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  • Abstract Number: 814 • 2014 ACR/ARHP Annual Meeting

    Tocilizumab in Giant Cell Arteritis: Multicenter Open-Label Study of 22 Patients

    Montserrat Santos-Gómez1, Javier Loricera1, Ricardo Blanco1, Jose L. Hernández2, Antonio Mera3, Eva Pérez-Pampin4, M. Enriqueta Peiró1, Santos Castañeda-Sanz5, Alicia Humbría6, Jaime Calvo-Alen7, Elena Aurrecoechea8, Javier Narváez9, Amalia Sánchez-Andrade10, Paloma Vela11, Elvira Díez Álvarez12, Cristina Mata13, Pablo Lluch Mesquida14, Concepcion Moll Tuduri14, Vanesa Calvo-Río1, Francisco Ortiz-Sanjuán1, Trinitario Pina Murcia15, Carmen Gonzalez-Vela16, Leyre Riancho-Zarrabeitia1 and Miguel A. González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Clínico Universitario de Santiago de Compostela. Spain, Santiago de Compostela, Spain, 4Rheumatology, Hospital Clínico Universitario de Santiago de Compostela. Spain, Santiago de Compostela, Spain, 5Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain, 6Rheumatology, Hospital Universitario de La Princesa. IIS-Princesa, Madrid, Madrid, Spain, 7Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, 8Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, 9Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 10Rheumatology, Hospital Universitario Lucus Augusti. Lugo. Spain, Lugo, Spain, 11Rheumatology, Hospital General de Alicante. Spain, Alicante, Spain, 12Rheumatology, Hospital de León. Spain, León, Spain, 13Rheumatology, Hospital Comarcal de Laredo. Spain, Laredo, Spain, 14Hospital Mateu Orfila. Menorca. Spain, Mahón (Menorca), Spain, 15Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 16Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose  Giant cell arteritis (GCA) is a primary vasculitis that involves the aorta and its major branches. It usually affects people aged more than 50…
  • Abstract Number: 813 • 2014 ACR/ARHP Annual Meeting

    Long-Term Outcomes of Takayasu’s Arteritis Patients with Renal Artery Involvement

    Corisande Baldwin1, Aladdin Mohammad2 and David Jayne3, 1Rheumatology, University of British Columbia, Vancouver, BC, Canada, 2Dept. of Rheumatology, Lund University Hospital, Lund University, Lund, Lund, Sweden, 3Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: Takayasu's Arteritis (TAK) is a chronic inflammatory large vessel vasculitis characterized by granulomatous inflammation of the aorta and its branches. TAK incidence is 2.6/million…
  • Abstract Number: 800 • 2014 ACR/ARHP Annual Meeting

    Hospitalization Rates and Utilization Among Patients with Giant Cell Arteritis: A Population-Based Study from 1987 to 2012

    C. John Michet III1, Sara J. Achenbach2, Cynthia S. Crowson3 and Eric L. Matteson4, 1Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose Patients with giant cell arteritis (GCA) may experience serious vascular and visual complications. It is unknown, however, to what extent the difficulties of the…
  • Abstract Number: 812 • 2014 ACR/ARHP Annual Meeting

    Prognosis of Clinically Inactive Takayasu’s Arteritis

    Seung-Hyeon Bae, Seokchan Hong, Soo Min Ahn, Doo-Ho Lim, Yong-Gil Kim, Chang-Keun Lee and Bin Yoo, Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Prognosis of Clinically Inactive Takayasu's Arteritis Background/Purpose: Takayasu's arteritis (TA) is a chronic inflammatory vasculitis, and immunosuppressants including glucocorticoids are generally required for treatment. Although,…
  • Abstract Number: 798 • 2014 ACR/ARHP Annual Meeting

    Frequency and Predictive Variables of Relapses in Patients with Biopsy-Proven Giant Cell Arteritis

    Luigi Boiardi1, Giovanna Restuccia2, Francesco Muratore1, Alberto Cavazza3, Luca Cimino4, Raffaella Aldigeri5, Pierluigi Macchioni1, Maria Grazia Catanoso6, Nicolò Pipitone1 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 5Clinical and experimental Medicine, Università di parma, Parma, Italy, 6Rheumatology Service, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Relapses and recurrences of…
  • Abstract Number: 797 • 2014 ACR/ARHP Annual Meeting

    PET/CT for the Diagnosis of Giant Cell Arteritis: A Prospective Study

    Alison Clifford1, Elana Murphy1, Steven Burrell2, Matthew Bligh3, Godfrey Heathcote3, Mathieu Castonguay3, Kara Thompson4 and John G. Hanly5, 1Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, 2Diagnostic imaging, Dalhousie University and Capital Health, Halifax, NS, Canada, 3Dalhousie University and Capital Health, Halifax, NS, Canada, 4Department of Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, 5Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada

    Background/Purpose: Temporal artery (TA) biopsies are negative in up to 50% of patients with giant cell arteritis (GCA). In such cases, increased uptake in large…
  • Abstract Number: 796 • 2014 ACR/ARHP Annual Meeting

    Early Halo Sign Features on Ultrasound Examination of Treated Patients with Giant Cell Arteritis

    Ana Sofia Serafim1, Surjeet Singh1, Jennifer Piper1, Andrew Hutchings2, Mike Bradburn3, Cristina Ponte4, Bhaskar Dasgupta5, Wolfgang A. Schmidt6, Andreas P. Diamantopoulos7, Eugene McNally8 and Raashid Luqmani9, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3Clinical Trials Research Unit (CTRU), Sheffield University, Sheffield, United Kingdom, 4Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, 5Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 6Rheumatology, Immanuel Krankenhaus, Berlin, Germany, 7Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, United Kingdom, 9Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom

    Background/Purpose The TABUL study (Temporal Artery Biopsy Vs Ultrasound in diagnosis of Giant Cell Arteritis) is assessing the relative performance of ultrasound and temporal artery…
  • Abstract Number: 795 • 2014 ACR/ARHP Annual Meeting

    High Interobserver Agreement on Ultrasonographic Findings in Patients with Large Vessel Vasculitis

    Andreas P. Diamantopoulos1, Julia Geiger2, Frode Lohne3, Geirmund Myklebust1 and Wolfgang A. Schmidt4, 1Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 2Department of Radiology, University Children's Hospital, Zurich, Switzerland, 3Unilabs Røntgen Kristiansand, Kristiansand, Norway, 4Rheumatology, Immanuel Krankenhaus, Berlin, Germany

    Background/Purpose Ultrasound has a high sensitivity and specificity regarding the diagnosis of giant cell arteritis (GCA). Ultrasound can also depict extracranial large vessel vasculitis (LVV)…
  • Abstract Number: 794 • 2014 ACR/ARHP Annual Meeting

    Color Doppler Ultrasonography Findings in Giant Cell Arteritis and Their Relationship with Clinical Manifestations

    Cristina Ponte1,2, Ruth Geraldes3, Anthea Craven1, Andrew Judge4, Peter C. Grayson5, Ravi Suppiah6, Joanna Robson1, Richard A. Watts7, Peter A. Merkel8 and Raashid Luqmani1, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 2Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, 3Neurology Department, Lisbon Academic Medical Centre, Lisbon, Portugal, 4Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 5NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, 6Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, 7Rheumatology Department Ipswich Hospital and University of East Anglia, Ipswich, United Kingdom, 8University of Pennsylvania, Philadelphia, PA

    Background/Purpose Colour Doppler ultrasonography (CDU) of the temporal (TA), axillary (AA) and common carotid arteries (CA) has excellent sensitivity and specificity for the diagnosis of…
  • Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting

    Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients

    Surjeet Singh1, Andrew Hutchings2, Wulf Forrester-Barker3, Bhaskar Dasgupta4, Andreas P. Diamantopoulos5, Peter Lanyon6, Malgorzata Magliano7, Brendan McDonald8, Konrad Wolfe9 and Raashid Luqmani10, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 4Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 5Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 6Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 7Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, 8Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, 9Department of Pathology, Southend University Hospital, Essex, United Kingdom, 10Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom

    Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
  • Abstract Number: 792 • 2014 ACR/ARHP Annual Meeting

    Is Temporal Artery Biopsy the Gold Standard for the Diagnosis of Giant Cell Arteritis?

    Marina Scolnik1, Aldo Fabian Ojeda2, Valeria Scaglioni3 and Enrique R. Soriano4, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Departamento de Reumatología, Hospital de Clínicas, FCM-UNA, Asuncion, Paraguay, 3Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 4Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina

    Background/Purpose: The only test that confirms diagnosis of Giant Cell Arteritis (GCA) is a temporal artery biopsy showing vasculitis with mononuclear cell inflammatory infiltrates, often with…
  • Abstract Number: 791 • 2014 ACR/ARHP Annual Meeting

    Comparison of Clinical Manifestations in Different Histological Subsets of Biopsy-Proven Giant Cell Arteritis

    Luigi Boiardi1, Francesco Muratore1, Alberto Cavazza2, Giovanna Restuccia3, Pierluigi Macchioni1, Giuseppe Germanò1, Nicolò Pipitone1, Gianluigi Bajocchi4 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Japan

    Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold standard for the diagnosis of giant cell arteritis (GCA). In some cases of…
  • Abstract Number: 790 • 2014 ACR/ARHP Annual Meeting

    Correlations Between Histopathological Findings and Clinical Manifestations in a Large Monocentric Cohort of Patients with Biopsy-Proven Giant Cell Arteritis

    Luigi Boiardi1, Francesco Muratore1, Giovanna Restuccia2, Alberto Cavazza3, Pierluigi Macchioni1, Giuseppe Germanò1, Nicolò Pipitone1 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Temporal artery biopsy (TAB)…
  • Abstract Number: 789 • 2014 ACR/ARHP Annual Meeting

    Association Between Histological Features and Clinical Features of Patients with Biopsy Positive Giant Cell Arteritis

    Kimberley Ting1, Susan Lester2 and Catherine L. Hill3, 1Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia, 2Rheumatology Unit, Queen Elizabeth Hospital, Woodville South, Australia, 3Discipline of Medicine, University of Adelaide, Adelaide, Australia

    Background/Purpose: Temporal artery biopsy is the gold standard for diagnosing giant cell arteritis (GCA). The pathology of GCA characteristically involves transmural infiltrates, giant cell formation…
  • Abstract Number: 788 • 2014 ACR/ARHP Annual Meeting

    Fast-Track Diagnostic Procedure for Giant Cell Arteritis

    Alojzija Hočevar1, Ziga Rotar2 and Matija Tomsic3, 1Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 3Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia

    Background/Purpose Giant cell arteritis (GCA) represents the most common primary vasculitis among adults aged 50 years or above. Recently, the national annual incidence rate in…
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