korea, 6Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 7Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 8Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 9Rheumatology, College of Medicine, Seoul National University, Seoul, South Korea, 10Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 11Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, 12Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 13Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 14Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). We sought to quantify survival and determine factors predictive…
  • Abstract Number: 620 • 2013 ACR/ARHP Annual Meeting

    Human Papillomavirus and Precancerous Lesions In Patients With Systemic Lupus Erythematosus

    Eleonora Lucero1, Laura Juarez1, Veronica Bellomio1, Francisco Colombres2, Maximiliano Machado Escobar1, Raúl Nicolás Martínez1, Teresita Alvarellos3, Agustina Lacaze3, Ariel Sanchez4, Pablo Agustín Apas Perez de Nucci5, Guillermo Cohen Imach5, Sonia Marcela Ortiz Mayor6, Iris Aybar Odstrcil6, Ana Cerón6, Ricardo V. Juárez7, Mirta Santana8 and Alberto Berman1, 1Rheumatology Unit, Padilla Hospital, Tucumán, Argentina, 2Centro Medico Privado de Reumatologia, Tucumán, Argentina, 3Biological Molecular Laboratory, Córdoba Private Hospital, Córdoba, Argentina, 4Biological Molecular Unit, Córdoba Private Hospital, Córdoba, Argentina, 5Ginecology Unit, Padilla Hospital, Tucumán, Argentina, 6Pathology Unit, Padilla Hospital, Tucumán, Argentina, 7Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, 8Padilla Hospital, Tucumán, Argentina

    Background/Purpose: To evaluate the presence of Precancerous Lesions (PL) in uterine cervix  in patients with Systemic Lupus Erythematosus  (SLE) and its relationship with Human Papillomavirus…
  • Abstract Number: 621 • 2013 ACR/ARHP Annual Meeting

    Baseline Characteristics That Predict a Short-Term Response To Immunosuppressive Treatment In Patients With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

    Hidekata Yasuoka1, Yuichiro Shirai1, Yuichi Tamura2, Toru Satoh3, Tsutomu Takeuchi1 and Masataka Kuwana1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Cardiology, Keio University School of Medicine, Tokyo, Japan, 3Department of Cardiology, Kyorin University School of Medicine, Tokyo, Japan

    Background/Purpose: Pulmonary arterial hypertension (PAH) is one of devastating organ involvements in patients with connective tissue diseases (CTDs). Recent introduction of molecular-targeting PAH drugs, such…
  • Abstract Number: 591 • 2013 ACR/ARHP Annual Meeting

    Elevated Level Of cfDNA Mainly Derive From Netosis Of Common Neutrophils As Well As Low-Density Granulocytes In Systemic Lupus Erythematosus and Is Associated With Lupus Nephritis Severity

    Sigong Zhang1, Guochun Wang2 and Xin Lu2, 1Department of Rheumatology,, China-Japan Friendship Hospital, Beijing, China, Beijing, China, 2Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China, Beijing, China

    Background/Purpose: Insufficient clearance of neutrophil extracellular traps (NETs) has been involved in lupus nephritis and can cause the increase of residual NETs in vivo, which…
  • Abstract Number: 598 • 2013 ACR/ARHP Annual Meeting

    Gender Influence On Lupus Nephritis Outcomes In An Urban, Multiethnic Population

    Cindy Johnston, Catarina Vila-Inda and Irene Blanco, Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is a disease predominately of young women that disproportionately affects minorities.   Lupus Nephritis (LN) causes major morbidity and mortality in…
  • Abstract Number: 582 • 2013 ACR/ARHP Annual Meeting

    A Real-World Survey Of Clinical Practice Among Rheumatologists and Nephrologists In The United States Reveals Differences In Care Of Non-Nephritis Systemic Lupus Erythematosus and Lupus Nephritis As Compared With American College Of Rheumatology Treatment Guidelines

    Neelufar Mozaffarian1, Steve Lobosco2 and Adam Roughley2, 1AbbVie, North Chicago, IL, 2Adelphi Real World Ltd., Macclesfield, United Kingdom

    Background/Purpose: Current pharmacotherapy for systemic lupus erythematosus (SLE) and lupus nephritis (LN) includes combinations of nonsteroidal anti–inflammatory drugs (NSAIDs), antimalarials (AMs), glucocorticoids (GCs), and cytotoxic…
  • Abstract Number: 583 • 2013 ACR/ARHP Annual Meeting

    Prognostic Significance Of Visit-To-Visit Variability, Maximum Systolic Blood Pressure, and Episodic Hypertension In Sytemic Lupus Erythematosus

    George Stojan1, Hong Fang2, Laurence S. Magder3 and Michelle Petri2, 1Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD

    Background/Purpose: SLE is considered a coronary heart disease equivalent and aggressive management of all traditional risk factors is recommended. Hypertension is a major problem in…
  • Abstract Number: 584 • 2013 ACR/ARHP Annual Meeting

    The Effect Of Ramipril On Endothelial Function and Endothelial Progenitor Cells In Patients With Systemic Lupus Erythematosus

    Emilia I. Sato1, Luiz Samuel G. Machado2 and Ana Cecilia Machado3, 1Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 2Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil, 3Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    Background/Purpose: Cardiovascular diseases (CVD) are one of major causes of morbidity and mortality in SLE patients. Traditional cardiovascular risk factors and disease intrinsic factors contribute…
  • Abstract Number: 585 • 2013 ACR/ARHP Annual Meeting

    Breast Cancer In Systemic Lupus (SLE): Do Demographic and Clinical Factors, Including DNA serology, Influence Risk?

    Sasha Bernatsky1, Rosalind Ramsey-Goldman2, Michelle Petri3, Murray B. Urowitz4, Dafna D. Gladman5, Christine Peschken6, William Foulkes1, Yvan St. Pierre7, Patrice Chrétien Raymer7, Basile Tessier Cloutier8, Guillermo Ruiz-Irastorza9, Ann E. Clarke1 and Systemic Lupus International Collaborating Clinics (SLICC)10, 1McGill University, Montreal, QC, Canada, 2Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 6Medicine & Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 7Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 8Clinical Epidemiology, McGill University, Montreal, QC, Canada, 9Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain, 10(coordinating centre), Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: There is an increase in cancer in SLE over-all, but decrease in other cancers, such as breast cancer. Of particular interest are autoantibodies targeting…
  • Abstract Number: 586 • 2013 ACR/ARHP Annual Meeting

    Blood Pressure Variability and Age-Related Blood Pressure Patterns In Systemic Lupus Erythematosus

    George Stojan1, Laurence S. Magder2 and Michelle Petri3, 1Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 3Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Increased visit-to-visit blood pressure (BP) variability has been associated with an increased risk of all-cause mortality, stroke, left ventricular diastolic dysfunction, and cognitive impairment…
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