Abstract Number: 629 • 2013 ACR/ARHP Annual Meeting
Altered ER Stress-Induced Autophagic Reactions Are Associated With Increased Apoptosis of T Lymphocytes in Systemic Lupus Erythematosus
Background/Purpose: The autophagic responses to ER stress are involved in the regulation of the maintenance of lymphocyte homeostasis and has been implicated in the pathogenesis…Abstract Number: 630 • 2013 ACR/ARHP Annual Meeting
Galectin-3-Binding Protein Is Highly Increased On Circulating Microparticles In SLE Patients and Co-Localizes With IgG In Glomerular Deposits In Human Lupus Nephritis
Background/Purpose: The origin of autoantigens in glomerular immune complex (IC) deposits in lupus nephritis patients is unknown. They may derive from the circulation (microparticle (MP)-ICs…Abstract Number: 631 • 2013 ACR/ARHP Annual Meeting
Type I IFN Regulation Of IL-10 Is Detrimental To Endothelial Cell Differentiation and May Enhance Cardiovascular Risk In Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a heterogeneous disease resulting in organ damage and an elevated risk of cardiovascular disease (CVD). Previous reports have suggested…Abstract Number: 632 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal-Phosphoprotein Autoantibodies Penetrate Into Neuronal Cells Via Neuron Growth Associated Protein (GAP43)
Background/Purpose: Autoantibodies targeting ribosomal phosphoproteins (anti-Ribos.P) are detected in the sera of 10-45% patients with neuropsychiatric-systemice-lupus-erythemathosus-(NPSLE) and correlate with disease-activity. Intracerebroventricular administration of anti-Ribos.P induce…Abstract Number: 633 • 2013 ACR/ARHP Annual Meeting
Reduced PD-1 Signaling Promotes Suppressive Function Of CD4+ Regulatory T Cells In Patients With Systemic Lupus Erythematosus
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…Abstract Number: 634 • 2013 ACR/ARHP Annual Meeting
IL-21/IL-21R Interaction On Lymphocyte Subsets From Lupus Patients
Background/Purpose: We have previously shown that IL-21 promotes autoimmunity in a mouse model of lupus through both CD4 and B cell intrinsic mechanisms. Recent studies…Abstract Number: 635 • 2013 ACR/ARHP Annual Meeting
Multiple Altered Soluble Inflammatory Mediators Correlate With Disease Activity and Mark Impending Disease Flare In European-American Lupus Patients
Background/Purpose: SLE is a waxing and waning disease characterized by immune dysregulation, major organ involvement, and disease flares. Identifying mechanistic mediators of altered disease activity…Abstract Number: 636 • 2013 ACR/ARHP Annual Meeting
Neutrophil-Mediated Interferon Activation In Systemic Lupus Erythematosus Bone Marrow
Background/Purpose: Although SLE is known to be associated with a type I interferon signature in the peripheral blood, the precise site and mechanism of IFN…Abstract Number: 637 • 2013 ACR/ARHP Annual Meeting
Proteomic Approach and Validation Of Urinary Biomarkers In Lupus Nephritis
Background/Purpose: Renal involvement occurs in about half of systemic lupus erythematosus (SLE) patients. A number of biochemical markers are currently used to clinically assess lupus…Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting
Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…Abstract Number: 639 • 2013 ACR/ARHP Annual Meeting
Examination Of The Cytokine Profile Of The Cerebrospinal Fluid In Neuropsychiatric Systemic Lupus Erythematosus
Examination of the cytokine profile of the cerebrospinal fluid in neuropsychiatric systemic lupus erythematosusBackground/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in systemic…Abstract Number: 640 • 2013 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Patients With Atherosclerosis Are Characterised By a Distinct Invariant Natural Killer T Cell Phenotype and Altered CD1d-Mediated Lipid Antigen Presentation
Background/Purpose: It is widely reported that systemic lupus erythematosus (SLE) patients have an increased risk of atherosclerosis compared to the general population, irrespective of traditional…Abstract Number: 641 • 2013 ACR/ARHP Annual Meeting
Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD). Vitamin D deficiency is common in SLE and an independent…Abstract Number: 614 • 2013 ACR/ARHP Annual Meeting
Causes Of Mortality In Lupus Patients Followed Prospectively At a Large Single-Centre Lupus Clinic
Background/Purpose: Survival rates of patients with systemic lupus erythematosus (SLE) have improved significantly over the last four decades. Mortality rates remain high, however, and are…Abstract Number: 602 • 2013 ACR/ARHP Annual Meeting
Repeat Biopsy In Lupus Nephritis: A Single-Center Experience
Background/Purpose: Renal involvement in systemic lupus erythematosus (SLE) is an important cause of morbidity and even mortality. Lupus nephritis has diverse morphologic manifestations with varying clinical…