Abstract Number: 988 • 2014 ACR/ARHP Annual Meeting
Serum CXCL13 As a Biomarker of Disease Activity and Severity in Rheumatoid Arthritis: Comparison with Acute Phase Reactants and the Autoantibody Profile
Background/Purpose The B cell chemoattractant CXCL13 has recently emerged as a new candidate biomarker of disease activity capable of identifying patients with persistent synovitis and…Abstract Number: 987 • 2014 ACR/ARHP Annual Meeting
Novel Auto-Antigen in Aortic Aneurysms of Large Vessel Vasculitis
Background/Purpose Large Vessel Vasculitides (LVV) are a group of autoimmune diseases characterized by injury and anatomic modifications of large vessels that may include the aorta…Abstract Number: 986 • 2014 ACR/ARHP Annual Meeting
Integrated Comprehensive Analysis of Immune Cell Subsets and Serum Protein Profile Identifies the Role of Pre-Germinal Center B Cells in Sjogren’s Syndrome Pathogenesis
Background/Purpose Whole blood flow cytometric analysis and serum protein profiling were commonly utilized to characterize disease-specific alterations in a wide variety of autoimmune diseases. However,…Abstract Number: 985 • 2014 ACR/ARHP Annual Meeting
Labial Salivary Gland Antibody-Secreting Cell Specificity and Characteristics in Sjögren’s Patients
Background/Purpose Studies were approved by the OMRF and the University of Oklahoma Health Sciences Center Institutional Review Boards. Samples and data were obtained from 9…Abstract Number: 984 • 2014 ACR/ARHP Annual Meeting
Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease
Background/Purpose Borrelia burgdorferi-induced autoimmunity in affected joints has been hypothesized to be a contributing factor to antibiotic-refractory Lyme arthritis (ARLA). Our prior study, which combined…Abstract Number: 983 • 2014 ACR/ARHP Annual Meeting
Identification of Annexin A2 As an Autoantigen in Rheumatoid Arthritis and in Lyme Arthritis
Background/Purpose Disease-associated HLA-DR molecules are the greatest genetic risk factor for rheumatoid arthritis (RA) and for antibiotic-refractory Lyme arthritis (LA). We have developed a novel…Abstract Number: 982 • 2014 ACR/ARHP Annual Meeting
Identification of Potential SERUM Autoantibody Biomarkers in Rheumatic Diseases Using a New Generation of Protein Arrays
Background/Purpose Osteoarthritis (OA) is characterized by the loss of structural components from the extracelullar matrix (ECM) of articular cartilage. The progressive release of proteins from…Abstract Number: 981 • 2014 ACR/ARHP Annual Meeting
The Effect of Compression Gloves in Hand Osteoarthritis: A Pre-Post-Test Trial
Background/Purpose: Compression gloves are used in Hand Osteoarthritis (HOA) to reduce pain (day and/or night), stiffness and improve hand function. A systematic review identified only…Abstract Number: 980 • 2014 ACR/ARHP Annual Meeting
Annual Medical Care Expenditures Among US Adults with Osteoarthritis, 2008 – 2011
Background/Purpose: As the US population ages, concerns continue to grow about the cost of medical treatment for osteoarthritis (OA). We estimated all-cause medical care expenditures…Abstract Number: 1000 • 2014 ACR/ARHP Annual Meeting
Pathogenic Role of CXC Chemokine receptor 3-Positive B Cells in Bone Destruction of Rheumatoid Arthritis
Background/Purpose ：B cells can function as potent effector cells by production of autoantibody, immune complex formation and inflammatory cytokines. Clinical efficacy of B-cell depletion therapy…Abstract Number: 999 • 2014 ACR/ARHP Annual Meeting
Microrna-155 As an Epigenetic Regulator of B-Cell Activation in Rheumatoid Arthritis: In Vivo and in Vitro Evidences
Background/Purpose: MicroRNAs (miRs) are a novel class of post-transcriptional regulators. miR-155 was shown to be a regulator of B cell biology in haematological diseases as…Abstract Number: 998 • 2014 ACR/ARHP Annual Meeting
β2 Adrenoceptor Signal Is Augmented in B Cells in the Course of Arthritis to Increase IL-10
Background/Purpose Splenic B cells from collagen-induced arthritis (CIA) mice react to a β2-adrenoceptor (AR) stimulus with increased IL-10 production and adoptive transfer of these cells…Abstract Number: 997 • 2014 ACR/ARHP Annual Meeting
Explore Translational Pharmacokinetics/Pharmacodynamics Response/Efficacy Relationship of a Novel Bruton’s Tyrosine Kinase Inhibitor in Rat Collagen-Induced Arthritis Model
Background/Purpose: Abnormal B cell activation is an essential part of autoimmune inflammation. B cell depletion is proven to be an efficacious treatment in patients as…Abstract Number: 996 • 2014 ACR/ARHP Annual Meeting
Memory B Cell Subtype Modulation in Patients with Rheumatoid Arthritis
Background/Purpose . Memory B cells have been shown to play important roles in the pathogenesis of rheumatoid arthritis (RA). With the advent of B cell…Abstract Number: 995 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients Have Alterations in Inherently Autoreactive 9G4+ B-Cell Subpopulations in Peripheral Blood
Background/Purpose B-cells utilizing the VH-region immunoglobulin gene VH4-34 produce natural autoreactive antibodies. The rat monoclonal antibody 9G4 recognizes B-cells with VH4-34-encoded B-cell receptors (9G4+ B-cells)…
ACR Meeting Abstracts