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  • Abstract Number: 563 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Clinical Parameters and Quality of Life in Smokers with Ankylosing Spondylitis: Results from the Scotland Registry for Ankylosing Spondylitis

    Linda E. Dean1, Fabiola Azeni1,2, Tiara Ratz1, Alan G. MacDonald3, Roger D. Sturrock1,4, John Hunter5, David Marshall6, Gary J. Macfarlane1 and Gareth T. Jones1, 1Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 2Rheumatology Unit, L.Sacco University Hospital, Milan, Italy, 3Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Department of Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom, 6Department of Rheumatology, Inverclyde Royal Hospital, Greenock, United Kingdom

    Background/Purpose: Several studies have shown that smoking is associated with increased disease activity, worse physical function and poor quality of life in ankylosing spondylitis (AS). …
  • Abstract Number: 562 • 2014 ACR/ARHP Annual Meeting

    Clinical Response and Remission in Patients with Non-Radiographic Axial Spondyloarthritis after Three Years of Adalimumab Therapy

    Désirée M. van der Heijde1, Joachim Sieper2, Walter P. Maksymowych3, Dominique L. Baeten4, Yinglin Xia5, Jaclyn K. Anderson5 and Aileen L. Pangan5, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Department of Medicine, University of Alberta, Edmonton, AB, Canada, 4Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 5AbbVie Inc., North Chicago, IL

    Background/Purpose: Adalimumab (ADA) has been previously shown to be effective for the treatment of non-radiographic axial spondyloarthritis (nr-axSpA) patients (pts) in the ABILITY-1 trial.1 Week…
  • Abstract Number: 561 • 2014 ACR/ARHP Annual Meeting

    A Psychometric Analysis of Outcome Measures in Trials of Peripheral Spondyloarthritis

    Sofia Ramiro1, Maureen C. Turina2, Dominique L. Baeten3, Philip J. Mease4, Jacqueline E. Paramarta2, In-Ho Song5, Aileen L. Pangan6 and Robert Landewé7, 1Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center/University of Amsterdam, Amsterdam, Netherlands, 2Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 4Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, 5AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 6AbbVie Inc., North Chicago, IL, 7Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: We assessed the discriminatory aspects of disease activity measures and response criteria between adalimumab (ADA) and placebo (PBO) in 2 studies of patients (pts)…
  • Abstract Number: 560 • 2014 ACR/ARHP Annual Meeting

    High Sensitivity of the ASAS Classification Criteria in Patients with HLA-B27 Positive Undifferentiated Spondyloarthritis with Onset of Disease after Age 45

    Ignazio Olivieri1, Michele Gilio2, Salvatore D'Angelo1, Angela Padula1, Pietro Leccese1, Silvana Di Bello1, Norullah Akkoc3, Nicola Ferrara4 and Carlo Palazzi1, 1Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy, 2San Carlo Hospital, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy, 3Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, 4Department of Translational Medical Sciences, Federico II University, Naples, Italy

    Background/Purpose: The spondyloarthritis (SpA) complex also includes forms that do not meet criteria for the definite forms and are called undifferentiated SpA (uSpA). Recently the…
  • Abstract Number: 578 • 2014 ACR/ARHP Annual Meeting

    Female Patients but Not Male Patients with Ankylosing Spondylitis Are at Increased Risk of Developing Ischemic Heart Disease: A Population-Based Cohort Study

    Ivette Essers1,2, Carmen Stolwijk1,2, Annelies Boonen3,4, Marie L. De Bruin5, Marloes Bazelier5, Frank de Vries5,6,7,8 and Astrid Van Tubergen1,2, 1School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, 2Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 3Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 4Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, Netherlands, 5Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, 6Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, Netherlands, 7MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, United Kingdom, 8Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands

    Background/Purpose: It is well recognized that rheumatoid arthritis is an independent risk factor for cardiovascular disease. For ankylosing spondylitis (AS), the literature on this risk…
  • Abstract Number: 577 • 2014 ACR/ARHP Annual Meeting

    A Substantial Decrease in Work Productivity and Physical Health-Related Quality of Life in Chronic Back Pain of Recent Onset: Data from the SPACE-Cohort

    A Roeterink1, M de Hooge2, R. van den Berg2, H Dagfinrud3, M Turina4, M. van Oosterhout5, D. van der Heijde1 and F van Gaalen2, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Oslo City Dept of Rheumat, Diakonhjemmet Hospital, Oslo, Norway, 4Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Groene Hartziekenhuis, Gouda, Netherlands

    Background/Purpose: Ankylosing spondylitis is associated with work productivity (WP) loss and a decreased health-related quality of life (HRQoL).  Little is known about WP loss and…
  • Abstract Number: 576 • 2014 ACR/ARHP Annual Meeting

    Dikkopf-1 (Dkk-1) Serum Levels in Axial Spondyloarthritis (axSpA) Are Related to Disease Duration

    Victoria Navarro-Compán1, Enrique Melguizo-Madrid2, Concepción González-Rodríguez3, Federico Navarro-Sarabia4 and Rafael Ariza-Ariza4, 1Rheumatology, University Hospital La Paz and Leiden University Medical Center, Madrid, Spain, 2Biochemistry, University Hospital Virgen Macarena, Sevilla, Spain, 3University Hospital Virgen Macarena, Sevilla, Spain, 4Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain

    Background/Purpose: Tumor necrosis factor (TNF) alpha is responsible for induction of dkk-1 which down-regulates bone formation. Therefore, it was expected that TNF-blocker therapy would inhibit…
  • Abstract Number: 575 • 2014 ACR/ARHP Annual Meeting

    Disease Activity Strongly Influences Work Productivity and Physical Health Related Quality of Life in Early Axial Spondyloarthritis: Data from the SPACE-Cohort

    A Roeterink1, M de Hooge2, R. van den Berg2, H Dagfinrud3, R Landewé4, M. van Oosterhout5, R Ramonda6, D. van der Heijde1 and F van Gaalen2, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Oslo City Dept of Rheumat, Diakonhjemmet Hospital, Oslo, Norway, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Groene Hartziekenhuis, Gouda, Netherlands, 6Rheumatology Unit, University of Padova, Padova, Italy

    Background/Purpose: In early onset axial spondyloarthritis (axSpA), not much is known about the relationship between disease activity and work productivity loss (WPL) or disease activity…
  • Abstract Number: 574 • 2014 ACR/ARHP Annual Meeting

    Do Extra-Articular Manifestations Influence Outcome in Ankylosing Spondylitis? a 12 Year Follow-up Study

    Ivette Essers1,2, Sofia Ramiro3,4, Carmen Stolwijk1,2, Marc Blaauw5, Robert Landewé6,7, Désirée M. van der Heijde8, Filip van Den Bosch9, Maxime Dougados10 and Astrid van Tubergen2,11, 1School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, 2Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 3Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center/University of Amsterdam, Amsterdam, Netherlands, 4Rheumatology, Hospital Garcia de Orta, Almada, Portugal, 5Department of Internal Medicine, Catharina Hospital, Eindhoven, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 7Rheumatology, Atrium Medical Center, Heerlen, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, 10Rheumatology, Hopital Cochin, Descartes University, Paris, France, 11Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose: Extra-articular manifestations (EAMs), such as acute anterior uveitis (AAU), inflammatory bowel disease (IBD), and psoriasis contribute to diagnosis, classification criteria, and choice of treatment…
  • Abstract Number: 573 • 2014 ACR/ARHP Annual Meeting

    Three-Year Course and Prediction of Physical Functioning in Ankylosing Spondylitis Patients Treated with TNF-Inhibitors

    Salima F.E. van Weely1, Eva L. Kneepkens1, Mike T. Nurmohamed1, Joost Dekker1,2 and Irene E. van der Horst-Bruinsma3, 1Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 2Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 3Rheumatology, VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Currently, only limited information is available on the long-term course of limitations in physical functioning and spinal mobility in Ankylosing Spondylitis (AS) patients receiving…
  • Abstract Number: 572 • 2014 ACR/ARHP Annual Meeting

    Objective Evaluation of Physical Functioning after TNFi Therapy in Ankylosing Spondylitis Patients; A Selection of Three Feasible Performance-Based Tests

    Salima F.E. van Weely1, Joost Dekker1,2, Martijn P.M. Steultjens3, Christiaan J. Van Denderen1, Mike T. Nurmohamed1, Ben A.C. Dijkmans4 and Irene E. van der Horst-Bruinsma4, 1Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 2Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 3Institute for Applied Health Research and School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, 4Rheumatology, VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Physical functioning is considered an important outcome domain for the evaluation of the effectiveness of therapy and the course of the disease. In an effort…
  • Abstract Number: 571 • 2014 ACR/ARHP Annual Meeting

    Unraveling the Familial Tendency for Ankylosing Spondylitis in Korea

    Hye Won Kim1, Hye Rim Choe2, Won Ik Chang3, Yong-Gil Kim4, Bin Yoo4, Jin Wook Hur1, Tae-Hwan Kim5, Sungim Lee6 and Eun Young Lee7, 1Division of Rheumatology, Department of Internal Medicine, Eulji University of Medicine, Eulji General Hospital, Seoul, South Korea, 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 3Seoul National University College of Medicine, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 6Department of Applied Statistics, Dankook University, Yongin, South Korea, 7Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose : Despite of the evidence of familial aggregation of ankylosing spondylitis (AS), familial tendencies are not fully explored. The purpose of this study was…
  • Abstract Number: 570 • 2014 ACR/ARHP Annual Meeting

    Sleep Disturbances in Korean Patients with Ankylosing Spondylitis Are Associated with Increased Disease Activity

    Hye-Jin Jeong1, Yun Sung Kim2, Chang-Nam Son3, Ji-Min Kim3 and Sang-Hyon Kim3, 1Keimyung University Dongsan Medical Center, Daegu, South Korea, 2Internal Medicine, Chosun University Hospital, Gwangju, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea

    Background/Purpose: Sleep problems have been reported to be more frequent in rheumatic disease than normal population. Other studies indicate various sleep problems have been reported…
  • Abstract Number: 569 • 2014 ACR/ARHP Annual Meeting

    Better Outcomes in Ankylosing Spondylitis: The Synergistic Association Between Exercise and Tumor Necrosis Factor Inhibitors

    Sarah L. Patterson1, John D. Reveille2,3, MinJae Lee4, Michael M. Ward5, Mohammad H. Rahbar6, Matthew A. Brown7, Michael H. Weisman8 and Lianne S. Gensler9, 1Internal Medicine, University of California, San Francisco, San Francisco, CA, 2Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 3Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, 4Medicine, University of Texas Health Science Center at Houston, Houston, TX, 5Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, 6The University of Texas Health Science Center at Houston, Houston, TX, 7University of Queensland Diamantina Institute, Brisbane, Australia, 8Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Exercise is an important component of Ankylosing Spondylitis (AS) management.  The purpose of this study was to determine if the amount patients exercise associates…
  • Abstract Number: 567 • 2014 ACR/ARHP Annual Meeting

    Use of Monotherapy Anti-Tnf Agents in Ankylosing Spondylitis Patients from the rhumadata® Registry: 8-Year Comparative Effectiveness of Adalimumab, Etanercept and Infliximab

    Denis Choquette1, Louis Bessette2, Isabelle Fortin3, Boulos Haraoui1, Jean Pierre Pelletier1, Jean-Pierre Raynauld1, Diane Sauvageau1, Edith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada

    Background/Purpose: Anti-TNF agents namely adalimumab (ADA), etanercept (ETA) and infliximab (INF) are approved for the treatment of signs and symptoms of ankylosing spondylitis. Their efficacy…
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