Abstract Number: 770 • 2014 ACR/ARHP Annual Meeting
Detection of Proteins in Lung Tissues of Patients with Systemic Sclerosis Using Tissue Microarrays
Background/Purpose: Research on systemic sclerosis (SSc)-associated interstitial lung disease (ILD) has been hindered by the paucity of lung tissues, as SSc patients with lung involvement…Abstract Number: 768 • 2014 ACR/ARHP Annual Meeting
Transforming Growth Factor Beta Induces anti Angio and Vasculo-Genesis Phenotype in Dermal Fibroblasts through Secretion of Pigment Epithelium Derived Factor
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterized by tissue fibrosis and vasculopathy. A proteomic analysis of the secretome of SSc dermal fibroblasts (SSc-FBs)…Abstract Number: 769 • 2014 ACR/ARHP Annual Meeting
Anti-Fibrotic Effects of an Investigational Drug: Bis-Oxetanyl Sulfoxide
Background/Purpose: The hallmark of pulmonary fibrosis is thickening and scarring of the tissue caused by increased deposition of extracellular matrix (ECM) proteins like collagen…Abstract Number: 767 • 2014 ACR/ARHP Annual Meeting
The Impact of Plasmacytoid Dendiritc Cells (pDCs) on Fibrosis in bleomycin–induced Murine Model of Systemic Sclerosis (SSc)
Background/Purpose Pathogenesis of systemic sclerosis (SSc) remains unclear. Alterations in adaptive and innate immune responses, with increased T-cells that produce type 2 cytokines and impaired…Abstract Number: 766 • 2014 ACR/ARHP Annual Meeting
Endothelial Fli1 Deficiency Delays Wound Healing Due to Impaired Anastomosis of Newly Formed Vessels – a Possible Mechanism of Refractory Skin Ulcers in Systemic Sclerosis
Background/Purpose Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in fibrosis of the skin and certain internal organs. Although the pathogenesis of…Abstract Number: 765 • 2014 ACR/ARHP Annual Meeting
Gene-Gene Interaction of IRF5 and BLK Polymorphisms in US and Spanish Cohorts of Systemic Sclerosis (SSc)
Background/Purpose Systemic sclerosis (SSc) is a complex autoimmune disease and several genetic loci increasing SSc susceptibility have been identified with small to modest effect sizes.…Abstract Number: 764 • 2014 ACR/ARHP Annual Meeting
ERG and FLI1 in Systemic Sclerosis-Associated Pulmonary Complications
Background/Purpose: Pulmonary arterial hypertension (PAH) and pulmonary fibrosis (PF) are the two major lung complications associated with the autoimmune disease systemic sclerosis (SSc), and constitute…Abstract Number: 763 • 2014 ACR/ARHP Annual Meeting
Caveolin-1 and Peroxisome Proliferator-Activated Receptor Gamma Co-Regulate the Differentiation of Monocytes to Adipocytes and Myofibroblasts in Vivo and in Vitro
Background/Purpose Skin fibrosis in scleroderma is associated with the loss of subcutaneous adipose tissue (lipodystrophy). The mechanisms underlying lipodystrophy and its relationship to fibrosis are…Abstract Number: 762 • 2014 ACR/ARHP Annual Meeting
IQGAP1 Enhances Contractility of Scleroderma Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis
Background/Purpose Scleroderma associated interstitial lung disease (SSc-ILD) is an irreversible and progressive complication and a leading cause of death among SSc patients. Constitutive overexpression of…Abstract Number: 761 • 2014 ACR/ARHP Annual Meeting
Specific Autoantibody Profiles and Disease Subgroups Correlate with Circulating Micro-RNA in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a serious autoimmune disease with clinical phenotypes of different prognosis, progression rate, and different extent of involvement of internal organs.…Abstract Number: 760 • 2014 ACR/ARHP Annual Meeting
Use of Multiplex Cytokine Analysis of Dermal Blister Fluid to Assess Local Inflammatory and Immune Activity in Systemic Sclerosis
Background/Purpose Clinical diversity in systemic sclerosis (SSc) suggests complex multifaceted pathogenesis involving interplay of growth factors or cytokines within the lesional microenvironment. We analysed dermal…Abstract Number: 778 • 2014 ACR/ARHP Annual Meeting
PTPN22 rs2476601 and Susceptibility to Biopsy Proven Giant Cell Arteritis (GCA) in an Australian Sample
Background/Purpose: The aetiology and genetic background of GCA remains unclear, although genetic susceptibility is known to play a role. Recently, an association with the minor,…Abstract Number: 779 • 2014 ACR/ARHP Annual Meeting
Toll-like Receptor 2 Agonism Induces Inflammation, Angiogenesis and Cell Migration in Giant Cell Arteritis
Background/Purpose Activation of dendritic cells (DCs) is one of the earliest inciting events in Giant Cell Arteritis (GCA). TLR 2 is expressed on DCs in…Abstract Number: 777 • 2014 ACR/ARHP Annual Meeting
Influence of the IL17A Locus in Giant Cell Arteritis Susceptibility
Background/Purpose: A recent study has showed that the number of Th17 lymphocytes is significantly increased in patients with GCA, resulting in an imbalance between Th17…Abstract Number: 744 • 2014 ACR/ARHP Annual Meeting
Integrin Inhibitor Modulates Pulmonary Fibrosis in the Reactive Oxygen Species Murine Model of Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is an acquired connective tissue disorder in which inflammation, immune dysregulation and vascular damage lead to fibroblast activation that results in…
ACR Meeting Abstracts