Abstracts Archive - Page 2191 of 2607 - ACR Meeting Abstracts

Abstract Number: 633 • 2014 ACR/ARHP Annual Meeting
Immunological and Clinical Relationships of Synovial IL-17+ T Cells in Psoriatic Arthritis
Bruce Kirkham¹, Bina Menon² and Leonie S. Taams³, ¹Rheumatology, Guy's & St Thomas NHS Foundation Trust, London, United Kingdom, ²Rheumatology, Guy's and St. Thomas' Foundation Hospital NHS Trust, London, United Kingdom, ³Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom
Background/Purpose We recently reported elevated numbers of synovial fluid IL-17+CD4- T cells (mainly CD8+ (Tc17) cells) in Psoriatic Arthritis (PsA), correlating with clinical, serological and…
Abstract Number: 632 • 2014 ACR/ARHP Annual Meeting
IL-23 Mediates Psoriasis-like Inflammation in the SKG Mouse Model of Spondyloarthropathy
Helen Benham¹, Linda Rehaume¹, Athan Baillet¹, Zaied Bhuyan¹, Jaclyn Bowman¹, Dimeng Pang¹, Kristine Kikly², Geoffrey Strutton³, Matthew Brown¹ and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ³Department of Pathology, Princess Alexandra Hospital, Brisbane, Australia
Background/Purpose Psoriasis (Ps) is a common immune-mediated inflammatory skin disease and is a well- recognised extra-articular manifestation of the spondyloathopathies (SpA). Genetic studies implicate IL-23…
Abstract Number: 631 • 2014 ACR/ARHP Annual Meeting
Joint and Bone Related Pathways Discriminate Psoriatic Arthritis Lesional Skin from Psoriasis vulgaris Lesional Skin
Jennifer Belasco¹, James S. Louie², Nicholas Gulati¹, Nathan Wei³, Kristine Nograles⁴, Hiroshi Mitsui¹, Mayte Suarez-Farinas¹ and James G. Krueger¹, ¹Krueger Laboratory, The Rockefeller University, New York, NY, ²Rheumatology, UCLA School of Medicine, Los Angeles, CA, ³Arthritis & Osteoporosis Center of MD, Frederick, MD, ⁴The Rockefeller University, New York, NY
Background/Purpose: It is preferable to start therapy as early as possible in psoriatic arthritis (PsA) because of the destructive nature of the arthritis. Starting treatment…
Abstract Number: 630 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Bone Remodeling Are Elevated in Psoriatic Arthritis
Fatima Abji¹, Arane Thavaneswaran¹, Vinod Chandran^1,2 and Dafna D. Gladman^1,3, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis that develops in about a third of patients with cutaneous psoriasis (PsC). The identification of biomarkers to…
Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis
Natasja Stæhr Gudman¹, Heidi Lausten Munk², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Morten A. Karsdal⁶, Anne C. Bay-Jensen⁷, Yi He⁸, Anne Sofie Siebuhr⁹ and Peter Junker², ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Department of Rheumatology, Odense University Hospital, Odense, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, ⁶Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁷Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁸Nordic Bioscience, Herlev, Denmark, ⁹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…
Abstract Number: 628 • 2014 ACR/ARHP Annual Meeting
The Predictive Value of Cardiovascular and Metabolic Biomarkers for Progression of Atherosclerosis in Psoriatic Disease
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose The pathophysiologic mechanisms underlying the accelerated atherosclerosis in patients with psoriatic disease (PsD) are unknown. We aimed to investigate candidate pathways involved in this…
Abstract Number: 627 • 2014 ACR/ARHP Annual Meeting
HLA Markers for Disease Severity Are Associated with a Higher Burden of Atherosclerosis in Patients with Psoriatic Disease
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose Recent evidence supports the link between the extent of inflammation and cardiovascular risk in patients with psoriatic disease (PsD). We aimed to investigate the…
Abstract Number: 626 • 2014 ACR/ARHP Annual Meeting
The Impact of the Interaction Between Human Leukocyte Antigen Alleles and Obesity on Psoriatic Arthritis Risk
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Proton Rahman³, Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Human Leukocyte Antigen (HLA) class I alleles and obesity are risk factors for psoriatic arthritis (PsA). We aimed to assess whether there is an…
Abstract Number: 625 • 2014 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Associations Identified Contribution of Multiple Class I and II HLA Genes on Risk of Psoriasis and Its Clinical Subtypes
Yukinori Okada¹, Buhm Han², Lam C. Tsoi³, Philip E. Stuart⁴, Eva Ellinghaus⁵, Trilokraj Tejasvi⁶, Vinod Chandran⁷, Fawnda Pellett⁸, Remy Pollock⁹, Anne M. Bowcock¹⁰, Gerald G. Krueger¹¹, Michael Weichenthal⁵, John J. Voorhees⁶, Proton Rahman¹², Peter K. Gregersen¹³, Andre Franke¹⁴, Rajan P. Nair⁶, Gonçalo R. Abecasis¹⁵, Dafna D. Gladman⁷, James T. Elder⁶, Paul IW. de Bakker¹⁶ and Soumya Raychaudhuri¹⁷, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, ³Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, ⁴Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Christian-Albrechts-University of Kiel, Kiel, Germany, ⁶University of Michigan Medical School, Ann Arbor, MI, ⁷University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸University of Toronto, Toronto, ON, Canada, ⁹Rheumatology, University of Toronto, Toronto, ON, Canada, ¹⁰Imperial College, London, United Kingdom, ¹¹Dermatology, University of Utah, Salt Lake City, UT, ¹²Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ¹³The Feinstein Institute for Medical Research, Manhasset, NY, ¹⁴Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶University Medical Center, Utrecht, Netherlands, ¹⁷Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Psoriasis vulgaris (PsV) risk is strongly associated with genetic variation within the major histocompatibility complex (MHC) region, although its fine genetic architecture has not…
Abstract Number: 624 • 2014 ACR/ARHP Annual Meeting
Genome-Wide Methylome Investigation Reveals New Candidate Genes Associated with Arthritis Mutilans
Vinod Chandran¹, Darren O'Reilly², Amir Haddad¹, Yuhua Zhang³, Guangju Zhai³, Dianne Codner², Arane Thavaneswaran⁴, Proton Rahman^5,6 and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Rheumatology, St. Claires Mercy Hospital, St. Johns, NF, Canada, ⁶Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose Arthritis mutilans is a severe form of psoriatic arthritis (PsA). Why some patients develop this rapidly progressive destructive disease remains unclear. We hypothesized that…
Abstract Number: 623 • 2014 ACR/ARHP Annual Meeting
Epigenetic Studies in Maternally Versus Paternally Transmitted Psoriatic Disease
Darren D. O'Rielly¹, Remy Pollock², Yuhua Zhang³, Nayef Al Ghanim¹, Sean Hamilton¹, Dafna D. Gladman², Vinod Chandran², Rose Ardern¹, Guangju Zhai³ and Proton Rahman¹, ¹Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Epidemiological studies have noted excess paternal transmission in psoriasis and psoriatic arthritis. To date, there has been no molecular explanation to account for this…
Abstract Number: 622 • 2014 ACR/ARHP Annual Meeting
Gut Microbiota Variations Correlate with Disease Activity in Spondyloarthritis (SpA) and Rheumatoid Arthritis (RA)
Julien Tap^1,2, Jad Abou-Ghantous¹, Ariane Leboime³, Roula Said Nahal³, Philippe Langella¹, Henri-Jean Garchon⁴, Gilles Chiocchia⁵, Jean-Pierre Furet¹ and Maxime Breban^3,4, ¹UMR INRA-AgroParisTech 1319, Equipe ProbiHote, MICALIS Institute, National Institute for Agronomical research (INRA), Jouy-en-Josas, France, ²Metagenopolis, INRA, Jouy-en-Josas, France, ³Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, ⁴INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ⁵Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France
Background/Purpose Inflammatory bowel diseases (IBD) are associated with changes in microbiota which may be responsible for sustained gut inflammation and/or a consequence of it. Whether…
Abstract Number: 621 • 2014 ACR/ARHP Annual Meeting
ERAP1 Knockdown Affects HLA-B27 Misfolding and Endoplasmic Reticulum Stress in HLA-B27 Transgenic Rat Macrophages
Sohee Hong and Robert A. Colbert, NIAMS/NIH, Bethesda, MD
Background/Purpose Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in the processing of peptide cargo for major histocompatibility complex (MHC) class I complexes,…
Abstract Number: 620 • 2014 ACR/ARHP Annual Meeting
Innate Immune Stimulation Triggers Altered IL-1a/b Gene Expression and Experimental Spondyloarthritis in HLA-B27/huβ2m Transgenic Rats
Melissa N. van Tok^1,2, Leonie M. van Duivenvoorde³, Nimman Satumtira⁴, Martha L. Dorris⁴, Joel D. Taurog⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Spondyloarthritis (SpA) does not display typical features of autoimmune diseases such as female predominance, presence of autoantibodies, or clinical response to T- and/or B…
Abstract Number: 639 • 2014 ACR/ARHP Annual Meeting
Lack of Response Gene to Complement-32 Impairs Th17 Differentiation and Attenuates Lupus-like Chronic Graft Versus Host Disease
Vinh Nguyen¹, Cosmin Tegla², Cornelia Cudrici³, Tudor Badea⁴, Horea Rus² and Violeta Rus¹, ¹Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ²Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ³Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁴NIH, National Eye Institute, Bethesda, MD
Background/Purpose . Response Gene to Complement (RGC)-32 was cloned and characterized by our group as one of the genes induced by complement activation. It encodes…

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