Abstract Number: 652 • 2014 ACR/ARHP Annual Meeting
Identification of Eat-2 As a Lupus Susceptibility Gene in New Zealand Black (NZB) Mice That Regulates Dendritic Cell Function
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous NZB chromosome (c) 1 interval (70 to 100 cM) develop high titres of…Abstract Number: 651 • 2014 ACR/ARHP Annual Meeting
Inhibiting Tweak (TNF-like weak inducer of apoptosis) Signaling Improves Blood Brain Barrier Integrity and Protects from Neuronal Damage in Murine Neuropsychiatric Lupus
Background/Purpose: While neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is relatively common and appears early, the underlying mechanisms are not fully understood. The disruption of…Abstract Number: 650 • 2014 ACR/ARHP Annual Meeting
Decreased Severity of Pristane Induced Lupus in miR155 Deficient Mice
Background/Purpose MicroRNAs (miRs) are an important class of regulators of gene expression that are associated with a variety of biological functions. Deregulation of endogenous miR155…Abstract Number: 649 • 2014 ACR/ARHP Annual Meeting
Enhance Translatability Using Multi-Modality Disease Evaluation Approach in Lupus Model
Background/Purpose: Rodent models mimic some aspects of human lupus disease manifestations in various tissues, such as kidney, skin, joint, and CNS. NZB/NZW F1 and MRL/lpr…Abstract Number: 648 • 2014 ACR/ARHP Annual Meeting
Influenza A (H1N1) Virus Infection Triggers Severe Pulmonary Inflammation in Lupus-Prone Mice Following Viral Clearance
Background/Purpose: Each year, up to one fifth of the United States population is infected with influenza virus. Although mortality rates are low, hundreds of thousands…Abstract Number: 647 • 2014 ACR/ARHP Annual Meeting
Helminthes Derivative for Treating Lupus and Colitis in Mice Models
Background/Purpose: In areas where helminthes infections are common, autoimmune diseases are rare. Treatment with ova from helminthes, improved clinical findings of inflammatory bowel disease and…Abstract Number: 645 • 2014 ACR/ARHP Annual Meeting
The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes CD4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus
Background/Purpose: Autoreactive CD4 T cells are key effectors in Systemic Lupus Erythematosus (SLE). Cell metabolism is an important checkpoint for T cell activationand differentiation. Both…Abstract Number: 644 • 2014 ACR/ARHP Annual Meeting
HM-0523, a Novel Syk Inhibitor Blocks Glomerulonephritis and Extends Life Spans in Lupus Prone MRL/Lpr Mice
Background/Purpose: Syk is a key mediator of signaling events downstream of a wide array of receptors important for immune functions, including the B cell receptor,…Abstract Number: 643 • 2014 ACR/ARHP Annual Meeting
The Effect of TNF Inhibition on the Autoreactive B Cell Repertoire in SLE Prone Mice
Background/Purpose: TNF inhibitors are widely used for inflammatory diseases but often induce ANAs that sometimes progress to overt SLE. TNF deficient mice fail to generate…Abstract Number: 642 • 2014 ACR/ARHP Annual Meeting
Treatment with a Glycolipid Ameliorates Lupus Dermatitis and Expands Skin ãä T Cells That Promote the Migration of Langerhans Dendritic Cells
Background/Purpose: Self antigens are taken from tissues to local lymphoid organs to acquire ability to avoid self-reactivity. This important immune function is accomplished by dendritic…Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice
Background/Purpose: An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…Abstract Number: 640 • 2014 ACR/ARHP Annual Meeting
A Peptide Mimic Inhibits the Cross Reaction of Anti-DNA Antibodies with Glomerular Antigens
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high titers of multiple autoantibodies. Of those, anti-DNA antibodies play a key role in…Abstract Number: 659 • 2014 ACR/ARHP Annual Meeting
Breakdown of Tolerance at the Tissue Level in Systemic Autoimmunity: Role of Tissue-Resident Dendritic Cells
Background/Purpose Systemic autoimmune diseases such as lupus affect multiple organs including skin and kidneys, usually in a diverse fashion where only certain organs are affected…Abstract Number: 646 • 2014 ACR/ARHP Annual Meeting
ONO-4059 – a Highly Potent and Dual Oral Inhibitor of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase: Improves Anti-Nuclear Antibodies–mediated SLE in Mice
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease associated with the over production of high affinity autoantibodies, mainly raised against nuclear…Abstract Number: 634 • 2014 ACR/ARHP Annual Meeting
Characterization of CD4+ T Cell Response and Effects of Regulatory T Cells in Pristane Induced Lupus (PIL)
Background/Purpose CD4+ T cells and the Th1 and Th17 subsets in particular play a pivotal role in SLE. Regulatory T cells (Treg) are essential for…
ACR Meeting Abstracts