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  • Abstract Number: 359 • 2014 ACR/ARHP Annual Meeting

    14-3-3η Cit:Arg Antibody Ratios:  Are We Overlooking the Prognostic Utility of Citrullinated Antibodies By Only Looking at Titers?

    Anthony Marotta1, Samina Turk2, Mairead Murphy3, Walter P. Maksymowych4 and Dirkjan van Schaardenburg5, 11423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada, 2Reade, Amsterdam, Netherlands, 3Augurex Life Sciences Corp., North Vancouver, BC, Canada, 4Department of Medicine, University of Alberta, Edmonton, AB, Canada, 5Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands

    Background/Purpose Citrullination is a post-translational modification whereby arginine (Arg) is deiminated by PAD enzymes to form citrulline (Cit). In RA, there are auto-antibodies (AAb) to…
  • Abstract Number: 378 • 2014 ACR/ARHP Annual Meeting

    The Use of Week 12 CDAI, RAPID3 and DAS28(CRP) Responses to Predict Optimal Response to Methotrexate

    Gerd Burmester1, Gurjit S. Kaeley2, Jeffrey R. Curtis3, Yusuf Yazici4, Benoit Guerette5, Xin Wang5, Alan Friedman5 and Vibeke Strand6, 1Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 2College of Medicine, University of Florida, Jacksonville, FL, 3University of Alabama at Birmingham, Birmingham, AL, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 5AbbVie, Inc., North Chicago, IL, 6Adjunct, Division of Immunology / Rheumatology, Stanford University, Palo Alto, CA

    Background/Purpose The prediction of treatment outcomes based on early response could guide treatment decisions in patients (pts) with rheumatoid arthritis (RA). The objective was to…
  • Abstract Number: 377 • 2014 ACR/ARHP Annual Meeting

    Fatigue Fluctuates Substantially over Time in Rheumatoid Arthritis Patients Despite Stable Disease Activity during Treatment with Biological Agents

    Emilie Lund Egsmose1, René Cordtz1 and Ole Rintek Madsen2, 1Dept. of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup, Denmark, 2Dept. of Rheumatoglogy/C, Copenhagen University Hospital Gentofte, Hellerup, Denmark

    Background/Purpose Fatigue (FTG) is a symptom commonly reported by patients with rheumatoid arthritis (RA). Little is known about its nature and etiology. The number of…
  • Abstract Number: 376 • 2014 ACR/ARHP Annual Meeting

    Using the Multi-Biomarker Disease Activity Score As a Complementary Inclusion Criterion for Clinical Trials in Rheumatoid Arthritis May Enhance Recruitment

    Ronald F. van Vollenhoven1, Rebecca J. Bolce2, Karen Hambardzumyan3, Saedis Saevarsdottir4, Kristina Forslind4, Ingemar Petersson5, Eric H. Sasso2, CC Hwang6, Oscar Segurado2 and Pierre Geborek7, 1Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden, 2Crescendo Bioscience Inc., South San Francisco, CA, 3ClinTRID, the Karolinska Institute, Stockholm, Sweden, 4Department of Medicine, Karolinska Institute, Stockholm, Sweden, 5Lund University, Department of Orthopedics, Clinical Sciences Lund, Lund, Sweden, 6Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA, 7Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    Background/Purpose Clinical trials in rheumatoid arthritis (RA) often require elevated C-reactive protein (CRP) as an inclusion criterion, which may limit recruitment by excluding some patients…
  • Abstract Number: 375 • 2014 ACR/ARHP Annual Meeting

    Evaluation of RAPID3 with Minimal Joint Count and ACR/EULAR Provisional Remission Definitions As Predictors of Future Good Radiographic + Functional Outcome in a Double-Blind, Phase 3, Randomized Controlled Trial of Tocilizumab

    Martin J. Bergman1, Jeffrey Yourish2, Jinglan Pei2, Jenny Devenport2, William Reiss2 and Edward Keystone3, 1Taylor Hospital, Ridley Park, PA, 2Genentech, South San Francisco, CA, 3University of Toronto and Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Based on treat-to-target guidelines, the goal of treatment should be remission. Definitions for remission recommended by the ACR/EULAR task force include joint counts and…
  • Abstract Number: 374 • 2014 ACR/ARHP Annual Meeting

    IL-33 and Soluble ST2 Levels As Novel Predictors for Remission and Progression of Carotid Plaque in Early Rheumatoid Arthritis: A Prospective Study

    Jiayun Shen1, Qing Shang1, Ying Ying Leung2, Shui Lian Yu1, Chun-Kwok Wong3, Edmund Li1, Tracy Y. Zhu1 and Lai-Shan Tam1, 1Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 3Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose Clinical remission is achievable for patients with early rheumatoid arthritis (ERA). Identification of predictors for response of treatment may provide risk estimation and help…
  • Abstract Number: 373 • 2014 ACR/ARHP Annual Meeting

    Biomarkers of Cardiac Dysfunction and Inflammation in Plasma Predict Occult Coronary Plaque Burden and Composition in Rheumatoid Arthritis

    George A. Karpouzas1, Joel Estis2, John Todd2 and Matthew Budoff3, 1Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Singulex, Alameda, California, Alameda, CA, 3Cardiology, Harbor-UCLA Medical Center, Torrance, CA

    Background/Purpose Rheumatoid arthritis (RA) is associated with accelerated coronary atherogenesis, myocardial infarction, and mortality. We previously reported a higher prevalence, severity, and different composition of…
  • Abstract Number: 372 • 2014 ACR/ARHP Annual Meeting

    Diagnostic Accuracy and Associated Costs of Rheumatoid Factor Testing in Primary Care: A Population-Based Cohort Study in Spain

    Raashid Luqmani1, Klara Morsley2, Anne Miller3, Christopher J. Edwards4, M. Kassim Javaid5, Daniel Prieto-Alhambra6, Rafael Pinedo-Villanueva7,8, Manuel Medina Peralta9, Sebastian Calero Munoz9, Nigel Arden10,11, Francesc Fina-Aviles9 and Cyrus Cooper12, 1Oxford NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom, 2Oxford University Hospitals NHS Trust, Nuffield Orthopaedic Centre, Oxford, United Kingdom, 3Rheumatology, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 4University Hospital Southampton, Southampton, United Kingdom, 5Rheumatology, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Oxford, United Kingdom, 6NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom, 7NDORMS, University of Oxford, Oxford, United Kingdom, 8MRC Lifecourse Epidemiology Unit, Southampton, United Kingdom, 9Institut Català de la Salut, Barcelona, Spain, 10NIHR Musculoskeletal Biomedical Research Unit University of Oxford, Oxford, United Kingdom, 11University of Southampton, Southampton, United Kingdom, 12MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom

    Background/Purpose: To assess the sensitivity, specificity, and predictive values of rheumatoid factor (RF) as a test for rheumatoid arthritis (RA) in primary care, and to…
  • Abstract Number: 371 • 2014 ACR/ARHP Annual Meeting

    The Impact of Missing Anti-Citrullinated Protein Antibody (ACPA) on Outcomes in Early Rheumatoid Arthritis: From the Canadian Early Arthritis Cohort

    Jenny Shu1, Vivian P. Bykerk2, Gilles Boire3, Carol A. Hitchon4, J. Carter Thorne5, Diane Tin6, Edward C. Keystone7, Boulos Haraoui8 and Janet E. Pope9, 1Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, 4Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 7Medicine, University of Toronto, Toronto, ON, Canada, 8Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 9St Joseph Health Care, London, ON, Canada

    Background/Purpose: The impact of missing ACPA in early inflammatory arthritis patients was studied to determine if failure to perform ACPA testing could cause a care…
  • Abstract Number: 358 • 2014 ACR/ARHP Annual Meeting

    Parity and Severity of ACPA-Positive/Negative Rheumatoid Arthritis. Results from the Swedish EIRA Study

    Mitra Pikwer1, Cecilia Orellana2, Henrik Källberg2, Andreas Pikwer3, Carl Turesson4, Lars Klareskog5, Lars Alfredsson6,7, Saedis Saevarsdottir8 and Camilla Bengtsson9, 1Rheumatology Unit, Mälarhospital, Institute of Environmental Medicine, Eskilstuna, Sweden, 2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 3Centre of Clinical Research Sörmland, Eskilstuna, Sweden, 4Rheumatology, Department of Clinical Sciences, Malmö, Sweden, 5Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska institutet, Stockholm, Sweden, 6Institute of Environmental Medicine, Stockholm, Sweden, 7Centre of Occupational and Environmental Medicine, Stockholm, Sweden, 8Institute of Environmental Medicine, Karolinska Institutet,, Stockholm, Sweden, 9The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose Female sex and older age are known risk factors for rheumatoid arthritis (RA). The disease is however heterogeneous, and a common division occurs between…
  • Abstract Number: 357 • 2014 ACR/ARHP Annual Meeting

    Development and Validation of a Diagnostic Bead-Based Multiplex Autoantibody Assay:Screening for Autoantibodies to Detect “Seronegative” Rheumatoid Arthritis

    Stefan Vordenbäumen1, Angelika Lueking2, Carmen Theek2, Ralph Brinks1, Rebecca Fischer-Betz1, Jutta Richter1, Ellen Bleck1, Jacqueline Detert3, Gerd Burmester4, Peter Schulz-Knappe2 and Matthias Schneider1, 1Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, 2Protagen AG, Dortmund, Germany, 3Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 4Departement of Rhe, University Medicine, Berlin, Germany

    Background/Purpose: Autoantibodies (auto-Ab) against citrullinated peptides (ACPA) and rheumatoid factor (RF) are important biomarkers in the diagnostic process of rheumatoid arthritis (RA). However, RF or…
  • Abstract Number: 356 • 2014 ACR/ARHP Annual Meeting

    The Rheumatoid Arthritis Impact of Disease Score Is Associated with Disease Activity By Clinical, Laboratory and Ultrasonographic Measures: Validation in an inception Cohort of DMARD naïve Patients with Rheumatoid Arthritis

    Lena Bugge Nordberg1, Elisabeth Lie2, Anna-Birgitte Aga1, Marthe Thoresen Maehlen3, Inge Olsen C4, Till Uhlig4, Tore K. Kvien4, Espen A. Haavardsholm5 and the Arctic study Group5, 1Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Department of rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Diakonhjemmet Hospital, Oslo, Norway

     Background/Purpose: The Rheumatoid arthritis impact of disease (RAID) score is a relatively new patient-derived composite score assessing the seven most important domains of the impact…
  • Abstract Number: 355 • 2014 ACR/ARHP Annual Meeting

    Increased Left Ventricular Mass Index and Decreased Ejection Fraction Are Associated with Disease Activity in Rheumatoid Arthritis Patients without Cardiac Symptoms; Comparison Between Non-Biologic and Biologic Dmards Treatment Groups, Using a Cardiac Magnetic Resonance Imaging

    Hitomi Kobayashi1, Yasuyuki Kobayashi2, Atsuma Nishiwaki3, Hirotake Inomata1, Noboru Kitamura1, Hidetake Shiraiwa3, Takamasa Nozaki3, Natsumi Ikumi4 and Masami Takei5, 1Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 2Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, 3Nihon University School of Medicine, Tokyo, Japan, 4Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 5Dept of Med Rheumatology, Nihon University School of Medicine, Itabashi Tokyo, Japan

    Background/Purpose Patients with rheumatoid arthritis (RA) experience an excess risk of congestive heart failure (CHF), but effects of disease-modifying anti-rheumatic drugs (DMARDs) on cardiac structure…
  • Abstract Number: 354 • 2014 ACR/ARHP Annual Meeting

    Increased Vascular Wall Inflammation in Patients with Active Rheumatoid Arthritis As Measured By an 18F-FDG-PET/CT Scan

    Rabia Agca1,2, Alper M. van Sijl2,3, Yvo M. Smulders4, Alexandre E. Voskuyl5, Connie J. van der Laken6, Ronald Boellaard7, Karel-Jan D.F. Lensen8 and Michael T. Nurmohamed1,2, 1Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 2VU University Medical Center, Amsterdam, Netherlands, 3[email protected], Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 4Internal Medicine, VU University Medical Center, Amsterdam, Netherlands, 5Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 6Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 7Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, 8Department of Internal Medicine, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose : Patients with rheumatoid arthritis (RA)  have an elevated risk of developing cardiovascular  disease (CVD). Like active RA, atherosclerosis is an inflammatory process. There…
  • Abstract Number: 353 • 2014 ACR/ARHP Annual Meeting

    Sensitivity of Unique Multidimensional Health Assessment Questionnaire Items Compared to Items on Both the HAQ and MDHAQ in Patients with RA and SLE

    Narender Annapureddy1, David Giangreco1, Isabel Castrejón1, Nisha Shetty2, Theodore Pincus1, Joel Block1 and Meenakshi Jolly1, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2St. Anthony's Hospital, St. Louis, MO

    Background/Purpose: Patients with rheumatic diseases have significantly better clinical status in recent years than in previous decades, including rheumatoid arthritis (RA)1 and systemic lupus erythematosus…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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