ACR Meeting Abstracts

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  • Abstract Number: 884 • 2013 ACR/ARHP Annual Meeting

    Treatment Of Lupus Nephritis With Abatacept Plus Low-Dose Pulse Cyclophosphamide Followed By Azathioprine (the Euro-Lupus Regimen): Twenty-Four Week Data From a Double-Blind Controlled Trial

    David Wofsy1, Anca Askanase2, Patricia C. Cagnoli3, W. Winn Chatham4, Gabriel Contreras5, Maria Dall'era6, Mary Anne Dooley7, Hilda Fragoso-Loyo8, David R. Karp9, Meenakshi Jolly10, Kenneth Kalunian11, Diane L. Kamen12, Iris Lee13, Marc C. Levesque14, S. Sam Lim15, Meggan Mackay16, Cesar Ramos-Remus17, Brad H. Rovin18, Tammy O. Utset19, Swamy Venuturupalli20, Robert Winchester21, Linna Ding22, Wendy Gao22, Lynette Keyes-Elstein23 and Patti Tosta24, 1Rheumatology/Immunology, University of California San Francisco and NIAID Autoimmunity Centers of Excellence, San Francisco, CA, 2NYU School of Medicine, New York, NY, 3Int Med/Div of Rheum, University of Michigan Health, Ann Arbor, MI, 4University of Alabama at Birmingham, Birmingham, AL, 5University of Miami, Miami, FL, 6Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 7University of North Carolina at Chapel Hill, Chapel Hill, NC, 8Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, 9Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, 10Rheumatology, Rush University Medical Center, Chicago, IL, 11UCSD School of Medicine, La Jolla, CA, 12Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 13Nephrology, Temple University, Philadelphia, PA, 14Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 15Emory University School of Medicine, Division of Rheumatology, Atlanta, GA, 16Autoimmune & Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, NY, 17Unidad de Investigacion en Enfermedades Cronico-Degenerativas, Guadalajara, Mexico, 18Division of Nephrology, Ohio State University Medical Center, Columbus, OH, 19Rheumatology, University of Chicago Medical Center, Chicago, IL, 20Cedars-Sinai Medical Center, West Hollywood, CA, 21Dept of Medicine & Pathology, Columbia University, New York, NY, 22NIAID, Bethesda, MD, 23Rho Federal Systems, Inc., Chapel Hill, NC, 24Immune Tolerance Network, San Francisco, CA

    Background/Purpose: Studies in murine models for SLE have shown that CTLA4Ig can ameliorate murine lupus nephritis.  Moreover, the combination of CTLA4Ig plus intravenous cyclophosphamide (IVC)…
  • Abstract Number: 885 • 2013 ACR/ARHP Annual Meeting

    Fatigue In SLE Is Associated With Upregulation Of Interferon- Alpha Related Gene Transcripts

    Maureen A. McMahon1, Jennifer M. Grossman2, Bevra H. Hahn3, Lori Sahakian4, Isao Matsuura5, Elaine Lourenco6 and Brian Skaggs6, 1Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, 3Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 4Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, 5UCLA David Geffen School of Medicine, Los Angeles, CA, 6Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Fatigue is a major complaint in at least 80% of SLE patients, and is often listed as the most disabling symptom of the disease;…
  • Abstract Number: 886 • 2013 ACR/ARHP Annual Meeting

    Lupus Neutrophil Extracellular Traps Render High Density Lipoprotein Oxidized and proatherogenic 

    Carolyne K. Smith1, Anuradha Vivekanandan-Giri2, Jason S. Knight3, Paul Ryan Thompson4, Subramaniam Pennathur2 and Mariana J. Kaplan5, 1Rheumatology and Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, 2Internal Medicine/Nephrology, University of Michigan Nephrology, Ann Arbor, MI, 3Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 4The Scripps Research Institute, Jupiter, FL, 5Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD

    Background/Purpose: Cardiovascular risk is significantly increased in systemic lupus erythematosus (SLE) patients. This phenomenon cannot be explained by the Framingham risk equation.  Previous reports suggest that…
  • Abstract Number: 887 • 2013 ACR/ARHP Annual Meeting

    Atherosclerosis and Cardiovascular Disease In Systemic Lupus Eryhematosus Are Related To An Inflammatory/Oxidative Status Linked To The Autoimmune Condition and The Clinical Activity Of The Disease. Effect Of Statins Treatment

    Chary Lopez-Pedrera1, Patricia Ruiz-Limon1, Carlos Perez-Sanchez1, Mª Angeles Aguirre2, Nuria Barbarroja1, Tomás Cerdó-Ráez3, Maria Laura Bertolaccini4, Munther A. Khamashta5, Antonio Rodriguez-Ariza6, Yolanda Almaden7, Husam Khraiwesh8, Jose Antonio Gonzalez-Reyes9, Jose Manuel Villalba10, Eduardo Collantes11 and Mª Jose Cuadrado12, 1Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, 2Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 3Imibic, Córdoba, Spain, 4Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, 5Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, 6Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 7Imibic, Códoba, Spain, 8UCO, Córdoba, Spain, 9Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, 10Cell Biology, Physiology and Immunology, University of Cordoba, Agrifood Campus of International Excelence (ciA3), Cordoba, Spain, 11Rheumatology, Hospital Reina Sofia, Cordoba, Spain, 12Lupus Research Unit, The Rayne Institute, London, United Kingdom

    Background/Purpose: Atherosclerosis (AT) and cardiovascular disease (CVD) are enhanced systemic lupus erythematosus (SLE). Although there is evidence that statins have anti-inflammatory properties, their mechanism of…
  • Abstract Number: 848 • 2013 ACR/ARHP Annual Meeting

    Human Papillomavirus Vaccine Uptake Among Children and Young Adults With Autoimmune Diseases

    Candace H. Feldman1, Linda T. Hiraki2, Joyce Lii3 and Seoyoung C. Kim4, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 3Department of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 4Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Autoimmune diseases such as lupus and inflammatory bowel disease are associated with increased rates of human papillomavirus (HPV), the most common sexually transmitted disease…
  • Abstract Number: 849 • 2013 ACR/ARHP Annual Meeting

    Reasons For Failure To Obtain Influenza and Pneumococcal Vaccines Among Immunosuppressed Individuals With Systemic Lupus Erythematosus

    Erica F. Lawson1, Laura Trupin2, Emily von Scheven3, Edward H. Yelin2 and Jinoos Yazdany2, 1Pediatrics, University of California, San Francisco, San Francisco, CA, 2Medicine, UC San Francisco, San Francisco, CA, 3Pediatrics, UC San Francisco, San Francisco, CA

    Background/Purpose: Infection is the third-leading cause of death in individuals with systemic lupus erythematosus (SLE) in developed countries. Nearly half of those deaths are attributed…
  • Abstract Number: 850 • 2013 ACR/ARHP Annual Meeting

    Salivary Gland Ultrasonography: A Highly Specific Tool For The Early Diagnosis Of Primary Sjögren’s Syndrome

    Nicoletta Luciano1, Chiara Baldini1, Gaia Tarantini2, Rachele Pascale2, Francesca Sernissi1, Linda Carli1, Francesco Ferro1, Rosaria Talarico1, Marta Mosca3, Davide Caramella4 and Stefano Bombardieri1, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Pisa, Pisa, Italy, 4University of Pisa, Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy

    Background/Purpose: Recently, Cornec D. et al. reported that salivary gland ultrasonography (SGUS) was characterized by a sensitivity of 65.8% and a specificity of 95.3%, in…
  • Abstract Number: 851 • 2013 ACR/ARHP Annual Meeting

    Salivary Gland Ultrasonography Improves The Diagnostic Performance Of ACR 2012 Classification Criteria For Sjögren’s Syndrome, Even In The Early Stages Of The Disease

    Divi Cornec1, Sandrine jousse-Joulin2, Thierry Marhadour3, Jacques-Olivier Pers4, Yves Renaudineau4, Alain Saraux5 and Valerie Devauchelle-Pensec6, 1Department of rheumatology, Brest Occidentale University, Brest, France, 2Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, 3Rheumatology, CHU de la Cavale Blanche, Brest, France, 4Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, 5Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, 6Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France

    Background/Purpose: Recently published ACR classification criteria for primary Sjögren’s syndrome (pSS) include only 3 objective tests: 1) a serological item: anti-SSA/SSB antibodies or [antinuclear antibody…
  • Abstract Number: 852 • 2013 ACR/ARHP Annual Meeting

    Systemic Lupus Erythematosous and Primary Sjogren’s Syndrome May Display Joint Erosions On MRI As Well As Healthy Control, But Cannot Be Considered As Erosive Disease Such As Rheumatoid Arthritis: : An MRI Observational Study Of 90 Subjects

    Frédérique Gandjbakhch1, Violaine Foltz2, Jérôme Renoux3, Nahalie Cozic4, Nathalie Costedoat-Chalumeau5, Damien Sene6, Guillaume Mercy7, Zahir Amoura8, Jean-Charles Piette9, Nathalie Morel10, Pierre Bourgeois11 and Bruno Fautrel12, 1Department of Rheumatology, APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, 2APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, 3Radiology, Pitie-Salpetriere Hospital, Paris, France, 4APHP, Pitie Salpetriere Hospital, department of statistics, Paris, France, 5Internal Medicine, Hopital Cochin, Paris, France, 6Internal Medicine, Hopital Lariboisière, Paris, France, 7APHP, Pitie-Salpétrière Hospital, paris, France, 8Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, 9Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France, 10Internal Medicine, Groupe Hospitalier Pitié-Salpétrière, Paris, France, 11Rheumatology, APHP,Pitie-Salpetriere Hospital, Paris 6, Paris, France, 12Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France

    Background/Purpose: Recent studies tend to demonstrate presence of MRI erosion in Systemic Lupus Erythematosous (SLE) and primary Sjogren’s syndrome (pSS). The objective of this study…
  • Abstract Number: 853 • 2013 ACR/ARHP Annual Meeting

    Capillaroscopy Compared With Color Doppler Ultrasound Of Digital Arteries For Distinguishing Primary From Secondary Raynaud’s Phenomenon

    Wolfgang A. Schmidt1, Katharina Pagel2, Bernd Schicke3 and Andreas Krause4, 1Med Ctr Rheumatology Berlin Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 2Medical Ctr Rheumatol Berlin Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 3Tumorzentrum Berlin, Berlin, Germany, 4Immanuel Krankenhaus Berlin, Berlin, Germany

    Background/Purpose: Raynaud’s phenomenon (RP) is commonly seen in rheumatology practice. Differentiating primary from secondary RP is important for disease management and prognosis. How does capillaroscopy…
  • Abstract Number: 854 • 2013 ACR/ARHP Annual Meeting

    Aortic Wall Thickness In Patients Without Aortitis:  a Computed Tomography-Based Study Of 100 Patients

    Afif Nakhleh1, Irina Rukhkyan2, Vladimir Wolfson3, Itzhak A. Rosner4, Majed Odeh4 and Gleb Slobodin5, 1Internal Medicine, Bnai Zion Medical Center, Haifa, Israel, 2Rehabilition, Bnai Zion Medical Center, Haifa, Israel, 3Radiology, Bnai Zion Medical Center, Haifa, Israel, 4Bnai Zion Medical Center, Haifa, Israel, 5Rheumatology, Bnai Zion Medical Center, Haifa, Israel

    Background/Purpose: Thickening of the aortic wall, probably the earliest CT sign of aortitis, is frequently missed as there are no accepted criteria for normal aortic…
  • Abstract Number: 855 • 2013 ACR/ARHP Annual Meeting

    Ultrasound Evaluation Of The Greater Trochanter Pain Syndrome: Bursitis Or Tendinopathy?

    Cristian Quiroz1, Santiago Ruta2, Javier Rosa3, David A. Navarta1, Ricardo Garcia-Monaco4 and Enrique R. Soriano5, 1Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Radiology and Imagenology Department, Hospital italiano de Buenos Aires, Buenos Aires, Argentina, 5Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina

    Background/Purpose: Greater trochanteric pain syndrome (GTPS) is a common clinical problem that may be caused by a variety of either intra-articular o peri-articular pathologies. Inflammation…
  • Abstract Number: 856 • 2013 ACR/ARHP Annual Meeting

    Cost-Effectiveness Of Urate Lowering Strategies For The Management Of Gout

    Eric Jutkowitz1, Karen Kuntz2, Laura T Pizzi3 and Hyon Choi4,5, 1Divisions of Health Policy and Management (EJ, KMK), School of Public Health, University of Minnesota, Minneapolis, MN, 2Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, 3Thomas Jefferson University, Philadelphia, PA, 4Section of Rheumatology and the Clinical Epidemiology, Boston University School of Medicine, Boston, MA, 5Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose:  The new 2012 ACR guidelines for the management of gout have provided updated recommendations; however, the employed method do not address the societal costs…
  • Abstract Number: 857 • 2013 ACR/ARHP Annual Meeting

    Impact of Urate Lowering Therapy On Renal Disease Progression in Patients With Hyperuricemia

    Gerald D. Levy1, T. Craig Cheetham2, Nazia Rashid3 and Fang Niu2, 1Int Med/Rheumatology, Southern California Permanente Medical Group, Downey, CA, 2Pharmacy Analytical Services, Kaiser Permanente, Downey, CA, 3Pharmacy Analytical Services, Kaiser Permanente Southern California, Downey, CA

    Background/Purpose: The relationship between elevated serum Uric Acid [sUA] and progression of chronic kidney disease is well established.1-3 There are a several small studies on…
  • Abstract Number: 858 • 2013 ACR/ARHP Annual Meeting

    Monosodium Urate Crystal Induced Macrophage Inflammation Is Attenuated By Chondroitin Sulfate: Pre-Clinical Model For Gout Prophylaxis?

    Eric W. Orlowsky1, Thomas V. Stabler2, Eulalia Montell3, Josep Verges3 and Virginia B. Kraus2, 1Divsion of Rheumatology, Dept of Internal Medicine, Duke University Medical Center, Durham, NC, 2Medicine/Rheumatology, Duke University Medical Center, Durham, NC, 3Pre-Clinical R&D Area, Pharma Science Division, Bioibérica, Barcelona, Spain

    Background/Purpose:  Gout is one of the most common forms of inflammatory arthritis and is characterized by acute episodes of joint pain. Monosodium urate (MSU) crystals…
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