Abstract Number: 719 • 2013 ACR/ARHP Annual Meeting
Mammalian Target Of Rapamycin (mTOR) Skews T Cell Lineage Development In Systemic Lupus Erythematosus (SLE)
Background/Purpose: mTOR activity is increased in SLE T cells and its blockade has therapeutic efficacy in SLE. Murine studies showed essential roles of mTORC1 in…Abstract Number: 720 • 2013 ACR/ARHP Annual Meeting
Abatacept Efficacy Is Overruled By IL-7 In TSLP-Primed Myeloid Dendritic cell driven T Cell Activation From Rheumatoid Arthritis Patients
Background/Purpose: Abatacept is an effective treatment for a subset of rheumatoid arthritis (RA) patients, interfering in the interaction between antigen-presenting cells and T cells preventing…Abstract Number: 721 • 2013 ACR/ARHP Annual Meeting
T Cell Activation Induces Increased mRNA Expression Of The Splicing Factor SF2/ASF But Simultaneous Protein Downregulation Via Proteasome Mediated Degradation
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) are poor producers of the vital cytokine interleukin (IL)-2. We recently showed that SLE…Abstract Number: 722 • 2013 ACR/ARHP Annual Meeting
BAFF Promotes T Follicular Helper Cell Development and Germinal Center Generation In Mice
Background/Purpose: BAFF (B cell activating factor belonging to the TNF family) promotes B cells maturation in germinal center. The generation of germinal center depends on…Abstract Number: 723 • 2013 ACR/ARHP Annual Meeting
Abatacept Is Highly Effective At Inhibiting T Cell Priming and Induces a Unique Transcriptional Profile In CD4+ t Cells
Background/Purpose: Absence of co-stimulation in the presence of TCR-stimulation has been proposed to induce tolerance via deletion or anergy. Abatacept is a CTLA-4-Ig molecule that…Abstract Number: 724 • 2013 ACR/ARHP Annual Meeting
Dose-Dependent Suppression Of Cytokine Production From T Cells By a Novel Phosphoinositide 3-Kinase Delta Inhibitor
Background/Purpose: The use of specific cytokine inhibitors to treat inflammatory autoimmune conditions is common but typically utilizes monoclonal antibodies, fusion proteins, and other molecules whose…Abstract Number: 725 • 2013 ACR/ARHP Annual Meeting
Localization At The Immunological Synapse Of Adaptor Protein Grb2 and PLC Gamma-1 In Non-Stimulated Peripheral Blood T Lymphocytes From Patients With Systemic Lupus Erythematosus Suggests An In Vivo dysregulated Activation State
Background/Purpose: We previously showed an increased metabolic rate of transmembrane adaptor protein LAT in TCR/CD3 stimulated lupus T cells, associated with delocalization of this adaptor…Abstract Number: 726 • 2013 ACR/ARHP Annual Meeting
Tofacitinib Does Not Inhibit Dendritic Cell Maturation and T Cell Proliferation In Vitro
Background/Purpose: Tofacitinib is the first approved Janus Kinase (JAK) Inhibitor for the treatment of rheumatoid arthritis (RA). The JAK/STAT pathway-inhibition leads to dysfunction of several…Abstract Number: 687 • 2013 ACR/ARHP Annual Meeting
Role Of Class II Human Leukocyte Antigens In The Progression From Early To Definite Systemic Sclerosis
Background/Purpose: Criteria for the diagnosis of Early Systemic Sclerosis (EaSSc) have been formalized by LeRoy and Medsger in 2001 and later validated by Koenig et…Abstract Number: 688 • 2013 ACR/ARHP Annual Meeting
Minimal Clinically Important Investigations In Systemic Sclerosis
Background/Purpose: The optimal management of Systemic Sclerosis (SSc) is a challenge due to the complexity of early diagnosis and identification of patients who are at…Abstract Number: 689 • 2013 ACR/ARHP Annual Meeting
Subclinical Biventricular Systolic Function Is Impaired In Patients With Systemic Sclerosis: A Speckle Tracking-Based Echocardiographic Study
Subclinical biventricular systolic function is impaired in patients with systemic sclerosis: A speckle tracking-based echocardiographic studyBackground/Purpose : Myocardial involvement is associated with poor prognosis in…Abstract Number: 690 • 2013 ACR/ARHP Annual Meeting
Assessment Of The New American and European Classification Criteria For Systemic Sclerosis In The Norwegian Systemic Connective Tissue Disease and Vasculitis Registry
Background/Purpose: To assess the newly established ACR/EULAR classification criteria for systemic sclerosis 1 (SSc) in a large Norwegian SSc registry cohort. Methods: The Norwegian systemic…Abstract Number: 691 • 2013 ACR/ARHP Annual Meeting
Descriptive Review Of Morphea Subjects From a Single Cohort Center
Descriptive review of Morphea subjects from a single cohort center Background/Purpose: Morphea, or localized scleroderma, is an idiopathic, rare fibrotic skin disorder that may result…Abstract Number: 692 • 2013 ACR/ARHP Annual Meeting
Characterization Of Lower Limb Cutaneous Ulcers In Systemic Sclerosis: The Analysis of 424 Lesions
Background/Purpose: Cutaneous ulcers reppresent one of the most frequent complications in course of systemic sclerosis (SSc). They are often disabling and difficult to treat. The…Abstract Number: 693 • 2013 ACR/ARHP Annual Meeting
Pulmonary Involvement In Mixed Connective Tissue Disease: Slow Progression After 10 Years Of Follow-Up
Background/Purpose: Evaluate the progression of interstitial lung disease (ILD) in a 10-year period of a group of 53 MCTD patients previously evaluated 10 years ago.Methods:…