Abstracts Archive - Page 2189 of 2425 - ACR Meeting Abstracts

Abstract Number: 919 • 2013 ACR/ARHP Annual Meeting
B Cell Derived IFN-γ Contributes To The Negative Regulation Of T-Regulatory Cell Differentiation In Arthritis
Susan Olalekan¹, Yanxia Cao² and Alison Finnegan², ¹Immunology, Rush University Medical Center, Chicago, IL, ²Dept of Medicine, Rush University Medical Center, Chicago, IL
Background/Purpose: Depletion of B cells using a monoclonal antibody against CD20 expressed on mature B cells has proven efficacious in patients with rheumatoid arthritis (RA).…
Abstract Number: 920 • 2013 ACR/ARHP Annual Meeting
Fms-Like Tyrosine Kinase 3 Signaling Is Essential For Differentiation Of Antigen Specific Plasma Cells During Experimental Arthritis
Mattias Svensson¹, Kersti Månsson¹, Karin Andersson¹, Mats Bemark², Mikael Brisslert¹ and Maria Bokarewa¹, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Signaling through the tyrosine kinase receptor Flt3 plays an important role in early B-cell development. Mice lacking either Flt3 or its ligand (Flt3L) have…
Abstract Number: 921 • 2013 ACR/ARHP Annual Meeting
Blocking The Complement Receptor 2 (CR2) Ligand-Receptor Interaction With a Novel Mouse Anti-Mouse CR2 Monoclonal Antibody Decreases Antigen-Specific Humoral Immune Responses and The Evolution Of Collagen-Induced Arthritis
Rosa Rodriguez¹, Liudmila Kulik¹, Joshua Thurman², Jonathan Hannan¹, Steve Tomlinson³ and V. Michael Holers¹, ¹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ²Renal Division, University of Colorado School of Medicine, Aurora, CO, ³Microbiology and Immunology, Medical University of South Carolina, Charleston, NC
Background/Purpose: The CR2/CD19 complex on B cells serves as a co-receptor for membrane IgM and amplifies B cell responses through physical associations of the bound…
Abstract Number: 922 • 2013 ACR/ARHP Annual Meeting
Role Of B Cells and/Or Autoantibodies In Pulmonary Manifestations Of Inflammatory Arthritis
Lisa K. Peterson¹, Jeremy Sokolove², Paul Jedlicka³, Lauren J. Lahey⁴, William H. Robinson⁵ and Leonard L. Dragone⁶, ¹Pediatrics, National Jewish Health, Denver, CO, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Pathology, University of Colorado Denver, Aurora, CO, ⁴Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁵VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Dept of Pediatrics, National Jewish Health, Denver, CO
Background/Purpose: RA is a systemic condition affecting approximately 1% of the general population leading to progressive arthritis and extra-articular manifestations (ExRA), including interstitial lung disease…
Abstract Number: 923 • 2013 ACR/ARHP Annual Meeting
Redox Dependent Conformational Changes Of The Autoantigen La Are Responsible For Its Shuttling, Translocation and a Pathophysiological Role Of Anti-La Autoantibodies
Irene Michalk¹, Nicole Berndt¹, Claudia C. Bippes¹, Holger Bartsch², Stefanie Koristka³, Claudia Arndt¹, Anja Feldmann¹, Biji T. Kurien⁴, Robert Hal Scofield⁵, A. Darise Farris⁶, Judith A. James⁷, Marc Cartellieri¹ and Michael Bachmann¹, ¹Inst. Immunology, Carl Gustav Carus TU-Dresden, Dresden, Germany, ²Inst. Immunol., Carl Gustav Carus TU-Dresden, Dresden, Germany, ³Carl Gustav Carus TU-Dresden, Dresden, Germany, ⁴College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁶Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁷Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Since their detection a pathophysiological role of antibodies (abs) to extractable nuclear autoantigens including anti-La abs has been controversially discussed. Stainings of anti-La abs…
Abstract Number: 924 • 2013 ACR/ARHP Annual Meeting
B Cell Subsets and Dysfunction Of Regulatory B Cells In IgG4-Related Diseases and Primary Sjögren Syndrome: The Similarities and Differences
Wei Lin¹, Lixia Jin², Wen Zhang¹, Hua Chen³, QingJun Wu⁴, Yunyun Fei¹, Yan Zhao¹, Xiaofeng Zeng⁵ and Fengchun Zhang³, ¹Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ²Tsinghua University, Beijing, China, ³Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁴Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ⁵Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Background/Purpose: IgG4 related disease (IgG4-RD) is a chronic, multisystem-involved autoimmune disease. Abnormally activated and differentiated B cells may play important roles. Regulatory B cells (Breg)…
Abstract Number: 925 • 2013 ACR/ARHP Annual Meeting
B Cell Subset Phenotypes In Patients With Granulomatosis With Polyangiitis (Wegener’s)
Atul A. Khasnis¹, Carol A. Langford², Leonard H. Calabrese³, Julia M. Sugalski⁴, Michael Lederman⁵ and Donald D. Anthony⁶, ¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ²Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH, ⁴Medicine/infectious disease, Case Western Reserve University, Cleveland, OH, ⁵Infectious Diseases, Case Western Reserve University, Cleveland, OH, ⁶Medicine, Case Western Reserve University, Cleveland, OH
Background/Purpose: B cells are pathogenic in granulomatosis with polyangiitis (Wegener’s) (GPA). Rituximab (RTX), an anti-CD20 monoclonal antibody, is effective therapy however B cell reconstitution patterns…
Abstract Number: 926 • 2013 ACR/ARHP Annual Meeting
Autoantibodies to the Th/To Complex Are the Most Common Antibodies in Systemic Sclerosis (SSc) Patients Without Other Autoantibodies
Michael Mahler¹, Jason Y.F. Chan², Edward K.L. Chan³, Minoru Satoh², Marie Hudson⁴, Murray Baron⁵, James Wick⁶ and Marvin J. Fritzler⁷, ¹Research, INOVA Diagnostics, San Diego, CA, ²Medicine, University of Florida, Gainesville, FL, ³Oral Biology, University of Florida, Gainesville, FL, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁶Department of medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Antinuclear antibodies (ANA) play an important role in the diagnosis of systemic sclerosis (SSc) being present in about 80-90% of the patients. In the…
Abstract Number: 927 • 2013 ACR/ARHP Annual Meeting
The Role of HIF-1 and HIF-2 During Angiogenesis and Metabolic Adaptation of Human Microvascular Endothelial Cells Towards Hypoxia
Martin Hahne¹, Cindy Strehl¹, Manuela Jakstadt¹, Paula Hoff¹, Timo Gaber¹, Gerd Burmester² and Frank Buttgereit³, ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Rheumatology and Clinical Immunology, Campus Mitte, Charite University Hospital, Berlin, Germany, ³Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Hypoxia is a feature of RA synovitis. In the present study, we focused on the two transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2.…
Abstract Number: 888 • 2013 ACR/ARHP Annual Meeting
Role of Calcium/Calmodulin Kinase IV On Podocyte Function in Lupus Nephritis
Kunihiro Ichinose¹, Takeshi Ushigusa², Tomohiro Koga³, George C. Tsokos⁴ and Atsushi Kawakami⁵, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ⁵Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Role of calcium/calmodulin kinase IV on podocyte function in lupus nephritis Background/Purpose: Kidney podocytes and their slit diaphragms settle the integrity of renal basement membrane…
Abstract Number: 889 • 2013 ACR/ARHP Annual Meeting
Podocytes Take Up Adsdna Autoantibody Complexes
Anja Hillmann¹, Elisabeth Jung², Annika Engbers¹, Hedda Wardemann³, Annett M. Jacobi² and Thomas Pap⁴, ¹Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Rheumatology Internal Medicine D, University Hospital Münster, Münster, Germany, ³Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, resulting in inflammation and tissue damage in several organs. This autoimmune reaction is caused by autoantibodies,…
Abstract Number: 890 • 2013 ACR/ARHP Annual Meeting
Quantitative Cell Distance Mapping In Human Nephritis Reveals Organization Of In Situ Adaptive Immune Responses
Marcus R. Clark¹, Vladimir M. Liarski¹, Natalya Kavernia², Maryellen L. Giger³, Anthony Chang⁴, Yahui Peng³ and Daniel F. Brandt², ¹Rheumatology and Knapp Center for Lupus Research, University of Chicago, Chicago, IL, ²Rheumatology, University of Chicago, Chicago, IL, ³Radiology, University of Chicago, Chicago, IL, ⁴Pathology, University of Chicago, Chicago, IL
Background/Purpose: Inflammatory infiltrates contain multiple cell types that could interact in myriad ways to amplify in situ immune responses. However, there currently are no methods…
Abstract Number: 891 • 2013 ACR/ARHP Annual Meeting
A Single Amino Acid In The β1 Chain Of HLA-DR Explains The Majority Of The HLA Association With Giant Cell Arteriti
Javier Martin¹, F. David Carmona², Jose Ezequiel Martin³, Aurora Serrano¹, Lara Bossini-Castillo⁴, Roser Solans⁵, Jose A. Miranda-Filloy⁶, Santos Castañeda⁷, Maria C. Cid⁸, Jose A. Hernandez⁹, Inmaculada C. Morado¹⁰, Javier Narvaez¹¹, Ricardo Blanco¹², Bernardo Sopeña¹³, M. Jesus García-Villanueva¹⁴, Jordi Monfort¹⁵, Norberto Ortego-Centeno¹⁶, Ainhoa Unzurrunzaga¹⁷, Begoña Marí-Alfonso¹⁸, Cesar Magro¹⁹, Ana Hidalgo-Conde²⁰, Marta Conde-Jaldon²¹, María F. González-Escribano²¹, Paul de Bakker²², Bobby P.C. Koeleman²³ and Miguel A. González-Gay²⁴, ¹Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ²Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, ³Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ⁴Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ⁵Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ⁶Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ⁸Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁹Hospital Clinic. University of Barcelona, IDIBAPS,, Barcelona, Spain, ¹⁰Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ¹²Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, ¹³Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, ¹⁴Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹⁵Reumatologia, Hospital del Mar, Barcelona, Spain, ¹⁶Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain, ¹⁷Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, ¹⁸Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, ¹⁹Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ²⁰Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain, ²¹Immunology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ²²Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ²³Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ²⁴Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: Giant cell arteritis (GCA) is a polygenic inflammatory disease affecting medium- and large-sized blood vessels in people elder than 50-years old. Although it is…
Abstract Number: 892 • 2013 ACR/ARHP Annual Meeting
The Functional PTPN22 Variant R620W Is Strongly Associated With Giant Cell Artetitis Predisposition
F. David Carmona¹, Sarah L. Mackie², Aurora Serrano³, Ana Marquez⁴, Roser Solans⁵, Jose A. Miranda-Filloy⁶, Jose Hernández-Rodríguez⁷, Maria C. Cid⁸, Santos Castañeda⁹, Inmaculada C. Morado¹⁰, Javier Narvaez¹¹, Ricardo Blanco¹², Bernardo Sopeña¹³, M. Jesus García-Villanueva¹⁴, Jordi Monfort¹⁵, Norberto Ortego-Centeno¹⁶, Ainhoa Unzurrunzaga¹⁷, Begoña Marí-Alfonso¹⁸, Julio Sánchez-Martín¹⁹, Eugenio de Miguel²⁰, Cesar Magro²¹, Enrique Raya²², Niko Braun²³, Joerg Latus²⁴, Øyvind Molberg²⁵, Benedicte A. Lie²⁶, Frank Moosig²⁷, Torsten Witte²⁸, Ann W. Morgan², Miguel A. González-Gay²⁹ and Javier Martin³, ¹Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ⁴Instituto de Parasitología y Biomedicina 'López-Neyra' (IPBLN-CSIC), Granada, Spain, ⁵Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ⁶Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁷Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁸Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ¹⁰Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ¹²Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ¹³Thrombosis and Vasculitis Unit-Internal Medicine, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain, ¹⁴Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹⁵Reumatologia, Hospital del Mar, Barcelona, Spain, ¹⁶Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹⁷Internal Medicine, Hospital de Galdakano, Vizcaya, Spain, ¹⁸Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Spain, ¹⁹Rheumatology,, Hospital Universitario 12 de Octubre, Madrid, Spain, ²⁰Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain, ²¹Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ²²Rheumatology, University Hospital San Cecilio, Granada, Spain, ²³Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ²⁴Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ²⁵Oslo University Hospital, Oslo, Norway, ²⁶Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, ²⁷Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, ²⁸Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ²⁹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: The PTPN22/CSK signaling represents one of the common susceptibility pathways in autoimmunity. Considering that the genetic basis of giant cell arteritis (GCA), an autoimmune…
Abstract Number: 893 • 2013 ACR/ARHP Annual Meeting
Association Between Human Leukocyte Antigen-B’s Amino Acid Variation and Disease-Susceptibility To Takayasu’s Arteritis
Hajime Yoshifuji¹, Chikashi Terao², Kosaku Murakami³, Daisuke Kawabata³, Koichiro Ohmura¹, Takao Fujii⁴, Yasushi Kawaguchi⁵, Hisashi Yamanaka⁵ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ³Dept of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: HLA-B52 and HLA-B51 are frequently seen in Asian population and are almost identical except two amino acid residues(the 63rd and 67th), but HLA-B52 is…

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