Abstracts Archive - Page 2171 of 2607 - ACR Meeting Abstracts

Abstract Number: 926 • 2014 ACR/ARHP Annual Meeting
Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study
Feng Pan¹, Hussain Khan¹, Changhai Ding¹, Tania Winzenberg², Johanne Martel-Pelletier³, Jean-Pierre Pelletier³, Flavia Cicuttini⁴ and Graeme Jones¹, ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Genetic factors appear to play an important role in the pathogenesis of both knee pain and radiographic osteoarthritis (OA) based on cross-sectional studies but…
Abstract Number: 925 • 2014 ACR/ARHP Annual Meeting
Cortical Reorganization after Duloxetine Treatment-Related Pain Decrease in Knee Osteoarthritis
Pascal Tetreault¹, Marwan Baliki¹, Etienne Vachon-Presseau¹, Renita Evonne Yeasted², Thomas J. Schnitzer³ and A. Vania Apkarian^1,4, ¹Physiology, Northwestern University, Chicago, IL, ²PM&R, Northwestern University, Chicago, IL, ³PM&R and Int Med, Northwestern University, Chicago, IL, ⁴Anaesthesia and Surgery, Northwestern University, Chicago, IL
Background/Purpose: Structural brain properties of patients coping with chronic painful conditions are becoming better understood but knowledge on how pain treatment affects these properties is…
Abstract Number: 924 • 2014 ACR/ARHP Annual Meeting
Characteristics of Pain Flares in Knee Osteoarthritis
Susan L. Murphy¹, Angela K. Lyden², Arnold Gammaitoni³, David A. Williams⁴, Daniel J. Clauw⁵, J. Ryan Scott⁶ and Kristine Phillips⁷, ¹Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ²Department of Anesthesiology, University of Michigan, Ann Arbor, MI, ³Zogenix, Inc, San Diego, CA, ⁴Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, ⁵Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁶Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: For inclusion in osteoarthritis clinical trials, participants often need to have a pain ‘flare’, usually defined as a pain increase over a period of…
Abstract Number: 923 • 2014 ACR/ARHP Annual Meeting
Phenotypes of Osteoarthritis-Related Knee Pain and Their Transitions over Time: The Osteoarthritis Initiative
Na Lu¹, Tuhina Neogi¹, K. Douglas Gross², Jingbo Niu³, Hyon K. Choi⁴ and Yuqing Zhang¹, ¹Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: The WOMAC questionnaire is one of most commonly used instruments to assess knee pain in persons with or at risk of knee osteoarthritis (OA).…
Abstract Number: 922 • 2014 ACR/ARHP Annual Meeting
A Potential Role for TLR4 Activation in Osteoarthritis Associated Pain
Rachel E. Miller¹, Shingo Ishihara², Phuong Tran³, Richard J. Miller⁴ and Anne-Marie Malfait⁵, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁵Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose - Damage associated molecular patterns (DAMPs) result from cellular stress and extracellular matrix breakdown. They may contribute to osteoarthritis (OA) pathogenesis by promoting synovitis…
Abstract Number: 921 • 2014 ACR/ARHP Annual Meeting
Comparison of Infection Rates in Patients Receiving Denosumab, Denosumab and Biologics and Biologics Alone in a Suburban Rheumatology Clinic
Sajina Prabhakaran¹ and Charles Pritchard², ¹Drexel Rheumatology, Drexel University College of Medicine, Philadelphia, PA, ²Drexel University College of Medicine, Willow Grove, PA
Background/Purpose: Biologics including rituximab, abatacept and belimumab increase the risk of infection in patients. Denosumab, a RANK-ligand inhibitor used in the treatment of osteoporosis may…
Abstract Number: 920 • 2014 ACR/ARHP Annual Meeting
Randomized Controlled Trial to Assess the Safety and Efficacy of Odanacatib in the Treatment of Men with Osteoporosis
Eric Orwoll¹, Silvano Adami², Neil Binkley³, Roland Chapurlat⁴, Bente Langdahl⁵, Steven Doleckyj⁶, Hilde Giezek⁷, Boyd Scott⁸ and Arthur Santora⁸, ¹Oregon Health and Science University, Portland, OR, ²Rheumatology Department, University of Verona, Verona, Italy, ³University of Wisconsin, Madison, WI, ⁴Pavillon F Rheumatology, Hopital Edouard Herriot, Lyon, France, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Merck & Co., Inc., Whitehouse Station, NJ, ⁷MSD Belgium, Brussels, Belgium, ⁸Merck Sharp & Dohme Corp., Whitehouse Station, NJ
Background/Purpose Osteoporosis in men is an important clinical problem, associated with significant morbidity, mortality and societal expense. Men with osteoporosis represent between 20 and 25%…
Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Sanjay Garg¹, Dipak R. Patel² and Raymond Yung³, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Internal Med-Univ Michigan, University of Michigan, Ann Arbor, MI
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…
Abstract Number: 938 • 2014 ACR/ARHP Annual Meeting
C1q Is Mandatory for Disease Development in Experimental Arthritis and Expression of Its Receptors Correlates with Disease Activity in Patients
Matthieu Ribon¹, Julie Mussard¹, Roxane Herve¹, Marina Botto², Marie-Christophe Boissier³ and Patrice Decker¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²Centre for Complement & Inflammation Research, Imperial College, London, United Kingdom, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose The complement system is a major effector mechanism of innate and adaptive immunity. It is activated in rheumatoid arthritis (RA) patients but the pathway…
Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting
A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis
W. Alexander Stinson¹, Phillip L. Campbell¹, Jeffrey Ruth², Gautam Edhayan², Ray A. Ohara², Nicholas Lepore³, Alisa E. Koch⁴, David A. Fox² and M. Asif Amin², ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
Abstract Number: 936 • 2014 ACR/ARHP Annual Meeting
Active Invasion of Periodontal Bacteria into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice
Sasanka Chukkapalli¹, Mercedes Rivera-Kweh¹, Irina Velsko¹, Indraneel Bhattacharyya², S. John Calise³, Edward Chan⁴, Minoru Satoh⁵ and Lakshmyya Kesavalu¹, ¹Periodontology, College of Dentistry, University of Florida, Gainesville, FL, ²Oral Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, FL, ³Oral Biology, University of Florida, Gainesville, FL, ⁴Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, ⁵Clinical Nursing, Univ. Occupational and Environmental Health, Kitakyushu, Fukuoka, FL, Japan
Background/Purpose: Periodontitis (PD) is a chronic immunoinflammatory disease caused by complex subgingival periodontal bacteria. Rheumatoid Arthritis (RA) and PD both are chronic inflammatory disorders characterized…
Abstract Number: 935 • 2014 ACR/ARHP Annual Meeting
Targeting Glycolysis in Rheumatoid Arthritis
Monica Guma¹, Alessia Lodi², Ajit Divakaruni³, Anne Murphy³, Stefano Tiziani⁴ and Gary S. Firestein⁵, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²nutritional Sciences, University of Texas at Austin, Austin, TX, ³Pharmacology, University of California, San Diego, La Jolla, CA, ⁴Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁵Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Many of the signaling pathways activated in inflammation have a profound effect on cell metabolism. However, little is known about metabolome in rheumatoid arthritis…
Abstract Number: 934 • 2014 ACR/ARHP Annual Meeting
Amelioration of Inflammatory Arthritis By Anti-TNF Therapy Is Associated with Restoration of Lymphatic Contraction
Echoe M. Bouta¹, Igor Kuzin², Karen de Mesy-Bentley¹, Ronald Wood³, Homaira Rahimi⁴, Rui-Cheng Ji⁵, Christopher T. Ritchlin⁶, Andrea Bottaro², Lianping Xing⁷ and Edward M. Schwarz⁸, ¹University of Rochester, Rochester, NY, ²Cooper Medical School, Camden, NJ, ³Department of Urology, University of Rochester Medical Center, Rochester, NY, ⁴Rheumatology, University of Rochester/Golisano Children's Hospit, Rochester, NY, ⁵Department of Anatomy, Biology and Medicine, Oita University, Oita, Japan, ⁶Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁷Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁸Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with episodic flares. In tumor necrosis factor transgenic (TNF-Tg) mice, a model of inflammatory-erosive arthritis,…
Abstract Number: 933 • 2014 ACR/ARHP Annual Meeting
A Multi-Center, Double-Blind, Randomized-Withdrawal Trial of Subcutaneous Golimumab in Pediatric Patients with Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy: Week 48 Results
Hermine I. Brunner¹, Nicolino Ruperto², N Tzaribachev³, Gerd Horneff⁴, Carine Wouters⁵, Violeta Vladislava Panaviene⁶, Vyacheslav Chasnyk⁷, Carlos Abud-Mendoza⁸, Ruben Cuttica⁹, Andreas Reiff¹⁰, M Maldonado-Velázquez¹, Nadina Rubio-Pérez¹¹, Rik Joos¹², V Keltsev¹³, Evgeny Nasonov¹⁴, Daniel Kingsbury¹⁵, M Bandeira¹⁶, Earl Silverman¹⁷, F Weller-Heinemann¹¹, A van Royen-Kerkhof¹⁸, Alan M. Mendelsohn¹⁹, Lilianne Kim²⁰, Daniel Lovell²¹ and A Martini²², ¹PRCSG, Cincinnati, OH, ²Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy, ³PRINTO & PRCSG, Bramstedt, Germany, ⁴Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, ⁵Pediatric Rheumatology, University Hosp Gasthuisberg, Leuven, Belgium, ⁶Istituto Giannina Gaslini, Genoa, Italy, ⁷Litovskaya Str., 2, Novartis Pharma, Saint-Peterburg, Russia, ⁸Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁹Tilcara 3023, Hospital de Ninos Pedro de Elizalde, Capital Federal, Argentina, ¹⁰Children’s Hospital of Los Angeles, Los Angeles, CA, ¹¹PRINTO, Genoa, Italy, ¹²UZ Gent, Gent, Belgium, ¹³Paediatric Rheumatology International Trials Organisation–IRCCS [PRINTO], Genoa, Italy, ¹⁴State Institute of Rheumatology of RAMS, Moscow, Russia, ¹⁵Pediatric Rheumatology, Randall Children's Hospital at Legacy Emanuel, Portland, OR, ¹⁶Pediatrics, Hospital Infantil Pequeno Príncipe, Curitiba, Brazil, ¹⁷Division of Rheumatology, Hosp for Sick Children, Toronto, ON, Canada, ¹⁸Department of Pediatric Immunology & Rheumatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁹Immunology, Janssen Research & Development, LLC., Spring House, PA, ²⁰Janssen Research & Development, LLC., Spring House, PA, ²¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, ²²Istituto Gaslini-PRINTO, Genova, Italy
Background/Purpose: To assess efficacy and safety of SC golimumab (GLM) in polyarticular pediatric juvenile idiopathic arthritis pts (aged 2 to
Abstract Number: 932 • 2014 ACR/ARHP Annual Meeting
MRP8/14 Serum Level As Predictor of Response to Starting and Stopping Anti-TNF Treatment in Non-Systemic Juvenile Idiopathic Arthritis
Janneke Anink¹, Marieke H. Otten¹, Lisette W.A. van Suijlekom-Smit¹, Marion A.J. Van Rossum², Koert M. Dolman³, Esther P.A. Hoppenreijs⁴, Rebecca ten Cate⁵, Simona Ursu⁶, Lucy R Wedderburn⁷, Gerd Horneff⁸, Thomas Vogl^9,10, Dirk Föll^10,11, Johannes Roth^9,12 and Dirk Holzinger^10,13, ¹Pediatric Rheumatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands, ²Pediatric Rheumatology, Emma Kinderziekenhuis Academic Medical Center, Amsterdam, Netherlands, ³Pediatric Rheumatology, St. Lucas Andreas Hospital and Reade Institute, Amsterdam, Netherlands, ⁴Pediatric Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Pediatric Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁷Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁸Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, ⁹Immunology, Institute of Immunology University of Muenster, Muenster, Germany, ¹⁰Interdisciplinary Centre for Clinical Research IZKF, University Hospital Muenster, Muenster, Germany, ¹¹Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany, ¹²University Hospital Muenster, Muenster, Germany, ¹³Pediatric Rheumatology and Immunology, University Children’s Hospital Muenster, Muenster, Germany
Background/Purpose: Biological therapy has dramatically improved the treatment of patients with JIA. However, there is still a group of patients that shows a lack of…

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