Abstract Number: 713 • 2013 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 2 Haploinsufficiency Deteriorates Imiquimod-Induced Psoriasis-Like Skin Inflammation
Background/Purpose: Psoriasis is a T-cell-mediated immunological skin disease with a complex pathogenesis where both genetic and environmental factors are involved. Interferon regulatory factor (IRF)-2 is one…Abstract Number: 714 • 2013 ACR/ARHP Annual Meeting
Combination Blocking Of Interleukin-6 and Interleukin-21 In Experimental Arthritis Inhibits Their Redundant Role In T Helper 17-Driven Joint Pathology
Background/Purpose: Both IL-6 and IL-21 have been described to drive in vitro Th17 differentiation in the presence of TGF-β. We explored whether also in vivo…Abstract Number: 716 • 2013 ACR/ARHP Annual Meeting
The Active Metabolite Of Spleen Tyrosine Kinase Inhibitor Fostamatinib Abrogates The T Cell Priming Capacity Of Dendritic Cells
Background/Purpose: Spleen tyrosine kinase (SYK) is a core signaling protein that drives inflammatory responses and is fundamental to the propagation of signals via numerous immune-receptors…Abstract Number: 717 • 2013 ACR/ARHP Annual Meeting
Patients With Rheumatoid Arthritis Have Impaired Candida Albicans Specific Th17 Responses But Preserved Oral Candida Albicans Protective Immunity
Background/Purpose: Rheumatoid arthritis (RA) patients are susceptible to infections, even after controlling for the effects of medications. Recent data suggest an important role for the…Abstract Number: 718 • 2013 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells and Skin Fibroblasts Both Suppress Early Steps In T Cell Activation In a Nitric-Oxide Dependent Manner
Background/Purpose: Mesenchymal stem cells (MSCs) are multipotent cells with capacity to differentiate into osteoblasts, chondrocytes, and adipocytes. A phase II study in Europe has shown…Abstract Number: 719 • 2013 ACR/ARHP Annual Meeting
Mammalian Target Of Rapamycin (mTOR) Skews T Cell Lineage Development In Systemic Lupus Erythematosus (SLE)
Background/Purpose: mTOR activity is increased in SLE T cells and its blockade has therapeutic efficacy in SLE. Murine studies showed essential roles of mTORC1 in…Abstract Number: 720 • 2013 ACR/ARHP Annual Meeting
Abatacept Efficacy Is Overruled By IL-7 In TSLP-Primed Myeloid Dendritic cell driven T Cell Activation From Rheumatoid Arthritis Patients
Background/Purpose: Abatacept is an effective treatment for a subset of rheumatoid arthritis (RA) patients, interfering in the interaction between antigen-presenting cells and T cells preventing…Abstract Number: 721 • 2013 ACR/ARHP Annual Meeting
T Cell Activation Induces Increased mRNA Expression Of The Splicing Factor SF2/ASF But Simultaneous Protein Downregulation Via Proteasome Mediated Degradation
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) are poor producers of the vital cytokine interleukin (IL)-2. We recently showed that SLE…Abstract Number: 722 • 2013 ACR/ARHP Annual Meeting
BAFF Promotes T Follicular Helper Cell Development and Germinal Center Generation In Mice
Background/Purpose: BAFF (B cell activating factor belonging to the TNF family) promotes B cells maturation in germinal center. The generation of germinal center depends on…Abstract Number: 723 • 2013 ACR/ARHP Annual Meeting
Abatacept Is Highly Effective At Inhibiting T Cell Priming and Induces a Unique Transcriptional Profile In CD4+ t Cells
Background/Purpose: Absence of co-stimulation in the presence of TCR-stimulation has been proposed to induce tolerance via deletion or anergy. Abatacept is a CTLA-4-Ig molecule that…Abstract Number: 724 • 2013 ACR/ARHP Annual Meeting
Dose-Dependent Suppression Of Cytokine Production From T Cells By a Novel Phosphoinositide 3-Kinase Delta Inhibitor
Background/Purpose: The use of specific cytokine inhibitors to treat inflammatory autoimmune conditions is common but typically utilizes monoclonal antibodies, fusion proteins, and other molecules whose…Abstract Number: 725 • 2013 ACR/ARHP Annual Meeting
Localization At The Immunological Synapse Of Adaptor Protein Grb2 and PLC Gamma-1 In Non-Stimulated Peripheral Blood T Lymphocytes From Patients With Systemic Lupus Erythematosus Suggests An In Vivo dysregulated Activation State
Background/Purpose: We previously showed an increased metabolic rate of transmembrane adaptor protein LAT in TCR/CD3 stimulated lupus T cells, associated with delocalization of this adaptor…Abstract Number: 726 • 2013 ACR/ARHP Annual Meeting
Tofacitinib Does Not Inhibit Dendritic Cell Maturation and T Cell Proliferation In Vitro
Background/Purpose: Tofacitinib is the first approved Janus Kinase (JAK) Inhibitor for the treatment of rheumatoid arthritis (RA). The JAK/STAT pathway-inhibition leads to dysfunction of several…Abstract Number: 687 • 2013 ACR/ARHP Annual Meeting
Role Of Class II Human Leukocyte Antigens In The Progression From Early To Definite Systemic Sclerosis
Background/Purpose: Criteria for the diagnosis of Early Systemic Sclerosis (EaSSc) have been formalized by LeRoy and Medsger in 2001 and later validated by Koenig et…Abstract Number: 688 • 2013 ACR/ARHP Annual Meeting
Minimal Clinically Important Investigations In Systemic Sclerosis
Background/Purpose: The optimal management of Systemic Sclerosis (SSc) is a challenge due to the complexity of early diagnosis and identification of patients who are at…
ACR Meeting Abstracts