ACR Meeting Abstracts

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  • Abstract Number: 1190 • 2013 ACR/ARHP Annual Meeting

    The Synergistic Effects Of Metabolic Syndrome Indicators and Hyperuricemia In Contributing To Cardiac Event Risk: A Cross-Sectional Examination Of The Nhanes III Data

    Daniel A. Albert1,2 and Sayyad Kyazimzade3, 1Medicine/Rheumatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 2Rheumatology, The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH, 3The Dartmouth Institute for Health Policy & Clinical Practice, Lebanon, NH, Lebanon, NH

    Background/Purpose: The focus of this project is to assess the contribution of hyperuricemia and gout to the risk for cardiovascular events. In a preliminary analysis…
  • Abstract Number: 1191 • 2013 ACR/ARHP Annual Meeting

    Low-Dose Anakinra Is Effective For The Prophylaxis Of Acute Episodes Of Inflammation In Severe Tophaceous Gout

    Fernando Perez-Ruiz1,2, Ana M. Herrero-Beites3, Monike de Miguel4 and Joana Atxotegi5,6, 1BioCruces Health Research Institute, Baracaldo, Spain, 2Servicio de Reumatologia, Hospital Universitario Cruces, Baracaldo, Spain, 3Physical Medicine Division, Hospital de Gorliz, Gorliz, Spain, 4Pharmacy Division, Hospital Universitario Cruces, Baracaldo, Spain, 5Rheumatology Division, Hospital de Cruces, Baracaldo, Spain, 6BioCruces Health Institute, Baracaldo, Spain

    Background/Purpose: anakinra has been used off-label for the treatment of severe episodes of acute inflammation (EAIs) in gout. Only a retrospective series of 3 patients…
  • Abstract Number: 1192 • 2013 ACR/ARHP Annual Meeting

    Pharmacovigilance Update On Pegloticase For Treatment Refractory Gout: United States Clinical Experience Demonstrates The Value Of Serum Uric Acid Monitoring As a Biomarker Of Risk and Efficacy

    Robert T. Keenan1, Raymond L. Malamet2, Tina L. Howson3 and Kenneth M. Bahrt4, 1Rheumatology, Duke University, Durham, NC, 2Global Medical Affairs, Savient Pharmaceuticals, Inc., Bridgewater, NJ, 3Savient Pharmaceuticals, Inc., Bridgewater, NJ, 4Medical Affairs, Savient Pharmaceuticals, Inc., Bridgewater, NJ

    Background/Purpose: Pegloticase was approved in the US in late 2010 for patients with chronic gout refractory to xanthine oxidase inhibitors (XOIs). The clinical development program…
  • Abstract Number: 1193 • 2013 ACR/ARHP Annual Meeting

    Target Tophus Size and Complete Response Rates In Patients Treated With Open-Label Pegloticase For Chronic Gout Refractory To Conventional Therapy

    Robert T. Keenan1, Nicola Dalbeth2 and Herbert S. B. Baraf3, 1Rheumatology, Duke University, Durham, NC, 2Medicine, University of Auckland, Auckland, New Zealand, 3Arthritis & Rheumatism Associates, PC, Wheaton, MD

    Background/Purpose: Pegloticase, a methoxyPEG-conjugated mammalian recombinant uricase, has been approved in the US and EU for the treatment of chronic gout refractory to xanthine oxidase…
  • Abstract Number: 1167 • 2013 ACR/ARHP Annual Meeting

    A Possible Mechanism Of NLRP3 Inflammasome Hypersensitivity In Cryopyrin-Associated Periodic Syndrome

    Sayaka Ito, Chie Tagami, Yukichi Hara and Tetsuo Kubota, Tokyo Medical and Dental University, Tokyo, Japan

    Background/Purpose: NLRP3 in monocytes and other cell types plays a role in innate immunity as one of the intracellular pathogen recognition receptors, and its mutation…
  • Abstract Number: 1153 • 2013 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Synovial Fibroblasts Lack Tolerization Of Inflammatory Cytokines and Matrix Degrading Enzymes After Repeated LPS Stimulation

    Kerstin Klein1, Renate E. Gay2, Christoph Kolling3, Adrian Ciurea4, Beat A. Michel5, Lih-Ling Lin6, Steffen Gay1 and Caroline Ospelt1, 1Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 2Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 3Schultess Clinic, Zurich, Switzerland, 4Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, 5Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 6Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA

    Background/Purpose: In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to adaptation of signaling pathways and epigenetic modifications resulting in a tolerant state of…
  • Abstract Number: 1154 • 2013 ACR/ARHP Annual Meeting

    Poly(I:C)-Induced Cell Death Of Synovial Fibroblasts via an Unknown dsRNA Receptor

    Jörg Hamann1, Paul P. Tak2 and Olga N. Karpus3, 1Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 31Departments of Experimental Immunology and Internal Medicine, Academic Medical Center, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplasia of the synovial tissue due to local proliferation of stromal and recruitment of inflammatory immune cells. Accumulation…
  • Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting

    Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis

    Katalin Mikecz1, Julia Kurko1, Timea Ocsko1, Andras Vida1, Beata Tryniszewska1, Tibor A. Rauch1, Joel A. Block2, Robert S. Katz3, Anjali Nair2, Carla R. Scanzello4 and Tibor T. Glant1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Section of Rheumatology, Rush University Medical Center, Chicago, IL, 3Rush Medical College, Chicago, IL, 4Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
  • Abstract Number: 1157 • 2013 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular Damage In Mice

    Jason S. Knight1, Wei Luo2, Alexander A. O'Dell1, Wenpu Zhao3, Venkataraman Subramanian4, Chiao Guo2, Robert C. Grenn3, Paul Ryan Thompson4, Daniel T. Eitzman2 and Mariana J. Kaplan5, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan Cardiology, Ann Arbor, MI, 3University of Michigan Rheumatology, Ann Arbor, MI, 4The Scripps Research Institute, Jupiter, FL, 5Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD

    Background/Purpose:   Neutrophil extracellular trap (NET) formation promotes vascular damage, while stimulating interferon alpha (IFN-α) production in diseased arteries.  Patients with rheumatoid arthritis and systemic…
  • Abstract Number: 1158 • 2013 ACR/ARHP Annual Meeting

    Decreased NK-Cell Numbers and Upregulation Of Markers Of Systemic Inflammation In Autoantibody –Positive Arthralgia Patients and Early Rheumatoid Arthritis Patients But Not In Autoantibody-Negative Rheumatoid Arthritis Patients

    Paulina Chalan1, Johan Bijzet2, Kornelis S.M. van der Geest1, Bart-Jan Kroesen3, Annemieke M.H. Boots4,5 and Elisabeth Brouwer1, 1Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 3Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Groningen Research initiative on healthy Ageing and Immune Longevity (GRAIL), Groningen, Netherlands

    Background/Purpose: Identification of seropositive individuals at risk for arthritis development would open opportunities for early clinical intervention. In a recent study on seropositive arthalgia patients…
  • Abstract Number: 1159 • 2013 ACR/ARHP Annual Meeting

    Exercise Suppresses Systemic Inflammation Via Inhibition Of NF-κB Activation In Monocytes

    Alisa Blazek1, Derrick Knapik2, Lai-Chu Wu3, Nicholas A. Young3, Wael N. Jarjour4 and Sudha Agarwal5, 1Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH, 2College of Medicine, The Ohio State University, Columbus, OH, 3Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 5Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Inflammation is integral to joint damage and bone erosion in rheumatoid arthritis.  We reported previously that physiologic levels of exercise are anti-inflammatory and suppress local…
  • Abstract Number: 1160 • 2013 ACR/ARHP Annual Meeting

    Oxidative Stress As a Disease Marker and Therapeutic Target In Patients With Tumor Necrosis Factor Receptor Associated Periodic Fever Syndrome

    Cornelia Cudrici1, Ariel Bourla1, Martin Pelletier2, Leah Billingham1, Amanda K. Ombrello3, Michael Murphy4, Daniel L. Kastner5 and Richard M. Siegel6, 1NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, 2Niams, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, 3National Human Genome Research Institute,National Institute of Health, Bethesda, MD, 4Medical research council mitochondria biology unit Cambridge ,UK, Cambridge, United Kingdom, 5Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: TRAPS (Tumor necrosis factors receptor associated periodic fever syndrome) is an autosomal dominant autoinflammatory disease associated with missense mutations in TNFRSF1A (tumor necrosis factor…
  • Abstract Number: 1161 • 2013 ACR/ARHP Annual Meeting

    Microrna-155 As a Proinflammatory Regulator via SHIP-1 Down-Regulation In Acute Gouty Arthritis

    Hye Mi Jin1, Young-Nan Cho1, Seung-Jung Kee2, Dong-Jin Park3, Yong-Wook Park3, Shin-Seok Lee4 and Tae-Jong Kim1, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 3Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 4Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose: Gout is characterised by episodes of intense joint inflammation in response to intra-articular monosodium urate monohydrate (MSU) crystals. miR-155 is crucial for the proinflammatory…
  • Abstract Number: 1162 • 2013 ACR/ARHP Annual Meeting

    The Role Of Microrna 155 In Innate Immunity and Arthritis

    Antonia Puchner1, Victoria Saferding2, Eliana Goncalves-Alves3, Josef S. Smolen4, Kurt Redlich5 and Stephan Blueml6, 1Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3rheumatology, Medical University of Vienna, Vienna, Austria, 4Medical University of Vienna, Vienna, Austria, 5Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: MicroRNA 155 (miR155) has been demonstrated to be essential for the development of collagen induced arthritis by controlling the generation of autoreactive T and…
  • Abstract Number: 1163 • 2013 ACR/ARHP Annual Meeting

    The Receptor For Advanced Glycation End Products (RAGE) As a Modulator Of Inflammatory Responses and Its Contribution To Gender-Specific Effects During Arthritis

    Timo Wirth1, Christoph Kessel1, Philipp Becker2, Toni Weinhage3, Nadine Nippe4 and Dirk Foell5, 1Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, 2University of Muenster, Muenster, Germany, 3Pediatric Rheumatology and Immunology, University of Muenster, Münster, Germany, 4Department of Dermatology, University of Muenster, Münster, Germany, 5Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany

    Background/Purpose: The receptor for advanced glycation end products (RAGE) is a multi-ligand receptor expressed on various cells which interacts with a diverse class of ligands,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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