Abstracts Archive - Page 2172 of 2607 - ACR Meeting Abstracts

Abstract Number: 931 • 2014 ACR/ARHP Annual Meeting
Response to Canakinumab Treatment Is Maintained in Systemic Juvenile Idiopathic Arthritis Patients
N.M. Wulffraat^1,2, N. Ruperto², H.I. Brunner³, S. Oliveira², Y. Uziel², K. Nistala², R. Cimaz², M. Ferrandiz², B. Flato², M.L. Gamir², I. Koné-Paut², C. Gaillez⁴, K. Lheritier⁴, K. Abrams⁵, A. Martini² and D.J. Lovell³, ¹Pediatric Rheumatology, UMC Utrecht, Utrecht, Netherlands, ²PRINTO-Istituto Gaslini, Genova, Italy, ³PRCSG, Cincinnati, OH, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Canakinumab, a selective, human, anti-interleukin (IL) -1β monoclonal antibody, is approved for the treatment of systemic juvenile idiopathic arthritis (SJIA) patients (≥ 2 years…
Abstract Number: 930 • 2014 ACR/ARHP Annual Meeting
An Exploratory Analysis of Predictors of Response from 12-Weeks of Canakinumab Therapy in Patients with Active Systemic Juvenile Idiopathic Arthritis
Hermine I. Brunner¹, Nicola Ruperto², Isabelle Koné-Paut², Bo Magnusson², Seza Ozen², Flavio Sztajnbok², Jordi Anton², Judith Barash², Reinhard Berner², Fabrizia Corona², Karine Lheritier³, Corine Gaillez³, Alberto Martini² and Daniel Lovell¹, ¹PRCSG, Cincinnati, OH, ²PRINTO-Istituto Gaslini, Genova, Italy, ³Novartis Pharma AG, Basel, Switzerland
Background/Purpose Systemic juvenile idiopathic arthritis (SJIA), an interleukin-1β (IL-1β)-mediated autoinflammatory disease, is characterized by recurrent flares of active disease. Canakinumab (CAN), a selective, human, anti-…
Abstract Number: 929 • 2014 ACR/ARHP Annual Meeting
Antibiotic Exposure and the Development of Juvenile Idiopathic Arthritis: A Population-Based Case-Control Study
Daniel B. Horton^1,2, Frank I. Scott IV^1,3, Kevin Haynes¹, Mary E. Putt¹, Carlos D. Rose², James D. Lewis^1,3 and Brian L. Strom^1,4, ¹Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Pediatrics, Division of Rheumatology, Nemours A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, ³Medicine, Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁴Rutgers Biomedical and Health Sciences, Newark, NJ
Background/Purpose: Dysregulation of the human microbiome has been implicated in the development of several autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). Moreover,…
Abstract Number: 928 • 2014 ACR/ARHP Annual Meeting
A Multinational Study of the Epidemiology, Treatment and Outcome of Childhood Arthritis: Preliminary Data from 6,940 Patients
Alessandro Consolaro¹, Amita Aggarwal², Troels Herlin³, Olga Vougiouka⁴, Rubén Burgos-Vargas⁵, Ilonka Orban⁶, Nahid Shafaie⁷, Maria Trachana⁸, Lidia Rutkowska-Sak⁹, Ingrida Rumba-Rozenfelde¹⁰, Dimitrina Mihaylova¹¹, Alberto Martini^12,13 and Angelo Ravelli^1,14, ¹Pediatria II, Istituto Giannina Gaslini, Genova, Italy, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, ⁴P. A. Kyriakou Childrens Hospital of Athens University, Athens, Greece, ⁵Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, ⁶National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁷Rheumatology Research Centre, Tehran University of Medical Sciences, Tehran, Iran, ⁸Aristotle University, Thessaloniki, Greece, ⁹Institute of Rheumatology, Warsaw, Poland, ¹⁰University of Latvia, Riga, Latvia, ¹¹University Children Hospital, Sofia, Bulgaria, ¹²Istituto Giannina Gaslini, Genova, Italy, ¹³University of Genova, Genova, Italy, ¹⁴Istituto Giannina Gaslini and University of Genova, Genova, Italy
Background/Purpose The epidemiology of juvenile idiopathic arthritis (JIA) is known to be variable worldwide and the therapeutic approach to JIA is not standardized. Moreover, the…
Abstract Number: 912 • 2014 ACR/ARHP Annual Meeting
A Consensus Hybrid Definition Using a Conjoint Analysis Is the Proposed As Response Criteria for Minimal and Moderate Improvement for Adult Polymyositis and Dermatomyositis Clincal Trials
Rohit Aggarwal¹, Lisa G. Rider², Nicolino Ruperto³, Nastaran Bayat², Brian Erman⁴, Brian M. Feldman⁵, Adam M. Huber⁶, Chester V. Oddis⁷, Ingrid E. Lundberg⁸, Anthony A. Amato, MD^9,10, Robert G. Cooper, MD, FRCP¹¹, Hector Chinoy¹², Maryam Dastmalchi¹³, David Fiorentino¹⁴, David Isenberg¹⁵, James D. Katz¹⁶, Andrew L. Mammen¹⁷, Marianne de Visser¹⁸, Steven R. Ytterberg¹⁹, Katalin Danko²⁰, Luca Villa²¹, Mariangela Rinaldi²¹, Howard Rockette²², Peter A. Lachenbruch², Frederick W. Miller² and Jiri Vencovsky, MD, DSc²³, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ³Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy, ⁴Social and Scientific Systems, Inc., Durham, NC, ⁵Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶IWK Health Centre, Halifax, NS, Canada, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁰Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹¹MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ¹²Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, ¹³Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ¹⁴Dermatology, Stanford University, Redwood City, CA, ¹⁵Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ¹⁶NIAMS, NIH, Bethesda, MD, ¹⁷Neurology and Medicine, Johns Hopkins University, Baltimore, MD, ¹⁸Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands, ¹⁹Rheumatology Division, Mayo Clinic, Rochester, MN, ²⁰Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, ²¹Pediatria II, Reumatologia, PRINTO, IRCCS Istituto G. Gaslini, Genova, Italy, ²²University of Pittsburgh, Pittsburgh, PA, ²³Institute of Rheumatology, Charles University, Prague, Czech Republic
Background/Purpose: To develop consensus on definitions of improvement (DOIs) for minimal and moderate improvement (and draft preliminary criteria for major improvement) in adult dermatomyositis (DM)…
Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Nicholas A. Young¹, Lai-Chu Wu¹, Michael Bruss², Wael N. Jarjour³ and Dana P. Ascherman⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology, Miami VAMC, Miami, FL
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …
Abstract Number: 910 • 2014 ACR/ARHP Annual Meeting
The Selective Sphingosine-1- Phosphate Receptor 1/5 Modulator Siponimod (BAF312) Shows Beneficial Effects in Patients with Active, Treatment Refractory Polymyositis and Dermatomyositis: A Phase IIa Proof-of-Concept, Double-Blind, Randomized Trial
Katalin Danko¹, Jiri Vencovsky², Ingrid E. Lundberg³, Anthony A Amato⁴, Chester V. Oddis⁵, Maria Molnar⁶, Antonette Mallari Moher⁷, Laurence Colin⁸, Florian Muellershausen⁹, David Lee¹⁰ and Peter Gergely⁹, ¹Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, ²Institute of Rheumatology, Charles University, Prague, Czech Republic, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary, ⁷Translational Medicine, Novartis Institutes for Biomedical Research (former emplyee), Basel, Switzerland, ⁸Novartis Pharma, Basel, Switzerland, ⁹Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, ¹⁰Novartis Pharmaceuticals Corporation, Basel, Switzerland
Background/Purpose Polymyositis and dermatomyositis (PM/DM) comprise a heterogeneous group of chronic inflammatory muscle diseases where infiltration of lymphocytes in the skeletal muscle plays a key…
Abstract Number: 909 • 2014 ACR/ARHP Annual Meeting
A Diagnostic Protocol for Giant Cell Arteritis (GCA) Using Ultrasound Assessment
Jennifer Piper¹, Ana Sofia Serafim¹, Cristina Ponte¹, Surjeet Singh², Bhaskar Dasgupta³, Wolfgang A. Schmidt⁴, Eugene McNally⁵, Andreas P. Diamantopoulos⁶, Andrew Hutchings⁷ and Raashid Luqmani⁸, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²University of Oxford, Sciences, Oxford, England, ³Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁴Rheumatology, Immanuel Krankenhaus, Berlin, Germany, ⁵Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, United Kingdom, ⁶Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁷Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁸Oxford NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom
Background/Purpose Ultrasound (US) has not yet superseded temporal artery biopsy as a diagnostic test. This may reflect poor consistency of the scanning technique, due to…
Abstract Number: 908 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Detected Tenosynovitis Independently Associates with Flare in Patients with Rheumatoid Arthritis in Clinical Remission
Emanuela Bellis¹, Greta Carrara², Carlo Alberto Scirè², Alessandra Bortoluzzi³, Alberto Batticciotto⁴, Antonella Adinolfi⁵, Giovanni Cagnotto⁶, Marta Caprioli⁷, Marco Canzoni⁸, Francesco Cavatorta⁹, Fulvia Ceccarelli¹⁰, Orazio De Lucia¹¹, Valentina Di Sabatino¹², Antonella Draghessi¹³, Georgios Filippou¹², Ilaria Farina³, Maria Cristina Focherini¹⁴, Paola Frallonardo¹⁵, Alessandra Gabba¹⁶, Angelica Gattamelata¹⁰, Marwin Gutierrez¹³, Luca Idolazzi¹⁷, Filippo Luccioli¹⁸, Pierluigi Macchioni¹⁹, Marco Massarotti²⁰, Claudio Mastaglio²¹, Luana Menza²¹, Giulia Mirabelli¹⁸, Maurizio Muratore²², Simone Parisi²³, Valentina Picerno¹², Matteo Piga²⁴, Roberta Ramonda²⁵, Bernd Raffeiner²⁶, Daniela Rossi²⁷, Paola Rossini²⁸, Garifallia Sakellariou^29,30, Crescenzio Scioscia³¹, Carlo Venditti³², Annamaria Iagnocco¹⁰ and Marco Matucci-Cerinic³³, ¹Rheumatology, Ospedale Mauriziano, Turin, Italy, ²Italian Society for Rheumatology, Milan, Italy, ³A.O.U. S.Anna di Cona, Ferrara, Italy, ⁴L.Sacco University Hospital, Milan, Italy, ⁵Policlinico le Scotte, Siena, Italy, ⁶IRCCS Policlinico San Matteo, Pavia, Italy, ⁷Istituto di Cura Città di Pavia, Pavia, Italy, ⁸A.O. Sant'Andrea, Rome, Italy, ⁹A.O.U.P. Santa Chiara, Trento, Italy, ¹⁰Sapienza University of Rome, Rome, Italy, ¹¹Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, ¹²University of Siena, Siena, Italy, ¹³Università Politecnica delle Marche, Jesi, Italy, ¹⁴Ospedale Infermi, Rimini, Italy, ¹⁵Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ¹⁶A.O.U. di Cagliari, Cagliari, Italy, ¹⁷Ospedale Civile Maggiore, Verona, Italy, ¹⁸University of Perugia, Perugia, Italy, ¹⁹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²⁰Istituto Clinico Humanitas, Rozzano, Italy, ²¹Moriggia-Pelascini, Gravedona, Italy, ²²Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy, ²³A.O. Città della Salute e della Scienza di Torino, Turin, Italy, ²⁴Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ²⁵Rheumatology Unit, Department of Medicine, University of Padua, Padova, Italy, ²⁶Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, ²⁷University of Turin, Turin, Italy, ²⁸P.O. “Destra Secchia”, Pieve di Coriano, Italy, ²⁹Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ³⁰Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, ³¹University of Bari, Bari, Italy, ³²A.O. Rummo, Benevento, Italy, ³³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Background/Purpose Clinical remission is now an achievable goal in patients with rheumatoid arthritis (RA). Much has been done in order to better understand and define…
Abstract Number: 907 • 2014 ACR/ARHP Annual Meeting
Ultrasonographic Tenosynovitis Score Is Responsive to Biologic Treatment in Patients with Rheumatoid Arthritis
Hilde B. Hammer¹ and Tore K. Kvien², ¹Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

Background/Purpose: Ultrasound (US) is sensitive for detecting tenosynovitis in patients with rheumatoid arthritis (RA), where the synovitis can be assessed by grey scale (GS) and…
Abstract Number: 906 • 2014 ACR/ARHP Annual Meeting
How Long Does Sonographic Joint Activity Continue in Clinically Remittive Joints of Patients with Rheumatoid Arthritis?
Miriam Gärtner¹, Farideh Alasthi², Gabriela Supp¹, Peter Mandl², Josef Smolen¹ and Daniel Aletaha¹, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Devision of Rheumatology, Medical University of Vienna, Vienna, Austria
How long does sonographic joint activity continue in clinically remittive joints of patients with rheumatoid arthritis? M. Gärtner, F. Alasthi, G. Supp, P. Mandl, JS…
Abstract Number: 905 • 2014 ACR/ARHP Annual Meeting
First Step in the Development of an Ultrasound Joint Inflammation Score for Rheumatoid Arthritis: A Data Driven Approach
Anna-Birgitte Aga¹, Hilde Berner Hammer², Inge C. Olsen¹, Till Uhlig², Tore K. Kvien³, Désirée van der Heijde⁴, Elisabeth Lie³, Espen A. Haavardsholm⁵ and the Arctic study Group⁵, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, ³Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose The use of ultrasonography (US) in rheumatoid arthritis (RA) is rapidly increasing. Currently, there is no consensus regarding which joints and tendons should be…
Abstract Number: 904 • 2014 ACR/ARHP Annual Meeting
Ultrasound Synovitis Reflects Synovial Inflammation at a Histopathological Level
Nora Ng, Stephen Kelly, Frances Humby, Maria DiCicco, Vidalba Rocher, Rebecca Hands, Michele Bombardieri and Costantino Pitzalis, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: Ultrasound (US) is widely used by rheumatologists to assess inflammatory burden on patients with inflammatory arthritis. Some studies have shown that US measures of…
Abstract Number: 903 • 2014 ACR/ARHP Annual Meeting
Poor Adherence to Medications for Systemic Lupus Erythematosus Predicts Higher Health Care Utilization in U.S. Medicaid Beneficiaries
Jinoos Yazdany¹, Candace H. Feldman², Hongshu Guan³ and Karen H. Costenbader⁴, ¹Medicine, University of California, San Francisco, San Francisco, CA, ²Rheumatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Immunosuppressive and antimalarial drugs improve outcomes in systemic lupus erythematosus (SLE), including reducing disease activity, damage and mortality. Although prior studies have found…
Abstract Number: 902 • 2014 ACR/ARHP Annual Meeting
Co-Management for Children with JIA: A Survey of Primary Care Providers Regarding Current Practices and Willingness to Provide Services
Amanda Mroczek¹, Gary Freed² and Meredith Riebschleger¹, ¹Pediatric Rheumatology & Health Services Research, University of Michigan, Ann Arbor, MI, ²Pediatrics, University of Michigan, Ann Arbor, MI
Background/Purpose: Pediatric Rheumatology (PR) is among the smallest and least geographically accessible of the pediatric subspecialties. This problem may be addressed by utilizing the more…

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