Abstracts Archive - Page 2193 of 2607 - ACR Meeting Abstracts

Abstract Number: 604 • 2014 ACR/ARHP Annual Meeting
Characterisation of Mucosal-Associated Invariant T (MAIT) Cells in Ankylosing Spondylitis Patients
Ibrahim Almaghlouth¹, Eric Gracey², Zoya Qaiyum², Robert D. Inman³ and Ammepa Anton⁴, ¹Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Immunology, University of Toronto, Toronto, ON, Canada, ³Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose: Ankylosing spondylitis (AS) is chronic inflammatory disease of unknown origin. Studies into the molecular basis of AS have demonstrated exaggerated innate and adaptive immune…
Abstract Number: 603 • 2014 ACR/ARHP Annual Meeting
Periostin May Have a Role in Ankylosing Spondylitis and It Is Associated with Wnt Signalling Pathway Regulators
Servet Akar¹, Saadettin Uslu², Leyla Didem Kozaci³, Gercek Can⁴, Neslihan Karaca⁵, Emine Figen Tarhan⁴, Mustafa Ozmen⁶ and Dilek Solmaz⁷, ¹Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine,, Izmir, Turkey, ²Department of Internal Medicine, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ³Department of Medical Biochemistry, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁴Internal Medicine Clinic, Division of Rheumatology, Izmir Ataturk Education and Reseach Hospital, Izmir, Turkey, ⁵Adnan Menderes University, Science Thecnology Research and Application Center, Aydin, Turkey, ⁶Internal Medicine Clinic, D,v,s,on of Rheumatology, Izmir Ataturk Education and Reseach Hospital, Izmir, Turkey, ⁷Department of Internal Medicine, Division of Rheumatology, Namik Kemal University School of Medicine, Tekirdag, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is a chronic rheumatic disease characterized by sacroiliac and spinal inflammationand new bone formation (syndesmophyte). Molecular mechanisms underlying this process have…
Abstract Number: 602 • 2014 ACR/ARHP Annual Meeting
A Phase 3, Randomized, Controlled Trial of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, for Treatment of Psoriatic Arthritis: Long-Term (52-Week) Improvements in Physical Function
Alvin Wells¹, Jacob A. Aelion², Adewale O. Adebajo³, Alan Kivitz⁴, Paul Bird⁵, ChiaChi Hu⁶, Randall M. Stevens⁶ and Christopher J. Edwards⁷, ¹Rheumatology & Immunotherapy Center, Franklin, WI, ²West Tennessee Research Institute, Jackson, TN, ³University of Sheffield, Sheffield, United Kingdom, ⁴Altoona Center for Clinical Research, Duncansville, PA, ⁵Combined Rheumatology Practice, Kogarah, Australia, ⁶Celgene Corporation, Warren, NJ, ⁷University Hospital Southampton, Southampton, United Kingdom
Background/Purpose: Apremilast (APR) is a phosphodiesterase 4 inhibitor that helps regulate the immune response that causes inflammation and skin disease associated with psoriatic arthritis (PsA).…
Abstract Number: 601 • 2014 ACR/ARHP Annual Meeting
Combined Hip Abduction Angle Measured By Using Iphone Compass Application; A Novel Measurement Tool to Asses Hip Mobility
Handan Yarkan, Berrin Zengin, Gokce Kenar, Pinar Cetin, Ismail Sari, Fatos Onen and Nurullah Akkoc, Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey
Background/Purpose Intermalleolar distance (IMD) is a component of the Bath ankylosing spondylitis metrology index (BASMI) and measures abduction of the hips. New generations of smartphones…
Abstract Number: 600 • 2014 ACR/ARHP Annual Meeting
Differing Patterns of Axial Spondyloarthritis in Females and Males
Ibrahim Almaghlouth^1,2, Arane Thava³, Nigil Haroon⁴ and Robert D. Inman⁵, ¹Internal medicine, University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, Toronto, ON, Canada, ⁴Toronto Western Research Institute, Toronto, ON, Canada, ⁵Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Sex effects have been noted in axial spondyloarthritis (AS) however controversy still exists regarding male and female clinical manifestations of AS. This includes uncertainty…
Abstract Number: 618 • 2014 ACR/ARHP Annual Meeting
A Gender Bias in Gut Microbiota of SKG Mice Colonized with a Limited Bacterial Consortium Associated with Severity of Spondyloarthritis and Ileitis Triggered By Beta-Glucan
Linda Rehaume, Olga Zbarskaya, Alicia Kang, Helen Benham, Paraic O Cuiv, Mark Morrison and Ranjeny Thomas, University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose Beta-glucan (curdlan)-treated BALB/c ZAP-70W163C(SKG) mutant mice develop IL-23-dependent spondyloarthritis, and curdlan promotes ileitis in SKG mice housed under specific pathogen-free (SPF) but not germ-free…
Abstract Number: 619 • 2014 ACR/ARHP Annual Meeting
Effect of ERAP1 Knockdown on Conformation of HLA-B27 and Other HLA Class I Molecules in Human Monocytic Cells
Tri M. Tran¹, Sohee Hong¹, Jehad H. Edwan² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS NIH, Bethesda, MD
Background/Purpose Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with ankylosing spondylitis, Behcet’s disease, and psoriasis/psoriatic arthritis, where HLA class I alleles are…
Abstract Number: 617 • 2014 ACR/ARHP Annual Meeting
Shared HLA Class I and II Alleles in Susceptibility to Ankylosing Spondylitis Among Three Ethnic Groups
Mark Hwang¹, Xiaodong Zhou², Michael H. Weisman³, Michael M. Ward⁴, Jiucun Wang⁵, Lianne S. Gensler⁶, Hejian Zou⁵, Dongyi He⁷, Matthew A. Brown⁸, Paul Scheet⁹ and John D. Reveille^10,11, ¹Medicine, University of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁵Rheumatology, Huashan Hospital, Shanghai, China, ⁶Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷No.540 xinhua Road .Shanghai, Shanghai Guanghua Hospital, Shanghai, China, ⁸University of Queensland Diamantina Institute, Brisbane, Australia, ⁹MD Anderson Cancer Center, Houston, TX, ¹⁰Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹¹Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose : The purpose of this study is to examine associations of HLA class I and class II alleles with AS in different patients populations of…
Abstract Number: 606 • 2014 ACR/ARHP Annual Meeting
The Immunological Basis of the Sex-Bias in Ankylosing Spondylitis: Th17 Expansion Is Restricted to Male Patients and Correlates with Sex-Related Alteration in Vitamin D Metabolism
Eric Gracey^1,2, Blerta Green², Paul Yip³, Renise Ayearst⁴, Ammepa Anton⁵, Aifeng Lin² and Robert D. Inman⁶, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, University Health Network, Toronto, ON, Canada, ³Clinical Biochemistry, University Health Network, Toronto, ON, Canada, ⁴University Health Network, Toronto, ON, Canada, ⁵Rheumatology, University Health Network, Toronto, ON, Canada, ⁶Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose : Ankylosing spondylitis (AS) is an inflammatory arthritis of the spine, which has a major impact on function and quality of life. AS is…
Abstract Number: 597 • 2014 ACR/ARHP Annual Meeting
Inflammatory Burden in Recent-Onset Axial Spondyloarthritis
Juan Jose Aznar Sánchez¹, Raul Veroz Gonzalez¹, Adela Gallego Flores¹, Tamara Libertad Rodriguez Araya¹, Piter José Cossio Jimenez² and Eugenio Chamizo Carmona¹, ¹Rheumatology, Hospital de Mérida, Mérida, Spain, ²Hospital de Mérida, Mérida, Spain
Background/Purpose Patients with Non-Radiographic Axial Spondylarthritis (non-Rx AxSpA) don't presnt with different clinical manifestations than patients with Ankilosing Spondylitis (AS), although the inflammatory burden measured…
Abstract Number: 596 • 2014 ACR/ARHP Annual Meeting
Clinical Value of ASDAS Index in Spanish Patients with Ankylosing Spondylitis
Agusti Sellas-Fernandez¹, Jose Luis Guerra Vázquez², Jose Luis Casals³, Carlos Gonzalez Fernandez⁴, Roberto Miguelez⁵, José Rosas⁶, Antonio Fernandez-Nebro⁷, Cilia Peralta Ginés⁸, Carlos Montilla-Morales⁹, Xavier Juanola¹⁰, Miguel Ángel Abad¹¹, Alberto Alonso¹², Azucena Hernández-Sanz¹³, Luis Francisco Linares¹⁴, Julio Medina¹⁵, Joana Rovira¹⁶, Juan Carlos Torre-Alonso¹⁷, Alfredo Willisch¹⁸, Eduardo Collantes-Estevez¹⁹ and Ana Ruiz-Zorrilla²⁰, ¹H. Vall d'Hebron, Barcelona, Spain, ²H. Arquitecto Marcide, La Coruña, Spain, ³H. Virgen de la Victoria, Málaga, Spain, ⁴Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁵H. de Móstoles, Madrid, Spain, ⁶Rheumatology, Hospital Marina Baixa, Villajoyosa, Valencia, Alicante, Spain, ⁷Rheumatology, Hospital Regional Universitario Carlos Haya, Málaga, Spain, ⁸H. Clínico Lozano Blesa, Zaragoza, Spain, ⁹H. de Salamanca, Salamanca, Spain, ¹⁰Rheumatology, University Hospital Bellvitge, Barcelona, Spain, ¹¹Hospital Virgen del Puerto, Cáceres, Spain, ¹²Hospital de Cruces, Bilbao, Spain, ¹³H. Virgen de la Salud, Toledo, Spain, ¹⁴Hospital Virgen de la Arrixaca., Murcia, Spain, ¹⁵Hospital Clínico, Valladolid, Spain, ¹⁶Mutua Terrasa, Barcelona, Spain, ¹⁷Rheumatology Department, H. Monte Naranco, Oviedo, Spain, ¹⁸Complexo Hospitalario de Ourense, Ourense, Spain, ¹⁹Hospital Reina Sofía, Córdoba, Spain, ²⁰Abbvie, Madrid, Spain
Background/Purpose The ASDAS (ankylosing spondylitis disease activity score) was developed to overcome some of the deficiencies of BASDAI (Bath Ankylosing Disease Activity Spondyltis Index). In…
Abstract Number: 595 • 2014 ACR/ARHP Annual Meeting
Radiographic Sacroiliitis Progression in an Early Axial Spondyloarthritis Cohort
Concepcion Castillo-Gallego¹, Jesus Sanz², Carmen Martin-Hervas³, Mireia Moreno⁴, Victoria Navarro-Compán⁵, Diana Peiteado¹, Jorge Gratacos-Masmitja⁶, Eugenio De Miguel⁷ and Emilio Martín-Mola¹, ¹Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ²Rheumatology, Hospital Puerta de Hierro Majadahonda, Madrid, Spain, ³Radiology, Hospital Universitario La Paz, Madrid, Spain, ⁴Rheumatology, University Hospital Parc Taulí, Sabadell, Spain, ⁵Rheumatology, Rheumatologist, Madrid, Spain, ⁶Parc Tauli, S/N, Hospital Parc Tauli, Sabadell, Spain, ⁷Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
Background/Purpose: The current concept of axial Spondyloarhtritis (axSpA) considers non-radiographic axSpA (nr-axSpA) and Ankylosing Spondylitis (AS) as two stages of one disease. There are limited…
Abstract Number: 594 • 2014 ACR/ARHP Annual Meeting
Do Bone Marrow Edema Lesions in the Sacroiliac Joint Change into Fatty Lesions over a 1-Year Period in Patients with Axial Spondyloarthritis or Possible Spondyloarthritis
Pauline Bakker¹, Rosaline van den Berg², Manouk de Hooge¹, Floris van Gaalen², Monique Reijnierse¹, T.W.J. Huizinga¹ and Désirée van der Heijde³, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Bone marrow edema (BME) lesions in the sacroiliac joint (SIJ) may change into fatty lesions over time. Fatty lesions are regarded as the earliest…
Abstract Number: 593 • 2014 ACR/ARHP Annual Meeting
The Clinimetric Outcomes of Two Bath Ankylosing Spondyltis Metrology Indices in Treatment with TNF-á Blockers
Eon Jeong Nam¹, Jeong Soo Eun², Sang Hoon Kwon³ and Young Mo Kang⁴, ¹Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ²Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ³Internal medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ⁴Dept of Internal Medicine, Kyungpook National Univ Hosp, Daegu, South Korea
Background/Purpose Bath Ankylosing Spondyltis Metrology Index (BASMI) was developed to quantify the accurate axial status and to assess the clinical changes in spinal movement. The…
Abstract Number: 592 • 2014 ACR/ARHP Annual Meeting
Clinical and Psychological Correlates of Sleep Difficulties in Patients with Spondyloarthropathies Compared to Patients with Rheumatoid Arthritis
Konstantinos Kotsis¹, Thomas Hyphantis², Paraskevi V. Voulgari³, Andre F. Carvalho⁴ and Alexandros A. Drosos⁵, ¹Department of Psychiatry, Medical School, University of Ioannina, 45110, Ioannina, Greece., Department of Psychiatry, Medical School, University of Ioannina, 45110, Ioannina, Greece., Ioannina, Greece, ²Department of Psychiatry, Medical School, University of Ioannina, Ioannina 45110, Greece., Department of Psychiatry, Medical School, University of Ioannina, Ioannina 45110, Greece., Ioannina, Greece, ³Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Associate Professor of Rheumatology, Ioannina, Greece, ⁴Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Fortaleza, Brazil, ⁵Rheumatology Clinic, Department of Internal Medicine, University of Ioannina, Ioannina, Greece
Background/Purpose Sleep difficulties are common in patients with rheumatological disorders. Patients with Rheumatoid Arthritis (RA) report frequently poor quality sleep, numerous night awakening and difficulty…

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