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  • Abstract Number: 503 • 2014 ACR/ARHP Annual Meeting

    Does a Higher Dose of Folic Acid Reduce Adverse Effects of Methotrexate in Rheumatoid Arthritis? a Randomized Controlled Trial

    Varun Dhir1, Amit Sandhu1, Jasbinder Kaur2, Nidhi Gupta1, Prabhdeep Kaur1, Ankita Sood1, Aman Sharma3 and Shefali Sharma1, 1Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Government Medical College and hospital Sector 32, Chandigarh, India, 3Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Background/Purpose There is good evidence that folic acid 5-10mg per week leads to reduction in methotrexate (MTX) toxicity in rheumatoid arthritis (RA). However, this data…
  • Abstract Number: 502 • 2014 ACR/ARHP Annual Meeting

    Tocilizumab Use in Patients with Rheumatoid Arthritis Having Failed One Previous Anti-TNF Agent: Comparison with Adalimumab, Etanercept and Infliximab

    Denis Choquette1, Marie-Pier Payette1, Jean-Pierre Raynauld1, Jean-Pierre Pelletier2, Louis Bessette3, Edith Villeneuve1, Boulos Haraoui1, Isabelle Fortin4, Marie-Anaïs Rémillard5, Diane Sauvageau1 and Louis Coupal1, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 3Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada, 4Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada, 5Rhumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada

    Background/Purpose : Tocilizumab, as an intra-venous agent, has been approved for rheumatoid arthritis (RA) in Canada in April 30th, 2010. It was the sixth approved…
  • Abstract Number: 501 • 2014 ACR/ARHP Annual Meeting

    Bio-naïve Patients with Rheumatoid Arthritis Benefit More from Abatacept Treatment Compared to Those Who Are Inadequate Responders to Other Biologics – Results from the National Swedish Rheumatology Quality Register

    Carl Turesson1, Leszek Stawiarz2, Staffan Lindblad3 and Saedis Saevarsdottir4, 1Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 3Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska institutet and Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose Abatacept is a biological anti-rheumatic drug used in Rheumatoid Arthritis (RA). Data on patient characteristics, diagnosis, previous treatment and outcomes of abatacept have been…
  • Abstract Number: 500 • 2014 ACR/ARHP Annual Meeting

    Prediction of Successful Dose Reduction or Discontinuation of Adalimumab or Etanercept Using Serum Drug Levels and Antidrug Antibody Measurement

    Noortje van Herwaarden1, Chantal Bouman2, Aatke van der Maas3, Ronald F. van Vollenhoven4, Johannes W.J. Bijlsma5, Frank H.J. van den Hoogen6, Alfons A. den Broeder1 and Bart van den Bemt7, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Sint Maartenskliniek, Nijmegen, Netherlands, 3Hengstdal 3, Sint Maartenskliniek, Nijmegen, Netherlands, 4Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden, 5Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 6Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 7Pharmacy, Sint Maartenskliniek, Nijmegen, Netherlands

    Background/Purpose Dose reduction and discontinuation of TNF inhibitors (TNFi) is feasible in many rheumatoid arthritis (RA) patients, but leads to (temporary) worsening of disease activity…
  • Abstract Number: 499 • 2014 ACR/ARHP Annual Meeting

    Biologic Discontinuation in Rheumatoid Arthritis: Experience from a Canadian Clinic

    Denis Choquette1, Louis Coupal1, Marie-Claude Laliberté2 and Olivier Desjardins2, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2AbbVie, St. Laurent, QC, Canada

    Background/Purpose: Adherence and persistence to treatment are a cornerstone of treatment success in chronic diseases such as rheumatoid arthritis (RA). The purpose of this study…
  • Abstract Number: 518 • 2014 ACR/ARHP Annual Meeting

    Risk of Infection Associated with Subsequent Biologic Use Following Rituximab—Results from a National RA Patient Registry

    Leslie R. Harrold1, George W. Reed1,2, Chitra Karki3, Robert Magner1, Ashwini Shewade4, Ani John4, Joel M. Kremer5 and Jeffrey D. Greenberg3,6, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC., Southborough, MA, 3Corrona, LLC, Southborough, MA, 4Genentech, Inc, South San Francisco, CA, 5Albany Medical College and The Center for Rheumatology, Albany, NY, 6NYU School of Medicine, New York, NY

    Background/Purpose: Rituximab is a chimeric monoclonal antibody for the treatment of rheumatoid arthritis (RA). Prolonged B-cell depletion from repeated doses of rituximab may be associated…
  • Abstract Number: 517 • 2014 ACR/ARHP Annual Meeting

    Real-World Use of Tocilizumab in Rheumatoid Arthritis Patients in Canada: Interim Results

    Boulos Haraoui1, Shahin Jamal2, Vandana Ahluwalia3, Tarang Manchanda4 and Majed Khraishi5, 1Department of Medicine, Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada, 2Department of Rheumatology, University of British Columbia, Vancouver, BC, Canada, 3William Osler Health Center, Brampton, ON, Canada, 4Hoffmann-La Roche Canada, Mississauga, ON, Canada, 5Nexus Clinical Research, St John's, NF, Canada

    Background/Purpose Tocilizumab (TCZ) has been approved for the treatment of adults with rheumatoid arthritis (RA) either as monotherapy or as combination with disease-modifying antirheumatic drugs…
  • Abstract Number: 516 • 2014 ACR/ARHP Annual Meeting

    The Safety and Treatment Efficacy of Abatacept in Rheumatoid Arthritis Patients with Pulmonary Complications: From the Tsurumai Biologics Communication Registry (TBCR) Multicenter Study

    Shinya Hirabara1, Toshihisa Kojima2, Nobunori Takahashi2, Yuji Hirano1, Atsushi Kaneko3, Daihei Kida4, Yasuhide Kanayama5 and Naoki Ishiguro2, 1Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan, 2Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya, Japan, 4Orthopedic Surgery and Rheumatology, Nagoya Medical Center, National Hospital Organization, Nagoya, Japan, 5Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital, Toyota, Japan

    Background/Purpose: Roughly 10-30% of rheumatoid arthritis (RA) patients reportedly develop pulmonary complications. These patients are at increased risk of MTX or biologics-induced damage, which often…
  • Abstract Number: 506 • 2014 ACR/ARHP Annual Meeting

    Trial of Six Weeks Interval of Tocilizumab Infusion in Patients with Rheumatoid Arthritis

    Osamu Saiki1, Hiroshi Uda1 and Koji Shigematsu2, 1Rheumatology, Higashiosaka City General Hospital, Higashiosaka, Japan, 2Orthopedics, Higashiosaka City General Hospital, Higashiosaka, Japan

    Background/Purpose: For active rheumatoid arthritis (RA) patients with inadequate response to synthetic DMARDs, biologic agents, such as TNF inhibitor and IL-6 receptor inhibitor, are indicated.…
  • Abstract Number: 507 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety of Adalimumab Therapy in Japanese Patients with Rheumatoid Arthritis

    Yosuke Hattori, 4-1-1 Sannomaru, Naka-ku, National Hospital Organization Nagoya Medical, Nagoya, Japan

    HIGH RATE OF IMPROVEMENT IN SERUM MATRIX METALLOPROTEINASE-3 LEVELS AT 4 WEEKS PREDICT REMISSION AT 52 WEEKS IN RA PATIENTS WITH ADALIMUMAB THERAPY Background/Purpose : Serum…
  • Abstract Number: 508 • 2014 ACR/ARHP Annual Meeting

    Relationship Between NK Cell Count and Important Safety Events in Rheumatoid Arthritis Patients Treated with Tofacitinib

    R. van Vollenhoven1, Y. Tanaka2, R. Riese3, M. Lamba3, T. Kawabata3, T. Hirose4, S. Toyoizumi4, A. Hazra3 and S. Krishnaswami3, 1The Karolinska Institute, Stockholm, Sweden, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, Tokyo, Japan

    Background/Purpose: Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). Cytokines (e.g. interleukin [IL]-2, -4, -7, -15, -21) involved…
  • Abstract Number: 509 • 2014 ACR/ARHP Annual Meeting

    Etanercept Have Better Drug Survival Than Monoclonal Antibodies in Rheumatoid Arthritis: Results of Single Center Hur-BIO Registry

    Umut Kalyoncu1, Murat Torgutalp2, Hakan Babaoglu2, Sadettin Kilickap3, Sedat Kiraz4, Ali Akdogan5, Omer Karadag5, Abdulsamet Erden6, Sule Apras Bilgen7 and Ihsan Ertenli5, 1Rheumatology,Hacettepe University Faculty of Medicine, Associate Proffesor, Ankara, Turkey, 2Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey, 3Preventive Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey, 4SAMANPAZARI MH ALTINDAG 06110, Hacettepe Unv.Tip Fakultesi-Romatoloji Servis, Ankara, Turkey, 5Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 6Rheumatology,Hacettepe University Faculty of Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey, 7Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey

    Etanercept have better drug survival than monoclonal antibodies in Rheumatoid Arthritis: Results of single center HÜR-BÝO registryBackground/Purpose: In routine practice, observational registries may show retention…
  • Abstract Number: 510 • 2014 ACR/ARHP Annual Meeting

    Similar Short Term Survival on Drug for Patients with Rheumatoid Arthritis Treated with Subcutaneous and Intravenous Abatacept – Results from the National Swedish Rheumatology Quality Register

    Carl Turesson1, Leszek Stawiarz2, Staffan Lindblad3 and Saedis Saevarsdottir4, 1Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 3Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska institutet and Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose Abatacept is a biological anti-rheumatic drug used in Rheumatoid Arthritis (RA). Data on patient characteristics, diagnosis, previous treatment and outcomes of abatacept have been…
  • Abstract Number: 511 • 2014 ACR/ARHP Annual Meeting

    First and Second Line Continuation Rates of Non Anti-TNF-α Biological DMARD for the Treatment of Rheumatoid Arthritis

    Tristan Pascart1, Rene-Marc Flipo2, Xavier Deprez3 and Eric Houvenagel4, 1Rheumatology, Saint-Philibert Hospital, Lille, France, 2Rheumatology, University Hospital Lille, Lille, France, 3Rhumatologie, Ch De Valenciennes, Valenciennes, France, 4Rheumatology, Saint-Philibert Hospital, LOMME, France

    Background/Purpose The 2013 update of the EULAR recommendations for the management of RA with synthetic and biological DMARDs set non-anti-TNF- α as first-line biological treatments.…
  • Abstract Number: 512 • 2014 ACR/ARHP Annual Meeting

    Effect and Safety of Concomitant Methotrexate and Tacrolimus on Clinical Response of Abatacept in Rheumatoid Arthritis Patients with Prior Use of Biological Dmards

    Nobunori Takahashi1, Toshihisa Kojima1, Yuji Hirano2, Yasuhide Kanayama3, Koji Funahashi4 and Naoki Ishiguro1, 1Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan, 3Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital, Toyota, Japan, 4Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Background/Purpose Abatacept (ABT) is a new class of biologic agents for the treatment of rheumatoid arthritis (RA) that inhibits T cell activation by binding to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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