Abstracts Archive - Page 2192 of 2607 - ACR Meeting Abstracts

Abstract Number: 638 • 2014 ACR/ARHP Annual Meeting
Commensal Microbiota Influence Systemic Autoimmune Responses
Jens Van Praet¹, Erin Donovan², Michael Drennan¹, Fons Van de Loo³, Sylvie Rabot⁴, Jeroen Raes⁵, Tom Van De Wiele⁶, Carl Ware⁷ and Dirk Elewaut⁸, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²department of Rheumatology, Ghent University Hospital, ghent, Belgium, ³Rheumatology, Raboud University Medical Center, Utrecht, Netherlands, ⁴AgroParisTech, Micalis,, Jouy-en-Josas, France, ⁵Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium, ⁶Laboratory of Microbial Ecology and Technology, Ghent University Hospital, Ghent, Belgium, ⁷Infectious and Inflammatory Disease Center,, Sanford-Burnham Medical Research Institute, La Jolla, CA, ⁸Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the processes underlying the loss of…
Abstract Number: 637 • 2014 ACR/ARHP Annual Meeting
Decreased Inflammatory Dendritic Cells in Lupus-Prone Estrogen Receptor Alpha Knockout (ERαKO) Mice Correlate with Increased Survival
Melissa A. Cunningham¹, Jena R. Wirth², Jackie G. Eudaly³, Jennifer L. Scott⁴, Osama S. Naga³ and Gary S. Gilkeson⁵, ¹Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Med/Rheumatology, MUSC, Charleston, SC, ³Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: SLE is a disease that disproportionately affects females. The etiology of the sex bias in this disease is unclear. We previously showed that a…
Abstract Number: 636 • 2014 ACR/ARHP Annual Meeting
Liposomal-Glucocorticoids: A Novel Approach to the Therapy of SLE
Yaakov Naparstek¹, Eli Moallem², Rina Ulmansky³, Erez Koren³ and Yechezkel Barenholz³, ¹Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ²Dept. of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ³Hadassah - Hebrew University Medical Center, Jerusalem, Israel
Background/Purpose Glucocorticoids (GCs) have been known for years to be the most effective therapy in SLE. Their use is however limited by the need of…
Abstract Number: 635 • 2014 ACR/ARHP Annual Meeting
Mir-663 Impairs the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on MRL/Lpr Mice
Linyu Geng¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Previously we have shown that miR-663 was increased in bone marrow derived mesenchymal stem cells (BMSCs) from SLE patients and involved in the functional…
Abstract Number: 616 • 2014 ACR/ARHP Annual Meeting
In Situ Analysis of Mechanisms of New Bone Formation in Zygapophyseal Joints from Patients with Ankylosing Spondylitis
Janine Bleil¹, Joachim Sieper², Rene Maier³, Uwe Schlichting⁴, Axel Hempfing⁵, Heiner Appel⁶ and Uta Syrbe⁷, ¹Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Deutsches Rheumaforschungszentrum, Berlin, Germany, ⁴Department of Pathology, Charite, Berlin, Germany, ⁵Werner-Wicker-Klinik, Bad Wildungen, Germany, ⁶Rheumatology and Nephrology Practice, Hamm, Germany, ⁷Charité, Berlin, Germany
Background/Purpose Osteoproliferation leading to joint ankylosis is a characteristic feature of ankylosing spondylitis (AS). In general, there are two ways of bone formation: a) endochondral…
Abstract Number: 615 • 2014 ACR/ARHP Annual Meeting
Analysis of the Gut Transcriptome in HLA-B27 Transgenic Rats By RNA-Seq Reveals Prominent Interferon and IL-23/IL-17 Axis Signatures
Tejpal Gill¹, Mark Asquith², Steve Brooks¹, James T. Rosenbaum² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²OHSU, Portland, OR
Background/Purpose: Expression of HLA-B27 and human beta 2-microglobulin (hb2m) in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). SpA overlaps with IBD in…
Abstract Number: 614 • 2014 ACR/ARHP Annual Meeting
The Association of PPM1A with Inflammasome Activation in Ankylosing Spondylitis
Soo Min Ahn¹, Seung-Hyeon Bae¹, Seokchan Hong¹, Eun-Ju Lee¹, Eun-Jin Lee², Eun-Ju Chang², Doo-Ho Lim¹, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
The Association of PPM1A with Inflammasome Activation in Ankylosing SpondylitisBackground/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disorder usually affecting axial skeleton and joints. The…
Abstract Number: 613 • 2014 ACR/ARHP Annual Meeting
The Amount of Free Heavy Chain and β2-Microglobulin in the Cytoplasm of B*2705 Ankylosing Spondylitis Patients Compared to B*2705 and B*2709 Healthy Subjects Does Not Support the UPR Theory. Influence of ERAP1 Polymorphisms
Alberto Cauli, Grazia Dessole, Giovanni Porru, Matteo Piga, Alessandra Vacca and Alessandro Mathieu, Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy
Background/Purpose : Ankylosing Spondylitis (AS) is a chronic inflammatory disease of the spine strongly associated with the majority of HLA-B27 alleles, with the exception of…
Abstract Number: 612 • 2014 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and beta1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seong-Wook Kang¹, Seung-Taek Song¹, Su-Jin Yoo², Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴, In-Seol Yoo², Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁴Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea
Background/Purpose Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 611 • 2014 ACR/ARHP Annual Meeting
Autophagy and Unfolded Protein Response: A Fine Balance That Can Influence the Pathogenesis of Ankylosing Spondylitis and Inflammatory Bowel Disease
Nigil Haroon¹, Giuliana Guggino², Zhenbo Zhang¹, Kirby Yee³, Hasan Abdullah⁴, Ricardo Alessandro⁵, Stefania Raimondo⁵, Giovanni Triolo⁵ and Francesco Ciccia², ¹Toronto Western Research Institute, Toronto, ON, Canada, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³McMaster University, Hamilton, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Palermo, Palermo, Italy
Background/Purpose We have shown an increase in the unfolded protein response (UPR) with decreased ERAP1 or ERAP2 function in an in vitrosystem. Similarly UPR has…
Abstract Number: 610 • 2014 ACR/ARHP Annual Meeting
Functional Implications of the Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Association with Ankylosing Spondylitis and Crohn’s Disease: Impact on the Unfolded Protein Response
Zhenbo Zhang¹, Francesco Ciccia², Kirby Yee³, Giuliana Guggino², Hasan Abdullah⁴, Ricardo Alessandro⁵, Stefania Raimondo⁵, Giovanni Triolo⁵ and Nigil Haroon^1,6,7, ¹Toronto Western Research Institute, Toronto, ON, Canada, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³McMaster University, Hamilton, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Palermo, Palermo, Italy, ⁶Rheumatology, University Health Network, Toronto, ON, Canada, ⁷Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) has found to be associated with AS and Crohn’s Disease (CD). The functional implications of this association have not…
Abstract Number: 609 • 2014 ACR/ARHP Annual Meeting
Induced Pluripotent Stem Cells (iPSCs) As a Tool for Unraveling the Role of Different Cell Types in the Disease Process of Spondyloarthritis Pathogenesis
Gerlinde Layh-Schmitt¹, Shjia Lu², Fatemeh Navid², Massimo Gadina² and Robert A. Colbert², ¹10 Center Drive., NIAMS/NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Many genetic factors and cell types contribute to the axial inflammation, trabecular bone loss, and aberrant bone formation that result in ankylosing spondylitis. The…
Abstract Number: 608 • 2014 ACR/ARHP Annual Meeting
Identification of Novel Autoantibodies in Patients with Ankylosing Spondylitis Using Human Protein Microarray
Matthew Presby¹, Mark J. Soloski¹, John A. Flynn², Clifton O. Bingham III¹, Michael M. Ward³ and Grant H. Louie⁴, ¹Johns Hopkins University, Baltimore, MD, ²Dept of Medicine, Johns Hopkins University, Baltimore, MD, ³Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Ankylosing spondylitis (AS) is an immune-mediated disease for which the search for autoantibodies has been elusive. Conventional immunoserological approaches are slow and limited…
Abstract Number: 607 • 2014 ACR/ARHP Annual Meeting
The HLA-B27 Peptidome in Vivo in Transgenic Rats
Joel D. Taurog¹, Yael Haimovich², Eilon Barnea³, Michal Bassani-Sternberg³, Shira Yair-Sabag², Martha L. Dorris¹, Nimman Satumtira¹, Mylinh Nguyen⁴, Robert E. Hammer⁴, Tri M. Tran⁵, Robert A. Colbert⁵ and Arie Admon³, ¹Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ²Technion-Israel Institute of Technology, Haifa, Israel, ³Biology, Technion-Israel Institute of Technology, Haifa, Israel, ⁴Biochemistry, UT Southwestern Medical Center, Dallas, TX, ⁵NIAMS/NIH, Bethesda, MD
Background/Purpose . In all current hypotheses for the association of B27 with SpA, the B27 peptide repertoire (peptidome) is likely to play a key role.…
Abstract Number: 605 • 2014 ACR/ARHP Annual Meeting
Decreased Frequencies of Circulating Follicular Helper T Cell Counterparts and Plasmablasts in Ankylosing Spondylitis Patients Naïve for TNF Blockers
M. Belén Bautista-Caro¹, Irene Arroyo-Villa¹, Concepcion Castillo-Gallego¹, Eugenio De Miguel², Diana Peiteado¹, Chamaida Plasencia-Rodriguez¹, Alejandro Villalba¹, Paloma Sanchez-Mateos³, Amaya Puig-Kröger⁴, Emilio Martín-Mola¹ and Maria Eugenia Miranda-Carus¹, ¹Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ²Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain, ³Immunology, Hospital Gregorio Marañon, Madrid, Spain, ⁴Laboratorio de Inmuno-Metabolismo, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
Background/Purpose: Follicular helper T cells (Tfh), localized in lymphoid organs, promote B cell differentiation and function. Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1…

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